Y Xu

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint Unfolding the pathophysiological role of bioactive lysophospholipids
    Yan Xu
    Department of Cancer Biology, The Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, OH 44195, USA
    Curr Drug Targets Immune Endocr Metabol Disord 3:23-32. 2003
  2. ncbi request reprint Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1
    Y Xu
    Department of Cancer Biology, Cleveland Clinic Foundation, OH 44195, USA
    Nat Cell Biol 2:261-7. 2000
  3. ncbi request reprint Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction
    Yan Xu
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Biochim Biophys Acta 1582:81-8. 2002
  4. ncbi request reprint Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4
    K Zhu
    Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 276:41325-35. 2001
  5. ncbi request reprint Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A
    J H Kabarowski
    Department of Microbiology, Immunology, and Molecular Genetics, Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Science 293:702-5. 2001
  6. ncbi request reprint Lysophospholipids increase interleukin-8 expression in ovarian cancer cells
    B M Schwartz
    Department of Cancer Biology, Department of Gynecology and Obstetrics, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Gynecol Oncol 81:291-300. 2001
  7. ncbi request reprint The role and clinical applications of bioactive lysolipids in ovarian cancer
    Y Xu
    Department of Cancer Biology, Lerner Research Institute, Cleveland, OH 44195, USA
    J Soc Gynecol Investig 8:1-13. 2001
  8. ncbi request reprint Electrospray ionization mass spectrometry analysis of lysophospholipids in human ascitic fluids: comparison of the lysophospholipid contents in malignant vs nonmalignant ascitic fluids
    Y J Xiao
    Department of Cancer Biology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Anal Biochem 290:302-13. 2001
  9. ncbi request reprint Fatty acid composition of lysophosphatidic acid and lysophosphatidylinositol in plasma from patients with ovarian cancer and other gynecological diseases
    Z Shen
    Department of Cancer Biology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Gynecol Oncol 83:25-30. 2001
  10. ncbi request reprint Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14
    Y Xu
    Department of Cancer Biology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA
    Genomics 35:397-402. 1996

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Unfolding the pathophysiological role of bioactive lysophospholipids
    Yan Xu
    Department of Cancer Biology, The Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, OH 44195, USA
    Curr Drug Targets Immune Endocr Metabol Disord 3:23-32. 2003
    ..It is important to further evaluate the significance of targeting these bioactive LPL receptors, their downstream signaling molecules, and/or metabolic enzymes in the treatment of cancers and other diseases...
  2. ncbi request reprint Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1
    Y Xu
    Department of Cancer Biology, Cleveland Clinic Foundation, OH 44195, USA
    Nat Cell Biol 2:261-7. 2000
    ..The specific binding of SPC to OGR1 also activates p42/44 mitogen-activated protein kinases (MAP kinases) and inhibits cell proliferation. In addition, SPC causes internalization of OGR1 in a structurally specific manner...
  3. ncbi request reprint Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction
    Yan Xu
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Biochim Biophys Acta 1582:81-8. 2002
    ..The signaling and ligand-binding properties of these receptors are reviewed here. These discoveries provide an intriguing opportunity and a novel approach in studying the pathophysiological roles of SPC and LPC and their receptors...
  4. ncbi request reprint Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4
    K Zhu
    Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 276:41325-35. 2001
    ..Taken together, our data indicate that GPR4 is a receptor with high affinity to SPC and low affinity to LPC, and that multiple cellular functions can be transduced via this receptor...
  5. ncbi request reprint Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A
    J H Kabarowski
    Department of Microbiology, Immunology, and Molecular Genetics, Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Science 293:702-5. 2001
    ..This finding implicates a role for LPC-G2A interaction in the etiology of inflammatory autoimmune disease and atherosclerosis...
  6. ncbi request reprint Lysophospholipids increase interleukin-8 expression in ovarian cancer cells
    B M Schwartz
    Department of Cancer Biology, Department of Gynecology and Obstetrics, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Gynecol Oncol 81:291-300. 2001
    ..The pathological significance of these regulations in ovarian cancer remains to be further investigated...
  7. ncbi request reprint The role and clinical applications of bioactive lysolipids in ovarian cancer
    Y Xu
    Department of Cancer Biology, Lerner Research Institute, Cleveland, OH 44195, USA
    J Soc Gynecol Investig 8:1-13. 2001
    ....
  8. ncbi request reprint Electrospray ionization mass spectrometry analysis of lysophospholipids in human ascitic fluids: comparison of the lysophospholipid contents in malignant vs nonmalignant ascitic fluids
    Y J Xiao
    Department of Cancer Biology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Anal Biochem 290:302-13. 2001
    ..However, the total phosphate content in ascites samples from patients with ovarian cancer is not significantly different compared to that from patients with nonmalignant disease...
  9. ncbi request reprint Fatty acid composition of lysophosphatidic acid and lysophosphatidylinositol in plasma from patients with ovarian cancer and other gynecological diseases
    Z Shen
    Department of Cancer Biology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Gynecol Oncol 83:25-30. 2001
    ..However, our results suggest that increased LPA/LPI species with unsaturated fatty acid chains may be associated with late-stage or recurrent ovarian cancer...
  10. ncbi request reprint Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14
    Y Xu
    Department of Cancer Biology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA
    Genomics 35:397-402. 1996
    ..OGR1 shares strongest homology (49-54%) with the human orphan receptor GPR4. The structural features of OGR1 suggest that the ligand for OGR1 is likely to be a small peptide or a small bioactive molecule...
  11. ncbi request reprint Lysophosphatidic acid downregulates tissue inhibitor of metalloproteinases, which are negatively involved in lysophosphatidic acid-induced cell invasion
    S Sengupta
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    Oncogene 26:2894-901. 2007
    ..LPA downregulates TIMP3, which may have targets other than metalloproteinases. Our in vivo metastasis mouse model is useful for studying the efficacy of therapeutic regimes of ovarian cancer...
  12. ncbi request reprint GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine
    Kwan Sik Kim
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    FASEB J 19:819-21. 2005
    ..Moreover, the effects of SPC on EC require SPC induced trans-phosphorylation and activation of the VEGF receptor 2. These results identify SPC and its receptor, GPR4, as critical regulators of the angiogenic potential of EC...
  13. pmc Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair
    A D Bulgar
    Department of Medicine, Division of Hematology Oncology, Case Western Reserve University, Cleveland, OH, USA
    Cell Death Dis 3:e252. 2012
    ..Thus, targeting BER-based therapy exhibits more selective cytotoxicity on cancer cells through a synthetic lethal mechanism...
  14. ncbi request reprint Sphingosine-1-phosphate induces a PDGFR-dependent cell detachment via inhibiting beta1 integrin in HEK293 cells
    Alexander Zaslavsky
    Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    FEBS Lett 579:3899-906. 2005
    ..G(i) protein and ERK activation were required for the cell detachment induced by S1P, suggesting an endogenous receptor for S1P is likely to be involved...
  15. ncbi request reprint Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific
    Linnea M Baudhuin
    Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, Ohio44195, USA
    Mol Pharmacol 62:660-71. 2002
    ..LPA/S1P-induced Akt activation may be involved in cell survival, because LPA and S1P treatment in HEY ovarian cancer cells results in a decrease in paclitaxel-induced caspase-3 activity in a PI3-K/MEK/p38-dependent manner...
  16. ncbi request reprint S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR)
    Linnea M Baudhuin
    Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    FASEB J 18:341-3. 2004
    ..This is the first report demonstrating a unique interaction between S1P3 and PDGFR, in addition to demonstrating a specific role for S1P3 in S1P-induced Akt activation...
  17. ncbi request reprint Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells
    Xiaoxian Zhao
    Department of Cancer Biology, The Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 281:29357-68. 2006
    ..Importantly, small interfering RNA-mediated down-regulation of endogenous iPLA(2) expression in ovarian carcinoma HEY cells results in decreased migration toward laminin, suggesting that our findings are pathophysiologically important...
  18. ncbi request reprint Plasma lysophosphatidylcholine levels: potential biomarkers for colorectal cancer
    Zhenwen Zhao
    Department of Cancer Biology, Lerner Research Institute, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA
    J Clin Oncol 25:2696-701. 2007
    ..Plasma levels of lysophospholipids were evaluated as potential biomarkers for colorectal cancer (CRC), where a highly reliable and minimally invasive blood test is lacking...
  19. ncbi request reprint Hypoxia enhances lysophosphatidic acid responsiveness in ovarian cancer cells and lysophosphatidic acid induces ovarian tumor metastasis in vivo
    Kwan Sik Kim
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Cancer Res 66:7983-90. 2006
    ..HIF1 alpha plays a critical role in enhancing and/or sensitizing the role of LPA on cell migration and invasion under hypoxic conditions, where cPLA(2) is required for LPA-induced cell migration...
  20. ncbi request reprint KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha
    Ying Jiang
    Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Clin Exp Metastasis 22:369-76. 2005
    ..These results suggest that KiSS1 is a metastasis suppressor of ovarian cancer and may be a potential molecular target for the treatment...
  21. ncbi request reprint A novel laminin-induced LPA autocrine loop in the migration of ovarian cancer cells
    Saubhik Sengupta
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, Ohio 44195, USA
    FASEB J 17:1570-2. 2003
    ..These findings have revealed a new mechanism of crosstalk between a beta1 integrin receptor and a G protein-coupled receptor...
  22. ncbi request reprint Lysophosphatidic acid is constitutively produced by human peritoneal mesothelial cells and enhances adhesion, migration, and invasion of ovarian cancer cells
    Juan Ren
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Cancer Res 66:3006-14. 2006
    ..Conditioned medium from peritoneal mesothelial cells stimulate migration, adhesion, and invasion of ovarian cancer cells, and may play similar roles in vivo...
  23. ncbi request reprint Role of ether-linked lysophosphatidic acids in ovarian cancer cells
    Jun Lu
    Department of Cancer Biology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Lipid Res 43:463-76. 2002
    ..On the other hand, cell migration induced by al-LPAs depended on activities of the G(i/o) protein, PI3K, and Rho, but not MEK. These data suggest that ether-linked LPAs may play an important role in ovarian cancer development...
  24. ncbi request reprint Homo- and hetero-dimerization of LPA/S1P receptors, OGR1 and GPR4
    Alexander Zaslavsky
    Department of Cancer Biology, The Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Biochim Biophys Acta 1761:1200-12. 2006
    ..Our results suggest that when studying a signal transduction induced by a stimulus, not only is the expression and activation of its own receptor(s), but also the status of the interacting receptors should be taken into consideration...
  25. ncbi request reprint Biology of LPA in health and disease
    Saubhik Sengupta
    Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Semin Cell Dev Biol 15:503-12. 2004
    ..LPA may function as a double-edged sword. While it helps maintain homeostasis against stress and insult, it may also augment the development and spread of pathological processes, including cancers...
  26. ncbi request reprint Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer
    Lisam Shanjukumar Singh
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, 975 W Walnut St, Indianapolis, IN 46202, USA
    J Natl Cancer Inst 99:1313-27. 2007
    ..The ovarian cancer G protein-coupled receptor 1 (OGR1) gene has been shown to be expressed at lower levels in metastatic compared with primary prostate cancer tissues...
  27. ncbi request reprint Targeting the platelet-derived growth factor receptor alpha with a neutralizing human monoclonal antibody inhibits the growth of tumor xenografts: implications as a potential therapeutic target
    Nick Loizos
    Department of Protein Chemistry, ImClone Systems, Inc, 180 Varick Street, New York, NY 10014, USA
    Mol Cancer Ther 4:369-79. 2005
    ..Antibody 3G3 significantly inhibited the growth of U118 (P=0.0004) and SKLMS-1 (P <0.0001) tumors relative to control. These data suggest that 3G3 may be useful for the treatment of tumors that express PDGFRalpha...
  28. ncbi request reprint Lysophosphatidylcholine as a ligand for immunoregulation
    Janusz H S Kabarowski
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, 5 748 MRL, 675 Charles E Young Drive South, Box 951662, Los Angeles, CA 90095 1662, USA
    Biochem Pharmacol 64:161-7. 2002
    ....
  29. pmc Purification, characterization, gene cloning, and expression of a novel alcohol dehydrogenase with anti-prelog stereospecificity from Candida parapsilosis
    Yao Nie
    Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Southern Yangtze University, Wuxi 214122, People s Republic of China
    Appl Environ Microbiol 73:3759-64. 2007
    ..This enzyme with unusual stereospecificity catalyzes an anti-Prelog reduction of 2-hydroxyacetophenone to (S)-1-phenyl-1,2-ethanediol...
  30. ncbi request reprint [Protective effects of the granule of Sambucus chinensis lindl on acute hepatic injury]
    Wei Yang
    School of Pharmacology, Shenyang Pharmaceutical University, Shenyang
    Zhong Yao Cai 28:1085-9. 2005
    ..To investigate the protective effects of the granule of Sambucus chinensis Lindl on acute hepatic injury...
  31. ncbi request reprint Di-(2-ethylhexyl)-phthalate affects lipid profiling in fetal rat brain upon maternal exposure
    Yan Xu
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Arch Toxicol 81:57-62. 2007
    ..These results suggest that in utero exposure to DEHP alters the lipid metabolome in the fetal brain, which may lead to aberrant neurodevelopment...
  32. pmc S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells
    Dongmei Wang
    Department of Obstetrics and Gynecology, Indiana University, 975 West Walnut Street IB355A, Indianapolis, IN 46202, USA
    Mol Cancer Ther 7:1993-2002. 2008
    ..These findings are important for the development of new therapeutics targeting S1P and LPA in EOC...
  33. pmc The cumate gene-switch: a system for regulated expression in mammalian cells
    Alaka Mullick
    Institut de Recherche en Biotechnologie, Conseil National de Recherches du Canada, 6100 Royalmount Avenue, Montreal, Quebec, H4P 2R2, Canada
    BMC Biotechnol 6:43. 2006
    ..Since some applications require the regulation of several genes, there is a need for a variety of independent yet compatible systems...
  34. doi request reprint Kruppel-like factor 5 is required for perinatal lung morphogenesis and function
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Development 135:2563-72. 2008
    ..KLF5 regulates genes controlling paracrine interactions during lung morphogenesis, as well as those regulating the maturation of the respiratory epithelium that is required for lung function after birth...
  35. ncbi request reprint Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice
    Stephan W Glasser
    Division of Pulmonary Biology, Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    J Immunol 181:621-8. 2008
    ..SP-C plays an important role in innate host defense of the lung, enhancing macrophage-mediated Pseudomonas phagocytosis, clearance and limiting pulmonary inflammatory responses...
  36. ncbi request reprint I-motif and quadruplex-based device that can control a protein release or bind and release small molecule to influence biological processes
    Yan Xu
    Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Bioorg Med Chem 15:1275-9. 2007
    ..These new functions undertaken by structured nucleic acids open many opportunities to create and expand the further functions and use of DNA and RNA...
  37. doi request reprint Mapping of cytotoxic T lymphocytes epitopes in E7 antigen of human papillomavirus type 11
    Yan Xu
    Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China
    Arch Dermatol Res 300:235-42. 2008
    ..We propose that this epitope could be more helpful in the characterization of HPV control mechanism and be useful for the development of immunotherapeutic approaches for low-risk HPV infectious diseases such as CA...
  38. ncbi request reprint Production of lysophosphatidylcholine by cPLA2 in the brain of mice lacking PPT1 is a signal for phagocyte infiltration
    Zhongjian Zhang
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Developement, The National Institutes of Health, Bethesda, MD 20892 1830, USA
    Hum Mol Genet 16:837-47. 2007
    ..We propose that increased cPLA(2)-catalyzed LPC production in the brain is at least one of the mechanisms that mediate phagocyte infiltration contributing to INCL neuropathology...
  39. ncbi request reprint The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
    Andrew M Tager
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, CNY149 8301, 149 13th Street, Charlestown, Massachusetts 02129 USA
    Nat Med 14:45-54. 2008
    ..LPA1 therefore represents a new therapeutic target for diseases in which aberrant responses to injury contribute to fibrosis, such as idiopathic pulmonary fibrosis...
  40. ncbi request reprint Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung
    David E Metzger
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Dev Dyn 236:1175-92. 2007
    ..5 lungs. These results demonstrate that Elf5 is an FGF-sensitive transcription factor in the lung with a dynamic pattern of expression and that FGF regulation of Elf5 by means of FGFR2b occurs through the PI3-Kinase/Akt pathway...
  41. ncbi request reprint Production of galacto-oligosaccharides by immobilized recombinant beta-galactosidase from Aspergillus candidus
    Pu Zheng
    Key Laboratory of Industry Biotechnology, Ministry of Education, Southern Yangtze University, Wuxi, PR China
    Biotechnol J 1:1464-70. 2006
    ..The average yield of GOSs was 32%, corresponding to the average productivity of 64 g/L.h, which implied that the immobilized recombinant beta-galactosidase has potential application for GOS production...
  42. ncbi request reprint (P)-helicene displays chiral selection in binding to Z-DNA
    Yan Xu
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda, Tokyo 101 0062, Japan
    J Am Chem Soc 126:6566-7. 2004
    ..The enantioselectivity of the helicenes offers a new route for the rational design of inhibitors of biological functions that may depend on Z-DNA...
  43. ncbi request reprint LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA)
    Liana C Chan
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    J Leukoc Biol 82:1193-200. 2007
    ..In summary, our results indicate that immature mouse DCs migrate preferentially in response to unsaturated LPA and that LPA(3) is important in this response...
  44. ncbi request reprint Recombined DNA vaccines encoding calreticulin linked to HPV6bE7 enhance immune response and inhibit angiogenic activity in B16 melanoma mouse model expressing HPV 6bE7 antigen
    Ke Jia Zhao
    Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, Zhejiang University Medical School, 3 East Qing Chun Road, Hangzhou, 310016, People s Republic of China
    Arch Dermatol Res 298:64-72. 2006
    ..This construct may be useful in preventing HPV-associated dermatosis and may be developed as a promising strategy to control CA...
  45. ncbi request reprint Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma
    Fumiaki Sato
    Gastroenterology Division, Department of Medicine, University of Maryland School of Medicine and Gastroenterology Service, Baltimore, Maryland 21201, USA
    Cancer Res 62:6820-2. 2002
    ..In conclusion, our data suggest that methylation of HPP1 is a relatively common early event in UC-associated carcinogenesis. HPP1 offers potential as a biomarker for the early detection of cancer or dysplasia in UC...
  46. ncbi request reprint Affinity partitioning of glucose-6-phosphate dehydrogenase and hexokinase in aqueous two-phase systems with free triazine dye ligands
    Yan Xu
    Department of Chemical Engineering, Hebei Institute of Technology, Tangshan, Hebei 063009, China
    J Chromatogr B Analyt Technol Biomed Life Sci 780:53-60. 2002
    ..Phosphate is a key factor affecting the enzyme partitioning in the PEG-PES system. Cibacron F3GA changed the partition coefficient of G6PDH from 0.73 to 1.59...
  47. ncbi request reprint Purification of glucose-6-phosphate dehydrogenase from baker's yeast in aqueous two-phase systems with free triazine dyes as affinity ligands
    Yan Xu
    Department of Chemical Engineering, Hebei Institute of Technology, Tangshan, Hebei, 063009, P R China
    Appl Biochem Biotechnol 105:853-65. 2003
    ..A two-step affinity extraction process was established for the purification of G6PDH from baker's yeast. The total yield of G6PDH was 66.9% and purification factor was 2.35...
  48. ncbi request reprint Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal
    Kirsten Lauber
    Department of Internal Medicine I, University of Tubingen, Tubingen, Germany
    Cell 113:717-30. 2003
    ..These data suggest that in addition to eat-me signals, apoptotic cells display attraction signals to ensure the efficient removal of apoptotic cells and prevent postapoptotic necrosis...
  49. ncbi request reprint NMR structure and dynamics of the second transmembrane domain of the neuronal acetylcholine receptor beta 2 subunit
    Victor E Yushmanov
    Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Biochemistry 42:13058-65. 2003
    ....
  50. ncbi request reprint [Expression of constructed eukaryotic vectors carrying encoding gene of soluble human interleukin-1 receptor in mammalian cells]
    Yan Xu
    Department of Oral Medicine, College of Stomatology, Nanjing Medical University, Nanjing 210029, China
    Hua Xi Kou Qiang Yi Xue Za Zhi 21:467-70. 2003
    ..This study is to make sure if the constructed pcDNA3 carrying encoding gene of sIL-1R can be expressed in mammalian cells in vitro...
  51. ncbi request reprint Highly efficient photochemical 2'-deoxyribonolactone formation at the diagonal loop of a 5-iodouracil-containing antiparallel G-quartet
    Yan Xu
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda, Tokyo 101 0062, Japan
    J Am Chem Soc 126:6274-9. 2004
    ..These results suggest that the present photochemical method can be used as a specific probe for the antiparallel G-quartet with the diagonal loop...
  52. ncbi request reprint Lysophospholipids are potential biomarkers of ovarian cancer
    Rebecca Sutphen
    Department of Interdisciplinary Oncology, College of Medicine and H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, 33612, USA
    Cancer Epidemiol Biomarkers Prev 13:1185-91. 2004
    ..To determine whether lysophosphatidic acid (LPA) and other lysophospholipids (LPL) are useful markers for diagnosis and/or prognosis of ovarian cancer in a controlled setting...
  53. ncbi request reprint The perlecan heparan sulfate proteoglycan mediates cellular uptake of HIV-1 Tat through a pathway responsible for biological activity
    Elias G Argyris
    The Dorrance H Hamilton Laboratories, Division of Infectious Diseases and Environmental Medicine, Center for Human Virology and Biodefense, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 330:481-6. 2004
    ..We conclude that the perlecan mediates Tat uptake and is required for HIV-1 LTR-directed transactivation in this human cell type...
  54. ncbi request reprint Effects of irbesartan on the expression of matrix metalloproteinase-2/tissue inhibitor of metalloproteinase-2 in streptozotocin-induced diabetic rat kidney
    Bi Cheng Liu
    Institute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing 210009, China
    Chin Med J (Engl) 118:1040-4. 2005
  55. ncbi request reprint Effects of PCBs and MeSO2-PCBs on adrenocortical steroidogenesis in H295R human adrenocortical carcinoma cells
    Yan Xu
    Department of Biology and Chemistry, Centre for Coastal Pollution and Conservation, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, China
    Chemosphere 63:772-84. 2006
    ..Overall, these findings suggest that PCBs and PCB metabolites can affect regulation of adrenocortical steroidogenesis...
  56. pmc Adaptation and increased susceptibility to infection associated with constitutive expression of misfolded SP-C
    James P Bridges
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Cell Biol 172:395-407. 2006
    ..The wide variability in the age of onset of ILD in patients with SFTPC mutations may be related to environmental insults that ultimately overwhelm the homeostatic cytoprotective response...
  57. ncbi request reprint Blocking of N-acetylglucosaminyltransferase V induces cellular endoplasmic reticulum stress in human hepatocarcinoma 7,721 cells
    Huan Fang
    State Key Laboratory of Genetic Engineering, Department of Biochemistry, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China
    Cell Res 16:82-92. 2006
    ..These results supported the mechanism that blocking of GnT-V expression impaired functions of chaperones and N-glycan-synthesizing enzymes, which caused UPR in vivo...
  58. ncbi request reprint [Construction of eukaryote expression vector carrying human soluble interleukin-1 receptor gene]
    Peng Li
    Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, China
    Hua Xi Kou Qiang Yi Xue Za Zhi 21:140-3. 2003
    ..The purpose of this study was to construct a eukaryote expression vector carrying human sIL-1R gene...
  59. pmc Upregulation of a tonoplast-localized cytochrome P450 during petal senescence in Petunia inflata
    Yan Xu
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    BMC Plant Biol 6:8. 2006
    ..Expression of a number of genes and various enzyme activities involved in the degradation and remobilization of macromolecules have been found to be upregulated during the early stages of petal senescence...
  60. ncbi request reprint [Establishment of murine cell line transfected with human CD14 gene]
    Bo tao Ning
    Department of Hematology and Oncology, Children s Hospital Affiliated to Zhejiang University, Hangzhon 310003, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:388-91. 2006
    ..In conclusion, the murine cell line B16/CD14 fransfected with human CD14 gene has been established which can be used for the study of human AML-M(5) antibody targeting therapy with mouse model...
  61. ncbi request reprint Determinations of dioxinlike activity in selected mollusks from the coast of the Bohai Sea, China, using the H4IIE-luc bioassay
    Maoyong Song
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, P O Box 2871, Beijing 100085, China
    Ecotoxicol Environ Saf 67:157-62. 2007
    ..33% of the extracts concentrations (0.83 microL extract well(-1)). All the dilutions of sample N1 were cytotoxic to the H4IIE cells...
  62. ncbi request reprint Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas
    David M Shibata
    Division of Surgical Oncology, Department of Surgery, University of Maryland School of Medicine, Baltimore 21201, USA
    Cancer Res 62:5637-40. 2002
    ..Moreover, hMLH1 hypermethylation occurs predominantly in the setting of HPP1 hypermethylation. HPP1 hypermethylation may represent an early event in mismatch repair-deficient gastric tumorigenesis...