Tadahiro Kitamura

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Insulin receptor knockout mice
    Tadahiro Kitamura
    Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Annu Rev Physiol 65:313-32. 2003
  2. pmc The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
    Tadahiro Kitamura
    Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    J Clin Invest 110:1839-47. 2002
  3. pmc Mosaic analysis of insulin receptor function
    Tadahiro Kitamura
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Clin Invest 113:209-19. 2004
  4. ncbi request reprint The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells
    Masayuki Adachi
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Gastroenterology 132:1434-46. 2007
  5. pmc Generation of functional insulin-producing cells in the gut by Foxo1 ablation
    Chutima Talchai
    Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, New York, USA
    Nat Genet 44:406-12, S1. 2012
  6. pmc Transgenic rescue of insulin receptor-deficient mice
    Haruka Okamoto
    Department of Medicine, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 114:214-23. 2004
  7. ncbi request reprint FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction
    Yukari Ido Kitamura
    Naomi Berrie Diabetes Center, Department of Medicine, Columbia University, New York, New York 10032, USA
    Cell Metab 2:153-63. 2005
  8. ncbi request reprint The forkhead transcription factor Foxo1 regulates adipocyte differentiation
    Jun Nakae
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Dev Cell 4:119-29. 2003
  9. pmc Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1
    Tadahiro Kitamura
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 100321, USA
    Mol Cell Biol 29:4417-30. 2009
  10. pmc A Foxo/Notch pathway controls myogenic differentiation and fiber type specification
    Tadahiro Kitamura
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Invest 117:2477-85. 2007

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Insulin receptor knockout mice
    Tadahiro Kitamura
    Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Annu Rev Physiol 65:313-32. 2003
    ....
  2. pmc The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
    Tadahiro Kitamura
    Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    J Clin Invest 110:1839-47. 2002
    ..We propose that insulin/IGFs regulate beta cell proliferation by relieving Foxo1 inhibition of Pdx1 expression in a subset of cells embedded within pancreatic ducts...
  3. pmc Mosaic analysis of insulin receptor function
    Tadahiro Kitamura
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Clin Invest 113:209-19. 2004
    ..These findings indicate that insulin regulates growth independently of metabolism and that the number of insulin receptors is an important determinant of the specificity of insulin action...
  4. ncbi request reprint The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells
    Masayuki Adachi
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Gastroenterology 132:1434-46. 2007
    ..Hepatic stellate cells (HSCs) play a crucial role in liver fibrosis. A fibrotic stimulus causes HSCs to transdifferentiate from a quiescent phenotype to a collagen-producing myofibroblast-like phenotype and to proliferate...
  5. pmc Generation of functional insulin-producing cells in the gut by Foxo1 ablation
    Chutima Talchai
    Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, New York, USA
    Nat Genet 44:406-12, S1. 2012
    ..The data indicate that Neurog3(+) enteroendocrine progenitors require active Foxo1 to prevent differentiation into Ins(+) cells. Foxo1 ablation in gut epithelium may provide an approach to restore insulin production in type 1 diabetes...
  6. pmc Transgenic rescue of insulin receptor-deficient mice
    Haruka Okamoto
    Department of Medicine, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 114:214-23. 2004
    ..These data indicate, surprisingly, that insulin receptor signaling in noncanonical insulin target tissues is sufficient to maintain fuel homeostasis and prevent diabetes...
  7. ncbi request reprint FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction
    Yukari Ido Kitamura
    Naomi Berrie Diabetes Center, Department of Medicine, Columbia University, New York, New York 10032, USA
    Cell Metab 2:153-63. 2005
    ..The findings provide a mechanism linking glucose- and growth factor receptor-activated pathways to protect beta cells against oxidative damage via FoxO proteins...
  8. ncbi request reprint The forkhead transcription factor Foxo1 regulates adipocyte differentiation
    Jun Nakae
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Dev Cell 4:119-29. 2003
    ..We propose that Foxo1 plays an important role in the integration of hormone-activated signaling pathways with the complex transcriptional cascade that promotes adipocyte differentiation...
  9. pmc Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1
    Tadahiro Kitamura
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 100321, USA
    Mol Cell Biol 29:4417-30. 2009
    ..We conclude that FoxO1+ Ins(-) juxtaductal cells represent a hitherto-unrecognized pancreatic cell population with in vitro capability of endocrine differentiation...
  10. pmc A Foxo/Notch pathway controls myogenic differentiation and fiber type specification
    Tadahiro Kitamura
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Invest 117:2477-85. 2007
    ..Notch/Foxo1 cooperation may integrate environmental cues through Notch with metabolic cues through Foxo1 to regulate progenitor cell maintenance and differentiation...
  11. pmc Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells
    Jun Tanaka
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Diabetes 58:2344-54. 2009
    ..Biochemical mechanism leading from hyperglycemia to oxLDL formation and eNOS dysfunction is unknown...
  12. pmc Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism
    Michihiro Matsumoto
    Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Invest 116:2464-72. 2006
    ....
  13. ncbi request reprint Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
    Tadahiro Kitamura
    Department of Medicine, Columbia University Medical Center, 1150 St Nicholas Avenue, New York, New York 10032, USA
    Nat Med 12:534-40. 2006
    ..Thus, FoxO1 represents a shared component of pathways integrating food intake and peripheral metabolism...
  14. pmc Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors
    Marta L Hribal
    Russ Berrie Research Pavilion, Rm 238, 1150 St Nicholas Avenue, New York, NY 10032, USA
    J Cell Biol 162:535-41. 2003
    ..Inhibition of Foxo expression by siRNA resulted in more efficient differentiation, associated with increased myosin expression. These observations indicate that Foxo proteins are key effectors of Akt-dependent myogenesis...
  15. pmc A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolism
    Joshua R Cook
    Department of Medicine, Columbia University, New York, NY
    Diabetes 64:1951-65. 2015
    ..These conclusions support a differential regulation of hepatic glucose and lipid metabolism by FoxO1 based on the mechanism by which it alters the expression of key target genes involved in each process...
  16. pmc Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor
    Shouhong Xuan
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 110:1011-9. 2002
    ..These observations reveal a requirement of IGF1R-mediated signaling for insulin secretion...
  17. ncbi request reprint Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
    Jun Nakae
    Naomi Berrie Diabetes Center, Berrie Research Pavilion, 1150 St Nicholas Avenue, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Nat Genet 32:245-53. 2002
    ..This has been corrected in the full-text online version of the article. The name will appear correctly in the print version...
  18. pmc The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathways
    Anaïs Perilhou
    Department of Endocrinology, Metabolism, and Cancer, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Mol Cell Biol 28:6568-79. 2008
    ..We demonstrate that this negative glucose effect involves ChREBP expression. We propose that COUP-TFII acts in a coordinate fashion to control insulin secretion and glucose metabolism...
  19. ncbi request reprint Role of FoxO Proteins in Pancreatic beta Cells
    Tadahiro Kitamura
    Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371 8512, Japan
    Endocr J 54:507-15. 2007
    ..Genetic or pharmacological manipulation of FoxO can be used to prevent beta cell failure or aid in the differentiation of uncommitted endocrine progenitors into beta cells for transplantation...
  20. pmc Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo
    Kinh Tung T Nguyen
    Department of Medicine, Medical Biophysics, Institute of Medical Science, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
    Mol Cell Biol 26:4511-8. 2006
    ..Parallel enhancement in PI3K signaling was found in PTEN-deficient hypothalamus and beta cells. Together, we have shown that PTEN in insulin-transcribing cells may play an integrative role in regulating growth and metabolism in vivo...