Dah Ren Hwang

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, New York, New York, USA
    J Nucl Med 45:682-94. 2004
  2. ncbi request reprint Quantitative analysis of (-)-N-(11)C-propyl-norapomorphine in vivo binding in nonhuman primates
    Dah Ren Hwang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Nucl Med 45:338-46. 2004
  3. ncbi request reprint Positron-labeled dopamine agonists for probing the high affinity states of dopamine subtype 2 receptors
    Dah Ren Hwang
    Department of Psychiatry, Columbia University, 1051 Riverside Drive, Unit 31, New York, New York 10032, USA
    Bioconjug Chem 16:27-31. 2005
  4. ncbi request reprint In vivo vulnerability to competition by endogenous dopamine: comparison of the D2 receptor agonist radiotracer (-)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Synapse 52:188-208. 2004
  5. doi request reprint Increased synaptic dopamine function in associative regions of the striatum in schizophrenia
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Arch Gen Psychiatry 67:231-9. 2010
  6. ncbi request reprint Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 29:1190-202. 2004
  7. ncbi request reprint The new PET imaging agent [11C]AFE is a selective serotonin transporter ligand with fast brain uptake kinetics
    Zhihong Zhu
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nucl Med Biol 31:983-94. 2004
  8. ncbi request reprint A new positron emission tomography imaging agent for the serotonin transporter: synthesis, pharmacological characterization, and kinetic analysis of [11C]2-[2-(dimethylaminomethyl)phenylthio]-5-fluoromethylphenylamine ([11C]AFM)
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Box 31, New York, NY 10032, USA
    Nucl Med Biol 31:543-56. 2004
  9. ncbi request reprint Serotonin transporter availability in patients with schizophrenia: a positron emission tomography imaging study with [11C]DASB
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 57:1510-6. 2005
  10. ncbi request reprint Synthesis and pharmacological characterization of a new PET ligand for the serotonin transporter: [11C]5-bromo-2-[2-(dimethylaminomethylphenylsulfanyl)]phenylamine ([11C]DAPA)
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nucl Med Biol 29:741-51. 2002

Research Grants

  1. Probing D2 receptor in vivo
    Dah Ren Hwang; Fiscal Year: 2003

Detail Information

Publications42

  1. ncbi request reprint Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, New York, New York, USA
    J Nucl Med 45:682-94. 2004
    ..The purpose of this study was to compare these 2 agents in healthy humans...
  2. ncbi request reprint Quantitative analysis of (-)-N-(11)C-propyl-norapomorphine in vivo binding in nonhuman primates
    Dah Ren Hwang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Nucl Med 45:338-46. 2004
    ..The goal of this study was to develop and evaluate analytic strategies to derive in vivo (11)C-NPA binding parameters...
  3. ncbi request reprint Positron-labeled dopamine agonists for probing the high affinity states of dopamine subtype 2 receptors
    Dah Ren Hwang
    Department of Psychiatry, Columbia University, 1051 Riverside Drive, Unit 31, New York, New York 10032, USA
    Bioconjug Chem 16:27-31. 2005
    ....
  4. ncbi request reprint In vivo vulnerability to competition by endogenous dopamine: comparison of the D2 receptor agonist radiotracer (-)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Synapse 52:188-208. 2004
    ..In conclusion, [11C]NPA might provide a superior radiotracer to probe presynaptic DA function with PET in health and disease...
  5. doi request reprint Increased synaptic dopamine function in associative regions of the striatum in schizophrenia
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Arch Gen Psychiatry 67:231-9. 2010
    ....
  6. ncbi request reprint Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 29:1190-202. 2004
    ..Additional research is warranted to unravel potential neurobiological traits that might confer vulnerability to relapse in detoxified CCD subjects...
  7. ncbi request reprint The new PET imaging agent [11C]AFE is a selective serotonin transporter ligand with fast brain uptake kinetics
    Zhihong Zhu
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nucl Med Biol 31:983-94. 2004
    ..In summary, [(11)C]AFE appears to be a PET radioligand with fast brain uptake kinetics and can be used for the visualization and quantification of SERT in vivo...
  8. ncbi request reprint A new positron emission tomography imaging agent for the serotonin transporter: synthesis, pharmacological characterization, and kinetic analysis of [11C]2-[2-(dimethylaminomethyl)phenylthio]-5-fluoromethylphenylamine ([11C]AFM)
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Box 31, New York, NY 10032, USA
    Nucl Med Biol 31:543-56. 2004
    ..In summary, [(11)C]AFM appears to be an excellent PET radioligand for the visualization and reliable quantification of SERT in vivo...
  9. ncbi request reprint Serotonin transporter availability in patients with schizophrenia: a positron emission tomography imaging study with [11C]DASB
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 57:1510-6. 2005
    ..The aim of this study was to compare SERT availability in vivo in patients with schizophrenia and matched control subjects...
  10. ncbi request reprint Synthesis and pharmacological characterization of a new PET ligand for the serotonin transporter: [11C]5-bromo-2-[2-(dimethylaminomethylphenylsulfanyl)]phenylamine ([11C]DAPA)
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nucl Med Biol 29:741-51. 2002
    ..In summary, [11C]DAPA appears to be a promising radioligand suitable for the visualization of SERT in vivo using PET...
  11. ncbi request reprint Effects of reduced endogenous 5-HT on the in vivo binding of the serotonin transporter radioligand 11C-DASB in healthy humans
    Peter S Talbot
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, New York 10032, USA
    Synapse 55:164-75. 2005
    ..These results suggest that (11)C-DASB in vivo binding is not affected by reductions in endogenous 5-HT...
  12. ncbi request reprint Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Psychiatry 164:622-9. 2007
    ..Furthermore, the relationship between this dopamine response and the choice to self-administer cocaine in a laboratory model of relapse was investigated...
  13. ncbi request reprint Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    J Cereb Blood Flow Metab 23:285-300. 2003
    ....
  14. ncbi request reprint Comparative evaluation in nonhuman primates of five PET radiotracers for imaging the serotonin transporters: [11C]McN 5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Cereb Blood Flow Metab 22:1377-98. 2002
    ....
  15. ncbi request reprint Measurement of the proportion of D2 receptors configured in state of high affinity for agonists in vivo: a positron emission tomography study using [11C]N-propyl-norapomorphine and [11C]raclopride in baboons
    Rajesh Narendran
    New York State Psychiatric Institute, 1051 Riverside Dr, Box 31, New York, NY 10032, USA
    J Pharmacol Exp Ther 315:80-90. 2005
    ....
  16. ncbi request reprint Prefrontal dopamine D1 receptors and working memory in schizophrenia
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 22:3708-19. 2002
    ..Increased D1 receptor availability observed in patients with schizophrenia might represent a compensatory (but ineffective) upregulation secondary to sustained deficiency in mesocortical DA function...
  17. ncbi request reprint NMDA antagonist effects on striatal dopamine release: positron emission tomography studies in humans
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Synapse 43:19-29. 2002
    ....
  18. ncbi request reprint Dopamine depletion and in vivo binding of PET D1 receptor radioligands: implications for imaging studies in schizophrenia
    Ningning Guo
    Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 28:1703-11. 2003
    ....
  19. ncbi request reprint Occupancy of brain serotonin transporters during treatment with paroxetine in patients with social phobia: a positron emission tomography study with 11C McN 5652
    Justine M Kent
    New York State Psychiatry Institute, New York, NY 10032, USA
    Psychopharmacology (Berl) 164:341-8. 2002
    ....
  20. ncbi request reprint A PET imaging agent with fast kinetics: synthesis and in vivo evaluation of the serotonin transporter ligand [11C]2-[2-dimethylaminomethylphenylthio)]-5-fluorophenylamine ([11C]AFA)
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Box 31, New York, NY 10032, USA
    Nucl Med Biol 31:727-38. 2004
    ..In summary, [11C]AFA appears to be an appropriate PET radioligand with a fast brain uptake kinetics:..
  21. ncbi request reprint Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Biol Psychiatry 58:779-86. 2005
    ..This study measured D2 receptors and dopamine transmission in human alcohol-dependent (AD) subjects using positron emission tomography (PET) and [11C]raclopride...
  22. ncbi request reprint Altered prefrontal dopaminergic function in chronic recreational ketamine users
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Psychiatry 162:2352-9. 2005
    ..In this study, dopamine D1 receptor availability was assessed by using positron emission tomography and the selective D1 receptor radioligand [11C]NNC 112 in a group of 14 recreational chronic ketamine users and matched healthy subjects...
  23. ncbi request reprint Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York 10032, USA
    Synapse 60:485-95. 2006
    ..This property might contribute to its higher vulnerability to endogenous DA compared to [11C]raclopride and [11C]NPA...
  24. ncbi request reprint Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, 1051 Riverside Dr, Box 31, New York, NY 10032, USA
    Am J Psychiatry 162:915-23. 2005
    ..This study evaluated regional serotonin transporter distribution in the brain of individuals with impulsive aggression by using positron emission tomography (PET) with the serotonin transporter PET radiotracer [(11)C]McN 5652...
  25. ncbi request reprint 11C-GR103545, a radiotracer for imaging kappa-opioid receptors in vivo with PET: synthesis and evaluation in baboons
    Peter S Talbot
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    J Nucl Med 46:484-94. 2005
    ..The (-)-isomer, GR103545, is the active enantiomer of GR89696. The aim of this study was to characterize the potential of 11C-GR103545 to image kappa-OR in vivo with PET...
  26. ncbi request reprint In vivo affinity of [18F]fallypride for striatal and extrastriatal dopamine D2 receptors in nonhuman primates
    Mark Slifstein
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Psychopharmacology (Berl) 175:274-86. 2004
    ..The high signal to noise ratio of [18F]fallypride has been attributed to its high affinity for D2 receptors (K(D) of 0.03 nM, measured in vitro at room temperature)...
  27. pmc Dopamine transporters, D2 receptors, and dopamine release in generalized social anxiety disorder
    Franklin R Schneier
    Anxiety Disorders Clinic, New York State Psychiatric Institute, Unit 69, 1051 Riverside Drive, New York, NY 10032, USA
    Depress Anxiety 26:411-8. 2009
    ..D2 receptors and DAT have not previously been studied within the same GSAD subjects, however, and prior GSAD studies have not assessed dopamine release or subdivided the STR into functional subregions...
  28. doi request reprint Synthesis and characterization of two PET radioligands for the metabotropic glutamate 1 (mGlu1) receptor
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Synapse 66:1002-14. 2012
    ..Radioligands with higher affinity and/or lower lipophilicity are needed to successfully image the mGlu1 receptor in humans...
  29. doi request reprint Increased prefrontal cortical D₁ receptors in drug naive patients with schizophrenia: a PET study with [¹¹C]NNC112
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Psychopharmacol 26:794-805. 2012
    ..We conclude that upregulation of D1 receptors in schizophrenia is related to the illness itself and may be corrected and normalized by chronic antipsychotic treatment...
  30. doi request reprint Measurement of the serotonin 1A receptor availability in patients with schizophrenia during treatment with the antipsychotic medication ziprasidone
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    J Psychopharmacol 25:734-43. 2011
    ..The finding of a relationship between 5-HT(1A) binding and the degree of improvement in negative symptoms provides further support for the role of the 5-HT(1A) receptor in the pathophysiology and treatment of this symptom domain...
  31. ncbi request reprint In vivo DA D(1) receptor selectivity of NNC 112 and SCH 23390
    Jesper Ekelund
    Department of Psychiatry, Columbia University, New York, NY, USA
    Mol Imaging Biol 9:117-25. 2007
    ..It is known that both have some affinity for serotonin 2A receptors, but previous studies have suggested this is negligible compared to D(1) affinity. We sought to verify this property in vivo...
  32. ncbi request reprint Effect of amphetamine on [(18)F]fallypride in vivo binding to D(2) receptors in striatal and extrastriatal regions of the primate brain: Single bolus and bolus plus constant infusion studies
    Mark Slifstein
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA
    Synapse 54:46-63. 2004
    ....
  33. ncbi request reprint Modulation of amphetamine-induced dopamine release by group II metabotropic glutamate receptor agonist LY354740 in non-human primates studied with positron emission tomography
    Bart N M van Berckel
    Department of Psychiatry, Columbia University, New York, NY, USA
    Neuropsychopharmacology 31:967-77. 2006
    ....
  34. ncbi request reprint Amphetamine-induced dopamine release: duration of action as assessed with the D2/3 receptor agonist radiotracer (-)-N-[(11)C]propyl-norapomorphine ([11C]NPA) in an anesthetized nonhuman primate
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Synapse 61:106-9. 2007
  35. pmc Positron emission tomography imaging of the serotonin transporter and 5-HT(1A) receptor in alcohol dependence
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    Biol Psychiatry 65:175-80. 2009
    ..This is the first report of combined tracers for pre- and postsynaptic serotonergic transmission in the same alcoholic subjects and the first study of 5-HT(1A) receptors in alcoholism...
  36. ncbi request reprint Biodistribution and radiation dosimetry of the dopamine D2 ligand 11C-raclopride determined from human whole-body PET
    Mark Slifstein
    Department of Psychiatry, Columbia University, New York, New York 10032, USA
    J Nucl Med 47:313-9. 2006
    ..Whole-body radiation dosimetry of 11C-raclopride was performed in healthy human volunteers...
  37. ncbi request reprint Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: reproducibility and comparison of methods
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, NY 10032, USA
    J Nucl Med 47:815-26. 2006
    ..The aim of the present study was to define the optimal analytic method to derive accurate and reliable serotonin transporter (SERT) receptor parameters with (11)C-3-amino-4-(2-[(dimethylamino)methyl]phenylthio)benzonitrile ((11)C-DASB)...
  38. pmc Extended characterisation of the serotonin 2A (5-HT2A) receptor-selective PET radiotracer 11C-MDL100907 in humans: quantitative analysis, test-retest reproducibility, and vulnerability to endogenous 5-HT tone
    Peter S Talbot
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Neuroimage 59:271-85. 2012
    ..We present an extended characterisation in healthy human subjects...
  39. pmc Dopamine D1 receptors in cocaine dependence measured with PET and the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neuropsychopharmacology 34:1774-82. 2009
    ....
  40. ncbi request reprint Serotonin transporters in obsessive-compulsive disorder: a positron emission tomography study with [(11)C]McN 5652
    H Blair Simpson
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 54:1414-21. 2003
    ..This study examined whether brain serotonin transporter (SERT) availability is altered in OCD using positron emission tomography (PET) and the SERT PET radiotracer [(11)C]McN 5652...
  41. ncbi request reprint Serotonin 1A receptor availability in patients with schizophrenia and schizo-affective disorder: a positron emission tomography imaging study with [11C]WAY 100635
    W Gordon Frankle
    Departments of Psychiatry and Radiology, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 189:155-64. 2006
    ..This study examines 5-HT(1A) availability in vivo in individuals with schizophrenia and schizo-affective disorder...
  42. ncbi request reprint How the biopharmaceutical industry uses molecular imaging
    Dah Ren Hwang
    Amgen, Thousand Oaks, CA, USA
    J Nucl Med 49:24N-25N. 2008

Research Grants1

  1. Probing D2 receptor in vivo
    Dah Ren Hwang; Fiscal Year: 2003
    ..In addition to schizophrenia, this radiotracer will provide a useful tool for characterization of dopamine transmission at the D2 receptor in a variety of other conditions, such as ADHD, Parkinson's disease, and substance abuse. ..