Affiliation: Columbia University
- School-based intervention acutely improves insulin sensitivity and decreases inflammatory markers and body fatness in junior high school studentsMichael Rosenbaum
New York Presbyterian Hospital, New York, New York 10032, USA
J Clin Endocrinol Metab 92:504-8. 2007..Risk factors for type 2 diabetes mellitus (T2DM) include obesity, family history, dyslipidemia, a proinflammatory state, impaired insulin secretory capacity, and insulin resistance...
- Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormonesMichael Rosenbaum
Columbia University, New York, New York, USA
J Clin Endocrinol Metab 87:2391-4. 2002..These data indicate that decrease leptin concentrations resulting from loss of fat mass account for some aspects of the endocrine/metabolic phenotype associated with the weight-reduced state...
- 20 years of leptin: role of leptin in energy homeostasis in humansMichael Rosenbaum
Division of Molecular GeneticsDepartments of Pediatrics and Medicine, College of Physicians and Surgeons, Columbia University, Russ Berrie Medical Science Pavilion, 6th Floor, 1150 St Nicholas Avenue, New York, New York 10032, USA
J Endocrinol 223:T83-96. 2014..Leptin, and pharmacotherapies affecting leptin signaling pathways, is likely to be most useful in sustaining weight loss. ..
- Racial/ethnic differences in clinical and biochemical type 2 diabetes mellitus risk factors in childrenMichael Rosenbaum
Pediatrics Department, New York Presbyterian Hospital Columbia University Medical Center, New York, New York, USA
Obesity (Silver Spring) 21:2081-90. 2013....
- Altered glucose disposition and insulin sensitivity in peri-pubertal first-degree relatives of women with polycystic ovary syndromeNouhad Raissouni
Division of Pediatric Endocrinology at Infants and Children s Hospital of Brooklyn at Maimonides and SUNY Downstate Medical Center, 1068 48th St, Brooklyn, NY, 11219, USA
Int J Pediatr Endocrinol 2012:14. 2012..First-degree relatives (FDRs) of women with PCOS are at increased risk for impaired insulin sensitivity and diabetes mellitus. Glucose tolerant FDR have evidence of insulin resistance and hyperinsulinemia prior to emergence of frank PCOS...
- Brain reorganization following weight lossMichael Rosenbaum
Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Nestle Nutr Inst Workshop Ser 73:1-20. 2012..Brain responses to food and the observed changes in energy expenditure that occur during maintenance of a reduced weight are largely reversed by the administration of the adipocyte-derived hormone, leptin. ...
- Epidemiology of pediatric obesityMichael Rosenbaum
New York Presbyterian Hospital, Columbia University College of Physicians and Surgeons, New York, USA
Pediatr Ann 36:89-95. 2007
- Effects of weight loss and leptin on skeletal muscle in human subjectsKenneth M Baldwin
Department of Physiology and Biophysics, School of Medicine, University of California at Irvine, Irvine, California, USA
Am J Physiol Regul Integr Comp Physiol 301:R1259-66. 2011..These findings are consistent with the leptin-reversible increase in skeletal muscle chemomechanical work efficiency and decrease in the ratio of glycolytic/oxidative enzyme activities observed in subjects following dietary weight loss...
- Adaptive thermogenesis in humansM Rosenbaum
Division of Molecular Genetics, Department of Pediatrics, Columbia University, College of Physicians and Surgeons, New York, NY, USA
Int J Obes (Lond) 34:S47-55. 2010..Important inferences can be drawn for therapeutic strategies by recognizing obesity as a disease in which the human body actively opposes the 'cure' over long periods of time beyond the initial resolution of symptomatology...
- Energy intake in weight-reduced humansMichael Rosenbaum
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Brain Res 1350:95-102. 2010..Much of this biological opposition to sustained weight loss is mediated by the adipocyte-derived hormone "leptin."..
- Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weightMichael Rosenbaum
Columbia University College of Physicians and Surgeons, New York Presbyterian Medical Center, New York, NY 10032, USA
Am J Clin Nutr 88:906-12. 2008..An important clinical issue is whether this reduction, which predisposes to weight regain, persists over time...
- Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuliMichael Rosenbaum
Department of Pediatrics, Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University Medical Center New York Presbyterian Medical Center, New York, New York, USA
J Clin Invest 118:2583-91. 2008..These data are consistent with a model of the weight-reduced state as one of relative leptin deficiency...
- Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weightMichael Rosenbaum
Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Clin Invest 115:3579-86. 2005..These responses suggest that the weight-reduced state may be regarded as a condition of relative leptin insufficiency. Prevention of weight regain might be achievable by strategies relevant to reversing this leptin-insufficient state...
- beta-Cell function and insulin sensitivity in early adolescence: association with body fatness and family history of type 2 diabetes mellitusMichael Rosenbaum
Department of Pediatrics, New York Presbyterian Medical Center, New York, New York 10032, USA
J Clin Endocrinol Metab 89:5469-76. 2004..These findings are consistent with a model for the physiology of T2DM in which a familial beta-cell dysfunction is unmasked by increasing insulin resistance secondary to overweight in this predominantly Latino population...
- Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjectsMichael Rosenbaum
Div of Molecular Genetics, Russ Berrie Medical Science Pavilion, 6th Fl, 1150 St Nicholas Ave, New York, NY 10032, USA
Am J Physiol Regul Integr Comp Physiol 285:R183-92. 2003..8 (20.5)%, P = 0.043]. Changes in muscle efficiency at altered body weight accounted for 35% of the change in daily energy expended in physical activity...
- Sexual dimorphism in circulating leptin concentrations is not accounted for by differences in adipose tissue distributionM Rosenbaum
Division of Molecular Genetics, Columbia University College of Physicians and Surgeons, New York, USA
Int J Obes Relat Metab Disord 25:1365-71. 2001..Gender-related differences in the relative amounts of SAT and VAT may account for the greater circulating leptin concentration relative to fat-mass in females than males...
- Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid functionM Rosenbaum
Rockefeller University, The Laboratory of Human Behavior and Metabolism, New York, NY, USA
Am J Clin Nutr 71:1421-32. 2000..Weight gain and loss increases and decreases energy expenditure, respectively, out of proportion to changes in metabolic mass...
- Effects of weight change on plasma leptin concentrations and energy expenditureM Rosenbaum
Laboratory of Human Behaviour and Metabolism, Rockefeller University, New York, New York 10021, USA
J Clin Endocrinol Metab 82:3647-54. 1997....
- Effects of experimental weight perturbation on skeletal muscle work efficiency, fuel utilization, and biochemistry in human subjectsRochelle Goldsmith
Department of Medicine, Division of Exercise Physiology, New York, New York, USA
Am J Physiol Regul Integr Comp Physiol 298:R79-88. 2010....
- Metabolic and hemodynamic responses to exercise in subcutaneous adipose tissue and skeletal muscleM Boschmann
Laboratory of Human Behavior and Metabolism, The Rockefeller University, New York, USA
Int J Sports Med 23:537-43. 2002..It is concluded that lipids stored in muscle are rather used than lipids stored in adipose tissue for fueling the energy metabolism of muscle during exercise. During exercise, lipid mobilization is much greater in women than in men...
- Effects of chronic weight perturbation on energy homeostasis and brain structure in miceY Ravussin
1Department of Pediatrics, Division of Molecular Genetics, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Am J Physiol Regul Integr Comp Physiol 300:R1352-62. 2011..The mouse model described here could help to identify the molecular/cellular mechanisms underlying both the defense mechanisms against sustained weight loss and the upward resetting of those mechanisms following sustained weight gain...
- Sexual dimorphism in the energy content of weight changeA Pietrobelli
New York Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University Institute of Human Nutrition, College of Physicians and Surgeons, New York, USA
Int J Obes Relat Metab Disord 26:1339-48. 2002..The energy content of weight change is assumed to be sex- and age-neutral at 3,500 kcal/pound or 32.2 MJ/kg...
- Diet composition and energy balance in humansJ Hirsch
Laboratory of Human Behavior and Metabolism, The Rockefeller University, New York, NY 10021 6399, USA
Am J Clin Nutr 67:551S-555S. 1998..The reverse occurred with a reduction in body weight. The set point at which energy storage is defended is clearly different in obese persons...
- Relationship between energy balance and complications after subarachnoid hemorrhageNeeraj Badjatia
Departments of Neurology, Neurosurgery, and Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY, USA
JPEN J Parenter Enteral Nutr 34:64-9. 2010..Subarachnoid hemorrhage patients are hypermetabolic and at risk for developing medical complications. A relationship was hypothesized between energy balance and complications following subarachnoid hemorrhage...
- Obesity is associated with macrophage accumulation in adipose tissueStuart P Weisberg
Division of Moleuclar Genetics, Department of Pediatrics, Columbia University, New York, New York 10032, USA
J Clin Invest 112:1796-808. 2003..Adipose tissue macrophage numbers increase in obesity and participate in inflammatory pathways that are activated in adipose tissues of obese individuals...