Kathleen M Friel
Affiliation: Columbia University
- Using motor behavior during an early critical period to restore skilled limb movement after damage to the corticospinal system during developmentKATHLEEN FRIEL
Department of Psychiatry, Columbia University, New York, New York 10032, USA
J Neurosci 32:9265-76. 2012..Restraint alone only restored CST connectivity. Our findings stress the need to reestablish the integrated functions of the CS system at multiple hierarchical levels in restoring skilled motor function after developmental injury...
- Effects of a rostral motor cortex lesion on primary motor cortex hand representation topography in primatesKathleen M Friel
Department of Molecular and Integrative Physiology, Landon Center on Aging, and Smith Mental Retardation Research Center, University of Kansas Medical Center, Kansas City, KS, USA
Neurorehabil Neural Repair 21:51-61. 2007..The goal of the present study was to determine if rehabilitative training has similar effects on functional topography of the spared M1 after rostral versus previously reported caudal M1 lesions...
- Dissociation of sensorimotor deficits after rostral versus caudal lesions in the primary motor cortex hand representationKathleen M Friel
Department of Molecular and Integrative Physiology, Landon Center on Aging, University of Kansas Medical Center, Kansas City, Kansas, USA
J Neurophysiol 94:1312-24. 2005..Rostral and caudal M1 lesions result in different deficits in sensory-dependent motor control that appear to correlate with broad segregation of motor outputs and previously described sensory inputs of M1...
- Post-infarct cortical plasticity and behavioral recovery using concurrent cortical stimulation and rehabilitative training: a feasibility study in primatesErik J Plautz
Department of Molecular and Integrative Physiology, Smith Mental Retardation Research Center, University of Kansas Medical Center, Kansas City, KS 66160, USA
Neurol Res 25:801-10. 2003..Results support the feasibility of using a therapy approach combining peri-infarct electrical stimulation with rehabilitative training to alleviate chronic motor deficits and promote recovery from cortical ischemic injury...
- Behavioral and neurophysiological effects of delayed training following a small ischemic infarct in primary motor cortex of squirrel monkeysScott Barbay
Landon Center on Aging and Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, USA
Exp Brain Res 169:106-16. 2006..These results indicate that post-injury behavioral experience, such as motor skill training, may modulate peri-infarct cortical plasticity in different ways in the acute versus chronic stages following stroke...
- Ipsilateral connections of the ventral premotor cortex in a new world primateNuma Dancause
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
J Comp Neurol 495:374-90. 2006..No statistical difference between the proportions of inputs and outputs for any location was observed, supporting the reciprocity of PMv intracortical connections...
- Topographically divergent and convergent connectivity between premotor and primary motor cortexNuma Dancause
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
Cereb Cortex 16:1057-68. 2006..To our knowledge, this is the first description of such a consistent clustering of PMv terminals within M1...
- Pyramidal tract stimulation restores normal corticospinal tract connections and visuomotor skill after early postnatal motor cortex activity blockadeIran Salimi
Department of Neuroscience, Columbia University, New York, New York 10032, USA
J Neurosci 28:7426-34. 2008..These findings show the importance of activity-dependent processes in specifying CST connections. They also provide a strategy for harnessing activity to rescue CST axons at risk of developing aberrant connections after CNS injury...
- A squirrel monkey model of poststroke motor recoveryRandolph J Nudo
Center on Aging, Department of Physiology, University of Kansas Medical Center, Kansas City, USA
ILAR J 44:161-74. 2003..This methodology is described in detail, and many of the resulting findings that are relevant for understanding stroke recovery and the effects of rehabilitative and pharmacotherapeutic interventions are summarized...
- Skilled Bimanual Training Drives Motor Cortex Plasticity in Children With Unilateral Cerebral PalsyKathleen M Friel
Burke Cornell Medical Research Institute, White Plains, NY, USA Teachers College, Columbia University, New York, NY, USA Weill Cornell Medical College, New York, NY, USA
Neurorehabil Neural Repair 30:834-44. 2016..Skill training is important for driving motor cortex plasticity in children with USCP. ..
- Bilateral activity-dependent interactions in the developing corticospinal systemKathleen M Friel
Department of Neuroscience, Columbia University, New York, New York 10032, USA
J Neurosci 27:11083-90. 2007..Our findings show that robust bilateral interactions between the developing CS systems on each side are important for achieving balance between contralateral and ipsilateral CS tract connections and visuomotor control...
- Pathophysiological mechanisms of impaired limb use and repair strategies for motor systems after unilateral injury of the developing brainKathleen M Friel
Burke Cornell Medical Research Institute, White Plains, NY, USA Department of Psychiatry, Columbia University, New York, NY, USA Department of Physiology, Pharmacology, and Neuroscience, City College of the City University of New York, New York, NY, USA
Dev Med Child Neurol 55:27-31. 2013....
- Activity- and use-dependent plasticity of the developing corticospinal systemJohn H Martin
Center for Neurobiology and Behavior, Columbia University, N Y S Psychiatric Institute, New York, NY 10032, USA
Neurosci Biobehav Rev 31:1125-35. 2007..This finding suggests that aspects of normal CS connectivity and function might some day be restored in hemiplegic cerebral palsy...
- Role of sensory-motor cortex activity in postnatal development of corticospinal axon terminals in the catKathleen M Friel
Center for Neurobiology and Behavior, Columbia University, New York State Psychiatric Institute, New York, New York 10032, USA
J Comp Neurol 485:43-56. 2005..Surprisingly, when a CS neuron's activity is blocked during early development, it does not recover lost connections later in development once activity resumes...
- Using diffusion tensor imaging to identify corticospinal tract projection patterns in children with unilateral spastic cerebral palsyHsing Ching Kuo
Department of Biobehavioral Sciences, Teachers College, Columbia University, New York, NY, USA
Dev Med Child Neurol . 2016..To determine whether diffusion tensor imaging (DTI) can be an independent assessment for identifying the corticospinal tract (CST) projecting from the more-affected motor cortex in children with unilateral spastic cerebral palsy (CP)...
- A telehealth approach to conducting clinical swallowing evaluations in children with cerebral palsyCagla Kantarcigil
Purdue University, Lyles Porter Hall, 715 Clinic Drive, West Lafayette, IN 47907, USA Teachers College, Columbia University, 525 W 120th Street, New York, NY 10027, USA Electronic address
Res Dev Disabil 55:207-17. 2016..Accurate and timely evaluation of dysphagia in children with cerebral palsy (CP) is critical. For children with limited access to quality healthcare, telehealth is an option; however, its reliability needs to be investigated...
- The effects of intensive bimanual training with and without tactile training on tactile function in children with unilateral spastic cerebral palsy: A pilot studyHsing Ching Kuo
Department of Biobehavioral Sciences, Teachers College, Columbia University, 525 West 120th Street, Box 93, New York, NY 10027, USA Electronic address
Res Dev Disabil 49:129-39. 2016..We conclude tactile spatial resolution can improve after bimanual training. Either intensive bimanual training alone or incorporation of materials with a diversity of shapes/textures may drive these changes...
- Corticospinal development after cortical inactivationKATHLEEN FRIEL; Fiscal Year: 2005....