Martha J Morrell
Affiliation: Columbia University
- Working toward an epilepsy cureMartha J Morrell
Neurological Institute, Columbia University College of Physicians and Surgeons, 710 West 168th Street, New York, NY 10032, USA
Curr Neurol Neurosci Rep 3:323-4. 2003
- Epilepsy in womenMartha J Morrell
Columbia University, New York City, New York, USA
Am Fam Physician 66:1489-94. 2002..This risk is reduced by using a single antiepileptic drug at the lowest effective dose and by providing preconceptional folic acid supplementation. Breastfeeding is generally thought to be safe for women using antiepileptic medications...
- Predictors of ovulatory failure in women with epilepsyMartha J Morrell
The Neurological Institute, Department of Neurology, Columbia University, 710 West 168th Street, New York, NY 10032, USA
Ann Neurol 52:704-11. 2002..WWE with anovulatory cycles may have no other signs of reproductive dysfunction. Therefore, clinicians must be alert to this potential complication of epilepsy...
- The KEEPER trial: levetiracetam adjunctive treatment of partial-onset seizures in an open-label community-based studyM J Morrell
The Neurological Institute, Columbia Presbyterian Medical Center, Columbia University, 710 West 168th Street, New York, NY, USA
Epilepsy Res 54:153-61. 2003..The purpose of this study was to gather additional safety and efficacy data on levetiracetam in the real-world setting of community-based practice...
- Reproductive and metabolic disorders in women with epilepsyMartha J Morrell
College of Physicians and Surgeons of Columbia University, and Columbia Comprehensive Epilepsy Center, New York Presbyterian Health System, New York, New York, USA
Epilepsia 44:11-20. 2003..In the meantime, practitioners can be alert to signs and symptoms of reproductive or metabolic health disturbances and participate in pregnancy registry efforts...
- Normal vitamin D and low free estradiol levels in women on enzyme-inducing antiepileptic drugsAlison M Pack
Department of Neurology, Columbia University, New York, NY, USA
Epilepsy Behav 21:453-8. 2011..04 and P=0.02) and a trend toward more bone loss at the lumbar spine (P=0.07 and P=0.08). These findings suggest that lower estrogen levels may contribute to bone loss in premenopausal women with epilepsy...
- Sexual dysfunction, sex steroid hormone abnormalities, and depression in women with epilepsy treated with antiepileptic drugsMartha J Morrell
The Neurological Institute, College of Physicians and Surgeons of Columbia University, New York, NY, USA
Epilepsy Behav 6:360-5. 2005..The mechanisms of sexual dysfunction in women with epilepsy are multifactorial, but AED choice appears to be one cause that is modifiable...
- Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapyAlison M Pack
Department of Neurology, Columbia University, New York, NY 10032, USA
Ann Neurol 57:252-7. 2005..Subjects receiving lamotrigine had no significant reductions in calcium or increases in markers of bone turnover, suggesting this agent is less likely to have long-term adverse effects on bone...
- Bone mineral density in an outpatient population receiving enzyme-inducing antiepileptic drugsAlison M Pack
Department of Neurology, Columbia University, New York, NY 10032, USA
Epilepsy Behav 4:169-74. 2003..There were no statistically significant differences found in the T or Z scores by gender; therefore all analyses combined both men and women. Significant reductions in both T and Z scores were present in men and women <50 and >or=50...
- Epilepsy and bone health in adultsAlison M Pack
Epilepsy Division, Department of Neurology, Columbia University, 710 West 168th Street, New York, NY 10032, USA
Epilepsy Behav 5:S24-9. 2004..Physicians should counsel patients taking AEDs about good bone health practices, and evaluation of bone health by measuring BMD is warranted after 5 years of AED treatment or before treatment in postmenopausal women...
- Higher androgens and weight gain with valproate compared with lamotrigine for epilepsyMartha J Morrell
Columbia University, New York, NY, USA
Epilepsy Res 54:189-99. 2003..This study was conducted to test the hypothesis that the antiepileptic drug lamotrigine, which also has a broad spectrum of anti-seizure efficacy, would not be associated with endocrine abnormalities and would not cause weight gain...
- Reproductive disturbances in patients with epilepsyMartha J Morrell
College of Physicians and Surgeons, Columbia University, New York, NY, USA
Cleve Clin J Med 71:S19-24. 2004..To provide the best care for patients with epilepsy, particularly women of reproductive age, clinicians must consider both the gender-based biology of epilepsy and the effects of antiepileptic drugs on reproductive health...
- Treatment of women with epilepsyAlison M Pack
Department of Neurology, The Neurological Institute, Columbia University, New York, New York, USA
Semin Neurol 22:289-98. 2002..Seizure frequency may change during pregnancy, seizures may cause pregnancy complications, some AEDs are teratogenic, and many cross into breast milk. The treatment of a woman with epilepsy must consider all these issues...
- Treatment of epilepsy in adults: expert opinion, 2005Steven Karceski
Columbia Epilepsy Center, Columbia University College of Physicians and Surgeons, 710 W 168th Street, NI 7, New York, NY 10032, USA
Epilepsy Behav 7:S1-64; quiz S65-7. 2005..We surveyed a group of US epileptologists again in 2004 and compared the results of the two surveys...
- Sex-steroid hormones in women with epilepsyNathalie Jette
Neurological Institute of New York, Comprehensive Epilepsy Center, Columbia University, New York, New York 10032, USA
Am J Electroneurodiagnostic Technol 45:36-48. 2005..By understanding the effects of hormones on seizures, clinicians are better equipped to treat hormonally mediated epilepsy...
- Review of lamotrigine and its clinical applications in epilepsyHyunmi Choi
Department of Neurology, Columbia University, New York, USA
Expert Opin Pharmacother 4:243-51. 2003..Its small risk of serious skin rash should be weighed against its potential benefits when choosing lamotrigine on an individual basis. Lamotrigine is an excellent therapeutic option in epilepsy...
- Antiepileptic medications for the treatment of epilepsyMartha J Morrell
Department of Neurology, The Neurological Institute, Columbia University, New York, New York 10032, USA
Semin Neurol 22:247-58. 2002..Contained herein is a review of the mechanism of action of AEDs, individual drugs and their potential drug interactions, and general principles to guide the clinician in selection, implementation, and long-term monitoring of AEDs...
- Women with epilepsy: current treatment strategiesSteven Karceski
Neurological Institute, College of Physicians and Surgeons of Columbia University, 710 W 168th St, NI 7, New York, NY 10032, USA
J Gend Specif Med 5:22-6. 2002..When this method is used to analyze opinion regarding the treatment of women with epilepsy, it is clear that the selection of therapy is influenced by the sex of the patient...
- Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigineMartha J Morrell
Stanford University, Stanford and Neuropace, Mountain View, CA 94043, USA
Ann Neurol 64:200-11. 2008..To evaluate development of components of polycystic ovary syndrome (PCOS) and PCOS in women with epilepsy initiating valproate or lamotrigine therapy...
- Responsive cortical stimulation for the treatment of epilepsyFelice T Sun
NeuroPace, Mountain View, California 94043, USA
Neurotherapeutics 5:68-74. 2008....