W H Wilson Tang

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint Trends and treatment of heart failure developing after acute myocardial infarction
    W H Wilson Tang
    Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am Heart Hosp J 1:216-8. 2003
  2. pmc Clinical and genetic association of serum paraoxonase and arylesterase activities with cardiovascular risk
    W H Wilson Tang
    Department of Cell Biology, Center for Cardiovascular Diagnostics and Prevention, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    Arterioscler Thromb Vasc Biol 32:2803-12. 2012
  3. pmc Relation of systemic and urinary neutrophil gelatinase-associated lipocalin levels to different aspects of impaired renal function in patients with acute decompensated heart failure
    Kevin Shrestha
    Heart and Vascular Institute, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 110:1329-35. 2012
  4. doi request reprint Impact of myocardial function on cystatin C measurements in chronic systolic heart failure
    W H Wilson Tang
    Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland Ohio 44195, USA
    J Card Fail 14:394-9. 2008
  5. doi request reprint Efficacy of the CHADS₂ scoring system to assess left atrial thrombogenic milieu risk before cardioversion of non-valvular atrial fibrillation
    Hirad Yarmohammadi
    Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA
    Am J Cardiol 112:678-83. 2013
  6. pmc Cystatin C identifies patients with stable chronic heart failure at increased risk for adverse cardiovascular events
    Matthias Dupont
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA
    Circ Heart Fail 5:602-9. 2012
  7. pmc Diminished antioxidant activity of high-density lipoprotein-associated proteins in systolic heart failure
    W H Wilson Tang
    Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Circ Heart Fail 4:59-64. 2011
  8. pmc Diminished antioxidant activity of high-density lipoprotein-associated proteins in chronic kidney disease
    David J Kennedy
    Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    J Am Heart Assoc 2:e000104. 2013
  9. doi request reprint Incremental prognostic value of assessing left ventricular myocardial mechanics in patients with chronic systolic heart failure
    Hirohiko Motoki
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA
    J Am Coll Cardiol 60:2074-81. 2012
  10. pmc Usefulness of cardiac biomarker score for risk stratification in stable patients undergoing elective cardiac evaluation across glycemic status
    W H Wilson Tang
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 111:465-70. 2013

Collaborators

Detail Information

Publications138 found, 100 shown here

  1. ncbi request reprint Trends and treatment of heart failure developing after acute myocardial infarction
    W H Wilson Tang
    Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am Heart Hosp J 1:216-8. 2003
    ....
  2. pmc Clinical and genetic association of serum paraoxonase and arylesterase activities with cardiovascular risk
    W H Wilson Tang
    Department of Cell Biology, Center for Cardiovascular Diagnostics and Prevention, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    Arterioscler Thromb Vasc Biol 32:2803-12. 2012
    ..The clinical prognostic use of measuring distinct PON-1 activities has not been established, and the genetic determinants of PON-1 activities are not known...
  3. pmc Relation of systemic and urinary neutrophil gelatinase-associated lipocalin levels to different aspects of impaired renal function in patients with acute decompensated heart failure
    Kevin Shrestha
    Heart and Vascular Institute, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 110:1329-35. 2012
    ..Both systemic and urine NGAL predict worsening renal function...
  4. doi request reprint Impact of myocardial function on cystatin C measurements in chronic systolic heart failure
    W H Wilson Tang
    Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland Ohio 44195, USA
    J Card Fail 14:394-9. 2008
    ..The influence of myocardial function on plasma levels of cystatin C (CysC), a sensitive marker of renal function, in chronic systolic heart failure (HF) has not been well established...
  5. doi request reprint Efficacy of the CHADS₂ scoring system to assess left atrial thrombogenic milieu risk before cardioversion of non-valvular atrial fibrillation
    Hirad Yarmohammadi
    Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA
    Am J Cardiol 112:678-83. 2013
    ....
  6. pmc Cystatin C identifies patients with stable chronic heart failure at increased risk for adverse cardiovascular events
    Matthias Dupont
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA
    Circ Heart Fail 5:602-9. 2012
    ..This study compares the prognostic use of CysC and derived glomerular filtration rate estimates with other measures of renal function in patients with chronic heart failure...
  7. pmc Diminished antioxidant activity of high-density lipoprotein-associated proteins in systolic heart failure
    W H Wilson Tang
    Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Circ Heart Fail 4:59-64. 2011
    ..In the present study, we sought to determine the prognostic role of serum arylesterase activity in subjects with systolic heart failure, particularly in relation to established cardiac biomarkers...
  8. pmc Diminished antioxidant activity of high-density lipoprotein-associated proteins in chronic kidney disease
    David J Kennedy
    Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    J Am Heart Assoc 2:e000104. 2013
    ..We sought to determine the prognostic value of serum PON-1 activity, as monitored by PON or arylesterase activities, in subjects with chronic kidney disease (CKD), particularly in relation to established cardiac biomarkers...
  9. doi request reprint Incremental prognostic value of assessing left ventricular myocardial mechanics in patients with chronic systolic heart failure
    Hirohiko Motoki
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA
    J Am Coll Cardiol 60:2074-81. 2012
    ..This study sought to examine the ability of left ventricular (LV) global longitudinal strain (GLS) to assess disease severity in patients with chronic systolic heart failure (HF)...
  10. pmc Usefulness of cardiac biomarker score for risk stratification in stable patients undergoing elective cardiac evaluation across glycemic status
    W H Wilson Tang
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 111:465-70. 2013
    ..82, 95% CI 3.82 to 30.6, p <0.001). In conclusion, an integrated assessment of cardiac biomarkers may provide independent prognostic value for long-term adverse clinical events in stable cardiac patients...
  11. pmc Prognostic role of pulmonary arterial capacitance in advanced heart failure
    Matthias Dupont
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Circ Heart Fail 5:778-85. 2012
    ..We examined the determinants, prognostic role, and response to treatment of pulmonary arterial capacitance (PAC, ratio of stroke volume over pulmonary pulse pressure), in relation to pulmonary vascular resistance (PVR) in heart failure...
  12. doi request reprint Sodium nitroprusside for advanced low-output heart failure
    Wilfried Mullens
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 52:200-7. 2008
    ..This study was designed to examine the safety and efficacy of sodium nitroprusside (SNP) for patients with acute decompensated heart failure (ADHF) and low-output states...
  13. pmc Risk prediction with serial myeloperoxidase monitoring in patients with acute chest pain
    Stephen J Nicholls
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA
    Clin Chem 57:1762-70. 2011
    ..Although myeloperoxidase (MPO) monitoring is predictive for cardiovascular outcomes in suspected acute coronary syndromes, the value of serial testing is unknown...
  14. pmc Usefulness of plasma galectin-3 levels in systolic heart failure to predict renal insufficiency and survival
    W H Wilson Tang
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Ohio, USA
    Am J Cardiol 108:385-90. 2011
    ..However, we did not observe a relation between galectin-3 and echocardiographic or hemodynamic indexes...
  15. doi request reprint Role of the CHADS2 score in the evaluation of thromboembolic risk in patients with atrial fibrillation undergoing transesophageal echocardiography before pulmonary vein isolation
    Sarinya Puwanant
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 54:2032-9. 2009
    ....
  16. pmc Nitric oxide bioavailability and adiponectin production in chronic systolic heart failure: relation to severity of cardiac dysfunction
    W H Wilson Tang
    Center for Cardiovascular Diagnostics and Prevention, Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Transl Res 162:26-33. 2013
    ....
  17. doi request reprint Impact of mitral regurgitation on reverse remodeling and outcome in patients undergoing cardiac resynchronization therapy
    David Verhaert
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Circ Cardiovasc Imaging 5:21-6. 2012
    ..We sought to evaluate the relationship between serial measurements of functional MR and reverse remodeling and outcomes in patients undergoing CRT...
  18. pmc Clinical and genetic association of serum ceruloplasmin with cardiovascular risk
    W H Wilson Tang
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Ave, Desk J3 4, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 32:516-22. 2012
    ..Cp has recently been shown to possess nitric oxide (NO) oxidase catalytic activity, but its impact on long-term cardiovascular outcomes in stable cardiac patients has not been explored...
  19. pmc Impact of left ventricular volume/mass ratio on diastolic function
    Adisai Buakhamsri
    Division of Cardiovascular Medicine, Department of Cardiology, Desk F 15, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Eur Heart J 30:1213-21. 2009
    ..To assess the impact of left ventricular (LV) volume/mass ratio on diastolic function parameters in subjects with dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM) and healthy controls...
  20. doi request reprint Clinical significance of endogenous vasoactive neurohormones in chronic systolic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    J Card Fail 16:635-40. 2010
    ..Neurohormonal activation is a pathophysiological hallmark of acute and chronic heart failure (HF). The clinical significance of more recently discovered endogenous vasoactive hormones has not been well-characterized...
  21. doi request reprint Persistent hemodynamic benefits of cardiac resynchronization therapy with disease progression in advanced heart failure
    Wilfried Mullens
    Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Coll Cardiol 53:600-7. 2009
    ..Our aim was to determine the potential hemodynamic contributions of cardiac resynchronization therapy (CRT) in patients admitted for advanced decompensated heart failure...
  22. pmc Diminished global arginine bioavailability and increased arginine catabolism as metabolic profile of increased cardiovascular risk
    W H Wilson Tang
    Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, Cleveland, OH, USA
    J Am Coll Cardiol 53:2061-7. 2009
    ..We hypothesized that an integrated assessment of arginine with its catabolic products might better predict cardiovascular risks than arginine levels alone...
  23. pmc Importance of venous congestion for worsening of renal function in advanced decompensated heart failure
    Wilfried Mullens
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Coll Cardiol 53:589-96. 2009
    ..To determine whether venous congestion, rather than impairment of cardiac output, is primarily associated with the development of worsening renal function (WRF) in patients with advanced decompensated heart failure (ADHF)...
  24. pmc Protein carbamylation in chronic systolic heart failure: relationship with renal impairment and adverse long-term outcomes
    W H Wilson Tang
    Center for Cardiovascular Diagnostics and Prevention, Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    J Card Fail 19:219-24. 2013
    ..We examine the relationship between plasma protein-bound homocitrulline (PBHCit) levels, a marker of protein lysine residue carbamylation, with cardiorenal function and long-term outcomes in chronic systolic heart failure (HF)...
  25. pmc Diminished global arginine bioavailability as a metabolic defect in chronic systolic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Card Fail 19:87-93. 2013
    ..Systemic alterations in arginine bioavailability occur in heart failure (HF) patients with more advanced myocardial dysfunction and poorer clinical outcomes, and they improve with beta-blocker therapy...
  26. doi request reprint Impact of left ventricular diastolic function on left atrial mechanics in systolic heart failure
    Hirohiko Motoki
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA
    Am J Cardiol 112:821-6. 2013
    ..In conclusion, more impaired LA mechanics are associated with more severe diastolic dysfunction and predict long-term adverse events in patients with chronic systolic HF...
  27. doi request reprint A randomized controlled pilot study of outcomes of strict allowance of fluid therapy in hyponatremic heart failure (SALT-HF)
    Nancy M Albert
    Nursing Research and Innovation, Nursing Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Card Fail 19:1-9. 2013
    ..Currently, fluid restriction recommendations in heart failure (HF) are based on expert opinion. After implementing a 1,000-mL/d fluid restriction for 60 days after discharge, outcomes were examined...
  28. doi request reprint QRS prolongation induced by cardiac resynchronization therapy correlates with deterioration in left ventricular function
    John Rickard
    Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Blvd, Cleveland, OH 44122, USA
    Heart Rhythm 9:1674-8. 2012
    ..A subset of "nonresponders" experience deterioration in LV function following cardiac resynchronization therapy (CRT). Characteristics of this patient population, however, have not been studied...
  29. doi request reprint Indications for TEE before cardioversion for atrial fibrillation: implications for appropriateness criteria
    Gaganpreet K Grewal
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JACC Cardiovasc Imaging 5:641-8. 2012
    ..In a minority of studies, TEE utilization was inappropriate. Incidence of LAT/sludge differed between indications...
  30. pmc Usefulness of myeloperoxidase levels in healthy elderly subjects to predict risk of developing heart failure
    W H Wilson Tang
    Department of Cell Biology, Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 103:1269-74. 2009
    ..In conclusion, an independent association between increased MPO and the development of HF in apparently healthy elderly subjects was observed, particularly beyond MI and traditional cardiac risk factors...
  31. doi request reprint Integrating plasma high-sensitivity C-reactive protein and myeloperoxidase for risk prediction in chronic systolic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Congest Heart Fail 17:105-9. 2011
    ..Combining hsCRP and MPO measurements provided distinct and complementary prognostic value in a patient cohort of chronic systolic HF...
  32. doi request reprint Prognostic evaluation of ambulatory patients with advanced heart failure
    Wilfried Mullens
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 101:1297-302. 2008
    ..0001). In conclusion, in ambulatory patients with advanced HF, hemodynamic and renal function assessments remain strong independent predictors of all-cause mortality...
  33. doi request reprint Impact of left ventricular remodeling on diagnostic and prognostic value of tissue Doppler indices in chronic systolic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Card Fail 17:128-34. 2011
    ..We aim to examine the impact of left ventricular (LV) dimensions on the relationship between lateral and septal E/Ea in the determination of diastolic dysfunction patterns in the setting of chronic systolic heart failure (HF)...
  34. doi request reprint Elevated intra-abdominal pressure in acute decompensated heart failure: a potential contributor to worsening renal function?
    Wilfried Mullens
    Section of Heart Failure and Cardiac Transplantation, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 51:300-6. 2008
    ..This study sought to determine whether changes in intra-abdominal pressure (IAP) with aggressive diuretic or vasodilator therapy are associated with improvement in renal function in acute decompensated heart failure (ADHF)...
  35. pmc Right ventricular response to intensive medical therapy in advanced decompensated heart failure
    David Verhaert
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Circ Heart Fail 3:340-6. 2010
    ..Our objective was to compare the clinical significance of changes in RV echocardiographic indices in response to intensive medical treatment in patients admitted to the hospital with acute decompensated heart failure (ADHF)...
  36. doi request reprint Insights from a cardiac resynchronization optimization clinic as part of a heart failure disease management program
    Wilfried Mullens
    Department of Cardiovascular Medicine, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 53:765-73. 2009
    ..Our aim was to determine the feasibility and value of a protocol-driven approach to patients with cardiac resynchronization therapy (CRT) who did not exhibit a positive response long after implant...
  37. doi request reprint Long-term reverse remodeling with cardiac resynchronization therapy: results of extended echocardiographic follow-up
    David Verhaert
    Department of Cardiovascular Medicine, Section of Cardiac Imaging, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Coll Cardiol 55:1788-95. 2010
    ..The purpose of this study was to describe the long-term course of left ventricular remodeling induced by cardiac resynchronization therapy (CRT), adjusting for the confounding effect of patient loss due to disease...
  38. doi request reprint Gender differences in patients admitted with advanced decompensated heart failure
    Wilfried Mullens
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 102:454-8. 2008
    ..Overall outcomes were similar between men and women, although subgroup analysis suggested better survival for women with a nonischemic cause...
  39. pmc An abundant dysfunctional apolipoprotein A1 in human atheroma
    Ying Huang
    Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    Nat Med 20:193-203. 2014
    ..Circulating oxTrp72-apoA1 levels may serve as a way to monitor a proatherogenic process in the artery wall. ..
  40. pmc Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide
    Zeneng Wang
    Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    Eur Heart J 35:904-10. 2014
    ..Our aim was to examine the prognostic value of systemic choline and betaine levels in stable cardiac patients...
  41. ncbi request reprint Risk stratification for patients undergoing nonurgent percutaneous coronary intervention using N-terminal pro-B-type natriuretic peptide: a Clopidogrel for the Reduction of Events During Observation (CREDO) substudy
    W H Wilson Tang
    Department of Cardiovascular Medicine, The Cleveland Clinic, Cleveland, OH 44195, USA
    Am Heart J 153:36-41. 2007
    ..The comparative prognostic values between NT-proBNP levels and left ventricular ejection fraction (LVEF) in the nonurgent PCI setting are unclear...
  42. doi request reprint Determinants of dynamic changes in serum creatinine in acute decompensated heart failure: the importance of blood pressure reduction during treatment
    Matthias Dupont
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Eur J Heart Fail 15:433-40. 2013
    ..We sought to establish the important haemodynamic determinants of alterations in serum creatinine...
  43. pmc Detectable subclinical myocardial necrosis is associated with cardiovascular risk in stable patients with diabetes
    W H Wilson Tang
    Cleveland Clinic, Cleveland, OH, USA
    Diabetes Care 36:1126-31. 2013
    ..To investigate the relationship between different degrees of subclinical myocardial necrosis, glycemic control, and long-term adverse clinical outcomes within a stable patient population with diabetes mellitus...
  44. pmc Increased exhaled nitric oxide levels after exercise in patients with chronic systolic heart failure with pulmonary venous hypertension
    Andres Schuster
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Card Fail 18:799-803. 2012
    ..Our objective was to prospectively examine the potential myocardial and functional determinants of exercise-induced rise of eNO in HF...
  45. pmc Lack of significant renal tubular injury despite acute kidney injury in acute decompensated heart failure
    Matthias Dupont
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, OH 44195, USA
    Eur J Heart Fail 14:597-604. 2012
    ..Our aim is to determine whether AKI during treatment of acute decompensated heart failure (ADHF) is accompanied by renal tubular injury...
  46. doi request reprint Impact of systemic venous congestion in heart failure
    Matthias Dupont
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Curr Heart Fail Rep 8:233-41. 2011
    ..Early detection, possibly with the help of novel implantable sensor technology, may allow for early detection and intervention long before overt congestion is established...
  47. pmc Renal dysfunction is a stronger determinant of systemic neutrophil gelatinase-associated lipocalin levels than myocardial dysfunction in systolic heart failure
    Kevin Shrestha
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Card Fail 17:472-8. 2011
    ..Recent studies have demonstrated that NGAL is up-regulated in cardiomyocytes within the failing myocardium. However, the overall relationship between systemic NGAL levels and myocardial structure and performance has not been established...
  48. pmc Subclinical myocardial necrosis and cardiovascular risk in stable patients undergoing elective cardiac evaluation
    W H Wilson Tang
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk J3 4, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 30:634-40. 2010
    ..Herein, we examine the relationship between different degrees of subclinical myocardial necrosis and long-term adverse clinical outcomes within a stable cardiac patient population with essentially normal renal function...
  49. ncbi request reprint Peroxisome proliferator-activated receptor gamma agonists for the Prevention of Adverse events following percutaneous coronary Revascularization--results of the PPAR study
    Deepak L Bhatt
    Cleveland Clinic, Department of Cardiovascular Medicine, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am Heart J 154:137-43. 2007
    ..We sought to determine whether peroxisome proliferator-activated receptor gamma agonists had any beneficial effect on patients with metabolic syndrome undergoing percutaneous coronary intervention (PCI)...
  50. pmc Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
    Robert A Koeth
    Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    Nat Med 19:576-85. 2013
    ..Intestinal microbiota may thus contribute to the well-established link between high levels of red meat consumption and CVD risk...
  51. doi request reprint Differential response to cardiac resynchronization therapy and clinical outcomes according to QRS morphology and QRS duration
    Matthias Dupont
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 60:592-8. 2012
    ..The goal of this study was to examine the relative impact of QRS morphology and duration in echocardiographic responses to cardiac resynchronization therapy (CRT) and clinical outcomes...
  52. pmc Pulmonary hypertension associated with advanced systolic heart failure: dysregulated arginine metabolism and importance of compensatory dimethylarginine dimethylaminohydrolase-1
    Zhili Shao
    Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Am Coll Cardiol 59:1150-8. 2012
    ..This study sought to examine the hemodynamic determinants of dysregulated arginine metabolism in patients with acute decompensated heart failure and to explore possible mechanisms of arginine dysregulation in human heart failure...
  53. doi request reprint Mechanical dyssynchrony in advanced decompensated heart failure: relation to hemodynamic responses to intensive medical therapy
    Wilfried Mullens
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Heart Rhythm 5:1105-10. 2008
    ..In patients with heart failure, the degree of intraventricular mechanical dyssynchrony (intra-VMD) at baseline may predict reversal of cardiac remodeling with cardiac resynchronization therapy (CRT)...
  54. doi request reprint Outcomes of patients with stable heart failure undergoing elective noncardiac surgery
    Ye Olivia Xu-Cai
    Department of Hospital Medicine, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Mayo Clin Proc 83:280-8. 2008
    ....
  55. pmc Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system
    Slava Epelman
    Department of Internal Medicine, Heart and Vascular Institute, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 52:750-4. 2008
    ..We sought to determine whether circulating soluble angiotensin-converting enzyme 2 (sACE2) is increased in the plasma of patients with heart failure (HF)...
  56. ncbi request reprint The year in heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 46:2125-33. 2005
  57. doi request reprint The impact of left ventricular size on response to cardiac resynchronization therapy
    John Rickard
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, OH, USA
    Am Heart J 162:646-53. 2011
    ..We examined changes in left ventricular ejection fraction (LVEF) and survival in patients with NDCM or SDCM compared with those with traditionally studied moderately dilated cardiomyopathy...
  58. doi request reprint Evaluation and long-term prognosis of new-onset, transient, and persistent anemia in ambulatory patients with chronic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 51:569-76. 2008
    ..This study sought to determine the characteristics and long-term prognosis of anemia in ambulatory patients with chronic heart failure...
  59. ncbi request reprint Patterns of beta-blocker utilization in patients with chronic heart failure: experience from a specialized outpatient heart failure clinic
    Ritesh Gupta
    Department of Internal Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am Heart J 147:79-83. 2004
    ..However, there is limited information regarding their use in clinical practice settings, and reasonable utilization targets for quality improvement initiatives have not been established...
  60. ncbi request reprint Emerging drugs for acute and chronic heart failure: current and future developments
    Stephen Y Chen
    Department of Internal Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Expert Opin Emerg Drugs 12:75-95. 2007
    ....
  61. pmc Protein carbamylation predicts mortality in ESRD
    Robert A Koeth
    Department of Cellular and Molecular Medicine, Cleveland Clinic, 4500 Euclid Avenue, NC 10, Cleveland, OH 44195, USA
    J Am Soc Nephrol 24:853-61. 2013
    ..01). In summary, serum PBHCit, a footprint of protein carbamylation, predicts increased cardiovascular risk in patients with ESRD, supporting a mechanistic link among uremia, inflammation, and atherosclerosis...
  62. pmc QRS narrowing is associated with reverse remodeling in patients with chronic right ventricular pacing upgraded to cardiac resynchronization therapy
    John Rickard
    Heart and Vascular Institute Cleveland Clinic, Cleveland, Ohio 44122, USA
    Heart Rhythm 10:55-60. 2013
    ..Little is known about the predictors of response in this population. We hypothesized that reversal of RVP-induced electrical dyssynchrony (indexed by QRS duration) by CRT would predict a favorable response...
  63. pmc Progressive rise in red cell distribution width is associated with disease progression in ambulatory patients with chronic heart failure
    Clay A Cauthen
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA
    J Card Fail 18:146-52. 2012
    ..The objective of this study was to determine the prognostic value of sequential RDW assessment in ambulatory patients with chronic heart failure...
  64. doi request reprint Cardiorenal outcomes after slow continuous ultrafiltration therapy in refractory patients with advanced decompensated heart failure
    Maria Patarroyo
    Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 60:1906-12. 2012
    ..The purpose of this study was to examine the clinical outcomes of using slow continuous ultrafiltration (SCUF) in patients with acute decompensated heart failure (HF) refractory to intensive medical therapy...
  65. doi request reprint Extracorporeal ultrafiltration vs. conventional diuretic therapy in advanced decompensated heart failure
    Mazen A Hanna
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA
    Congest Heart Fail 18:54-63. 2012
    ..In patients with advanced HF under hemodynamically tailored therapy, UF can be safely performed to achieve higher average volume removed than CD therapy without leading to adverse outcomes...
  66. pmc Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: potential mechanisms beyond nitric oxide synthase inhibition
    Zeneng Wang
    Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 29:1383-91. 2009
    ..We examine the relationship of related posttranslational modification products of arginine methylation and coronary artery disease (CAD) phenotypes...
  67. doi request reprint Plasma corin levels provide minimal prognostic utility incremental to natriuretic peptides in chronic systolic heart failure
    Kevin Shrestha
    Department of Cardiovascular Medicine, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Card Fail 16:621-7. 2010
    ..The relationship between soluble plasma corin levels, plasma natriuretic peptide levels, myocardial structure and performance, and long-term clinical outcomes in the setting of chronic systolic heart failure has not been described...
  68. pmc Serum neutrophil gelatinase-associated lipocalin (NGAL) in predicting worsening renal function in acute decompensated heart failure
    Arash Aghel
    Education Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Card Fail 16:49-54. 2010
    ..We sought to determine the relationship between admission serum NGAL levels and WRF in the setting of ADHF...
  69. pmc Plasma myeloperoxidase predicts incident cardiovascular risks in stable patients undergoing medical management for coronary artery disease
    W H Wilson Tang
    Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Cleveland Clinic, Cleveland, OH 44195, USA
    Clin Chem 57:33-9. 2011
    ..Myeloperoxidase (MPO) concentrations predict adverse clinical outcomes in the setting of acute coronary syndromes and heart failure, but the prognostic role of MPO in stable patients with known atherosclerotic burden is unclear...
  70. doi request reprint Prompt reduction in intra-abdominal pressure following large-volume mechanical fluid removal improves renal insufficiency in refractory decompensated heart failure
    Wilfried Mullens
    Section of Heart Failure and Cardiac Transplantation, Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Card Fail 14:508-14. 2008
    ..We hypothesize that in the setting of persistently elevated IAP and progressive renal insufficiency refractory to intensive medical therapy, mechanical fluid removal can be associated with improvements in IAP and renal function...
  71. ncbi request reprint Prognostic value and echocardiographic determinants of plasma myeloperoxidase levels in chronic heart failure
    W H Wilson Tang
    Section of Heart Failure and Cardiac Transplantation Medicine, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 49:2364-70. 2007
    ..The purpose of this study was to explore the relationship between myeloperoxidase (MPO) and cardiac structure, performance, and prognosis...
  72. doi request reprint Usefulness of C-reactive protein and left ventricular diastolic performance for prognosis in patients with left ventricular systolic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Cardiol 101:370-3. 2008
    ..High plasma hs-CRP levels portend poor long-term outcomes, particularly in those with severe concomitant systolic and diastolic dysfunctions...
  73. doi request reprint Statin treatment for patients with heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic Heart and Vascular Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Nat Rev Cardiol 7:249-55. 2010
    ..The results from these studies and their implications for the timing of initiating statin therapy in this patient population are also discussed...
  74. doi request reprint Transesophageal echocardiography and cardioversion trends in patients with atrial fibrillation: a 10-year survey
    Hirad Yarmohammadi
    Department of Internal Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    J Am Soc Echocardiogr 25:962-8. 2012
    ..However, little is known about its recent trends and current applications...
  75. doi request reprint Pre-operative risk factors and clinical outcomes associated with vasoplegia in recipients of orthotopic heart transplantation in the contemporary era
    Maria Patarroyo
    Department of Cardiovascular Medicine and Cardiothoracic Surgery, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Heart Lung Transplant 31:282-7. 2012
    ..Patients who underwent orthotopic heart transplant (OHT) can develop vasoplegia, which is associated with high mortality and morbidity. Herein we examine the pre-operative risk in OHT recipients at our institution...
  76. pmc Ventricular geometry, strain, and rotational mechanics in pulmonary hypertension
    Sarinya Puwanant
    Department of Cardiovascular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Circulation 121:259-66. 2010
    ..We tested the hypothesis that right ventricular (RV) pressure overload affects RV function and further influences left ventricular (LV) geometry, which adversely affects LV twist mechanics and segmental function...
  77. ncbi request reprint Why do patients fail to receive beta-blockers for chronic heart failure over time? A "real-world" single-center, 2-year follow-up experience of beta-blocker therapy in patients with chronic heart failure
    Anoop C Parameswaran
    Department of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am Heart J 149:921-6. 2005
    ..The long-term compliance rate for beta-blocker drugs outside the context of a clinical trial has not been established...
  78. doi request reprint Cardiorenal syndrome: diagnosis, treatment, and clinical outcomes
    Kevin Shrestha
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk J3 4, Cleveland, OH 44195, USA
    Curr Heart Fail Rep 7:167-74. 2010
    ....
  79. ncbi request reprint Plasma myeloperoxidase levels in patients with chronic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Cardiol 98:796-9. 2006
    ..7, 95% confidence interval 3.6 to 371.1). In conclusion, in a cohort of patients with chronic HF, plasma MPO levels were elevated compared with those of normal controls and were associated with worsening functional class...
  80. ncbi request reprint Drug insight: aldosterone-receptor antagonists in heart failure--the journey continues
    Srinivasa R Kalidindi
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA
    Nat Clin Pract Cardiovasc Med 4:368-78. 2007
    ....
  81. doi request reprint Biomarkers in advanced heart failure: diagnostic and therapeutic insights
    Vijaiganesh Nagarajan
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, OH, USA
    Congest Heart Fail 17:169-74. 2011
    ..Congest Heart Fail. Congest Heart Fail. 2011;17:169-174. © 2011 Wiley Periodicals, Inc...
  82. pmc Mast cell number, phenotype, and function in human pulmonary arterial hypertension
    Samar Farha
    Respiratory Institute, Cleveland, Ohio, USA
    Pulm Circ 2:220-8. 2012
    ..These results suggest that mast cells might contribute to the pulmonary vascular pathologic processes underlying PAH. More studies are needed to confirm their potential contribution to the disease...
  83. pmc Antiinflammatory autoimmune cellular responses to cardiac troponin I in idiopathic dilated cardiomyopathy
    Carmel M Halley
    Heart and Vascular Institute, Cleveland, Ohio 44195, USA
    J Card Fail 17:359-65. 2011
    ....
  84. pmc Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities
    Samar Farha
    Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Blood 117:3485-93. 2011
    ....
  85. ncbi request reprint Plasma B-type natriuretic peptide levels predict postoperative atrial fibrillation in patients undergoing cardiac surgery
    Oussama M Wazni
    Center for Atrial Fibrillation, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 110:124-7. 2004
    ..Recently, B-type natriuretic peptide (BNP) has been reported to predict occurrence of nonpostoperative AF. This study evaluates whether elevated preoperative (preop) plasma BNP levels predict the occurrence of postop AF...
  86. ncbi request reprint Ischemic heart disease and congestive heart failure in diabetic patients
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation 9500 Euclid Avenue, Desk F25, Cleveland, OH 44195, USA
    Med Clin North Am 88:1037-61, xi-xii. 2004
    ..Special consideration is given to new strategies for treating the adverse effects of abnormal glucose metabolism on the cardiovascular system...
  87. ncbi request reprint Comparative sensitivities between different plasma B-type natriuretic peptide assays in patients with minimally symptomatic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Section of Heart Failure and Cardiac Transplantation Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Clin Cornerstone 7:S18-24. 2005
    ..These findings suggest that there is a relationship between the decision statistics used in screening for left ventricular dysfunction and the type of diagnostic assay used...
  88. doi request reprint Aldosterone-receptor antagonists in heart failure: insights after EMPHASIS-HF
    Miriam S Jacob
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Curr Heart Fail Rep 8:7-13. 2011
    ....
  89. pmc Measuring impedance in congestive heart failure: current options and clinical applications
    W H Wilson Tang
    Heart and Vascular Institute, Cleveland Clinic, OH 44195, USA
    Am Heart J 157:402-11. 2009
    ....
  90. ncbi request reprint Changing conduction abnormalities in a dialysis patient with fever
    Walter Coats
    Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Cardiol Rev 14:158-60. 2006
    ..Hence, basic bedside diagnostic skills remain important in the era of sophisticated imaging techniques and laboratory analyses...
  91. ncbi request reprint B-type natriuretic peptide: a critical review
    W H Wilson Tang
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Congest Heart Fail 13:48-52. 2007
    ..The potential use of natriuretic peptide levels to monitor and guide patient management or detect subclinical disease states is currently under investigation...
  92. ncbi request reprint National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: clinical utilization of cardiac biomarker testing in heart failure
    W H Wilson Tang
    Cleveland Clinic, Foundation, Cleveland, OH, USA
    Clin Biochem 41:210-21. 2008
  93. doi request reprint Device monitoring strategies in acute heart failure syndromes
    Michael A Samara
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk J3 4, Cleveland, OH 44195, USA
    Heart Fail Rev 16:491-502. 2011
    ..A variety of implantable hemodynamic monitors are currently under investigation. How best to integrate these devices into a systematic approach to the management of patients before, during, and after AHFS is yet to be established...
  94. ncbi request reprint New approaches to detect and manage edema and renal insufficiency in heart failure
    W H Wilson Tang
    Section of Heart Failure and Cardiac Transplantation Medicine, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Cleve Clin J Med 73:S14-9; discussion S30-3. 2006
    ..In addition, diuretic-sparing approaches to heart failure management, novel drug classes, new devices, and nonpharmacologic therapies are emerging to reduce reliance on diuretic therapy and manage edema with less renal compromise...
  95. ncbi request reprint Do thiazolidinediones cause heart failure? A critical review
    W H Wilson Tang
    Section of Heart Failure and Cardiac Transplantation, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 73:390-7. 2006
    ..TZDs have many benefits for patients with diabetes and can even be used cautiously in patients with mild heart failure, with careful monitoring of volume status...
  96. ncbi request reprint PPARgamma agonists: safety issues in heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, The Cleveland Clinic, Cleveland, OH 44195, USA
    Diabetes Obes Metab 9:447-54. 2007
    ....
  97. ncbi request reprint In heart failure, all beta-blockers are not necessarily equal
    W H Wilson Tang
    The George M and Linda H Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 70:1081-7. 2003
    ..Given the overwhelming evidence of the benefit of carvedilol, metoprolol succinate, and bisoprolol in patients with heart failure, we should all strive to increase the use of these drugs in appropriate doses...
  98. doi request reprint Epidemiology of anemia in heart failure
    W H Wilson Tang
    Section of Heart Failure and Cardiac Transplantation Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk J3 4, Cleveland, OH 44195, USA
    Heart Fail Clin 6:271-8. 2010
    ..Different factors contribute to the development of anemia, including increasing age, renal insufficiency, hemodilution, chronic inflammation, and increasing heart failure disease severity...
  99. ncbi request reprint Natriuretic peptides in valvular heart diseases
    Arti Choure
    Cleveland Clinic, Cleveland, OH, USA
    Heart Fail Clin 2:345-52. 2006
  100. ncbi request reprint Natriuretic peptides in screening for cardiac dysfunction
    W H Wilson Tang
    Section of Heart Failure and Cardiac Transplantation Medicine, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Heart Fail Clin 2:323-32. 2006
  101. ncbi request reprint Neurohormonal upregulation in heart failure
    W H Wilson Tang
    Case Western Reserve University, Cleveland, OH, USA
    Heart Fail Clin 1:1-9. 2005