Genomes and Genes
S D Yan
Affiliation: Columbia University
- An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's diseaseS D Yan
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Nature 389:689-95. 1997..By interacting with intracellular amyloid-beta, ERAB may therefore contribute to the neuronal dysfunction associated with Alzheimer's disease...
- RAGE is a key cellular target for Abeta-induced perturbation in Alzheimer's diseaseShirley ShiDu Yan
Department of Surgery, Physicians and Surgeons College of Columbia University, New York, NY 10032, USA
Front Biosci (Schol Ed) 4:240-50. 2012..Blockade of RAGE significantly attenuates neuronal and synaptic injury. In this review, we summarize the role of RAGE in the pathogenesis of AD, specifically in Abeta-induced cellular perturbation...
- Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous systemShirley ShiDu Yan
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York, USA
Nat Med 9:287-93. 2003..These data reinforce the importance of RAGE-ligand interactions in modulating properties of CD4+ T cells that infiltrate the CNS...
- Mitochondrial dysfunction and Alzheimer's disease: role of amyloid-beta peptide alcohol dehydrogenase (ABAD)Shi Du Yan
Departments of Pathology, Surgery, Taub Institute for Research on Alzheimer s Disease and the Ageing Brain, College of Physicians and Surgeons of Columbia University, 650 West 168th Street, Black Building Rm 17 01, New York, NY 10032, USA
Int J Exp Pathol 86:161-71. 2005..These data suggest that mitochondria ABAD, ordinarily a contributor to metabolic homeostasis, has the capacity to become a pathogenic factor in an Abeta-rich environment...
- Amyloid beta -peptide-binding alcohol dehydrogenase is a component of the cellular response to nutritional stressS Du Yan
Departments of Pathology, Surgery, Physiology and Cellular Biophysics, Neurosurgery and Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
J Biol Chem 275:27100-9. 2000..These data suggest that ABAD contributes to the protective response to metabolic stress, especially in the setting of ischemia...
- Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosisS D Yan
Departments of Pathology, Physiology, and Surgery, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Nat Med 6:643-51. 2000..Antagonizing RAGE suppressed cell stress and amyloid deposition in mouse spleens. These data indicate that RAGE is a potential target for inhibiting accumulation of amyloid A and for limiting cellular dysfunction induced by amyloid A...
- Role of ERAB/L-3-hydroxyacyl-coenzyme A dehydrogenase type II activity in Abeta-induced cytotoxicityS D Yan
Departments of Pathology, Physiology and Surgery, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
J Biol Chem 274:2145-56. 1999..We conclude that the generalized alcohol dehydrogenase activity of ERAB/HADH II is central to the cytotoxicity observed in an Abeta-rich environment...
- RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's diseaseS D Yan
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York 10032, USA
Nature 382:685-91. 1996..Increased expressing of RAGE in Alzheimer's disease brain indicates that it is relevant to the pathogenesis of neuronal dysfunction and death...
- RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic diseaseL G Bucciarelli
College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Cell Mol Life Sci 59:1117-28. 2002..Implications for the role of these ligands interacting with RAGE in homeostasis and disease will be considered...
- Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissuesJ Brett
Department of Physiology and Cellular Biophysics and Surgery, Columbia University, College of Physicians and Surgeons, New York, New York 10032
Am J Pathol 143:1699-712. 1993....
- RAGE-Abeta interactions in the pathophysiology of Alzheimer's diseaseS D Yan
Department of Pathology, Surgery, Medicine and Physiology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Restor Neurol Neurosci 12:167-73. 1998..Taken together, our data suggest that RAGE-Abeta interactions play an important role in the pathophysiology of Alzheimer's Disease...
- Expression of Egr-1 in late stage emphysemaW Zhang
Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York, USA
Am J Pathol 157:1311-20. 2000....
- RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's diseaseFang Fang
P and S 17 410, Department Surgery, College of Physicians and Surgeons, Columbia University, 630 West 168th St, New York, NY 10032, USA
FASEB J 24:1043-55. 2010..G., Stern, D. M., Yan, S., Schmidt, A. M., Chen, J. X., Yan, S. S. RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease...
- Preventing activation of receptor for advanced glycation endproducts in Alzheimer's diseaseL F Lue
Laboratory of Neurovascular Inflammation, Sun Health Research Institute, Sun City, AZ 85351, USA
Curr Drug Targets CNS Neurol Disord 4:249-66. 2005..The potential for targeting RAGE mechanisms as therapeutic strategies for AD will be discussed...
- Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endotheliumRanjit Giri
Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
Am J Physiol Cell Physiol 283:C895-904. 2002..We suggest that Abeta in the AD brain parenchyma or cerebrovasculature initiates cellular signaling that induces PBM to transmigrate across the BBB and accumulate in the brain...
- Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitroL F Lue
Sun Health Research Institute, Sun City, Arizona 85372, USA
Glia 35:72-9. 2001..Taken together with previous in situ hybridization findings, these results demonstrate unequivocally that elderly human microglia provide a brain endogenous source for a wide range of inflammatory mediators...
- Recognition of structurally diverse substrates by type II 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD)A J Powell
Department of Biochemistry, University of Bristol, Bristol, UK
J Mol Biol 303:311-27. 2000....
- The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosiT Miyata
Department of Internal Medicine, Branch Hospital, Nagoya University School of Medicine, Japan
J Clin Invest 98:1088-94. 1996....
- Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteinsM Neeper
Department of Cellular and Molecular Biology, Merck Sharp and Dohme Research Laboratories, West Point, Pennsylvania 19486
J Biol Chem 267:14998-5004. 1992..These results suggest that RAGE functions as a cell surface receptor for AGEs, which could potentially mediate cellular effects of this class of glycosylated proteins...
- Chronic aminoguanidine attenuates renal dysfunction and injury in aging ratsJ F Reckelhoff
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505, USA
Am J Hypertens 12:492-8. 1999..These findings suggest that aminoguanidine attenuates aging renal dysfunction by inhibiting a pathophysiologic function of iNOS that is independent of free radical-mediated lipid peroxidation or significant effects on AGE deposition...
- ERAB, A BETA, NEUROTOXICITY AND ALZHEIMERS DISEASEShi Du Yan; Fiscal Year: 2003..abstract_text> ..
- The Role of RAGE and EAEShi Du Yan; Fiscal Year: 2005....