Bernadette Kalman

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Familial multiple sclerosis and other inherited disorders of the white matter
    Bernadette Kalman
    Department of Neurology, MS Research Center, SLRHC, Columbia University, New York, NY 10019, USA
    Neurologist 10:201-15. 2004
  2. ncbi request reprint Genetic variants of Complex I in multiple sclerosis
    Tamara Vyshkina
    Department of Neurology, SLRHC, Columbia University, 432W 58th Street, New York, NY 10019, USA
    J Neurol Sci 228:55-64. 2005
  3. ncbi request reprint Haplotypes within genes of beta-chemokines in 17q11 are associated with multiple sclerosis: a second phase study
    Tamara Vyshkina
    Department of Neurology, Saint Luke s Roosevelt Hospital Center, Columbia University, 432 West 58th Street, Room 226, New York, NY, 10019, USA
    Hum Genet 118:67-75. 2005
  4. ncbi request reprint CD45 (PTPRC) as a candidate gene in multiple sclerosis
    Tamara Vyshkina
    Department of Neurology, SLRHC, Columbia University, New York, NY 10019, USA
    Mult Scler 10:614-7. 2004
  5. ncbi request reprint Analyses of a MS-associated haplotype encompassing the CCL3 gene
    Tamara Vyshkina
    Department of Neurology, Saint Luke s Roosevelt Hospital Center, Columbia University, 432W 58th Street, Room 226, New York, NY 10019, United States
    J Neuroimmunol 176:216-8. 2006
  6. ncbi request reprint A mitochondrial component of neurodegeneration in multiple sclerosis
    Bernadette Kalman
    SLRHC Columbia University, Department of Neurology, Multiple Sclerosis Research Center, New York, NY 10019, USA
    Neuromolecular Med 3:147-58. 2003
  7. ncbi request reprint Role of mitochondria in multiple sclerosis
    Bernadette Kalman
    Department of Neurology, Saint Luke s Roosevelt Hospital Center, Columbia University, 432 West 58th Street, Room 226, New York, NY 10019, USA
    Curr Neurol Neurosci Rep 6:244-52. 2006
  8. ncbi request reprint Association of haplotypes in the beta-chemokine locus with multiple sclerosis
    Tamara Vyshkina
    Department of Neurology, SLRHC, Columbia University, 432W 58th Street, New York, NY 10019, USA
    Eur J Hum Genet 13:240-7. 2005
  9. pmc Involvement of beta-chemokines in the development of inflammatory demyelination
    Ileana Banisor
    SLRHC, Columbia University, New York, NY, USA
    J Neuroinflammation 2:7. 2005
  10. doi request reprint Pathogenesis of multiple sclerosis: what can we learn from the cuprizone model
    Peter Acs
    Department of Neurology, SUNY Upstate Medical University, VA Medical Center, Syracuse, NY, USA
    Methods Mol Biol 900:403-31. 2012

Collaborators

  • Thomas P Leist
  • Yin Yao Shugart
  • George C Ebers
  • Tamara Vyshkina
  • Ileana Banisor
  • Peter Acs
  • Andrei Blokhin
  • David A Dyment
  • Sun Hansrote
  • Eduardo Adonias DeSousa
  • Andrew Sylvester
  • Eduardo Bonilla
  • Samuel Komoly
  • Andras Perl
  • Jeff A Canter
  • Saud Sadiq
  • Gary Birnbaum
  • Zameel M Cader
  • A Dessa Sadovnick
  • Cristen J Willer
  • Holly Armstrong
  • Steven Wiltshire
  • Neil Risch
  • Sidney Croul
  • Ross H Albert
  • Mary Selak
  • Robert J Schwartzman

Detail Information

Publications20

  1. ncbi request reprint Familial multiple sclerosis and other inherited disorders of the white matter
    Bernadette Kalman
    Department of Neurology, MS Research Center, SLRHC, Columbia University, New York, NY 10019, USA
    Neurologist 10:201-15. 2004
    ..Nevertheless, the exclusion of other entities still remains an integral element of the diagnostic process...
  2. ncbi request reprint Genetic variants of Complex I in multiple sclerosis
    Tamara Vyshkina
    Department of Neurology, SLRHC, Columbia University, 432W 58th Street, New York, NY 10019, USA
    J Neurol Sci 228:55-64. 2005
    ..A mitochondrial mechanism contributes to neurodegeneration in multiple sclerosis (MS). Genetic variants of Complex I genes may influence the nature of tissue response to inflammation in the central nervous system (CNS)...
  3. ncbi request reprint Haplotypes within genes of beta-chemokines in 17q11 are associated with multiple sclerosis: a second phase study
    Tamara Vyshkina
    Department of Neurology, Saint Luke s Roosevelt Hospital Center, Columbia University, 432 West 58th Street, Room 226, New York, NY, 10019, USA
    Hum Genet 118:67-75. 2005
    ..Sequencing of the identified chromosomal segments and their flanking regions will be necessary to define specific variants with direct relevance to MS pathogenesis...
  4. ncbi request reprint CD45 (PTPRC) as a candidate gene in multiple sclerosis
    Tamara Vyshkina
    Department of Neurology, SLRHC, Columbia University, New York, NY 10019, USA
    Mult Scler 10:614-7. 2004
    ..0342. We conclude that the 77C-->G PTPRC polymorphism is present and preferentially transmitted in a small subgroup (<5%) of MS families, which may only be detected with complementary methods of analysis...
  5. ncbi request reprint Analyses of a MS-associated haplotype encompassing the CCL3 gene
    Tamara Vyshkina
    Department of Neurology, Saint Luke s Roosevelt Hospital Center, Columbia University, 432W 58th Street, Room 226, New York, NY 10019, United States
    J Neuroimmunol 176:216-8. 2006
    ....
  6. ncbi request reprint A mitochondrial component of neurodegeneration in multiple sclerosis
    Bernadette Kalman
    SLRHC Columbia University, Department of Neurology, Multiple Sclerosis Research Center, New York, NY 10019, USA
    Neuromolecular Med 3:147-58. 2003
    ..Considering the need for additional therapeutic strategies, we emphasize the degenerative components, and review a mitochondrial mechanism of tissue loss potentially involved in the process of MS...
  7. ncbi request reprint Role of mitochondria in multiple sclerosis
    Bernadette Kalman
    Department of Neurology, Saint Luke s Roosevelt Hospital Center, Columbia University, 432 West 58th Street, Room 226, New York, NY 10019, USA
    Curr Neurol Neurosci Rep 6:244-52. 2006
    ....
  8. ncbi request reprint Association of haplotypes in the beta-chemokine locus with multiple sclerosis
    Tamara Vyshkina
    Department of Neurology, SLRHC, Columbia University, 432W 58th Street, New York, NY 10019, USA
    Eur J Hum Genet 13:240-7. 2005
    ....
  9. pmc Involvement of beta-chemokines in the development of inflammatory demyelination
    Ileana Banisor
    SLRHC, Columbia University, New York, NY, USA
    J Neuroinflammation 2:7. 2005
    ..The survey reflects that the field is in a rapid expansion, and highlights some of the pathways which might be suitable to pharmaceutical interventions...
  10. doi request reprint Pathogenesis of multiple sclerosis: what can we learn from the cuprizone model
    Peter Acs
    Department of Neurology, SUNY Upstate Medical University, VA Medical Center, Syracuse, NY, USA
    Methods Mol Biol 900:403-31. 2012
    ..This chapter summarizes the classical and more contemporary concepts of MS, and provides methodologies for employing the cuprizone model for further explorations of the pathogenesis and treatment of the disease...
  11. ncbi request reprint Bcl-2 and its homologues in the brain of patients with multiple sclerosis
    Ileana Banisor
    Department of Neurology, SLRHC, Hospital of Columbia University, New York 10019, USA
    Mult Scler 10:176-81. 2004
    ..This finding indicates that both pro- and anti-apoptotic mechanisms are activated, not only within but also outside of plaques...
  12. ncbi request reprint Genetics of multiple sclerosis: determinants of autoimmunity and neurodegeneration
    Bernadette Kalman
    Department of Neurology, MS423, MCP Hahnemann University, 245N 15th Street, Philadelphia, PA 19102, USA
    Autoimmunity 35:225-34. 2002
    ..This approach may yield important insights with utility in clinical practice...
  13. ncbi request reprint Cognitive impairments in multiple sclerosis: a review
    Eduardo Adonias DeSousa
    Department of Neurology, MCP Hahnemann University, Philadelphia, Pennsylvania, USA
    Am J Alzheimers Dis Other Demen 17:23-9. 2002
    ..Until more powerful neuroprotective agents become available, simple neuropsychological screening and cognitive rehabilitation for memory and language impairments will remain important components in the care of MS patients...
  14. ncbi request reprint External ophthalmoplegia with severe progressive multiorgan involvement associated with the mtDNA A3243G mutation
    Sun Hansrote
    Department of Neurology, MCP Hahnemann University, MS 423, 245 North 15th Street, Philadelphia, PA 19102, USA
    J Neurol Sci 197:63-7. 2002
    ....
  15. ncbi request reprint Studies of mitochondrial DNA in Devic's disease revealed no pathogenic mutations, but polymorphisms also found in association with multiple sclerosis
    Bernadette Kalman
    Ann Neurol 51:661-2. 2002
  16. ncbi request reprint An extended genome scan in 442 Canadian multiple sclerosis-affected sibships: a report from the Canadian Collaborative Study Group
    David A Dyment
    The Wellcome Trust Center for Human Genetics, Oxford, UK
    Hum Mol Genet 13:1005-15. 2004
    ..This observation is most consistent with a model of genetic heterogeneity between HLA and other genetic loci. These findings offer guidance for future genetic studies including dense SNP linkage disequilibrium analysis...
  17. doi request reprint Autoantibodies and neurodegeneration in multiple sclerosis
    Tamara Vyshkina
    Veterans Administration Medical Center, Syracuse, NY 13210, USA
    Lab Invest 88:796-807. 2008
    ..A better understanding of molecular pathways leading to immune-mediated neurodegeneration may have key importance in the successful treatment of the disease...
  18. doi request reprint Variations in mitochondrial DNA copy numbers in MS brains
    Andrei Blokhin
    VA Medical Center, 800 Irving Avenue, Syracuse, NY 13210, USA
    J Mol Neurosci 35:283-7. 2008
    ..The age-related decline in mtDNA copy numbers may explain some features of late-onset MS...
  19. pmc Association of common mitochondrial DNA variants with multiple sclerosis and systemic lupus erythematosus
    Tamara Vyshkina
    VAMC Research, 800 Irving Avenue, Syracuse, NY 13210, USA
    Clin Immunol 129:31-5. 2008
    ..In addition, we detect the association of common variants of the mitochondrial ND2 and ATP6 genes with both MS and SLE, which raises the possibility of a shared mitochondrial genetic background of these two autoimmune diseases...
  20. ncbi request reprint The involvement of mitochondria in the pathogenesis of multiple sclerosis
    Bernadette Kalman
    VAMC, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    J Neuroimmunol 188:1-12. 2007
    ....