Charles A Powell

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Oligonucleotide microarray analysis of lung adenocarcinoma in smokers and nonsmokers identifies GPC3 as a potential lung tumor suppressor
    Charles A Powell
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Chest 121:6S-7S. 2002
  2. ncbi request reprint The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor
    Han Kim
    Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, 630 West 168th Street, Box 91, New York, New York 10032, USA
    Am J Respir Cell Mol Biol 29:694-701. 2003
  3. pmc Tgf-beta signaling pathway in lung adenocarcinoma invasion
    Rebecca L Toonkel
    Division of Pulmonary and Critical Care Medicine, Columbia University Medical Center, New York, NY, USA
    J Thorac Oncol 5:153-7. 2010
  4. doi request reprint Progression of human bronchioloalveolar carcinoma to invasive adenocarcinoma is modeled in a transgenic mouse model of K-ras-induced lung cancer by loss of the TGF-β type II receptor
    Alain C Borczuk
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Cancer Res 71:6665-75. 2011
  5. ncbi request reprint Utility of CD138 (syndecan-1) in distinguishing carcinomas from mesotheliomas
    Anjali Saqi
    Department of Pathology, New York Presbyterian Hospital, Columbia University Medical Center, NY 10032, USA
    Diagn Cytopathol 33:65-70. 2005
  6. ncbi request reprint Expression of syndecan-1 and expression of epidermal growth factor receptor are associated with survival in patients with nonsmall cell lung carcinoma
    Lori Shah
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cancer 101:1632-8. 2004
  7. ncbi request reprint Non-small cell lung cancer molecular profiles are associated with lung development
    Alain C Borczuk
    Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Chest 125:115S-6S. 2004
  8. doi request reprint International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society: international multidisciplinary classification of lung adenocarcinoma: executive summary
    William D Travis
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Am Thorac Soc 8:381-5. 2011
  9. doi request reprint Lysyl oxidase: a lung adenocarcinoma biomarker of invasion and survival
    May Lin Wilgus
    Division of Pulmonary, Allergy and Critical Care, Columbia University Medical Center, New York, New York, USA
    Cancer 117:2186-91. 2011
  10. ncbi request reprint Expression profiling and lung cancer development
    Alain C Borczuk
    Department of Pathology and Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Proc Am Thorac Soc 4:127-32. 2007

Detail Information

Publications42

  1. ncbi request reprint Oligonucleotide microarray analysis of lung adenocarcinoma in smokers and nonsmokers identifies GPC3 as a potential lung tumor suppressor
    Charles A Powell
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Chest 121:6S-7S. 2002
  2. ncbi request reprint The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor
    Han Kim
    Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, 630 West 168th Street, Box 91, New York, New York 10032, USA
    Am J Respir Cell Mol Biol 29:694-701. 2003
    ..These findings suggest that GPC3 is a candidate lung tumor suppressor gene whose expression may be regulated by exposure to cigarette smoke and functions to modulate cellular response to exogenous damage...
  3. pmc Tgf-beta signaling pathway in lung adenocarcinoma invasion
    Rebecca L Toonkel
    Division of Pulmonary and Critical Care Medicine, Columbia University Medical Center, New York, NY, USA
    J Thorac Oncol 5:153-7. 2010
    ..Taken together, these studies illustrate how information gained from global expression profiling of tumors can be used to identify key pathways and genes mediating tumor growth, invasion, and metastasis...
  4. doi request reprint Progression of human bronchioloalveolar carcinoma to invasive adenocarcinoma is modeled in a transgenic mouse model of K-ras-induced lung cancer by loss of the TGF-β type II receptor
    Alain C Borczuk
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Cancer Res 71:6665-75. 2011
    ....
  5. ncbi request reprint Utility of CD138 (syndecan-1) in distinguishing carcinomas from mesotheliomas
    Anjali Saqi
    Department of Pathology, New York Presbyterian Hospital, Columbia University Medical Center, NY 10032, USA
    Diagn Cytopathol 33:65-70. 2005
    ..It should be an integral component of the epithelial-mesothelial antibody panel...
  6. ncbi request reprint Expression of syndecan-1 and expression of epidermal growth factor receptor are associated with survival in patients with nonsmall cell lung carcinoma
    Lori Shah
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cancer 101:1632-8. 2004
    ..They hypothesized that genetic classifiers of histology would provide insight into lung tumorigenesis and would be associated with clinical outcome when evaluated in a broader set of specimens...
  7. ncbi request reprint Non-small cell lung cancer molecular profiles are associated with lung development
    Alain C Borczuk
    Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Chest 125:115S-6S. 2004
  8. doi request reprint International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society: international multidisciplinary classification of lung adenocarcinoma: executive summary
    William D Travis
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Am Thorac Soc 8:381-5. 2011
    ..The American Thoracic Society is a cosponsor of a newly published lung adenocarcinoma classification...
  9. doi request reprint Lysyl oxidase: a lung adenocarcinoma biomarker of invasion and survival
    May Lin Wilgus
    Division of Pulmonary, Allergy and Critical Care, Columbia University Medical Center, New York, New York, USA
    Cancer 117:2186-91. 2011
    ..The authors hypothesized that LOX expression is associated with extent of invasion and survival in patients with lung adenocarcinoma...
  10. ncbi request reprint Expression profiling and lung cancer development
    Alain C Borczuk
    Department of Pathology and Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Proc Am Thorac Soc 4:127-32. 2007
    ....
  11. ncbi request reprint Clinical predictors of metastatic disease to the brain from non-small cell lung carcinoma: primary tumor size, cell type, and lymph node metastases
    Amol Mujoomdar
    Department of Radiology, Columbia University Medical Center, New York, NY, USA
    Radiology 242:882-8. 2007
    ..To retrospectively assess possible clinical predictors of metastatic disease to the brain in patients with non-small cell lung carcinoma (NSCLC)...
  12. ncbi request reprint Epigenetic inactivation of Betaig-h3 gene in human cancer cells
    Genze Shao
    Center for Radiological Research and Department of Pathology, Columbia University, New York, New York 10032, USA
    Cancer Res 66:4566-73. 2006
    ..These results suggest that promoter methylation plays a critical role in promoter silencing of the Betaig-h3 gene in human tumor cells...
  13. pmc Lung adenocarcinoma global profiling identifies type II transforming growth factor-beta receptor as a repressor of invasiveness
    Alain C Borczuk
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Respir Crit Care Med 172:729-37. 2005
    ..Lung adenocarcinoma histology and clinical outcome are heterogeneous and associated with tumor invasiveness...
  14. pmc Invasive size is an independent predictor of survival in pulmonary adenocarcinoma
    Alain C Borczuk
    Department of Surgical Pathology, Columbia University Medical Center, New York, NY 10032, USA
    Am J Surg Pathol 33:462-9. 2009
    ..In conclusion, among lung adenocarcinomas, histologic assessment of invasive growth may provide valuable prognostic information, and tumors with invasion under 0.6 cm have a more indolent clinical course after resection...
  15. ncbi request reprint Molecular signatures in biopsy specimens of lung cancer
    Alain C Borczuk
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Respir Crit Care Med 170:167-74. 2004
    ..The procedures are safe and feasible; the efficacy and utility of this strategy will ultimately be determined by prospective clinical trials...
  16. ncbi request reprint Class prediction of lung nodule gene expression profiles
    Kristin L Walter
    Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Chest 125:104S. 2004
  17. pmc PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells
    Haiying Cheng
    Department of Medicine, Division of Hematology Oncology, Herbert Irving Comprehensive Cancer Center, New York Presbyterian Hospital Columbia University Medical Center, New York, NY 10032, USA
    Carcinogenesis 34:739-49. 2013
    ....
  18. doi request reprint Thymidylate synthase expression and molecular alterations in adenosquamous carcinoma of the lung
    Catherine Shu
    Department of Internal Medicine, New York Presbyterian Hospital Columbia University Medical Center, New York, NY, USA
    Mod Pathol 26:239-46. 2013
    ....
  19. doi request reprint The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification
    William D Travis
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York Dept d Anatomie et Cytologie Pathologiques, CHU Albert Michallon, University Joseph Fourier INSERM U823 Institut Albert Bonniot, Grenoble, France Department of Pathology, Royal Brompton Hospital, London, United Kingdom Department of Pathology, Aichi Cancer Center, Nagoya, Japan Department of Radiology, Columbia University Medical Center, New York, New York Department of Pathology, Ichan School of Medicine at Mt Sinai, New York, New York Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania Sullivan Nicolaides Pathology, The John Flynn Hospital, Tugun, Queensland, Australia Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi University of Colorado Cancer Center UCHSC, Aurora, Colorado Department of Pathology, The JFCR Cancer Institute, Tokyo, Japan Department of Pathology, Aberdeen Royal Infirmary, Aberdeen, Scotland
    J Thorac Oncol 10:1243-60. 2015
    ..to sclerosing pneumocytoma, (10) changing the name hamartoma to "pulmonary hamartoma," (11) creating a group of PEComatous tumors that include (a) lymphangioleiomyomatosis, (b) PEComa, benign (with clear cell tumor as a variant) and ..
  20. ncbi request reprint Gene expression in lung adenocarcinomas of smokers and nonsmokers
    Charles A Powell
    Department of Medicine, Columbia College of Physicians and Surgeons, New York, New York, USA
    Am J Respir Cell Mol Biol 29:157-62. 2003
    ..Our findings, although limited by small sample size, suggest that additional studies comparing noninvolved to tumor tissue may identify pathogenetic mechanisms and therapeutic targets that differ in AC of smokers and nonsmokers...
  21. pmc Non-small-cell lung cancer molecular signatures recapitulate lung developmental pathways
    Alain C Borczuk
    Department of Pathology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Am J Pathol 163:1949-60. 2003
    ..The identification of developmentally regulated pathways active in tumorigenesis provides insights into lung carcinogenesis and suggests early steps may differ according to the eventual tumor morphology...
  22. ncbi request reprint 17HSD 2 may be higher in African-American breast cancer and is associated with estrogen receptor-negative tumors
    Rona Yaeger
    Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Cancer Genomics Proteomics 4:341-8. 2007
    ..African-American women develop more aggressive breast cancers and at an earlier age compared with Caucasian women...
  23. ncbi request reprint CDX2 immunostaining as a gastrointestinal marker: expression in lung carcinomas is a potential pitfall
    Robert M Mazziotta
    Department of Pathology, Vanderbilt Clinic, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Appl Immunohistochem Mol Morphol 13:55-60. 2005
    ....
  24. pmc Genomics of lung cancer
    Alain C Borczuk
    Department of Pathology, Columbia University College of Physicaians and Surgeons, New York, New York, USA
    Proc Am Thorac Soc 6:152-8. 2009
    ..This review focuses on recent research using genomics to examine lung carcinogenesis, histologic differentiation, and progression...
  25. pmc Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD
    Seungyeul Yoo
    Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, New York, United States of America Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Genet 11:e1004898. 2015
    ....
  26. pmc Acquisition and processing of endobronchial ultrasound-guided transbronchial needle aspiration specimens in the era of targeted lung cancer chemotherapy
    William Bulman
    Division of Pulmonary and Critical Care Medicine, Columbia University Medical Center, New York, New York, USA
    Am J Respir Crit Care Med 185:606-11. 2012
    ....
  27. ncbi request reprint P16 loss and mitotic activity predict poor survival in patients with peritoneal malignant mesothelioma
    Alain C Borczuk
    Department of Pathology, Columbia University Medical Center, and the Columbia University Mesothelioma Center, New York, New York 10032, USA
    Clin Cancer Res 11:3303-8. 2005
    ..We hypothesized that pathologic variables would stratify patients into favorable and unfavorable survival subgroups...
  28. ncbi request reprint Patterns of allelic loss differ in lung adenocarcinomas of smokers and nonsmokers
    Charles A Powell
    Department of Medicine, Columbia College of Physicians and Surgeons, New York, NY, USA
    Lung Cancer 39:23-9. 2003
    ..Our results suggest that the early steps of lung carcinogenesis differ in nonsmokers compared with smokers. In addition, the chromosomal sites of LOH may identify genes important for lung carcinogenesis in nonsmokers...
  29. pmc International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma
    William D Travis
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Thorac Oncol 6:244-85. 2011
    ....
  30. doi request reprint Molecular testing in lung cancer: the time is now
    Haiying Cheng
    Division of Hematology Oncology, New York Presbyterian Hospital, Columbia University Medical Center, New York, NY 10032, USA
    Curr Oncol Rep 12:335-48. 2010
    ....
  31. pmc Molecular biology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines
    Serge Patrick Nana-Sinkam
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Ohio State University, Columbus, OH, USA
    Chest 143:e30S-9S. 2013
    ..We focus on research developments in the understanding of lung cancer somatic DNA mutations, chromosomal aberrations, epigenetics, and the tumor microenvironment, and how they can advance diagnostics and therapeutics...
  32. pmc Plasma carbonyls do not correlate with lung function or computed tomography measures of lung density in older smokers
    Sonia Mesia-Vela
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Biomarkers 13:422-34. 2008
    ..Plasma carbonyl content is a poor biomarker of oxidative stress in COPD and emphysema...
  33. pmc Patients rate physician communication about lung cancer
    Judith E Nelson
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Cancer 117:5212-20. 2011
    ..In this study, the authors evaluated communication with patients at all stages across multiple topics...
  34. ncbi request reprint Structural emphysema does not correlate with lung compliance: lessons from the mouse smoking model
    Robert F Foronjy
    Department of Medicine, Division of Molecular Medicine and Pulmonary Medicine, Columbia University, New York, USA
    Exp Lung Res 31:547-62. 2005
    ..This lack of correlation suggests that the mechanisms involved in anatomic emphysema may be distinct from those that cause the loss of elastic recoil...
  35. pmc MODMatcher: multi-omics data matcher for integrative genomic analysis
    Seungyeul Yoo
    Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
    PLoS Comput Biol 10:e1003790. 2014
    ..We further demonstrate that MODMatcher can be broadly applied to large genomic data sets containing multiple types of omics data, such as The Cancer Genome Atlas (TCGA) data sets. ..
  36. pmc Outcomes after Stereotactic Body Radiotherapy versus Limited Resection in Older Patients with Early-Stage Lung Cancer
    Nicole Ezer
    Department of Medicine, Respiratory Division and Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, Canada and Division of General Internal Medicine, Department of Radiation Oncology, and Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York
    J Thorac Oncol 10:1201-6. 2015
    ..Limited resection and stereotactic body radiotherapy (SBRT) have emerged as treatment options for older patients with early-stage non-small-cell lung cancer (NSCLC), who are not good candidates for lobectomy...
  37. pmc Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition
    Chi Ming Li
    Institute for Cancer Genetics, Columbia University, New York, New York, USA
    Am J Pathol 160:2181-90. 2002
    ..The WT-signature set also contained the Wnt receptor FZD7, the tumor antigen PRAME, the imprinted gene NNAT and the metastasis-associated transcription factor E1AF...
  38. pmc Update in lung cancer 2006
    Sarita Dubey
    Division of Hematology and Oncology, University of California, San Francisco, CA, USA
    Am J Respir Crit Care Med 175:868-74. 2007
  39. ncbi request reprint Combined endodontic-periodontic treatment of a palatal groove: a case report
    Scott A Schwartz
    Department of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    J Endod 32:573-8. 2006
    ....
  40. ncbi request reprint A 10-gene classifier for distinguishing head and neck squamous cell carcinoma and lung squamous cell carcinoma
    Anil Vachani
    University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 13:2905-15. 2007
    ..The distinction between a lung metastasis and a primary LSCC is currently based on certain clinical and histologic criteria, although the accuracy of this approach remains in question...
  41. pmc Update in lung cancer 2007
    Sarita Dubey
    Division of Hematology and Oncology, University of California, San Francisco, San Francisco, California, USA
    Am J Respir Crit Care Med 177:941-6. 2008
  42. pmc No effect of cigarette smoking dose on oxidized plasma proteins
    Chih Ching Yeh
    Department of Health Risk Management, China Medical University College of Public Health, Taichung, Taiwan
    Environ Res 106:219-25. 2008
    ..Our results indicate that the measurement of plasma carbonyls by this ELISA technique is still an easy and suitable method for studies of diseases related to oxidative stress...