JAN K KITAJEWSKI
Affiliation: Columbia University
- Anthrax toxin receptor 2 is expressed in murine and tumor vasculature and functions in endothelial proliferation and morphogenesisC V Reeves
Columbia University Medical Center, New York, NY 10035, USA
Oncogene 29:789-801. 2010..We conclude that ANTXR2/CMG2 functions to promote endothelial proliferation and morphogenesis during sprouting angiogenesis, consistent with the endothelial expression of ANTXR2/CMG2 in several vascular beds...
- Lymphatics in health and disease: a new thematic series in vascular cellJan Kitajewski
Pathology, Columbia University Medical Center, NY, NY, 10032, USA
Vasc Cell 5:14. 2013..Vascular Cell is launching new series on lymphatics, a vascular system required for physiological fluid balance and immunity, and whose damage leads to edema. ..
- Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activityClaire V Reeves
Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York, United States of America
PLoS ONE 7:e34862. 2012..We identified an ANTXR2/MT1-MMP complex and demonstrated that MT1-MMP activity is dependent on ANTXR2 expression levels in cells. Thus, we have discovered that ANTXR1 and ANTXR2 function as positive regulators of MT1-MMP activity...
- Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4)Vuk P Jovanovic
Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 W 168th Street, New York, NY 10032, USA
Reprod Biol Endocrinol 11:43. 2013..We hypothesized that blocking Notch pathways would disrupt follicular maturation in the mouse ovary...
- Studies in mice reveal a role for anthrax toxin receptors in matrix metalloproteinase function and extracellular matrix homeostasisClaire Reeves
Department of Ob Gyn, Columbia University Medical Center, New York, NY 10032, USA
Toxins (Basel) 5:315-26. 2013..Mice mutant in Antxr genes have defects in extracellular matrix homeostasis. We discuss how knowledge of physiological ANTXR function relates to what is already known about anthrax intoxication...
- "Large eaters" meet blood vessels: a new thematic series on macrophages and angiogenesisJan Kitajewski
Pathology, Ob Gyn, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St, Nicholas Ave, NY, NY, 10032, USA
Vasc Cell 4:17. 2012..Vascular Cell has launched a new series on macrophages and angiogenesis, a quickly evolving field critical to blood and lymphatic vessels during development, inflammation and tumorigenesis...
- Expression of HES and HEY genes in infantile hemangiomasOmotinuwe Adepoju
Department of Surgery, College of Physicians and Surgeons, 630 W168th St, New York, 10032, USA
Vasc Cell 3:19. 2011..We sought to investigate downstream activation of Notch signaling in hemangioma cells by evaluating the expression of the basic HLH family proteins, HES/HEY, in IHs...
- Notch modulates VEGF action in endothelial cells by inducing Matrix Metalloprotease activityYasuhiro Funahashi
Pathology and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, NY, NY 10032, USA
Vasc Cell 3:2. 2011..This study sought to determine if VEGF regulation of MMPs was mediated via Notch signaling and to determine how Notch regulation of MMPs influenced endothelial cell morphogenesis...
- Chloride intracellular channel 1 functions in endothelial cell growth and migrationJennifer J Tung
Department of Obstetrics Gynecology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St, Nicholas Ave, 926, New York, NY 10032, USA
J Angiogenes Res 2:23. 2010..Little is known about the role of CLIC1 in endothelium. These studies investigate CLIC1 as a regulator of angiogenesis by in vitro techniques that mimic individual steps in the angiogenic process...
- Notch regulates the angiogenic response via induction of VEGFR-1Yasuhiro Funahashi
Pathology, Obstetrics and Gynecology, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
J Angiogenes Res 2:3. 2010..In summary, we show that Notch1 plays a role in endothelial cells by regulating VEGFR-1, a function that may be important for physiological and pathological angiogenesis...
- Fine-tuning endothelial Notch: SIRT-ainly an unexpected mechanismJan Kitajewski
Department of Ob Gyn, Pathology, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
Dev Cell 20:577-8. 2011..This regulation is critical for vascular sprouting and raises intriguing questions about therapeutic targeting of SIRT1 in angiogenesis and the potential mechanisms that link vascular growth and energy homeostasis...
- Notch suppresses angiogenesis and progression of hepatic metastasesDebarshi Banerjee
Department of Pediatrics, Columbia University Medical Center, New York, New York
Cancer Res 75:1592-602. 2015..Our findings have potentially serious implications for Notch inhibition therapy...
- A potential role for notch signaling in the pathogenesis and regulation of hemangiomasJune K Wu
Departments of Surgery, Columbia University College of Physicians and Surgeons, New York, New York, USA
J Craniofac Surg 20:698-702. 2009..These findings support a role for Notch in hemangiomas, meriting further analysis of the functional relevance of Notch signaling in hemangiomas...
- Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase RegulationNaikhoba C O Munabi
Department of Surgery, Columbia University College of Physicians and Surgeons, New York, New York, USA
Stem Cells Transl Med 5:45-55. 2016..We have thus demonstrated that propranolol acts on HemSCs in IH to suppress proliferation and promote apoptosis in a dose-dependent fashion via β2AR perturbation, resulting in reduced cAMP and MAPK activation...
- Propranolol accelerates adipogenesis in hemangioma stem cells and causes apoptosis of hemangioma endothelial cellsAlvin Wong
Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Plast Reconstr Surg 130:1012-21. 2012..The authors hypothesize that propranolol facilitates their involution by altering cellular behavior in both hemangioma endothelial and stem cells...
- Notch and VEGF pathways play distinct but complementary roles in tumor angiogenesisSonia L Hernandez
Department of Pediatrics, Columbia University Medical Center, New York, NY, USA
Vasc Cell 5:17. 2013....
- Propranolol promotes accelerated and dysregulated adipogenesis in hemangioma stem cellsRyan W England
From the Departments of Surgery, Obstetrics and Gynecology, and Pathology, College of Physicians and Surgeons, Columbia University, New York, NY
Ann Plast Surg 73:S119-24. 2014..We hypothesize that propranolol promotes dysregulated adipogenesis via the improper regulation of adipogenic genes...
- NOTCH FUNCTION IN VASCULAR BIOLOGY AND ANGIOGENESISJAN K KITAJEWSKI; Fiscal Year: 2010..In Aim II, we utilize mice to explore genetic interaction between Notch and integrins, using mice deficient in a2 integrin or defective in b4 signaling, crossed to mice defective for Notch. ..
- CHARACTERIZATION AND PURIFICATION OF A POLYCYSTIN LIGANDJan Kitajewski; Fiscal Year: 2002..These polypeptides are candidate polycystin ligands. The goals of this proposal are to identify and characterize these proteins and to test whether they are indeed polycystin ligands. ..
- WNT AND FRIZZLED SIGNALING IN MAMMARY ONCOGENESISJan Kitajewski; Fiscal Year: 2003..Thus, the Wnt signaling pathway is linked to the pathology of human cancers. It clearly represents an important problem in cancer biology with increasing relevance to human disease. ..
- Wnt Function in Angiogenesis and Vascular DevelopmentJan Kitajewski; Fiscal Year: 2009..These studies will define how aberrant Wnt/Frizzled signaling might contribute to vascular pathologies and diseases, such as familial exuditive vitreoretinopathy. ..