Affiliation: Columbia University
- Development by self-digestion: molecular mechanisms and biological functions of autophagyBeth Levine
Department of Medicine, Columbia University, New York, NY 10032, USA
Dev Cell 6:463-77. 2004..In this review, we summarize our current knowledge about the molecular machinery of autophagy and the role of the autophagic machinery in eukaryotic development...
- Eating oneself and uninvited guests: autophagy-related pathways in cellular defenseBeth Levine
Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75330, USA
Cell 120:159-62. 2005..2005). Other recent studies indicate that the autophagy machinery is also used to degrade foreign microbial invaders (xenophagy)...
- Autophagy fights disease through cellular self-digestionNoboru Mizushima
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
Nature 451:1069-75. 2008..Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health...
- Autophagy in the pathogenesis of diseaseBeth Levine
Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Cell 132:27-42. 2008..This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases...
- Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotesDaniel J Klionsky
Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
Autophagy 4:151-75. 2008..In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response...
- Viral evasion of autophagyAnthony Orvedahl
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
Autophagy 4:280-5. 2008..This review will briefly summarize the current understanding of autophagy as an antiviral pathway, and then discuss strategies that viruses may utilize to evade this host defense mechanism...
- Cardiac autophagy is a maladaptive response to hemodynamic stressHongxin Zhu
Department of Internal Medicine and Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
J Clin Invest 117:1782-93. 2007..Taken together, these findings implicate autophagy in the pathogenesis of load-induced heart failure and suggest it may be a target for novel therapeutic intervention...
- How shall I eat thee?Daniel J Klionsky
Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
Autophagy 3:413-6. 2007
- 4th International Symposium on Autophagy: exploiting the frontiers of autophagy researchEeva Liisa Eskelinen
Department of Biological and Environmental Sciences, Division of Biochemistry, University of Helsinki, Helsinki, Finland
Autophagy 3:166-73. 2007..Two themes were discussed in many sessions during the symposium: the role of autophagy in the degradation of aggregate-prone proteins and protein aggregates, and the possible role of p62 in autophagy...
- HIV and CXCR4 in a kiss of autophagic deathBeth Levine
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
J Clin Invest 116:2078-80. 2006..The HIV envelope glycoprotein interacts with CXC chemokine receptor 4 to activate the lysosomal degradation pathway of autophagy, which is necessary for both apoptotic and nonapoptotic cell death...
- The role of autophagy in mammalian development: cell makeover rather than cell deathFrancesco Cecconi
Dulbecco Telethon Institute at the Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
Dev Cell 15:344-57. 2008..Thus, autophagy is a process of cytosolic "renovation," crucial in cell fate decisions...