A Abi Dargham
Affiliation: Columbia University
- Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohortA Abi-Dargham
Department of Psychiatry, Yale University, New Haven, Conn, USA
Am J Psychiatry 155:761-7. 1998..The purpose of this study was to replicate this finding in a new cohort of schizophrenic patients and healthy subjects...
- Alterations of benzodiazepine receptors in type II alcoholic subjects measured with SPECT and [123I]iomazenilA Abi-Dargham
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
Am J Psychiatry 155:1550-5. 1998..The authors attempted to replicate these findings using single photon emission computed tomography and the benzodiazepine receptor radiotracer [123I]iomazenil...
- PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756A Abi-Dargham
Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York State Psychiatric Institute, New York 10032, USA
Synapse 32:93-109. 1999..These findings may also imply that a simple binding competition model is inadequate to account for the effects of manipulation of endogenous DA levels on the in vivo binding of radiolabeled antagonists...
- Increased baseline occupancy of D2 receptors by dopamine in schizophreniaA Abi-Dargham
Departments of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Proc Natl Acad Sci U S A 97:8104-9. 2000..This finding provides direct evidence of increased stimulation of D(2) receptors by dopamine in schizophrenia, consistent with increased phasic activity of dopaminergic neurons...
- Occupancy of dopamine D2 receptors by the atypical antipsychotic drugs risperidone and olanzapine: theoretical implicationsW G Frankle
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA
Psychopharmacology (Berl) 175:473-80. 2004..To examine the D2 occupancy of two commonly used antipsychotic medications and relate this to the D2 occupancy by endogenous dopamine in schizophrenia...
- COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PETM Slifstein
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Mol Psychiatry 13:821-7. 2008..These results confirm the prominent role of COMT in regulating DA transmission in cortex but not striatum, and the reliability of [11C]NNC 112 as a marker for low DA tone as previously suggested by studies in patients with schizophrenia...