Affiliation: Columbia University
- Obesity-related leptin regulates Alzheimer's AbetaDarius C Fewlass
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
FASEB J 18:1870-8. 2004..Thus, leptin can modulate bidirectional Abeta kinesis, reducing its levels extracellularly. Most strikingly, chronic administration of leptin to AD-transgenic animals reduced the brain Abeta load, underlying its therapeutic potential...
- Calcium oscillations in type-1 astrocytes, the effect of a presenilin 1 (PS1) mutationJane M Johnston
Department of Pharmacology and Physiology, Medical Sciences Building, University of Medicine, Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07103 2714, USA
Neurosci Lett 395:159-64. 2006..This indicates that PS1 mutation may introduce aberrations in the intracellular Ca2+ mobilization in astrocytes contributing to the accelerated pathogenesis in FAD...
- Microtubular interactions of presenilin direct kinesis of Abeta peptide and its precursorsNikolaos Tezapsidis
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, P and S 15 408, 630 W 168th St, New York, NY 10032, USA
FASEB J 17:1322-4. 2003..However, this approach may be hampered by a low efficiency, because it may also block Abeta clearance from the interstitial space of the CNS...
- Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cellsSteven J Greco
Neurotez Inc, Bridgewater, NJ, USA
Biochem Biophys Res Commun 376:536-41. 2008..Thus, leptin, which ameliorates both amyloid beta and tau-related pathological pathways, holds promise as a novel therapeutic for Alzheimer's disease...