Genomes and Genes
Affiliation: Columbia University
- Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1Haiying Hang
Center for Radiological Research, Columbia University, 630 West 168th Street, New York, New York 10032, USA
Genomics 79:487-92. 2002..Furthermore, overexpression of HUS1B but not HUS1 in human cells induces clonogenic cell death. We suggest that HUS1B and HUS1 have distinct but related roles in regulating cell cycle checkpoints and genomic integrity...
- Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissueKevin M Hopkins
Center for Radiological Research, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Cancer Res 63:5291-8. 2003..The findings also indicate that HRAD9B can serve as a biomarker in particular for testicular seminomas and might be causally related to the disease...
- Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethalityKevin M Hopkins
Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Mol Cell Biol 24:7235-48. 2004..These investigations establish Mrad9 as a key mammalian genetic element of pathways that regulate the cellular response to DNA damage, maintenance of genomic integrity, and proper embryonic development...
- Cadmium-induced germline apoptosis in Caenorhabditis elegans: the roles of HUS1, p53, and MAPK signaling pathwaysShunchang Wang
Key Laboratory of Ion Beam Bioengineering, Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui 230031, People s Republic of China
Toxicol Sci 102:345-51. 2008..Finally, our study demonstrates that C. elegans is a mammalian in vivo substitute model to study the mechanisms of Cd-induced apoptosis...
- Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathwaysZhigang Guo
Department of Radiation Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA
J Mol Biol 377:679-90. 2008..Replacement of one or more residues with an alanine in many cases leads to the complete loss of interaction, which may consequently lead to severe biological defects in mammals...
- Targeted deletion of Rad9 in mouse skin keratinocytes enhances genotoxin-induced tumor developmentZhishang Hu
National Laboratory of Biomacromolecules, Chinese Academy of Sciences, Beijing, China
Cancer Res 68:5552-61. 2008..These data suggest that Mrad9 plays an important role in maintaining genomic stability and preventing tumor development in keratinocytes...
- Phosphorylation sites on Tyr28 and the C-terminus of Rad9 are required for inhibition of premature chromosomal condensation across the entire S phaseChunbo Zhang
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
Cell Physiol Biochem 22:295-306. 2008..Taken together, these results suggest that phosphorylation of Rad9 plays a critical role in the activation of the S/M checkpoint, and that downstream proteins cdc2 and 14-3-3sigma mediate this function...