WILLIAM BLANER

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Effect of vitamin A depletion on nonvisual phototransduction pathways in cryptochromeless mice
    Carol L Thompson
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    J Biol Rhythms 19:504-17. 2004
  2. ncbi request reprint STRA6, a cell-surface receptor for retinol-binding protein: the plot thickens
    William S Blaner
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell Metab 5:164-6. 2007
  3. ncbi request reprint Vitamin A Absorption, Storage and Mobilization
    William S Blaner
    Department of Medicine, College of Physicians and Surgeons, Columbia University, 650 W 168th St, New York, NY, 10032, USA
    Subcell Biochem 81:95-125. 2016
  4. pmc Distinct populations of hepatic stellate cells in the mouse liver have different capacities for retinoid and lipid storage
    Diana N D'Ambrosio
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e24993. 2011
  5. pmc The adverse effects of alcohol on vitamin A metabolism
    Robin D Clugston
    Department of Medicine and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Nutrients 4:356-71. 2012
  6. ncbi request reprint Cellular metabolism and actions of 13-cis-retinoic acid
    W S Blaner
    Department of Medicine, College of Physicians and Surgeons, Columbia University, 701 W 168th St, New York, NY 10032, USA
    J Am Acad Dermatol 45:S129-35. 2001
  7. ncbi request reprint Retinoid inactivation: survival factor for male germ cells
    William S Blaner
    Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Endocrinology 148:4557-9. 2007
  8. pmc Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage
    William S Blaner
    Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Biochim Biophys Acta 1791:467-73. 2009
  9. ncbi request reprint Retinol-binding protein-deficient mice: biochemical basis for impaired vision
    Silke Vogel
    Department of Medicine, Institute of Human Nutrition, and Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Biochemistry 41:15360-8. 2002
  10. pmc Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT)
    Sheila M O'Byrne
    Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 280:35647-57. 2005

Research Grants

  1. Carotene Cleavage Enzyme: Properties and Physiology
    WILLIAM BLANER; Fiscal Year: 2007
  2. FASEB SUMMER RESEARCH CONFERENCE ON RETINOIDS
    WILLIAM BLANER; Fiscal Year: 2002
  3. THE VISUALLY DEFECTIVE PHENOTYPE OF RBP-DEFICIENT MICE
    WILLIAM BLANER; Fiscal Year: 2002
  4. 9 CIS RETINOL DEHYDROGENASE--PROPERTIES AND PHYSIOLOGY
    WILLIAM BLANER; Fiscal Year: 2004
  5. 12th FASEB Summer Research Conference on Retinoids
    WILLIAM BLANER; Fiscal Year: 2004
  6. Vitamin A Storage and Metabolism
    William S Blaner; Fiscal Year: 2010

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Effect of vitamin A depletion on nonvisual phototransduction pathways in cryptochromeless mice
    Carol L Thompson
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    J Biol Rhythms 19:504-17. 2004
    ..These data demonstrate that both cryptochromes and opsins regulate nonvisual photoresponses...
  2. ncbi request reprint STRA6, a cell-surface receptor for retinol-binding protein: the plot thickens
    William S Blaner
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell Metab 5:164-6. 2007
    ..2007) and Pasutto et al. (2007), provide compelling data regarding the molecular identity and properties of a RBP receptor and open new research avenues for a better understanding of retinoid biology...
  3. ncbi request reprint Vitamin A Absorption, Storage and Mobilization
    William S Blaner
    Department of Medicine, College of Physicians and Surgeons, Columbia University, 650 W 168th St, New York, NY, 10032, USA
    Subcell Biochem 81:95-125. 2016
    ....
  4. pmc Distinct populations of hepatic stellate cells in the mouse liver have different capacities for retinoid and lipid storage
    Diana N D'Ambrosio
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e24993. 2011
    ....
  5. pmc The adverse effects of alcohol on vitamin A metabolism
    Robin D Clugston
    Department of Medicine and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Nutrients 4:356-71. 2012
    ....
  6. ncbi request reprint Cellular metabolism and actions of 13-cis-retinoic acid
    W S Blaner
    Department of Medicine, College of Physicians and Surgeons, Columbia University, 701 W 168th St, New York, NY 10032, USA
    J Am Acad Dermatol 45:S129-35. 2001
    ..It is clear, however, that if we are to fully understand the basis for the clinical efficacy of 13-cis-retinoic acid, a better understanding of such biochemical actions is needed...
  7. ncbi request reprint Retinoid inactivation: survival factor for male germ cells
    William S Blaner
    Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Endocrinology 148:4557-9. 2007
  8. pmc Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage
    William S Blaner
    Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Biochim Biophys Acta 1791:467-73. 2009
    ..Collectively, the available information suggests that HSC lipid droplets are specialized organelles for hepatic retinoid storage and that loss of HSC lipid droplets may contribute to the development of hepatic disease...
  9. ncbi request reprint Retinol-binding protein-deficient mice: biochemical basis for impaired vision
    Silke Vogel
    Department of Medicine, Institute of Human Nutrition, and Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Biochemistry 41:15360-8. 2002
    ..This provides an explanation for the impaired vision phenotype of RBP-deficient mice...
  10. pmc Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT)
    Sheila M O'Byrne
    Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 280:35647-57. 2005
    ..The fatty acyl composition of these (chylomicron) retinyl esters suggests that they are synthesized via an acyl-CoA-dependent process suggesting the existence of a physiologically significant acyl-CoA:retinol acyltransferase...
  11. ncbi request reprint The role of extrahepatic retinol binding protein in the mobilization of retinoid stores
    Loredana Quadro
    Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Lipid Res 45:1975-82. 2004
    ..Thus, RBP is not required for intrahepatic transport and storage of retinoid. These and other observations are discussed...
  12. ncbi request reprint Increased neonatal mortality in mice lacking cellular retinol-binding protein II
    Xueping E
    Department of Medicine, Washington University, St Louis School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:36617-23. 2002
    ..These studies suggest that both fetal as well as maternal CRBP II are required to ensure adequate delivery of vitamin A to the developing fetus when dietary vitamin A is limiting...
  13. ncbi request reprint Lipids in the heart: a source of fuel and a source of toxins
    Tae Sik Park
    Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Curr Opin Lipidol 18:277-82. 2007
    ..How do lipids arrive in the heart and other tissues? This review focuses on new information on pathways of lipid uptake into the heart...
  14. pmc Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice
    Sheila M O'Byrne
    Institute of Human Nutrition, Columbia University, New York, NY 10032, USA
    Am J Physiol Endocrinol Metab 298:E862-70. 2010
    ..Our data show that compensatory pathways for the delivery of retinoids ensure their optimal delivery and that LRAT is the most important enzyme for milk retinyl ester formation...
  15. doi request reprint Decreased lipoprotein clearance is responsible for increased cholesterol in LDL receptor knockout mice with streptozotocin-induced diabetes
    Ira J Goldberg
    Division of Preventive Medicine, Columbia University, New York, New York 10032, USA
    Diabetes 57:1674-82. 2008
    ..Patients with diabetes often have dyslipidemia and increased postprandial lipidmia. Induction of diabetes in LDL receptor (Ldlr(-/-)) knockout mice also leads to marked dyslipidemia. The reasons for this are unclear...
  16. pmc Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation
    Konstantinos Drosatos
    Dept of Medicine, Columbia University, 630 West 168th St, New York, NY 10032, USA
    Am J Physiol Endocrinol Metab 300:E489-99. 2011
    ..Thus, several lipids that are increased in the setting of lipotoxicity can produce abnormalities in β-AR responsiveness. This can be attributed to PKC activation and reduced β-AR levels...
  17. pmc Chylomicron- and VLDL-derived lipids enter the heart through different pathways: in vivo evidence for receptor- and non-receptor-mediated fatty acid uptake
    Kalyani G Bharadwaj
    Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 285:37976-86. 2010
    ..In addition, our data show that lipolysis is involved in uptake of core lipids from TG-rich lipoproteins...
  18. ncbi request reprint Understanding the physiological role of retinol-binding protein in vitamin A metabolism using transgenic and knockout mouse models
    Loredana Quadro
    Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Aspects Med 24:421-30. 2003
    ..We discuss below the role of RBP in maintaining normal vision and a steady flux of retinol throughout the body in times of need...
  19. ncbi request reprint Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency
    Loredana Quadro
    Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Endocrinology 146:4479-90. 2005
    ..Finally, we demonstrate that accumulation of embryonic vitamin A stores does not depend on the expression of RBP in the fetal liver...
  20. pmc The molecular basis of retinoid absorption: a genetic dissection
    Nuttaporn Wongsiriroj
    Institute of Human Nutrition and Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 283:13510-9. 2008
    ..Contrary to what has been proposed in the literature based on in vitro studies, CRBPII does not directly prevent retinol from being acted upon by DGAT1 or other intestinal ARATs in vivo...
  21. ncbi request reprint Vitamin A: overlapping delivery pathways to tissues from the circulation
    Jisun Paik
    Department of Medicine, Columbia University, New York, NY 10032, USA
    J Nutr 134:276S-280S. 2004
    ..This may suggest that CCE and LDH-C act in concert to catalyze beta-carotene cleavage...
  22. ncbi request reprint Muscle expression of human retinol-binding protein (RBP). Suppression of the visual defect of RBP knockout mice
    Loredana Quadro
    Institute of Cancer Research, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 277:30191-7. 2002
    ..No human RBP was found in the retinal pigment epithelium of the transgenic mice, indicating that retinol uptake by the eye does not entail endocytosis of the carrier RBP...
  23. ncbi request reprint Cellular retinol-binding protein type III is needed for retinoid incorporation into milk
    Roseann Piantedosi
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 280:24286-92. 2005
    ..However, under conditions of high demand for retinoid, such as those experienced during lactation, this compensation was incomplete...
  24. ncbi request reprint Transplacental delivery of retinoid: the role of retinol-binding protein and lipoprotein retinyl ester
    Loredana Quadro
    Institute of Cancer Research, College of Physicians and Surgeons, Columbia Univ, New York, NY 10032, USA
    Am J Physiol Endocrinol Metab 286:E844-51. 2004
    ..Overall, our data indicate that both retinol-RBP and retinyl esters bound to lipoproteins are able to provide sufficient retinoid to the embryo to allow for normal embryonic development...
  25. pmc Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis
    Brendan N Reid
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 283:13087-99. 2008
    ....
  26. pmc Measures of postprandial lipoproteins are not associated with coronary artery disease in patients with type 2 diabetes mellitus
    Gissette Reyes-Soffer
    Departments of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    J Lipid Res 50:1901-9. 2009
    ..PP measurements of TG-rich lipoproteins do not predict the presence of CAD in individuals with DM...
  27. ncbi request reprint Vitamin A deficiency does not influence longitudinal growth in mice
    Alessia Sagazio
    Department of Medicine, Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nutrition 23:483-8. 2007
    ..Accordingly, epidemiologic studies have shown that short children have lower VA intake than do children with normal stature...
  28. pmc Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis
    Rebeca Acín-Pérez
    Department of Neurology and Neurobiology Weill Cornell Medical School, New York, New York, USA
    FASEB J 24:627-36. 2010
    ..The data provide a mechanistic explanation to the nearly 100-yr-old question of why vitamin A deficiency causes so many pathologies that are independent of retinoic acid action...
  29. ncbi request reprint Targeted disruption of the mouse cis-retinol dehydrogenase gene: visual and nonvisual functions
    Enyuan Shang
    The Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Lipid Res 43:590-7. 2002
    ..Thus, cRDH may act essentially in the visual cycle but is redundant for catalyzing 9-cis-retinoic acid formation and 3 alpha-hydroxysteroid metabolism...
  30. ncbi request reprint Retinoids, retinoic acid receptors, and breast cancer
    Jisun Paik
    Department of Medicine, Institute of Human Nutrition, Columbia University, New York, New York, USA
    Cancer Invest 21:304-12. 2003
    ....
  31. pmc Hepatic stellate cells are an important cellular site for β-carotene conversion to retinoid
    Igor Shmarakov
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Arch Biochem Biophys 504:3-10. 2010
    ..Collectively, our data establish that HSCs are an important cellular site for β-carotene accumulation and metabolism within the liver...
  32. pmc Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis
    Youn Kyung Kim
    Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 283:5611-21. 2008
    ..In contrast, the pathway of retinoic acid synthesis does not contribute significantly to regulating retinoid homeostasis during mammalian development except under conditions of severe maternal retinoid deficiency...
  33. pmc Metabolism and transactivation activity of 13,14-dihydroretinoic acid
    Alexander R Moise
    Department of Ophthalmology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:27815-25. 2005
    ..This new metabolite can also be an intermediate in a retinol degradation pathway or it can serve as a precursor for the synthesis of bioactive 13,14-dihydroretinoid metabolites...
  34. pmc Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina
    Xiaohong Fan
    OncoDevelopmental Biology Program Center for Neuroscience and Aging, Burnham Institute, La Jolla, California 92037, USA
    Mol Cell Biol 23:4637-48. 2003
    ..Our findings suggest that RA signaling may be necessary only during early stages of retina development and that if RA synthesis is needed in dorsal retina, it is catalyzed by multiple enzymes, including Raldh1...
  35. pmc Apolipoprotein AII is a regulator of very low density lipoprotein metabolism and insulin resistance
    Lawrence W Castellani
    Departments of Medicine Cardiology University of California, Los Angeles, Los Angeles, California 90095, USA
    J Biol Chem 283:11633-44. 2008
    ....
  36. pmc Increased fibronectin deposition in embryonic hearts of retinol-binding protein-null mice
    Christopher C Wendler
    Department of Cell Biology, Neurobiology and Anatomy and the Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Circ Res 92:920-8. 2003
    ..This murine model may have relevance to fetal development in human populations with inadequate retinoid intake...
  37. pmc Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina
    Marcin Golczak
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Biol Chem 283:9543-54. 2008
    ..Finally, we provide evidence for a crucial role of lecithin: retinol acyltransferase activity in mediating tissue specific absorption and long lasting therapeutic effects of retinoid-based visual cycle inhibitors...
  38. pmc Delivery of retinoid-based therapies to target tissues
    Alexander R Moise
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    Biochemistry 46:4449-58. 2007
    ..Future retinoid-based therapeutic strategies could involve targeted delivery mechanisms leading to lower toxicity and improved effectiveness of retinoids...
  39. ncbi request reprint Cis-retinol dehydrogenase: 9-cis-retinol metabolism and its effect on proliferation of human MCF7 breast cancer cells
    Jisun Paik
    Department of Pathobiology, University of Washington, Seattle, WA 98195, United States
    Exp Cell Res 303:183-96. 2005
    ..Our studies demonstrate that 9-cis-retinol in combination with cRDH inhibits breast cancer cell proliferation by production of retinol metabolites other than RA...
  40. pmc Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons
    Anne P Beigneux
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, and Children s Hospital Oakland Research Institute 94609, USA
    Cell Metab 5:279-91. 2007
    ..Expression of GPIHBP1 in cultured cells confers the ability to bind both LpL and chylomicrons. These studies strongly suggest that GPIHBP1 is an important platform for the LpL-mediated processing of chylomicrons in capillaries...
  41. ncbi request reprint Association of vitamin A and zinc status with altered intestinal permeability: analyses of cohort data from northeastern Brazil
    Ping Chen
    Center for Global Health, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville 22908, USA
    J Health Popul Nutr 21:309-15. 2003
    ..001) and HAZ scores (p = 0.007) improved with supplementation. It is concluded that impaired intestinal barrier function and linear growth shortfalls improve following supplementation of vitamin A and zinc in this setting...
  42. ncbi request reprint Retinol and retinol-binding protein in cerebrospinal fluid: can vitamin A take the "idiopathic" out of idiopathic intracranial hypertension?
    Jenny Libien
    J Neuroophthalmol 27:253-7. 2007
  43. ncbi request reprint Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro
    Jens M Baron
    Department of Dermatology and Allergology, University Hospital of the RWTH, Aachen, Germany
    J Invest Dermatol 125:143-53. 2005
    ....
  44. pmc In vitro and in vivo characterization of retinoid synthesis from beta-carotene
    Yvette Fierce
    Department of Comparative Medicine, University of Washington, Raitt Hall 324, Seattle, WA 98195, USA
    Arch Biochem Biophys 472:126-38. 2008
    ..Our studies provide new insights into the regulation of BCMO1 activity and the physiological role of BCMO1 in living organisms...

Research Grants6

  1. Carotene Cleavage Enzyme: Properties and Physiology
    WILLIAM BLANER; Fiscal Year: 2007
    ..In Aim 4, we propose to use a cDNA clone for human CCE to characterize the biochemical properties of the recombinant enzyme. ..
  2. FASEB SUMMER RESEARCH CONFERENCE ON RETINOIDS
    WILLIAM BLANER; Fiscal Year: 2002
    ..This overview should allow the evaluation of future directions and the development of new ideas as well critical review of the recent research. ..
  3. THE VISUALLY DEFECTIVE PHENOTYPE OF RBP-DEFICIENT MICE
    WILLIAM BLANER; Fiscal Year: 2002
    ..These studies will provide fundamental new information about the role(s) of RBP in vision. This information will be directly relevant to humans and human disease. ..
  4. 9 CIS RETINOL DEHYDROGENASE--PROPERTIES AND PHYSIOLOGY
    WILLIAM BLANER; Fiscal Year: 2004
    ....
  5. 12th FASEB Summer Research Conference on Retinoids
    WILLIAM BLANER; Fiscal Year: 2004
    ..This will stimulate new investigations that in time will provide needed insight into the essential actions of retinoids in preventing disease and maintaining good health. ..
  6. Vitamin A Storage and Metabolism
    William S Blaner; Fiscal Year: 2010
    ..Finally, in Aim 3 we will investigate how vitamin A is mobilized from HSCs and whether this requires direct involvement of serum retinol-binding protein (RBP) synthesized in hepatocytes. ..