Affiliation: Columbia University
- Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intakeManuela A Orjuela
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA
Cancer 118:5912-9. 2012..Maternal intake of naturally occurring folate from vegetables during pregnancy is associated inversely with the risk of retinoblastoma in offspring...
- Urinary naphthol metabolites and chromosomal aberrations in 5-year-old childrenManuela A Orjuela
Department of Pediatrics, Columbia University, New York, NY 10032, USA
Cancer Epidemiol Biomarkers Prev 21:1191-202. 2012..Although prenatal (maternal) PAH exposure predicts chromosomal aberrations in cord blood, few studies have examined chromosomal aberrations in school-age children and none has examined their association with metabolites of specific PAHs...
- Fruit and vegetable intake during pregnancy and risk for development of sporadic retinoblastomaManuela A Orjuela
Department of Pediatrics, Mailman School of Public Health at Columbia University, Room B106, 60 Haven Avenue, New York, New York 10032, USA
Cancer Epidemiol Biomarkers Prev 14:1433-40. 2005..Fruits and vegetables are important sources of carotenoids and folate. We examined whether decreased gestational maternal intake of fruits and vegetables may contribute to development of sporadic retinoblastoma...
- CD20 expression predicts survival in paediatric post-transplant lymphoproliferative disease (PTLD) following solid organ transplantationManuela A Orjuela
Departments of Pediatrics, Columbia University, New York Presbyterian Morgan Stanley Children s Hospital New York, NY, USA
Br J Haematol 152:733-42. 2011..56·3%, P = 0·01). EBV expression was unrelated to PTLD-related EFS or OS. CD20 expression is associated with timing of development of PTLD and predicts survival in PTLD diagnosed following paediatric SOT...
- Intensive multimodality therapy for patients with stage 4a metastatic retinoblastomaIra J Dunkel
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Pediatr Blood Cancer 55:55-9. 2010....
- Trilateral retinoblastoma: potentially curable with intensive chemotherapyIra J Dunkel
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Pediatr Blood Cancer 54:384-7. 2010..We describe a series of 13 patients treated with intensive chemotherapy, defined as the intention to include high-dose chemotherapy with autologous hematopoietic stem cell rescue...
- A pilot study of chemoimmunotherapy (cyclophosphamide, prednisone, and rituximab) in patients with post-transplant lymphoproliferative disorder following solid organ transplantationManuela Orjuela
Departments of Pediatrics, Columbia University, New York, New York 10032, USA
Clin Cancer Res 9:3945S-52S. 2003..The response rate to immunotherapy (rituximab) is only about 46% with a 54% relapse/progression rate. In this study, we investigated the use of a combination of Cy/Pred with rituximab as treatment for this disease...
- Traditional physical activity indexes derived from the Harvard alumni activity survey have low construct validity in a lower income, urban populationAndrew Rundle
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
J Urban Health 84:722-32. 2007..99 BMI units, 2.97 mmHg of diastolic blood pressure, and 3.96 mmHg of systolic blood pressure. This work suggests that the TWA scale has greater construct validity than the traditional PAI scale in this population...
- Androgen and c-Kit receptors in desmoplastic small round cell tumors resistant to chemotherapy: novel targets for therapyRobert L Fine
College of Physicians and Surgeons of Columbia University, New York Presbyterian Medical Center and Morgan Stanley Children s Hospital, New York, NY, USA
Cancer Chemother Pharmacol 59:429-37. 2007..This predilection in young males led us to examine the role of androgen receptors (AR), testosterone, and growth factors in the biology of DSRCT...
- Prenatal PAH exposure is associated with chromosome-specific aberrations in cord bloodManuela A Orjuela
Departments of Pediatrics Oncology, Environmental Health Sciences, Biostatistics and Genetics, Columbia University, New York, NY, United States
Mutat Res 703:108-14. 2010..The observed chromosome-specific effects of prenatal airborne PAHs raise concern about potential cancer risk...
- Role of immunosuppression regimen in post-transplant lymphoproliferative disorder in pediatric heart transplant patientsJeffrey D Dayton
Morgan Stanley Children s Hospital of New York Presbyterian, Columbia University College of Physicians and Surgeons, New York, NY, USA
J Heart Lung Transplant 30:420-5. 2011..Post-transplant lymphoproliferative disorder (PTLD) contributes to morbidity and mortality after transplantation. We examined the effect of immunosuppressive regimen on the risk of developing PTLD after pediatric heart transplantation...
- Folate Deficiency, Metabolism & Sporadic RetinoblastomaManuela Orjuela; Fiscal Year: 2006..If our results are as anticipated, this project may lead to the development of new preventive strategies for those populations with an elevated incidence of sporadic retinoblastoma. ..
- Prenatal Exposures & Procarcinogenic MutationsManuela Orjuela; Fiscal Year: 2007..Thus, the ultimate goal of this research is to contribute to the prevention of future childhood ALL. ..