Affiliation: Columbia University
- Effect of vitamin A depletion on nonvisual phototransduction pathways in cryptochromeless miceCarol L Thompson
Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
J Biol Rhythms 19:504-17. 2004..These data demonstrate that both cryptochromes and opsins regulate nonvisual photoresponses...
- STRA6, a cell-surface receptor for retinol-binding protein: the plot thickensWilliam S Blaner
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Cell Metab 5:164-6. 2007..2007) and Pasutto et al. (2007), provide compelling data regarding the molecular identity and properties of a RBP receptor and open new research avenues for a better understanding of retinoid biology...
- Vitamin A Absorption, Storage and MobilizationWilliam S Blaner
Department of Medicine, College of Physicians and Surgeons, Columbia University, 650 W 168th St, New York, NY, 10032, USA
Subcell Biochem 81:95-125. 2016....
- Distinct populations of hepatic stellate cells in the mouse liver have different capacities for retinoid and lipid storageDiana N D'Ambrosio
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America
PLoS ONE 6:e24993. 2011....
- The adverse effects of alcohol on vitamin A metabolismRobin D Clugston
Department of Medicine and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Nutrients 4:356-71. 2012....
- Cellular metabolism and actions of 13-cis-retinoic acidW S Blaner
Department of Medicine, College of Physicians and Surgeons, Columbia University, 701 W 168th St, New York, NY 10032, USA
J Am Acad Dermatol 45:S129-35. 2001..It is clear, however, that if we are to fully understand the basis for the clinical efficacy of 13-cis-retinoic acid, a better understanding of such biochemical actions is needed...
- Retinoid inactivation: survival factor for male germ cellsWilliam S Blaner
Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Endocrinology 148:4557-9. 2007
- Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storageWilliam S Blaner
Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
Biochim Biophys Acta 1791:467-73. 2009..Collectively, the available information suggests that HSC lipid droplets are specialized organelles for hepatic retinoid storage and that loss of HSC lipid droplets may contribute to the development of hepatic disease...
- Retinol-binding protein-deficient mice: biochemical basis for impaired visionSilke Vogel
Department of Medicine, Institute of Human Nutrition, and Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Biochemistry 41:15360-8. 2002..This provides an explanation for the impaired vision phenotype of RBP-deficient mice...
- Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT)Sheila M O'Byrne
Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Biol Chem 280:35647-57. 2005..The fatty acyl composition of these (chylomicron) retinyl esters suggests that they are synthesized via an acyl-CoA-dependent process suggesting the existence of a physiologically significant acyl-CoA:retinol acyltransferase...
- The role of extrahepatic retinol binding protein in the mobilization of retinoid storesLoredana Quadro
Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Lipid Res 45:1975-82. 2004..Thus, RBP is not required for intrahepatic transport and storage of retinoid. These and other observations are discussed...
- Increased neonatal mortality in mice lacking cellular retinol-binding protein IIXueping E
Department of Medicine, Washington University, St Louis School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 277:36617-23. 2002..These studies suggest that both fetal as well as maternal CRBP II are required to ensure adequate delivery of vitamin A to the developing fetus when dietary vitamin A is limiting...
- Lipids in the heart: a source of fuel and a source of toxinsTae Sik Park
Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Curr Opin Lipidol 18:277-82. 2007..How do lipids arrive in the heart and other tissues? This review focuses on new information on pathways of lipid uptake into the heart...
- Multiple pathways ensure retinoid delivery to milk: studies in genetically modified miceSheila M O'Byrne
Institute of Human Nutrition, Columbia University, New York, NY 10032, USA
Am J Physiol Endocrinol Metab 298:E862-70. 2010..Our data show that compensatory pathways for the delivery of retinoids ensure their optimal delivery and that LRAT is the most important enzyme for milk retinyl ester formation...
- Decreased lipoprotein clearance is responsible for increased cholesterol in LDL receptor knockout mice with streptozotocin-induced diabetesIra J Goldberg
Division of Preventive Medicine, Columbia University, New York, New York 10032, USA
Diabetes 57:1674-82. 2008..Patients with diabetes often have dyslipidemia and increased postprandial lipidmia. Induction of diabetes in LDL receptor (Ldlr(-/-)) knockout mice also leads to marked dyslipidemia. The reasons for this are unclear...
- Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activationKonstantinos Drosatos
Dept of Medicine, Columbia University, 630 West 168th St, New York, NY 10032, USA
Am J Physiol Endocrinol Metab 300:E489-99. 2011..Thus, several lipids that are increased in the setting of lipotoxicity can produce abnormalities in β-AR responsiveness. This can be attributed to PKC activation and reduced β-AR levels...
- Chylomicron- and VLDL-derived lipids enter the heart through different pathways: in vivo evidence for receptor- and non-receptor-mediated fatty acid uptakeKalyani G Bharadwaj
Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Biol Chem 285:37976-86. 2010..In addition, our data show that lipolysis is involved in uptake of core lipids from TG-rich lipoproteins...
- Understanding the physiological role of retinol-binding protein in vitamin A metabolism using transgenic and knockout mouse modelsLoredana Quadro
Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Mol Aspects Med 24:421-30. 2003..We discuss below the role of RBP in maintaining normal vision and a steady flux of retinol throughout the body in times of need...
- Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiencyLoredana Quadro
Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Endocrinology 146:4479-90. 2005..Finally, we demonstrate that accumulation of embryonic vitamin A stores does not depend on the expression of RBP in the fetal liver...
- The molecular basis of retinoid absorption: a genetic dissectionNuttaporn Wongsiriroj
Institute of Human Nutrition and Department of Medicine, Columbia University, New York, New York 10032, USA
J Biol Chem 283:13510-9. 2008..Contrary to what has been proposed in the literature based on in vitro studies, CRBPII does not directly prevent retinol from being acted upon by DGAT1 or other intestinal ARATs in vivo...
- Vitamin A: overlapping delivery pathways to tissues from the circulationJisun Paik
Department of Medicine, Columbia University, New York, NY 10032, USA
J Nutr 134:276S-280S. 2004..This may suggest that CCE and LDH-C act in concert to catalyze beta-carotene cleavage...
- Muscle expression of human retinol-binding protein (RBP). Suppression of the visual defect of RBP knockout miceLoredana Quadro
Institute of Cancer Research, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
J Biol Chem 277:30191-7. 2002..No human RBP was found in the retinal pigment epithelium of the transgenic mice, indicating that retinol uptake by the eye does not entail endocytosis of the carrier RBP...
- Cellular retinol-binding protein type III is needed for retinoid incorporation into milkRoseann Piantedosi
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Biol Chem 280:24286-92. 2005..However, under conditions of high demand for retinoid, such as those experienced during lactation, this compensation was incomplete...
- Transplacental delivery of retinoid: the role of retinol-binding protein and lipoprotein retinyl esterLoredana Quadro
Institute of Cancer Research, College of Physicians and Surgeons, Columbia Univ, New York, NY 10032, USA
Am J Physiol Endocrinol Metab 286:E844-51. 2004..Overall, our data indicate that both retinol-RBP and retinyl esters bound to lipoproteins are able to provide sufficient retinoid to the embryo to allow for normal embryonic development...
- Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosisBrendan N Reid
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
J Biol Chem 283:13087-99. 2008....
- Measures of postprandial lipoproteins are not associated with coronary artery disease in patients with type 2 diabetes mellitusGissette Reyes-Soffer
Departments of Medicine, Columbia University Medical Center, New York, NY 10032, USA
J Lipid Res 50:1901-9. 2009..PP measurements of TG-rich lipoproteins do not predict the presence of CAD in individuals with DM...
- Vitamin A deficiency does not influence longitudinal growth in miceAlessia Sagazio
Department of Medicine, Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nutrition 23:483-8. 2007..Accordingly, epidemiologic studies have shown that short children have lower VA intake than do children with normal stature...
- Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasisRebeca Acín-Pérez
Department of Neurology and Neurobiology Weill Cornell Medical School, New York, New York, USA
FASEB J 24:627-36. 2010..The data provide a mechanistic explanation to the nearly 100-yr-old question of why vitamin A deficiency causes so many pathologies that are independent of retinoic acid action...
- Targeted disruption of the mouse cis-retinol dehydrogenase gene: visual and nonvisual functionsEnyuan Shang
The Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
J Lipid Res 43:590-7. 2002..Thus, cRDH may act essentially in the visual cycle but is redundant for catalyzing 9-cis-retinoic acid formation and 3 alpha-hydroxysteroid metabolism...
- Retinoids, retinoic acid receptors, and breast cancerJisun Paik
Department of Medicine, Institute of Human Nutrition, Columbia University, New York, New York, USA
Cancer Invest 21:304-12. 2003....
- Hepatic stellate cells are an important cellular site for β-carotene conversion to retinoidIgor Shmarakov
Department of Medicine, Columbia University, New York, NY 10032, USA
Arch Biochem Biophys 504:3-10. 2010..Collectively, our data establish that HSCs are an important cellular site for β-carotene accumulation and metabolism within the liver...
- Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesisYoun Kyung Kim
Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, New Jersey 08901, USA
J Biol Chem 283:5611-21. 2008..In contrast, the pathway of retinoic acid synthesis does not contribute significantly to regulating retinoid homeostasis during mammalian development except under conditions of severe maternal retinoid deficiency...
- Metabolism and transactivation activity of 13,14-dihydroretinoic acidAlexander R Moise
Department of Ophthalmology, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 280:27815-25. 2005..This new metabolite can also be an intermediate in a retinol degradation pathway or it can serve as a precursor for the synthesis of bioactive 13,14-dihydroretinoid metabolites...
- Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retinaXiaohong Fan
OncoDevelopmental Biology Program Center for Neuroscience and Aging, Burnham Institute, La Jolla, California 92037, USA
Mol Cell Biol 23:4637-48. 2003..Our findings suggest that RA signaling may be necessary only during early stages of retina development and that if RA synthesis is needed in dorsal retina, it is catalyzed by multiple enzymes, including Raldh1...
- Apolipoprotein AII is a regulator of very low density lipoprotein metabolism and insulin resistanceLawrence W Castellani
Departments of Medicine Cardiology University of California, Los Angeles, Los Angeles, California 90095, USA
J Biol Chem 283:11633-44. 2008....
- Increased fibronectin deposition in embryonic hearts of retinol-binding protein-null miceChristopher C Wendler
Department of Cell Biology, Neurobiology and Anatomy and the Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Circ Res 92:920-8. 2003..This murine model may have relevance to fetal development in human populations with inadequate retinoid intake...
- Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retinaMarcin Golczak
Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
J Biol Chem 283:9543-54. 2008..Finally, we provide evidence for a crucial role of lecithin: retinol acyltransferase activity in mediating tissue specific absorption and long lasting therapeutic effects of retinoid-based visual cycle inhibitors...
- Delivery of retinoid-based therapies to target tissuesAlexander R Moise
Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
Biochemistry 46:4449-58. 2007..Future retinoid-based therapeutic strategies could involve targeted delivery mechanisms leading to lower toxicity and improved effectiveness of retinoids...
- Cis-retinol dehydrogenase: 9-cis-retinol metabolism and its effect on proliferation of human MCF7 breast cancer cellsJisun Paik
Department of Pathobiology, University of Washington, Seattle, WA 98195, United States
Exp Cell Res 303:183-96. 2005..Our studies demonstrate that 9-cis-retinol in combination with cRDH inhibits breast cancer cell proliferation by production of retinol metabolites other than RA...
- Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicronsAnne P Beigneux
Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, and Children s Hospital Oakland Research Institute 94609, USA
Cell Metab 5:279-91. 2007..Expression of GPIHBP1 in cultured cells confers the ability to bind both LpL and chylomicrons. These studies strongly suggest that GPIHBP1 is an important platform for the LpL-mediated processing of chylomicrons in capillaries...
- Association of vitamin A and zinc status with altered intestinal permeability: analyses of cohort data from northeastern BrazilPing Chen
Center for Global Health, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville 22908, USA
J Health Popul Nutr 21:309-15. 2003..001) and HAZ scores (p = 0.007) improved with supplementation. It is concluded that impaired intestinal barrier function and linear growth shortfalls improve following supplementation of vitamin A and zinc in this setting...
- Retinol and retinol-binding protein in cerebrospinal fluid: can vitamin A take the "idiopathic" out of idiopathic intracranial hypertension?Jenny Libien
J Neuroophthalmol 27:253-7. 2007
- Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitroJens M Baron
Department of Dermatology and Allergology, University Hospital of the RWTH, Aachen, Germany
J Invest Dermatol 125:143-53. 2005....
- In vitro and in vivo characterization of retinoid synthesis from beta-caroteneYvette Fierce
Department of Comparative Medicine, University of Washington, Raitt Hall 324, Seattle, WA 98195, USA
Arch Biochem Biophys 472:126-38. 2008..Our studies provide new insights into the regulation of BCMO1 activity and the physiological role of BCMO1 in living organisms...
- Carotene Cleavage Enzyme: Properties and PhysiologyWILLIAM BLANER; Fiscal Year: 2007..In Aim 4, we propose to use a cDNA clone for human CCE to characterize the biochemical properties of the recombinant enzyme. ..
- FASEB SUMMER RESEARCH CONFERENCE ON RETINOIDSWILLIAM BLANER; Fiscal Year: 2002..This overview should allow the evaluation of future directions and the development of new ideas as well critical review of the recent research. ..
- THE VISUALLY DEFECTIVE PHENOTYPE OF RBP-DEFICIENT MICEWILLIAM BLANER; Fiscal Year: 2002..These studies will provide fundamental new information about the role(s) of RBP in vision. This information will be directly relevant to humans and human disease. ..
- 9 CIS RETINOL DEHYDROGENASE--PROPERTIES AND PHYSIOLOGYWILLIAM BLANER; Fiscal Year: 2004....
- 12th FASEB Summer Research Conference on RetinoidsWILLIAM BLANER; Fiscal Year: 2004..This will stimulate new investigations that in time will provide needed insight into the essential actions of retinoids in preventing disease and maintaining good health. ..
- Vitamin A Storage and MetabolismWilliam S Blaner; Fiscal Year: 2010..Finally, in Aim 3 we will investigate how vitamin A is mobilized from HSCs and whether this requires direct involvement of serum retinol-binding protein (RBP) synthesized in hepatocytes. ..