Genomes and Genes
J A Knowles
Affiliation: Columbia University
- Results of a genome-wide genetic screen for panic disorderJ A Knowles
Department of Psychiatry, College of Physicians and Surgeons at Columbia University and New York State Psychiatric Institute, New York 10032, USA
Am J Med Genet 81:139-47. 1998..Analysis with SIBPAIR yielded P values equivalent to a lod score of 1.0 or greater (i.e., P < .016, one-sided, uncorrected for multiple tests) for 11 marker loci (2, 7p, 8p, 8q, 9p, 11q, 12q, 16p, 20p and 20q)...
- Drawbacks of GENEHUNTER for larger pedigrees: application to panic disorderR Goedken
Department of Psychiatry, The University of Iowa College of Medicine, Iowa City, Iowa 52242 1000, USA
Am J Med Genet 96:781-3. 2000..Careful consideration must be given when selecting linkage analysis programs. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:781-783, 2000...
- No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorderS P Hamilton
Department of Psychiatry, College of Physicians and Surgeons at Columbia University and the New York State Psychiatric Institute, USA
Mol Psychiatry 6:59-65. 2001..The results reported here provide little support for the role of these polymorphisms in panic disorder...
- Potential panic disorder syndrome: clinical and genetic linkage evidenceM M Weissman
Department of Psychiatry, College of Physicians and Surgeons at Columbia University, New York, New York, USA
Am J Med Genet 96:24-35. 2000..Am. J. Med. Genet.(Neuropsychiatr. Genet.) 96:24-35, 2000...
- Genome-wide association study of recurrent early-onset major depressive disorderJ Shi
Department of Psychiatry, Stanford University, Stanford, CA, USA
Mol Psychiatry 16:193-201. 2011..Larger samples will be required to confirm the hypothesis of association between MDD (and particularly the recurrent early-onset subtype) and common SNPs...
- Identification of a novel member of the TGF-beta superfamily highly expressed in human placentaL N Lawton
Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Gene 203:17-26. 1997..9 kb that is predominant in adult skeletal muscle. Most importantly, the 1.2-kb PTGFB transcript was shown to be expressed in placenta at much higher levels than in any other human fetal or adult tissue surveyed...
- Investigation of serotonin-related genes in antidepressant responseE J Peters
Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
Mol Psychiatry 9:879-89. 2004..Intriguingly, we observe that a number of the less frequent alleles of many of the SNP markers were associated with the nonresponse and nonspecific phenotypes...
- Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II geneZ Deng
Department of Psychiatry, College of Physicians and Surgeons at Columbia University and the New York State Psychiatric Institute, New York, NY, USA
Am J Hum Genet 67:737-44. 2000..These findings indicate that the bone morphogenetic protein-signaling pathway is defective in patients with primary pulmonary hypertension and may implicate the pathway in the nonfamilial forms of the disease...
- TULP1 mutation in two extended Dominican kindreds with autosomal recessive retinitis pigmentosaP Banerjee
Department of Genetics and Development, College of Physicians and Surgeons at Columbia University and New York State Psychiatric Institute, New York 10032, USA
Nat Genet 18:177-9. 1998..The mutation was not observed in 210 unrelated controls. The data indicate that impairment of TULP1 protein function is a rare cause of arRP and that the normal protein plays an essential role in the physiology of the retina...
- High-resolution mapping and transcript identification at the progressive epilepsy with mental retardation locus on chromosome 8pS Ranta
Department of Psychiatry, Columbia Genome Center, College of Physicians and Surgeons at Columbia University and New York State Psychiatric Institute, New York 10032, USA
Genome Res 7:887-96. 1997..Several partial gene sequences have been identified from the region and are being analyzed as candidate genes for EPMR...
- GENETIC RISK FACTORS FOR NICOTINE ADDICTIONAlexander Glassman; Fiscal Year: 2004..Detecting these genes would be a significant first step in our understanding of the genetic variation of addiction to nicotine and possibly other drugs of abuse. ..