Randall J Basaraba

Summary

Affiliation: Colorado State University
Country: USA

Publications

  1. ncbi request reprint Lymphadenitis as a major element of disease in the guinea pig model of tuberculosis
    Randall J Basaraba
    Mycobacteria Research Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Tuberculosis (Edinb) 86:386-94. 2006
  2. ncbi request reprint Decreased survival of guinea pigs infected with Mycobacterium tuberculosis after multiple BCG vaccinations
    Randall J Basaraba
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Vaccine 24:280-6. 2006
  3. pmc Pulmonary lymphatics are primary sites of Mycobacterium tuberculosis infection in guinea pigs infected by aerosol
    Randall J Basaraba
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1619, USA
    Infect Immun 74:5397-401. 2006
  4. pmc Increased expression of host iron-binding proteins precedes iron accumulation and calcification of primary lung lesions in experimental tuberculosis in the guinea pig
    Randall J Basaraba
    Department of Microbiology, Immunology and Pathology, 1619 Campus Delivery, Colorado State University, Fort Collins, CO 80523 1619, USA
    Tuberculosis (Edinb) 88:69-79. 2008
  5. doi request reprint Experimental tuberculosis: the role of comparative pathology in the discovery of improved tuberculosis treatment strategies
    Randall J Basaraba
    Mycobacterial Research Laboratory, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Tuberculosis (Edinb) 88:S35-47. 2008
  6. pmc Influence of Mycobacterium bovis BCG vaccination on cellular immune response of guinea pigs challenged with Mycobacterium tuberculosis
    Diane Ordway
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Clin Vaccine Immunol 15:1248-58. 2008
  7. pmc Drug treatment combined with BCG vaccination reduces disease reactivation in guinea pigs infected with Mycobacterium tuberculosis
    Shaobin Shang
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Vaccine 30:1572-82. 2012
  8. pmc Post-exposure vaccination against Mycobacterium tuberculosis
    Marcela Henao-Tamayo
    Colorado State University, Fort Collins, CO 80523 1682, USA
    Tuberculosis (Edinb) 89:142-8. 2009
  9. pmc Evaluation of standard chemotherapy in the guinea pig model of tuberculosis
    Diane J Ordway
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Antimicrob Agents Chemother 54:1820-33. 2010
  10. pmc Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs
    Shaobin Shang
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Antimicrob Agents Chemother 55:124-31. 2011

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Lymphadenitis as a major element of disease in the guinea pig model of tuberculosis
    Randall J Basaraba
    Mycobacteria Research Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Tuberculosis (Edinb) 86:386-94. 2006
    ..We discuss here the observation that the distribution and progression of lung and lymph node lesions in the guinea pig aerosol model of tuberculosis have considerable similarity to the naturally occurring disease in children...
  2. ncbi request reprint Decreased survival of guinea pigs infected with Mycobacterium tuberculosis after multiple BCG vaccinations
    Randall J Basaraba
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Vaccine 24:280-6. 2006
    ..These data indicate that multiple BCG vaccination, which is akin to super-infection with the living vaccine, leads to major organ failure pathology...
  3. pmc Pulmonary lymphatics are primary sites of Mycobacterium tuberculosis infection in guinea pigs infected by aerosol
    Randall J Basaraba
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1619, USA
    Infect Immun 74:5397-401. 2006
    ..This observation suggests that in addition to being a direct conduit from the lungs to the regional lymph nodes, pulmonary lymphatics are themselves sites of infection and could be the site of latent infection...
  4. pmc Increased expression of host iron-binding proteins precedes iron accumulation and calcification of primary lung lesions in experimental tuberculosis in the guinea pig
    Randall J Basaraba
    Department of Microbiology, Immunology and Pathology, 1619 Campus Delivery, Colorado State University, Fort Collins, CO 80523 1619, USA
    Tuberculosis (Edinb) 88:69-79. 2008
    ....
  5. doi request reprint Experimental tuberculosis: the role of comparative pathology in the discovery of improved tuberculosis treatment strategies
    Randall J Basaraba
    Mycobacterial Research Laboratory, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Tuberculosis (Edinb) 88:S35-47. 2008
    ..A better understanding of lesion pathogenesis across species may also aid in the identification of novel therapeutic targets or strategies that can be used alone or in combination with more conventional tuberculosis treatments in humans...
  6. pmc Influence of Mycobacterium bovis BCG vaccination on cellular immune response of guinea pigs challenged with Mycobacterium tuberculosis
    Diane Ordway
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Clin Vaccine Immunol 15:1248-58. 2008
    ....
  7. pmc Drug treatment combined with BCG vaccination reduces disease reactivation in guinea pigs infected with Mycobacterium tuberculosis
    Shaobin Shang
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Vaccine 30:1572-82. 2012
    ..The combining of BCG vaccination and drug therapy was more effective at resolving granulomas such that fewer animals had evidence of residual infection and thus less reactivation disease...
  8. pmc Post-exposure vaccination against Mycobacterium tuberculosis
    Marcela Henao-Tamayo
    Colorado State University, Fort Collins, CO 80523 1682, USA
    Tuberculosis (Edinb) 89:142-8. 2009
    ....
  9. pmc Evaluation of standard chemotherapy in the guinea pig model of tuberculosis
    Diane J Ordway
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Antimicrob Agents Chemother 54:1820-33. 2010
    ..Chemotherapy also prevented the emergence in lung tissues of high levels of interleukin-10 and Foxp3-positive cells, known markers of regulatory T cells...
  10. pmc Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs
    Shaobin Shang
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Antimicrob Agents Chemother 55:124-31. 2011
    ..These data indicate that TMC207 could be a useful addition to current treatment regimens for tuberculosis...
  11. doi request reprint Animal model of Mycobacterium abscessus lung infection
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    J Leukoc Biol 83:1502-11. 2008
    ..In conclusion, IFN-gamma is critically important in the host defense against M. abscessus. As the number of effective drugs against M. abscessus is limited, the GKO mice provide a model for in vivo testing of novel drugs...
  12. pmc A mutant of Mycobacterium tuberculosis lacking the 19-kDa lipoprotein Rv3763 is highly attenuated in vivo but retains potent vaccinogenic properties
    Marcela Henao-Tamayo
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80524, USA
    Vaccine 25:7153-9. 2007
    ..These data show that despite being highly attenuated, the Delta 19 mutant strongly retained vaccinogenic properties...
  13. pmc Mycobacteria lacking the RD1 region do not induce necrosis in the lungs of mice lacking interferon-gamma
    Ana Paula Junqueira-Kipnis
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Immunology 119:224-31. 2006
    ..These data support the hypothesis that proteins encoded in the RD1 region are a major cause of necrosis and contribute significantly to the pathogenesis of the disease...
  14. pmc A Toll-like receptor-2-directed fusion protein vaccine against tuberculosis
    Baolin Wang
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Clin Vaccine Immunol 14:902-6. 2007
    ....
  15. ncbi request reprint The hypervirulent Mycobacterium tuberculosis strain HN878 induces a potent TH1 response followed by rapid down-regulation
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 179:522-31. 2007
    ..This association may explain the paradoxical initial emergence of a TH1 response in these mice but their relatively short time of survival...
  16. ncbi request reprint The cellular immune response to Mycobacterium tuberculosis infection in the guinea pig
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 179:2532-41. 2007
    ..These data reveal new information about the cellular phenotypes which mediate protective immunity or host immunopathogenesis during M. tuberculosis infection in this key animal model...
  17. pmc Increased Foxp3 expression in guinea pigs infected with W-Beijing strains of M. tuberculosis
    Shaobin Shang
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Tuberculosis (Edinb) 91:378-85. 2011
    ..These observations support the hypothesis that W-Beijing strains are potent inducers of regulatory T cells, and that this event may enhance survival and transmission of these bacilli...
  18. ncbi request reprint Increased neutrophil influx but no impairment of protective immunity to tuberculosis in mice lacking the CD44 molecule
    Andre Kipnis
    Department of Microbiology, Immunology and Pathology, Colorado State University, 200 West Lake St, 1682 Campus Delivery, Fort Collins, CO 80523 1682, USA
    J Leukoc Biol 74:992-7. 2003
    ..These data indicate that loss of CD44 expression does not alter expression of T helper cell type 1 immunity to tuberculosis in the lungs but has major effects on the overall cellular composition of the immunopathological response...
  19. pmc Mycobacterium bovis BCG-mediated protection against W-Beijing strains of Mycobacterium tuberculosis is diminished concomitant with the emergence of regulatory T cells
    Diane J Ordway
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682
    Clin Vaccine Immunol 18:1527-35. 2011
    ....
  20. pmc Disseminated disease severity as a measure of virulence of Mycobacterium tuberculosis in the guinea pig model
    Gopinath S Palanisamy
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Tuberculosis (Edinb) 88:295-306. 2008
    ....
  21. pmc The protective effect of the Mycobacterium bovis BCG vaccine is increased by coadministration with the Mycobacterium tuberculosis 72-kilodalton fusion polyprotein Mtb72F in M. tuberculosis-infected guinea pigs
    Lise Brandt
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins 80523, USA
    Infect Immun 72:6622-32. 2004
    ..Collectively, these data suggest that enhancing BCG is a valid vaccination strategy for tuberculosis that is worthy of clinical evaluation...
  22. pmc Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis
    Donald R Hoff
    Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA
    Antimicrob Agents Chemother 52:4137-40. 2008
    ..Metronidazole treatment (for 6 weeks at 100 mg/kg of body weight) resulted in no reduction in the bacillary burden and significantly worsened lesion inflammation...
  23. pmc Memory T lymphocytes generated by Mycobacterium bovis BCG vaccination reside within a CD4 CD44lo CD62 Ligandhi population
    Andre Kipnis
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Infect Immun 73:7759-64. 2005
    ..Upon cell transfer, however, cells expressing a resting/naïve phenotype (CD44lo CD62Lhi) were capable of protecting the recipients from a virulent challenge infection, suggesting the emergence of T-cell memory from within this subset...
  24. pmc Evidence for oxidative stress and defective antioxidant response in guinea pigs with tuberculosis
    Gopinath S Palanisamy
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 6:e26254. 2011
    ..These data suggest that the therapeutic strategies that reduce oxidant-mediated tissue damage may be beneficial as an adjunct therapy in the treatment and prevention of tuberculosis in humans...
  25. pmc In vivo adaptation of the Wayne model of latent tuberculosis
    Lisa Woolhiser
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Infect Immun 75:2621-5. 2007
    ..Preimmunization of mice with a panel of selected vaccine candidates slowed or prevented this event. This simple model has potential for identifying vaccines targeting latent tuberculosis...
  26. pmc Magnetic resonance imaging of pulmonary lesions in guinea pigs infected with Mycobacterium tuberculosis
    Susan L Kraft
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Infect Immun 72:5963-71. 2004
    ..Further development of this technical approach could be very useful in tracking lesion size, number, and progression in the search for new tuberculosis vaccines...
  27. pmc Factors associated with severe granulomatous pneumonia in Mycobacterium tuberculosis-infected mice vaccinated therapeutically with hsp65 DNA
    Jennifer L Taylor
    Department of Microbiology, Immunology and Pathology, Colorado State University, 200 West Lake Street, 1682 Campus Delivery, Fort Collins, CO 80523 1682, USA
    Infect Immun 73:5189-93. 2005
    ..This was probably an anti-inflammatory response, since lung pathology was dramatically worsened in B-cell gene-disrupted mice...
  28. pmc Uptake and accumulation of oxidized low-density lipoprotein during Mycobacterium tuberculosis infection in guinea pigs
    Gopinath S Palanisamy
    Department of Microbiology, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 7:e34148. 2012
    ..Overall, this study provides additional evidence of oxidative stress in M. tuberculosis infected guinea pigs and the potential role OxLDL laden macrophages have in supporting intracellular bacilli survival and persistence...
  29. pmc Immune response to Mycobacterium tuberculosis and identification of molecular markers of disease
    Mercedes Gonzalez-Juarrero
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA
    Am J Respir Cell Mol Biol 40:398-409. 2009
    ..tuberculosis infection, and unique molecular markers associated with disease progression and state, were identified...
  30. pmc Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910
    Anne J Lenaerts
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Antimicrob Agents Chemother 51:3338-45. 2007
    ..These results show that this acellular rim may, therefore, be a primary location of persisting bacilli withstanding drug treatment...
  31. pmc Copper-boosting compounds: a novel concept for antimycobacterial drug discovery
    Alexander Speer
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Antimicrob Agents Chemother 57:1089-91. 2013
    ..tuberculosis and demonstrate that such copper-boosting compounds are effective against replicating and nonreplicating M. tuberculosis strains...
  32. pmc Evaluation of a mouse model of necrotic granuloma formation using C3HeB/FeJ mice for testing of drugs against Mycobacterium tuberculosis
    Emily R Driver
    Mycobacterial Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, Colorado, USA
    Antimicrob Agents Chemother 56:3181-95. 2012
    ..These results suggest that the Kramnik mouse model will be a valuable model to test antituberculosis drugs, especially against bacilli that persist within necrotic lesions...
  33. pmc Copper resistance is essential for virulence of Mycobacterium tuberculosis
    Frank Wolschendorf
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 108:1621-6. 2011
    ..Hence, this study reveals an Achilles heel of Mtb that might be a promising target for tuberculosis chemotherapy...
  34. pmc Role for matrix metalloproteinase 9 in granuloma formation during pulmonary Mycobacterium tuberculosis infection
    Jennifer L Taylor
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, 200 West Lake Street, 1682 Campus Delivery, Fort Collins, CO 80523 1682, USA
    Infect Immun 74:6135-44. 2006
    ....
  35. pmc Location of intra- and extracellular M. tuberculosis populations in lungs of mice and guinea pigs during disease progression and after drug treatment
    Donald R Hoff
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 6:e17550. 2011
    ..Drug development should be designed to target this bacillary population and should evaluate drug regimens in the appropriate animal models...
  36. doi request reprint Cigarette smoke increases susceptibility to tuberculosis--evidence from in vivo and in vitro models
    Shaobin Shang
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
    J Infect Dis 203:1240-8. 2011
    ..Cigarette smoke (CS) exposure is an epidemiological risk factor for tuberculosis, although the biological basis has not been elucidated...
  37. pmc Multiple M. tuberculosis phenotypes in mouse and guinea pig lung tissue revealed by a dual-staining approach
    Gavin J Ryan
    Department of Microbiology, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 5:e11108. 2010
    ..This is relevant information for approaches that study bacillary characteristics in pooled samples (using lipidomics and proteomics) as well as in M. tuberculosis drug development...
  38. doi request reprint Clinical strains of Mycobacterium tuberculosis display a wide range of virulence in guinea pigs
    Gopinath S Palanisamy
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Tuberculosis (Edinb) 89:203-9. 2009
    ..The use of appropriate animal models allows for this important question to be addressed...
  39. pmc Vaccination of guinea pigs using mce operon mutants of Mycobacterium tuberculosis
    Andrés Obregón-Henao
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Vaccine 29:4302-7. 2011
    ..This protection was demonstrated by a significant reduction in the numbers of bacilli harvested from the lungs, and dramatic improvements in lung histopathology...
  40. pmc Increased severity of tuberculosis in Guinea pigs with type 2 diabetes: a model of diabetes-tuberculosis comorbidity
    Brendan K Podell
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado
    Am J Pathol 184:1104-18. 2014
    ..This model will be beneficial in understanding the complex pathogenesis of TB in diabetic patients and to test new strategies to improve TB and diabetes control when the two diseases occur together. ..
  41. pmc Pulmonary necrosis resulting from DNA vaccination against tuberculosis
    Jennifer L Taylor
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Infect Immun 71:2192-8. 2003
    ..tuberculosis. This previously unanticipated safety problem indicates that DNA vaccines should be used with caution in individuals who may have already been exposed to tuberculosis...
  42. ncbi request reprint Florid pulmonary inflammatory responses in mice vaccinated with Antigen-85 pulsed dendritic cells and challenged by aerosol with Mycobacterium tuberculosis
    Mercedes Gonzalez-Juarrero
    Mycobacteria Research Laboratories, Department of Microbiology, Pathology and Immunology, Colorado State University, Fort Collins, CO 80523, USA
    Cell Immunol 220:13-9. 2002
    ..tuberculosis infection than mice immunized with LDC pulsed with an irrelevant protein. Instead, the potent inflammatory response in the LDC-Ag85 resulted in serious consolidation of the lung tissue...
  43. doi request reprint Flexible low-cost system for small animal aerosol inhalation exposure to drugs, proteins, inflammatory agents, and infectious agents
    William G Schroeder
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Biotechniques 46:Piii-Pviii. 2009
    ..This system was also used to immunize mice and guinea pigs in ovalbumin-based models of pulmonary inflammation. This design is appropriate for studies with limited budgets and lower-level biosafety containment...
  44. ncbi request reprint Investigation of the induction of antibodies against Crandell-Rees feline kidney cell lysates and feline renal cell lysates after parenteral administration of vaccines against feline viral rhinotracheitis, calicivirus, and panleukopenia in cats
    Michael R Lappin
    Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Am J Vet Res 66:506-11. 2005
    ....
  45. pmc Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis
    David F Ackart
    Department of Microbiology, Immunology and Pathology, Mycobacterial Research Laboratories, Colorado State University, Fort Collins, CO, USA
    Pathog Dis 70:359-69. 2014
    ..Modifications of this in vitro assay may prove beneficial in a high-throughput platform to screen new antituberculosis drugs especially those that target drug-tolerant bacilli...
  46. pmc Oral therapy using nanoparticle-encapsulated antituberculosis drugs in guinea pigs infected with Mycobacterium tuberculosis
    Christine M Johnson
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, 80523 1682, USA
    Antimicrob Agents Chemother 49:4335-8. 2005
    ..Both treatments significantly reduced the bacterial count and lung histopathology, suggesting that the nanoparticle drug delivery system has potential in intermitted treatment of tuberculosis...
  47. pmc Non-diabetic hyperglycemia exacerbates disease severity in Mycobacterium tuberculosis infected guinea pigs
    Brendan K Podell
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 7:e46824. 2012
    ....
  48. pmc Role of chemokine ligand 2 in the protective response to early murine pulmonary tuberculosis
    Andre Kipnis
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA
    Immunology 109:547-51. 2003
    ....
  49. pmc Immunopathogenesis of pulmonary granulomas in the guinea pig after infection with Mycobacterium tuberculosis
    Oliver C Turner
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins 80523, USA
    Infect Immun 71:864-71. 2003
    ..This hypothesis differs from the current dogma that excessive activity of T cells mediates delayed-type hypersensitivity and that cellular cytolysis is the root cause of the necrosis...
  50. pmc Interleukin-10 production by lung macrophages in CBA xid mutant mice infected with Mycobacterium tuberculosis
    Ana Paula Junqueira-Kipnis
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins 80523, USA
    Immunology 115:246-52. 2005
    ..In addition, macrophages from the lungs of xid mice also expressed high levels of CD14. These observations suggest that the xid mutation in cellular signalling has much wider effects on the immune system than previously thought...
  51. ncbi request reprint Interstitial nephritis in cats inoculated with Crandell Rees feline kidney cell lysates
    Michael R Lappin
    Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 1678, USA
    J Feline Med Surg 8:353-6. 2006
    ..Neither of the cats vaccinated with the FVRCP for intranasal administration had detectable renal inflammation. One cat in each of the three CRFK lysate sensitization groups had lymphocytic-plasmacytic interstitial nephritis...
  52. pmc Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis
    Scott M Irwin
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Dis Model Mech 8:591-602. 2015
    ..A more thorough understanding of the pathological progression of disease in C3HeB/FeJ mice could facilitate modulation of the immune response to produce the desired pathology, increasing the utility of this animal model. ..
  53. pmc Microhemorrhage is an early event in the pulmonary fibrotic disease of PECAM-1 deficient FVB/n mice
    Marta Lishnevsky
    Department of Microbiology, Immunology, and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO 80523, United States Electronic address
    Exp Mol Pathol 97:128-36. 2014
    ....
  54. pmc Localized immunosuppressive environment in the foreign body response to implanted biomaterials
    David M Higgins
    Department of Microbiology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Am J Pathol 175:161-70. 2009
    ..A better understanding of the FBR in vivo will allow the development of novel strategies to enhance biomaterial implant design to achieve better performance and safety of biomedical devices at the site of implant...
  55. doi request reprint A model of type 2 diabetes in the guinea pig using sequential diet-induced glucose intolerance and streptozotocin treatment
    Brendan K Podell
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Dis Model Mech . 2017
    ..This model will prove useful in the study of insulin-independent diabetes pathogenesis with or without comorbidities, where the guinea pig serves as a relevant model species...
  56. pmc Therapeutic vaccination against relevant high virulence clinical isolates of Mycobacterium tuberculosis
    Crystal A Shanley
    Mycobacteria Research Laboratories, Colorado State University, USA
    Tuberculosis (Edinb) 94:140-7. 2014
    ..In a biodefense situation, this prolonged survival would be potentially long enough to allow for the organism to be identified and a drug susceptibility profile determined. ..
  57. pmc Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole-based small molecules
    David F Ackart
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA
    Pathog Dis 70:370-8. 2014
    ..tuberculosis with 2-aminoimidazole-based small molecules as an adjunct to antimicrobial treatment has the potential to be an effective antituberculosis treatment strategy designed specifically to eradicate drug-tolerant M. tuberculosis...
  58. doi request reprint Influence of endurance exercise on serum concentrations of iron and acute phase proteins in racing sled dogs
    Christine L Kenyon
    Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, 80523, USA
    J Am Vet Med Assoc 239:1201-10. 2011
    ..To determine effects of long-distance racing exercise on iron status in endurance racing sled dogs, with or without anemia...
  59. pmc Host-directed therapy targeting the Mycobacterium tuberculosis granuloma: a review
    Dilara Kiran
    Department of Microbiology, Immunology and Pathology, Metabolism of Infectious Diseases Laboratory and Mycobacteria Research Laboratories, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 200 West Lake Street, 1619 Campus Delivery, Fort Collins, CO, 80523 1619, USA
    Semin Immunopathol 38:167-83. 2016
    ....
  60. doi request reprint The formation of the granuloma in tuberculosis infection
    Ian M Orme
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA Electronic address
    Semin Immunol 26:601-9. 2014
    ....
  61. pmc Hyperpolarized krypton-83 as a contrast agent for magnetic resonance imaging
    Galina E Pavlovskaya
    Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA
    Proc Natl Acad Sci U S A 102:18275-9. 2005
    ..Additionally, the influence of magnetic field strength and the presence of a breathable concentration of molecular oxygen on longitudinal relaxation are investigated...
  62. doi request reprint Assessment of necropsy findings in sled dogs that died during Iditarod Trail sled dog races: 23 cases (1994-2006)
    Michelle M Dennis
    Animal Population Health Institute, Department of Clinical Sciences and the Veterinary Diagnostic Laboratory, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    J Am Vet Med Assoc 232:564-73. 2008
    ..To describe the character and frequency of causes of death and associated lesions in long-distance racing sled dogs...
  63. ncbi request reprint The principal sigma factor sigA mediates enhanced growth of Mycobacterium tuberculosis in vivo
    Shiping Wu
    Department of Microbiology and Immunology, Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 US Highway 271, Tyler, TX, USA
    Mol Microbiol 51:1551-62. 2004
    ..This effect may be mediated in part by increased resistance to reactive oxygen intermediates...
  64. pmc Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis
    Joseph Hinchey
    Department of Microbiology and Immunology and Howard Hughes Medical Institute, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 117:2279-88. 2007
    ..bovis bacille Calmette-Guérin vaccination. Our results define a mechanism for a key immune evasion strategy of M. tuberculosis and provide what we believe to be a novel approach for improving mycobacterial vaccines...
  65. pmc Use of specific rRNA oligonucleotide probes for microscopic detection of Mycobacterium tuberculosis in culture and tissue specimens
    Allison L St Amand
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    J Clin Microbiol 43:5369-71. 2005
    ..We report a rapid and reliable in situ hybridization technique using rRNA oligonucleotide probes for the identification of M. tuberculosis in tissues and cultures...