M W Miller

Summary

Affiliation: Colorado Division of Wildlife
Country: USA

Publications

  1. ncbi request reprint PrP(CWD) lymphoid cell targets in early and advanced chronic wasting disease of mule deer
    Christina J Sigurdson
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 1671, USA
    J Gen Virol 83:2617-28. 2002
  2. ncbi request reprint Dynamics of prion disease transmission in mule deer
    Michael W Miller
    Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins 80526, USA
    Ecol Appl 16:2208-14. 2006
  3. pmc Mountain lions prey selectively on prion-infected mule deer
    Caroline E Krumm
    Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, CO 80526 2097, USA
    Biol Lett 6:209-11. 2010
  4. pmc Soil clay content underlies prion infection odds
    W David Walter
    United States Department of the Interior, United States Geological Survey, Colorado Cooperative Fish and Wildlife Research Unit, Fort Collins, Colorado 80523 1484, USA
    Nat Commun 2:200. 2011
  5. doi request reprint Phylogenetic and epidemiologic relationships among Pasteurellaceae from Colorado bighorn sheep herds
    Michael W Miller
    Colorado Division of Parks and Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, Colorado 80526 2097, USA
    J Wildl Dis 49:653-60. 2013
  6. ncbi request reprint Epidemiology of chronic wasting disease in captive white-tailed and mule deer
    Michael W Miller
    Colorado Division of Wildlife, Wildlife Research Center, Fort Collins 80526 2097, USA
    J Wildl Dis 40:320-7. 2004
  7. pmc Environmental sources of prion transmission in mule deer
    Michael W Miller
    Colorado Division of Wildlife, Fort Collins, 80526 2097, USA
    Emerg Infect Dis 10:1003-6. 2004
  8. ncbi request reprint Epidemiology of chronic wasting disease in captive Rocky Mountain elk
    M W Miller
    Colorado Division of Wildlife, Wildlife Research Center, Fort Collins 80526 2097, USA
    J Wildl Dis 34:532-8. 1998
  9. ncbi request reprint Prion disease: horizontal prion transmission in mule deer
    Michael W Miller
    Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, Colorado 80526, USA
    Nature 425:35-6. 2003
  10. pmc Lions and prions and deer demise
    Michael W Miller
    Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, Colorado, United States of America
    PLoS ONE 3:e4019. 2008

Collaborators

Detail Information

Publications57

  1. ncbi request reprint PrP(CWD) lymphoid cell targets in early and advanced chronic wasting disease of mule deer
    Christina J Sigurdson
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 1671, USA
    J Gen Virol 83:2617-28. 2002
    ..We conclude that in deer, PrP(CWD) accumulates primarily extracellularly and associated with FDCs and possibly B cells - a finding which raises questions as to the cells responsible for pathological prion production...
  2. ncbi request reprint Dynamics of prion disease transmission in mule deer
    Michael W Miller
    Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins 80526, USA
    Ecol Appl 16:2208-14. 2006
    ..Our findings demonstrate the apparent importance of indirect, environmental transmission in CWD and the challenges this presents for controlling the disease...
  3. pmc Mountain lions prey selectively on prion-infected mule deer
    Caroline E Krumm
    Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, CO 80526 2097, USA
    Biol Lett 6:209-11. 2010
    ..001), suggesting that mountain lions in this area actively selected prion-infected individuals when targeting adult mule deer as prey items...
  4. pmc Soil clay content underlies prion infection odds
    W David Walter
    United States Department of the Interior, United States Geological Survey, Colorado Cooperative Fish and Wildlife Research Unit, Fort Collins, Colorado 80523 1484, USA
    Nat Commun 2:200. 2011
    ..9%. Our findings suggest that soil clay content and related environmental properties deserve greater attention in assessing risks of prion disease outbreaks and prospects for their control in both natural and production settings...
  5. doi request reprint Phylogenetic and epidemiologic relationships among Pasteurellaceae from Colorado bighorn sheep herds
    Michael W Miller
    Colorado Division of Parks and Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, Colorado 80526 2097, USA
    J Wildl Dis 49:653-60. 2013
    ..g., M. haemolytica sensu stricto and lktA-positive B. trehalosi) and other select pathogens may be most informative for investigating and managing bighorn respiratory disease...
  6. ncbi request reprint Epidemiology of chronic wasting disease in captive white-tailed and mule deer
    Michael W Miller
    Colorado Division of Wildlife, Wildlife Research Center, Fort Collins 80526 2097, USA
    J Wildl Dis 40:320-7. 2004
    ..It follows that CWD epidemic dynamics in sympatric, free-ranging white-tailed and mule deer sharing habitats in western North American ranges also may be similar...
  7. pmc Environmental sources of prion transmission in mule deer
    Michael W Miller
    Colorado Division of Wildlife, Fort Collins, 80526 2097, USA
    Emerg Infect Dis 10:1003-6. 2004
    ..2 years earlier. Indirect transmission and environmental persistence of infectious prions will complicate efforts to control CWD and perhaps other animal prion diseases...
  8. ncbi request reprint Epidemiology of chronic wasting disease in captive Rocky Mountain elk
    M W Miller
    Colorado Division of Wildlife, Wildlife Research Center, Fort Collins 80526 2097, USA
    J Wildl Dis 34:532-8. 1998
    ..Transmission routes and rates, pathogenesis, antemortem diagnostic tools, and the potential role of reservoirs or environmental contamination in perpetuating CWD epidemics warrant further investigation...
  9. ncbi request reprint Prion disease: horizontal prion transmission in mule deer
    Michael W Miller
    Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, Colorado 80526, USA
    Nature 425:35-6. 2003
    ..Our results indicate that horizontal transmission is likely to be important in sustaining CWD epidemics...
  10. pmc Lions and prions and deer demise
    Michael W Miller
    Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, Colorado, United States of America
    PLoS ONE 3:e4019. 2008
    ..Despite this prospect, the ecological consequences of prion disease epidemics in natural populations have received little consideration...
  11. ncbi request reprint Epidemiology of chronic wasting disease in free-ranging mule deer: spatial, temporal, and demographic influences on observed prevalence patterns
    Michael W Miller
    Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, Colorado 80526 2097, USA
    J Wildl Dis 41:275-90. 2005
    ..These factors likely combine in various ways to influence epidemic dynamics on both local and broad geographic scales...
  12. ncbi request reprint Chronic wasting disease of cervids
    M W Miller
    Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, CO 80526 2097, USA
    Curr Top Microbiol Immunol 284:193-214. 2004
    ..Here, we review current understanding of CWD, its implications, and its management...
  13. ncbi request reprint Epizootiology of chronic wasting disease in free-ranging cervids in Colorado and Wyoming
    M W Miller
    Colorado Division of Wildlife, Wildlife Research Center, Fort Collins 80526 2097, USA
    J Wildl Dis 36:676-90. 2000
    ..Based on prevalence, spatial distribution, and modeling, we suggest CWD has been occurring in northeastern Colorado and southeastern Wyoming for >30 yr, and may be best represented as an epizootic with a protracted time-scale...
  14. ncbi request reprint PrP(CWD) in the myenteric plexus, vagosympathetic trunk and endocrine glands of deer with chronic wasting disease
    C J Sigurdson
    Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1671, USA
    J Gen Virol 82:2327-34. 2001
    ....
  15. ncbi request reprint Epidemic pasteurellosis in a bighorn sheep population coinciding with the appearance of a domestic sheep
    Janet L George
    Colorado Division of Wildlife, 6060 Broadway Street, Denver, Colorado 80216, USA
    J Wildl Dis 44:388-403. 2008
    ....
  16. ncbi request reprint Validation of monoclonal antibody F99/97.6.1 for immunohistochemical staining of brain and tonsil in mule deer (Odocoileus hemionus) with chronic wasting disease
    T R Spraker
    Department of Pathology, College of Veterinary Medicine, Colorado State University, Fort Collins, CO 80523, USA
    J Vet Diagn Invest 14:3-7. 2002
    ..This immunohistochemistry assay is a sensitive, specific, readily standardized diagnostic test for CWD in deer...
  17. ncbi request reprint Infectious prions in the saliva and blood of deer with chronic wasting disease
    Candace K Mathiason
    Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biological Sciences CVMBS, Colorado State University CSU, Fort Collins, CO 80523, USA
    Science 314:133-6. 2006
    ..The results help to explain the facile transmission of CWD among cervids and prompt caution concerning contact with body fluids in prion infections...
  18. ncbi request reprint Field validation and assessment of an enzyme-linked immunosorbent assay for detecting chronic wasting disease in mule deer (Odocoileus hemionus), white-tailed deer (Odocoileus virginianus), and Rocky Mountain elk (Cervus elaphus nelsoni)
    Charles P Hibler
    Veterinary Diagnostic Laboratory, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    J Vet Diagn Invest 15:311-9. 2003
    ..Based on these data, brELISA was determined to be an excellent rapid test for screening large numbers of samples in surveys designed to detect CWD infections in deer and elk populations...
  19. doi request reprint Experimental chronic wasting disease (CWD) in the ferret
    C J Sigurdson
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 1619, USA
    J Comp Pathol 138:189-96. 2008
    ..These findings indicate that CWD-infected ferrets share microscopical and biochemical features of CWD in cervids, but appear to be relatively resistant to oral infection by primary CWD inoculum of deer origin...
  20. ncbi request reprint A natural case of chronic wasting disease in a free-ranging moose (Alces alces shirasi)
    Laurie A Baeten
    Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, CO 80526 2097, USA
    J Wildl Dis 43:309-14. 2007
    ..In October 2006, two additional free-ranging moose were diagnosed with CWD. Epidemiology and implications of CWD in moose remain to be determined...
  21. ncbi request reprint PrPCWD in rectal lymphoid tissue of deer (Odocoileus spp.)
    Lisa L Wolfe
    Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, CO 80526 2097, USA
    J Gen Virol 88:2078-82. 2007
    ..i. and none of three 96SS individuals had PrP(CWD) in their rectal mucosa by 751 days p.i. These findings support further evaluation of rectal mucosa sampling in CWD surveillance...
  22. ncbi request reprint A weighted surveillance approach for detecting chronic wasting disease foci
    Daniel P Walsh
    Wildlife Health Program, Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, Colorado 80526 2097, USA
    J Wildl Dis 46:118-35. 2010
    ....
  23. ncbi request reprint Select tissue mineral concentrations and chronic wasting disease status in mule deer from North-central Colorado
    Lisa L Wolfe
    Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, CO 80526 2097, USA
    J Wildl Dis 46:1029-34. 2010
    ....
  24. ncbi request reprint Suspected secondary thiafentanil intoxication in a captive mountain lion (Puma concolor)
    Lisa L Wolfe
    Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, Colorado 80526 2097, USA
    J Wildl Dis 41:829-33. 2005
    ..In addition, caution is advised when using thiafentanil in animals that could be preyed upon before full metabolism of the drug...
  25. ncbi request reprint A bighorn sheep die-off in southern Colorado involving a Pasteurellaceae strain that may have originated from syntopic cattle
    Lisa L Wolfe
    Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, Colorado 80526 2097, USA
    J Wildl Dis 46:1262-8. 2010
    ..Our and others' findings suggest that intimate interactions between wild sheep and cattle should be discouraged as part of a comprehensive approach to health management and conservation of North American wild sheep species...
  26. ncbi request reprint Other animal prion diseases
    Christina J Sigurdson
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA
    Br Med Bull 66:199-212. 2003
    ..Here we review the epidemiology, transmission, clinical features and pathology of these other animal prion diseases...
  27. ncbi request reprint Immobilization of mule deer with thiafentanil (A-3080) or thiafentanil plus xylazine
    Lisa L Wolfe
    Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, Colorado 80526, USA
    J Wildl Dis 40:282-7. 2004
    ..v. Where feasible, we also recommend the use of transmitter darts when immobilizing mule deer with opioids in order to maximize recovery of darted deer and to ensure that missed darts are found...
  28. ncbi request reprint Detection of PrP(CWD) in mule deer by immunohistochemistry of lymphoid tissues
    M W Miller
    Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, CO 80526 2097, USA
    Vet Rec 151:610-2. 2002
  29. ncbi request reprint Persistent Bovine viral diarrhea virus infection in wild cervids of Colorado
    Colleen Duncan
    Colorado State University Veterinary Diagnostic Laboratory, Fort Collins, CO 80523 1619, USA
    J Vet Diagn Invest 20:650-3. 2008
    ..Consideration of a potential wild animal reservoir is important in the design and implementation of BVDV management practices in cattle...
  30. ncbi request reprint Evaluation of intramuscular butorphanol, azaperone, and medetomidine and nasal oxygen insufflation for the chemical immobilization of white-tailed deer, Odocoileus virginianus
    Patrice M Mich
    Colorado State University Department of Clinical Sciences, Department of Anesthesia, Fort Collins, Colorado 80523, USA
    J Zoo Wildl Med 39:480-7. 2008
    ..Because the BAM combination caused significant hypoxemia that is unreliably detected by pulse oximetry but that may be resolved with nasal oxygen insufflation, routine use of oxygen supplementation is recommended...
  31. ncbi request reprint Relative vulnerability of chronic wasting disease infected mule deer to vehicle collisions
    Caroline E Krumm
    Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, CO 80526 2097, USA
    J Wildl Dis 41:503-11. 2005
    ....
  32. ncbi request reprint Preclinical diagnosis of chronic wasting disease in captive mule deer (Odocoileus hemionus) and white-tailed deer (Odocoileus virginianus) using tonsillar biopsy
    Margaret A Wild
    Colorado Division of Wildlife, Wildlife Research Center, 317 W Prospect Road, Fort Collins, CO 80526, USA
    J Gen Virol 83:2629-34. 2002
    ..Tonsillar biopsy evaluated with IHC staining is a useful technique for the preclinical diagnosis of CWD in live mule deer and white-tailed deer when intensive management approaches are possible...
  33. ncbi request reprint Patterns of PrPCWD accumulation during the course of chronic wasting disease infection in orally inoculated mule deer (Odocoileus hemionus)
    Karen A Fox
    Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, CO 80526 2097, USA
    J Gen Virol 87:3451-61. 2006
    ..Data on the relative time frames for and genetic influences on PrP(CWD) accumulation may also offer insights about epidemic dynamics and potential control strategies...
  34. ncbi request reprint Estimating chronic wasting disease effects on mule deer recruitment and population growth
    Jessie Dulberger
    Graduate Degree Program in Ecology, Colorado State University, Fort Collins, Colorado 80523 1401, USA
    J Wildl Dis 46:1086-95. 2010
    ..We conclude that although CWD may affect mule deer recruitment, these effects seem to be sufficiently small that they can be omitted in estimating the influences of CWD on population growth rate...
  35. doi request reprint Paranasal sinus masses of Rocky Mountain bighorn sheep (Ovis canadensis canadensis)
    K A Fox
    Department of Microbiology, Colorado State University, Fort Collins, CO, USA
    Vet Pathol 48:706-12. 2011
    ..Specific immunohistochemistry and polymerase chain reaction for Jaagsiekte sheep retrovirus and enzootic nasal tumor virus were performed with negative results...
  36. ncbi request reprint Effects of selenium supplementation and sample storage time on blood indices of selenium status in bighorn sheep
    Laura E Rosen
    Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, CO 80526 2097, USA
    J Wildl Dis 45:795-801. 2009
    ..Blood Se and GSH-Px were not correlated in sampled bighorns; however, because all values for both measures were within normal limits, lack of correlation did not affect interpretation of these data in our study...
  37. ncbi request reprint Linking chronic wasting disease to mule deer movement scales: a hierarchical Bayesian approach
    Matthew L Farnsworth
    Natural Resources Ecology Laboratory, Colorado State University, Fort Collins, Colorado 80523 1499, USA
    Ecol Appl 16:1026-36. 2006
    ..Our analysis demonstrates how information on the scales of spatial processes that generate observed patterns can be used to gain insight when process data are sparse or unavailable...
  38. ncbi request reprint Detection of Yersinia pestis DNA in prairie dog-associated fleas by polymerase chain reaction assay of purified DNA
    Karen A Griffin
    Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, Colorado 80526 2097, USA
    J Wildl Dis 46:636-43. 2010
    ....
  39. ncbi request reprint Survey of cattle in northeast Colorado for evidence of chronic wasting disease: geographical and high-risk targeted sample
    Daniel H Gould
    Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Ft Collins, CO 80523, USA
    J Vet Diagn Invest 15:274-7. 2003
    ..Findings from this study suggest that large-scale spread of CWD from deer to cattle under natural range conditions in CWD-endemic areas of northeast Colorado is unlikely...
  40. pmc Comparison of abnormal prion protein glycoform patterns from transmissible spongiform encephalopathy agent-infected deer, elk, sheep, and cattle
    Richard E Race
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    J Virol 76:12365-8. 2002
    ..However, PrP-res patterns sometimes differed among individual animals, suggesting infection by different or multiple CWD strains in some species...
  41. ncbi request reprint Abundant PrP(CWD) in tonsil from mule deer with preclinical chronic wasting disease
    Katherine I O'Rourke
    Agricultural Research Service, U S Department of Agriculture, Animal Disease Research Unit, Pullman, WA 99164, USA
    J Vet Diagn Invest 15:320-3. 2003
    ..5 mg starting wet weight of tissue. The abundant PrP(CWD) in mule deer tonsil will facilitate development and validation of high-throughput screening tests for CWD in large populations of free-ranging deer...
  42. ncbi request reprint A processed pseudogene contributes to apparent mule deer prion gene heterogeneity
    Kelly A Brayton
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Gene 326:167-73. 2004
    ..Therefore, selection of a genotyping method specific for the functional gene is critical for large-scale studies to identify the role of the PRNP gene in susceptibility to CWD in mule deer...
  43. pmc Chronic wasting disease and potential transmission to humans
    Ermias D Belay
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 10:977-84. 2004
    ..More epidemiologic and laboratory studies are needed to monitor the possibility of such transmissions..
  44. pmc Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease
    Gregory J Raymond
    Laboratory of Persistent Viral Diseases, NIAID, NIH, Rocky Mountain Labs, 903 S 4th St, Hamilton, MT 59840, USA
    J Virol 80:596-604. 2006
    ..This demonstrates the utility of these cells in a rapid in vitro screening assay for PrP(CWD) inhibitors and suggests that these compounds have potential to be active against CWD in vivo...
  45. ncbi request reprint Prions in skeletal muscles of deer with chronic wasting disease
    Rachel C Angers
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA
    Science 311:1117. 2006
    ....
  46. ncbi request reprint Low frequency of PrP genotype 225SF among free-ranging mule deer (Odocoileus hemionus) with chronic wasting disease
    Jean E Jewell
    Department of Veterinary Sciences, University of Wyoming, Wyoming State Veterinary Laboratory, 1174 Snowy Range Road, Laramie, WY 82070, USA
    J Gen Virol 86:2127-34. 2005
    ..Data available from some of these animals suggest that the 225SF genotype could be associated with longer incubation periods in CWD infection compared with the 225SS genotype...
  47. pmc Transmission of prions from mule deer and elk with chronic wasting disease to transgenic mice expressing cervid PrP
    Shawn R Browning
    Department of Microbiology, University of Kentucky, 800 Rose St, Lexington, KY 40536, USA
    J Virol 78:13345-50. 2004
    ..Transmission studies indicated that the same prion strain caused CWD in the analyzed mule deer and elk. These mice provide a new and reliable tool for detecting CWD prions...
  48. pmc Transmission of elk and deer prions to transgenic mice
    GULTEKIN TAMGUNEY
    Institute for Neurodegenerative Diseases, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0518, USA
    J Virol 80:9104-14. 2006
    ..These findings suggest that CWD prions from elk, mule deer, and white-tailed deer can be readily transmitted among these three cervid species...
  49. pmc Test for detection of disease-associated prion aggregate in the blood of infected but asymptomatic animals
    Binggong Chang
    Institute of Pathology School of Medicine, Case Western Reserve University, Cleveland, Ohio 44107 1712, USA
    Clin Vaccine Immunol 14:36-43. 2007
    ..Application of this assay to cattle, sheep, and humans could safeguard food supplies and prevent human contagion...
  50. pmc Human prion disease and relative risk associated with chronic wasting disease
    Samantha Mawhinney
    University of Colorado at Denver, Health Sciences Center, Denver, Colorado 80262, USA
    Emerg Infect Dis 12:1527-35. 2006
    ..However, given uncertainties about the incubation period, exposure, and clinical presentation, the possibility that the CWD agent might cause human disease cannot be eliminated...
  51. pmc Transmission and adaptation of chronic wasting disease to hamsters and transgenic mice: evidence for strains
    Gregory J Raymond
    Laboratory of Persistent Viral Diseases, Rocky Mountain Veterinary Branch, NIAID, NIH, Rocky Mountain Labs, 903 S 4th St, Hamilton, MT 59840, USA
    J Virol 81:4305-14. 2007
    ....
  52. ncbi request reprint A meta-BACI approach for evaluating management intervention on chronic wasting disease in mule deer
    Mary M Conner
    Department of Wildland Resources, Utah State University, Logan, Utah 84322 5230, USA
    Ecol Appl 17:140-53. 2007
    ..Based on our observations, we offer recommendations for designing a management experiment with 80% power to detect a 0.10 drop in prevalence over a 6-12-year period...
  53. pmc Levels of abnormal prion protein in deer and elk with chronic wasting disease
    Brent L Race
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    Emerg Infect Dis 13:824-30. 2007
    ....
  54. doi request reprint PrP genotypes of free-ranging wapiti (Cervus elaphus nelsoni) with chronic wasting disease
    Matteo Perucchini
    Roslin Institute, Neuropathogenesis Unit, Edinburgh, UK
    J Gen Virol 89:1324-8. 2008
    ..24) and all three genotypes showed equivalent susceptibility to infection...
  55. pmc Strain fidelity of chronic wasting disease upon murine adaptation
    Christina J Sigurdson
    Universitatsspital Zurich, Institute of Neuropathology, Department of Pathology, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    J Virol 80:12303-11. 2006
    ..These findings indicate that the salient strain-specific properties of CWD are encoded by agent-intrinsic components rather than by host factors...
  56. ncbi request reprint Experimental transmission of chronic wasting disease agent from mule deer to cattle by the intracerebral route
    Amir N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
    J Vet Diagn Invest 17:276-81. 2005
    ....
  57. ncbi request reprint Chronic exposure to ethanol alters neurotrophin content in the basal forebrain-cortex system in the mature rat: effects on autocrine-paracrine mechanisms
    Michael W Miller
    Department of Neuroscience and Physiology, S U N Y Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA
    J Neurobiol 60:490-8. 2004
    ..Thus, the present data (a) support the concept that neurotrophins act through a nonretrograde system (i.e., a local autocrine/paracrine system), and (b) that chronic exposure to ethanol disrupts these regulatory mechanisms...