Howard B Lieberman

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene
    H B Lieberman
    Center for Radiological Research, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 93:13890-5. 1996
  2. pmc Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethality
    Kevin M Hopkins
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Cell Biol 24:7235-48. 2004
  3. pmc Rad9 protein contributes to prostate tumor progression by promoting cell migration and anoikis resistance
    Constantinos G Broustas
    Center for Radiological Research, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 287:41324-33. 2012
  4. pmc Mouse Rad9b is essential for embryonic development and promotes resistance to DNA damage
    Corinne Leloup
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Dev Dyn 239:2837-50. 2010
  5. ncbi request reprint Rad9, an evolutionarily conserved gene with multiple functions for preserving genomic integrity
    Howard B Lieberman
    Center for Radiological Research, Columbia University, 630 W 168th St, New York, New York 10032, USA
    J Cell Biochem 97:690-7. 2006
  6. pmc The role of RAD9 in tumorigenesis
    Howard B Lieberman
    Center for Radiological Research, Columbia University College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
    J Mol Cell Biol 3:39-43. 2011
  7. ncbi request reprint Mrad9 and atm haploinsufficiency enhance spontaneous and X-ray-induced cataractogenesis in mice
    Norman J Kleiman
    Center for Radiological Research, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Radiat Res 168:567-73. 2007
  8. ncbi request reprint Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue
    Kevin M Hopkins
    Center for Radiological Research, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cancer Res 63:5291-8. 2003
  9. pmc Mechanism of radiation-induced bystander effects: a unifying model
    Tom K Hei
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Pharm Pharmacol 60:943-50. 2008
  10. pmc RAD9 deficiency enhances radiation induced bystander DNA damage and transcriptomal response
    Shanaz A Ghandhi
    Center for Radiological Research, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Radiat Oncol 9:206. 2014

Collaborators

Detail Information

Publications32

  1. pmc A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene
    H B Lieberman
    Center for Radiological Research, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 93:13890-5. 1996
    ..1-13.2. This region contains a number of tumor suppressor loci, and based on the biology of checkpoint control genes, HRAD9 should be considered a strong candidate for one of them...
  2. pmc Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethality
    Kevin M Hopkins
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Cell Biol 24:7235-48. 2004
    ..These investigations establish Mrad9 as a key mammalian genetic element of pathways that regulate the cellular response to DNA damage, maintenance of genomic integrity, and proper embryonic development...
  3. pmc Rad9 protein contributes to prostate tumor progression by promoting cell migration and anoikis resistance
    Constantinos G Broustas
    Center for Radiological Research, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 287:41324-33. 2012
    ..We thus demonstrate for the first time that Rad9 contributes to prostate tumorigenesis by increasing not only tumor proliferation and survival but also tumor migration and invasion, anoikis resistance, and anchorage-independent growth...
  4. pmc Mouse Rad9b is essential for embryonic development and promotes resistance to DNA damage
    Corinne Leloup
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Dev Dyn 239:2837-50. 2010
    ..There is no evidence of spontaneous genomic instability in Mrad9b(-/-) cells. Our findings thus indicate that Mrad9b is essential for embryonic development and mediates resistance to certain DNA damaging agents...
  5. ncbi request reprint Rad9, an evolutionarily conserved gene with multiple functions for preserving genomic integrity
    Howard B Lieberman
    Center for Radiological Research, Columbia University, 630 W 168th St, New York, New York 10032, USA
    J Cell Biochem 97:690-7. 2006
    ....
  6. pmc The role of RAD9 in tumorigenesis
    Howard B Lieberman
    Center for Radiological Research, Columbia University College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
    J Mol Cell Biol 3:39-43. 2011
    ..It is not clear which of the many functions of RAD9 is critical for carcinogenesis, but several alternatives are considered herein and implications for the development of novel cancer therapies based on these findings are examined...
  7. ncbi request reprint Mrad9 and atm haploinsufficiency enhance spontaneous and X-ray-induced cataractogenesis in mice
    Norman J Kleiman
    Center for Radiological Research, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Radiat Res 168:567-73. 2007
    ..These findings demonstrate that Mrad9 and Atm are important determinants of lens opacification and, given the roles of Atm and Rad9 in maintaining genomic stability, are consistent with a genotoxic basis for radiation cataractogenesis...
  8. ncbi request reprint Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue
    Kevin M Hopkins
    Center for Radiological Research, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cancer Res 63:5291-8. 2003
    ..The findings also indicate that HRAD9B can serve as a biomarker in particular for testicular seminomas and might be causally related to the disease...
  9. pmc Mechanism of radiation-induced bystander effects: a unifying model
    Tom K Hei
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Pharm Pharmacol 60:943-50. 2008
    ....
  10. pmc RAD9 deficiency enhances radiation induced bystander DNA damage and transcriptomal response
    Shanaz A Ghandhi
    Center for Radiological Research, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Radiat Oncol 9:206. 2014
    ..The mechanism responsible includes intra-cellular and inter-cellular signaling by which the bystander response is propagated. However, details of the signaling mechanism are not well defined...
  11. pmc The DNA damage checkpoint protein RAD9A is essential for male meiosis in the mouse
    Ana Vasileva
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
    J Cell Sci 126:3927-38. 2013
    ..We therefore show for the first time that RAD9A is essential for male fertility and for repair of DNA DSBs during meiotic prophase I. ..
  12. pmc Contributions of Rad9 to tumorigenesis
    Constantinos G Broustas
    Center for Radiological Research, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Cell Biochem 113:742-51. 2012
    ....
  13. ncbi request reprint Combined haploinsufficiency for ATM and RAD9 as a factor in cell transformation, apoptosis, and DNA lesion repair dynamics
    Lubomir B Smilenov
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Cancer Res 65:933-8. 2005
    ....
  14. pmc Rad9 has a functional role in human prostate carcinogenesis
    Aiping Zhu
    Center for Radiological Research, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Cancer Res 68:1267-74. 2008
    ....
  15. doi request reprint DUSP1 is controlled by p53 during the cellular response to oxidative stress
    Yu Xin Liu
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Cancer Res 6:624-33. 2008
    ..Our results reveal a mechanism whereby p53 selectively regulates target genes and suggest a way in which subgroups of those target genes might be controlled independently...
  16. ncbi request reprint Methods to induce cell cycle checkpoints
    Howard B Lieberman
    Department of Radiation Oncology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Methods Mol Biol 241:3-10. 2004
  17. pmc Differential impact of mouse Rad9 deletion on ionizing radiation-induced bystander effects
    Aiping Zhu
    Center for Radiological Research, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Radiat Res 164:655-61. 2005
    ..Results are presented in the context of defining the function of Rad9 in the cellular response to radiation and its differential effects on individual bystander end points...
  18. pmc RAD9 enhances radioresistance of human prostate cancer cells through regulation of ITGB1 protein levels
    Constantinos G Broustas
    Center for Radiological Research, Columbia University College of Physicians and Surgeons, New York, New York
    Prostate 74:1359-70. 2014
    ..Likewise, integrin β1 is a known radioprotective factor. Previously, we showed that RAD9 downregulation in human prostate cancer cells reduces integrin β1 protein levels and ectopic expression of Mrad9 restores inherent high levels...
  19. pmc Regulation of NEIL1 protein abundance by RAD9 is important for efficient base excision repair
    Sunil K Panigrahi
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
    Nucleic Acids Res 43:4531-46. 2015
    ..Neil1 or Rad9 addition restored this incision activity. Thus, we demonstrate that RAD9 regulates BER by controlling NEIL1 protein levels, albeit by different mechanisms in human prostate cancer versus mouse ES cells. ..
  20. pmc PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells
    Haiying Cheng
    Department of Medicine, Division of Hematology Oncology, Herbert Irving Comprehensive Cancer Center, New York Presbyterian Hospital Columbia University Medical Center, New York, NY 10032, USA
    Carcinogenesis 34:739-49. 2013
    ....
  21. pmc Combined haploinsufficiency and genetic control of the G2/M checkpoint in irradiated cells
    Erik F Young
    Center for Radiological Research, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Radiat Res 177:743-50. 2012
    ..These findings suggest that checkpoint control does not contribute toward these intermediate phenotypes and that different biological processes can be activated at high doses compared to low doses...
  22. ncbi request reprint A novel function for human Rad9 protein as a transcriptional activator of gene expression
    Howard B Lieberman
    Center for Radiological Research, Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York, New York 10032, USA
    Cell Cycle 3:1008-10. 2004
    ..In this review, the newly defined ability of Rad9 to transactivate p21 and other downstream target genes is discussed in terms of the activities already associated with this protein...
  23. ncbi request reprint DNA damage repair and response proteins as targets for cancer therapy
    Howard B Lieberman
    Center for Radiological Research, Department of Radiation Oncology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Curr Med Chem 15:360-7. 2008
    ..Alteration of DNA damage response genes and proteins should thus be considered an important though as of yet not fully exploited avenue to enhance cancer therapy...
  24. pmc Human RAD9 checkpoint control/proapoptotic protein can activate transcription of p21
    Yuxin Yin
    Center for Radiological Research, Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 101:8864-9. 2004
    ..Furthermore, hRAD9 might regulate other cellular processes as well by modulating transcription of multiple down-stream target genes...
  25. ncbi request reprint Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1
    Haiying Hang
    Center for Radiological Research, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Genomics 79:487-92. 2002
    ..Furthermore, overexpression of HUS1B but not HUS1 in human cells induces clonogenic cell death. We suggest that HUS1B and HUS1 have distinct but related roles in regulating cell cycle checkpoints and genomic integrity...
  26. pmc Involvement of rhp23, a Schizosaccharomyces pombe homolog of the human HHR23A and Saccharomyces cerevisiae RAD23 nucleotide excision repair genes, in cell cycle control and protein ubiquitination
    Robert T Elder
    Children s Memorial Institute for Education and Research, Departments of Pediatrics and Microbiology Immunology, Northwestern University Medical School, 2430 North Halstead Street, 218, Chicago, IL 60614, USA
    Nucleic Acids Res 30:581-91. 2002
    ..Thus, the rhp23 gene plays a role not only in nucleotide excision repair but also in cell cycle regulation and the ubiquitination pathways...
  27. pmc Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repair
    Raj K Pandita
    Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park Ave, St Louis, MO 63108, USA
    Mol Cell Biol 26:1850-64. 2006
    ..Together, these findings provide evidence of roles for mammalian Rad9 in telomere stability and HR repair as a mechanism for promoting cell survival after IR exposure...
  28. ncbi request reprint Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival
    Larry M Karnitz
    Division of Oncology Research, Guggenheim 13, Mayo Clinic College of Medicine, 200 First Street, S W, Rochester, Minnesota 55905, USA
    Mol Pharmacol 68:1636-44. 2005
    ....
  29. ncbi request reprint Rad9 protects cells from topoisomerase poison-induced cell death
    David Loegering
    Division of Oncology Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 279:18641-7. 2004
    ..Collectively, these results suggest that the predominant role of Rad9 in ES cells is to promote survival after replicative stress and topoisomerase-mediated DNA damage...
  30. pmc Targeted deletion of Rad9 in mouse skin keratinocytes enhances genotoxin-induced tumor development
    Zhishang Hu
    National Laboratory of Biomacromolecules, Chinese Academy of Sciences, Beijing, China
    Cancer Res 68:5552-61. 2008
    ..These data suggest that Mrad9 plays an important role in maintaining genomic stability and preventing tumor development in keratinocytes...
  31. pmc Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathway
    Hongning Zhou
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 102:14641-6. 2005
    ..These results provide evidence that the COX-2-related pathway, which is essential in mediating cellular inflammatory response, is the critical signaling link for the bystander phenomenon...
  32. ncbi request reprint Phosphorylation of human Rad9 is required for genotoxin-activated checkpoint signaling
    Pia Roos-Mattjus
    Department of Biochemistry and Molecular Biology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 278:24428-37. 2003
    ..Collectively, these results demonstrate that the Rad9 phospho-tail is a key participant in the Chk1 activation pathway and point to additional roles for Rad9 in cellular responses to IR...