Paul Schoenhagen

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint Non-invasive coronary angiography with multi-detector computed tomography: comparison to conventional X-ray angiography
    Paul Schoenhagen
    Department of Radiology, Center for Integrated Non Invasive Cardiovascular Imaging, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Int J Cardiovasc Imaging 21:63-72. 2005
  2. ncbi request reprint Three-dimensional imaging for the guidance of coronary interventional procedures: impact on clinical decision making?
    Paul Schoenhagen
    Int J Cardiovasc Imaging 20:531-2. 2004
  3. doi request reprint Gender differences in survival in patients with severe left ventricular dysfunction despite similar extent of myocardial scar measured on cardiac magnetic resonance
    Deborah H Kwon
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Eur J Heart Fail 11:937-44. 2009
  4. ncbi request reprint Effects of obesity on lipid-lowering, anti-inflammatory, and antiatherosclerotic benefits of atorvastatin or pravastatin in patients with coronary artery disease (from the REVERSAL Study)
    Stephen J Nicholls
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Cardiol 97:1553-7. 2006
  5. doi request reprint Extent of left ventricular scar predicts outcomes in ischemic cardiomyopathy patients with significantly reduced systolic function: a delayed hyperenhancement cardiac magnetic resonance study
    Deborah H Kwon
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JACC Cardiovasc Imaging 2:34-44. 2009
  6. ncbi request reprint Intravascular ultrasound assessment of novel antiatherosclerotic therapies: rationale and design of the Acyl-CoA:Cholesterol Acyltransferase Intravascular Atherosclerosis Treatment Evaluation (ACTIVATE) Study
    Stephen J Nicholls
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am Heart J 152:67-74. 2006
  7. ncbi request reprint Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease
    Steven E Nissen
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 352:29-38. 2005
  8. doi request reprint Pre-procedural imaging of aortic root orientation and dimensions: comparison between X-ray angiographic planar imaging and 3-dimensional multidetector row computed tomography
    Vikram Kurra
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA
    JACC Cardiovasc Interv 3:105-13. 2010
  9. doi request reprint Preoperative multidetector computed tomograpy angiography for planning of minimally invasive robotic mitral valve surgery: impact on decision making
    Sashidaran Moodley
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 146:262-8.e1. 2013
  10. doi request reprint The metabolic syndrome, its component risk factors, and progression of coronary atherosclerosis
    Ozgur Bayturan
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, OH 44195, USA
    Arch Intern Med 170:478-84. 2010

Detail Information

Publications102 found, 100 shown here

  1. ncbi request reprint Non-invasive coronary angiography with multi-detector computed tomography: comparison to conventional X-ray angiography
    Paul Schoenhagen
    Department of Radiology, Center for Integrated Non Invasive Cardiovascular Imaging, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Int J Cardiovasc Imaging 21:63-72. 2005
    ..Its complementary role in the assessment of early and advanced stages of CAD is increasingly recognized...
  2. ncbi request reprint Three-dimensional imaging for the guidance of coronary interventional procedures: impact on clinical decision making?
    Paul Schoenhagen
    Int J Cardiovasc Imaging 20:531-2. 2004
  3. doi request reprint Gender differences in survival in patients with severe left ventricular dysfunction despite similar extent of myocardial scar measured on cardiac magnetic resonance
    Deborah H Kwon
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Eur J Heart Fail 11:937-44. 2009
    ....
  4. ncbi request reprint Effects of obesity on lipid-lowering, anti-inflammatory, and antiatherosclerotic benefits of atorvastatin or pravastatin in patients with coronary artery disease (from the REVERSAL Study)
    Stephen J Nicholls
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Cardiol 97:1553-7. 2006
    ..These results highlight the need for aggressive risk factor modification and a decrease in vascular inflammation in obese patients...
  5. doi request reprint Extent of left ventricular scar predicts outcomes in ischemic cardiomyopathy patients with significantly reduced systolic function: a delayed hyperenhancement cardiac magnetic resonance study
    Deborah H Kwon
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JACC Cardiovasc Imaging 2:34-44. 2009
    ....
  6. ncbi request reprint Intravascular ultrasound assessment of novel antiatherosclerotic therapies: rationale and design of the Acyl-CoA:Cholesterol Acyltransferase Intravascular Atherosclerosis Treatment Evaluation (ACTIVATE) Study
    Stephen J Nicholls
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am Heart J 152:67-74. 2006
    ..The aim of this study is to determine whether ACAT inhibition, when added to usual medical care, reduces atheroma progression in subjects with coronary artery disease...
  7. ncbi request reprint Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease
    Steven E Nissen
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 352:29-38. 2005
    ..Intensive treatment produced greater reductions in both low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP), suggesting a relationship between these two biomarkers and disease progression...
  8. doi request reprint Pre-procedural imaging of aortic root orientation and dimensions: comparison between X-ray angiographic planar imaging and 3-dimensional multidetector row computed tomography
    Vikram Kurra
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA
    JACC Cardiovasc Interv 3:105-13. 2010
    ..We sought to examine whether contrast-enhanced multidetector row computed tomography (MDCT) allows prediction of X-ray angiographic planes for the root angiogram in the context of transcatheter aortic valve implantation...
  9. doi request reprint Preoperative multidetector computed tomograpy angiography for planning of minimally invasive robotic mitral valve surgery: impact on decision making
    Sashidaran Moodley
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 146:262-8.e1. 2013
    ..We sought to use the strengths of 3-dimensional multidetector computed tomography (MDCT) in assessing aortoiliac atherosclerosis and mitral annular calcification (MAC) and its influence on decision for approach in MV surgery...
  10. doi request reprint The metabolic syndrome, its component risk factors, and progression of coronary atherosclerosis
    Ozgur Bayturan
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, OH 44195, USA
    Arch Intern Med 170:478-84. 2010
    ..We sought to investigate the association of MetS and its component risk factors with progression of coronary atherosclerosis...
  11. ncbi request reprint Coronary artery calcification and changes in atheroma burden in response to established medical therapies
    Stephen J Nicholls
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 49:263-70. 2007
    ..This study sought to determine the relationship between coronary calcification and plaque progression in response to established medical therapies...
  12. ncbi request reprint Determinants of arterial wall remodeling during lipid-lowering therapy: serial intravascular ultrasound observations from the Reversal of Atherosclerosis with Aggressive Lipid Lowering Therapy (REVERSAL) trial
    Paul Schoenhagen
    FAHA, Department of Cardiovascular Medicine, Cardiovascular Imaging, The Cleveland Clinic Foundation, HB 6, 9500 Euclid Ave, Cleveland OH 44195, USA
    Circulation 113:2826-34. 2006
    ..However, the remodeling response during plaque-stabilizing therapy and its relationship to markers of lipid metabolism and inflammation are incompletely understood...
  13. doi request reprint Prospective ECG-triggered, axial 4-D imaging of the aortic root, valvular, and left ventricular structures: a lower radiation dose option for preprocedural TAVR imaging
    Michael A Bolen
    Imaging Institute, Cleveland Clinic, 9500 Euclid Ave, Desk J1 5, Cleveland, OH 44195, USA
    J Cardiovasc Comput Tomogr 6:393-8. 2012
    ..Transcatheter valve interventions rely on imaging for patient selection, preprocedural planning, and intraprocedural guidance...
  14. doi request reprint Plaque progression in coronary arteries with minimal luminal obstruction in intravascular ultrasound atherosclerosis trials
    Andrea J Lavoie
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 105:1679-83. 2010
    ..These minimally diseased arteries demonstrated evidence of vessel and luminal constriction, regardless of the angiographic appearance...
  15. ncbi request reprint Paradoxical increase in lumen size during progression of coronary atherosclerosis: observations from the REVERSAL trial
    Ilke Sipahi
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Atherosclerosis 189:229-35. 2006
    ..Measurement of changes in lumen size may not be an accurate method to study progression and regression of atherosclerotic lesions with <50% stenosis...
  16. doi request reprint Comparison of rates of progression of coronary atherosclerosis in patients with diabetes mellitus versus those with the metabolic syndrome
    Ozgur Bayturan
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 105:1735-9. 2010
    ..This finding highlights the deleterious effects of DM on the arterial wall independent of its associated metabolic abnormalities...
  17. ncbi request reprint Comparison of coronary atherosclerotic volume in patients with glomerular filtration rates < or = 60 versus > 60 ml/min/1.73 m(2): a meta-analysis of intravascular ultrasound studies
    Stephen J Nicholls
    Department of Cardiovascular Medicine, Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Cardiol 99:813-6. 2007
    ..In conclusion, findings suggest that the increased incidence of clinical events in patients with impaired renal function may result from factors other than atherosclerotic burden...
  18. doi request reprint Optimization of acquisition and contrast injection protocol for C-arm CT imaging in transcatheter aortic valve implantation: initial experience in a swine model
    Uma D Numburi
    Chemical and Biomedical Engineering Department, Cleveland State University, Cleveland, OH, USA
    Int J Cardiovasc Imaging 29:405-15. 2013
    ..Ungated C-arm CT during rapid pacing with aortic root injection required minimal contrast, yielded high attenuation and few artifacts, and aortic root measurements and predicted angiographic planes similar to those from MDCT...
  19. doi request reprint Extent of thoracic aortic atheroma burden and long-term mortality after cardiothoracic surgery: a computed tomography study
    Vikram Kurra
    Imaging Institute, Cleveland Clinic, Cleveland, Ohio 44106, USA
    JACC Cardiovasc Imaging 3:1020-9. 2010
    ....
  20. doi request reprint Prevalence of significant peripheral artery disease in patients evaluated for percutaneous aortic valve insertion: Preprocedural assessment with multidetector computed tomography
    Vikram Kurra
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 137:1258-64. 2009
    ..Concomitant atherosclerotic peripheral artery disease limits transfemoral access. We evaluated the potential role of multidetector computed tomography in preoperative assessment of vascular anatomy...
  21. doi request reprint Attenuated plaque at nonculprit lesions in patients enrolled in intravascular ultrasound atherosclerosis progression trials
    Ozgur Bayturan
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    JACC Cardiovasc Interv 2:672-8. 2009
    ..We investigated attenuated plaque (hypoechoic plaque with deep ultrasonic attenuation despite absence of bright calcium) in nonculprit lesions...
  22. doi request reprint Clinical predictors of plaque progression despite very low levels of low-density lipoprotein cholesterol
    Ozgur Bayturan
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 55:2736-42. 2010
    ..The purpose of this study was to characterize the determinants of plaque progression despite achieving very low levels of low-density lipoprotein cholesterol (LDL-C)...
  23. doi request reprint Association of myocardial fibrosis, electrocardiography and ventricular tachyarrhythmia in hypertrophic cardiomyopathy: a delayed contrast enhanced MRI study
    Deborah H Kwon
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Int J Cardiovasc Imaging 24:617-25. 2008
    ..Delayed hyperenhancement magnetic resonance imaging (DHE-MRI) accurately detects myocardial fibrosis (scar). We sought to determine the association between septal thickness, myocardial scar and VT...
  24. ncbi request reprint Non-invasive assessment of plaque morphology and remodeling in mildly stenotic coronary segments: comparison of 16-slice computed tomography and intravascular ultrasound
    Paul Schoenhagen
    Department of Radiology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Coron Artery Dis 14:459-62. 2003
    ..Non-invasive identification and characterization of mildly stenotic atherosclerotic lesions is an increasingly important focus of coronary imaging...
  25. doi request reprint Prognostic utility of 64-slice computed tomography in patients with suspected but no documented coronary artery disease
    Thomas P Carrigan
    Department of Cardiovascular Medicine, Desk F 15, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Eur Heart J 30:362-71. 2009
    ..We sought to assess the incremental prognostic value of 64-slice CT in patients with suspected but no documented CAD...
  26. ncbi request reprint Relationship between cardiovascular risk factors and atherosclerotic disease burden measured by intravascular ultrasound
    Stephen J Nicholls
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 47:1967-75. 2006
    ..The goal of this study was to determine the relationship between established cardiovascular risk factors and the extent of coronary atherosclerotic plaque...
  27. doi request reprint Low-dose, wide-detector array thoracic aortic CT angiography using an iterative reconstruction technique results in improved image quality with lower noise and fewer artifacts
    Prabhakar Rajiah
    Division of Radiology, Imaging Institute, Cardiovascular Imaging, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, USA
    J Cardiovasc Comput Tomogr 6:205-13. 2012
    ..Iterative reconstruction techniques (IRTs) may improve image quality for low-dose imaging compared with filtered back projection (FBP) reconstruction...
  28. ncbi request reprint Rate of progression of coronary atherosclerotic plaque in women
    Stephen J Nicholls
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 49:1546-51. 2007
    ....
  29. ncbi request reprint Effect of atorvastatin (80 mg/day) versus pravastatin (40 mg/day) on arterial remodeling at coronary branch points (from the REVERSAL study)
    Stephen J Nicholls
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Cardiol 96:1636-9. 2005
    ..These results suggest that intensive lipid lowering can have a dramatic effect on atheroma-prone regions and that remodeling in response to changes in plaque is a heterogenous process...
  30. ncbi request reprint Effects of normal, pre-hypertensive, and hypertensive blood pressure levels on progression of coronary atherosclerosis
    Ilke Sipahi
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 48:833-8. 2006
    ..The purpose of this study was to evaluate the effects of normal blood pressure (BP), pre-hypertension, and hypertension on progression of coronary atherosclerosis...
  31. doi request reprint Aortic root morphology in patients undergoing percutaneous aortic valve replacement: evidence of aortic root remodeling
    Mateen Akhtar
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 137:950-6. 2009
    ..We compared morphologic characteristics of the aortic root in patients with aortic stenosis versus elderly gender-matched controls using multidetector computed tomography...
  32. doi request reprint Multidetector computed tomographic angiography in planning of reoperative cardiothoracic surgery
    Apur R Kamdar
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    Ann Thorac Surg 85:1239-45. 2008
    ..We sought to determine if high-risk preoperative MDCTA findings were associated with greater use of preventive surgical strategies during redo cardiac surgery in patients with prior CABG...
  33. ncbi request reprint Relationship between atheroma regression and change in lumen size after infusion of apolipoprotein A-I Milano
    Stephen J Nicholls
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 47:992-7. 2006
    ..The aim of this study was to determine the relationship between atheroma regression and arterial wall remodeling...
  34. ncbi request reprint Association of total cholesterol/ high-density lipoprotein cholesterol ratio with proximal coronary atherosclerosis detected by multislice computed tomography
    Deepu Nair
    Cardiovascular Imaging Laboratory, Heart and Vascular Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Prev Cardiol 12:19-26. 2009
    ..04) and significant CAD (19% vs 9%, P = .009). On multivariate logistic regression analysis, only age, sex, and TC/HDL-C ratio > or = 4 were associated with significant CAD and proximal plaque...
  35. doi request reprint Image quality, contrast enhancement, and radiation dose of ECG-triggered high-pitch CT versus non-ECG-triggered standard-pitch CT of the thoracoabdominal aorta
    Michael A Bolen
    Imaging Institute, Cardiovascular Section, Cleveland Clinic, OH 44195, USA
    AJR Am J Roentgenol 198:931-8. 2012
    ..We sought to compare image quality, contrast enhancement, and radiation dose in patients undergoing ECG-triggered high-pitch helical CT or non-ECG-synchronized helical CT of the thoracoabdominal aorta...
  36. ncbi request reprint Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial
    Steven E Nissen
    Department of Cardiovascular Medicine, Cleveland Clinic Lerner School of Medicine, Cleveland, Ohio 44195, USA
    JAMA 291:1071-80. 2004
    ..Statin drugs reduce both atherogenic lipoproteins and cardiovascular morbidity and mortality. However, the optimal strategy and target level for lipid reduction remain uncertain...
  37. ncbi request reprint Beta-blockers and progression of coronary atherosclerosis: pooled analysis of 4 intravascular ultrasonography trials
    Ilke Sipahi
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Intern Med 147:10-8. 2007
    ..However, whether a direct influence of beta-blockers on coronary atherosclerosis contributes to reduced recurrent myocardial infarction and total mortality rates is not known...
  38. doi request reprint Three-dimensional imaging of the aortic valve and aortic root with computed tomography: new standards in an era of transcatheter valve repair/implantation
    Paul Schoenhagen
    Imaging Institute and Heart and Vascular Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    Eur Heart J 30:2079-86. 2009
    ..Procedural planning based on 3D imaging has already become routine for other endovascular procedures including aortic stent grafts, but is in its infancy in the context of transcatheter valve insertion...
  39. ncbi request reprint Repeated intravascular ultrasound imaging in cardiac transplant recipients does not accelerate transplant coronary artery disease
    Kumudha Ramasubbu
    Department of Cardiology, The Cleveland Clinic Foundation, F25, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Coll Cardiol 41:1739-43. 2003
    ..This study was designed to examine the impact of repeated intravascular ultrasound (IVUS) examinations on transplant coronary artery disease (CAD)...
  40. ncbi request reprint Static and serial assessments of coronary arterial remodeling are discordant: an intravascular ultrasound analysis from the Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) trial
    Ilke Sipahi
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am Heart J 152:544-50. 2006
    ..Recently, performance of serial IVUS provided the opportunity for direct assessment of remodeling. Our aim was to study the concordance of the static and serial methods...
  41. doi request reprint Computed tomography evaluation for transcatheter aortic valve implantation (TAVI): imaging of the aortic root and iliac arteries
    Paul Schoenhagen
    Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Cardiovasc Comput Tomogr 5:293-300. 2011
    ..This Pictorial Essay describes the role of 3-dimensional imaging with multidetector row computed tomography for detailed reconstructions of the aortic valve, aortic root, and iliac arteries in the context of TAVI...
  42. ncbi request reprint Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosis
    Stephen J Nicholls
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JAMA 297:499-508. 2007
    ..However, no data exist describing the relationship between statin-induced changes in high-density lipoprotein cholesterol (HDL-C) and disease progression...
  43. doi request reprint Low levels of low-density lipoprotein cholesterol and blood pressure and progression of coronary atherosclerosis
    Adnan K Chhatriwalla
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 53:1110-5. 2009
    ..We investigated coronary atheroma progression in patients with low levels of low-density lipoprotein cholesterol (LDL-C) and systolic blood pressure (SBP)...
  44. doi request reprint Three-dimensional imaging in the context of minimally invasive and transcatheter cardiovascular interventions using multi-detector computed tomography: from pre-operative planning to intra-operative guidance
    Paul Schoenhagen
    Imaging Institute, Cleveland Clinic, Desk J 1 4, 9500 Euclid Avenue, Cleveland, OH, USA
    Eur Heart J 31:2727-40. 2010
    ..This is in particular true, because data showing improved outcome or even non-inferiority for most of the emerging transcatheter procedures are still lacking...
  45. ncbi request reprint Compensatory enlargement of human coronary arteries during progression of atherosclerosis is unrelated to atheroma burden: serial intravascular ultrasound observations from the REVERSAL trial
    Ilke Sipahi
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk F25, Cleveland, OH 44195, USA
    Eur Heart J 27:1664-70. 2006
    ..Our aim was to evaluate whether atheroma burden is a limiting factor for coronary arterial remodelling using in vivo serial intravascular ultrasound (IVUS)...
  46. ncbi request reprint Noninvasive imaging of coronary arteries: current and future role of multi-detector row CT
    Paul Schoenhagen
    Department of Radiology, Cleveland Clinic Foundation, Desk Hb 6, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Radiology 232:7-17. 2004
    ..It will describe how tomographic coronary imaging may eventually supplement traditional angiographic techniques in understanding the patterns of atherosclerotic CAD development...
  47. ncbi request reprint Effect of ACAT inhibition on the progression of coronary atherosclerosis
    Steven E Nissen
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 354:1253-63. 2006
    ..The enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT) esterifies cholesterol in a variety of tissues. In some animal models, ACAT inhibitors have antiatherosclerotic effects...
  48. ncbi request reprint Left atrial appendage filling defects identified by multidetector computed tomography in patients undergoing radiofrequency pulmonary vein antral isolation: a comparison with transesophageal echocardiography
    Yuli Y Kim
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Am Heart J 154:1199-205. 2007
    ..We sought to determine the accuracy of MDCT to qualitatively and quantitatively detect severe spontaneous echo contrast (SEC) or thrombus by TEE in the left atrial appendage (LAA)...
  49. doi request reprint Feasibility of dual-energy CT in the arterial phase: Imaging after endovascular aortic repair
    Uma D Numburi
    Imaging Institute, Cleveland Clinic, OH 44195, USA
    AJR Am J Roentgenol 195:486-93. 2010
    ..The purpose of this study was to investigate replacing unenhanced and arterial single-energy CT acquisitions after endovascular aneurysm repair with one dual-energy CT arterial acquisition...
  50. ncbi request reprint Coronary plaque morphology and frequency of ulceration distant from culprit lesions in patients with unstable and stable presentation
    Paul Schoenhagen
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Arterioscler Thromb Vasc Biol 23:1895-900. 2003
    ..However, the role of intravascular ultrasound in the diagnosis of lesion vulnerability before rupture is unclear...
  51. doi request reprint Endoleaks following endovascular repair of thoracic aortic aneurysm: etiology and outcomes
    Jose P Morales
    Department of Vascular and Endovascular Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
    J Endovasc Ther 15:631-8. 2008
    ..To evaluate the incidence and natural history of endoleaks following thoracic endovascular aortic repair (TEVAR) of thoracic aortic aneurysm (TAA)...
  52. ncbi request reprint Relationship between residual atheroma burden and neointimal growth in patients undergoing stenting: analysis of the atherectomy before MULTI-LINK improves lumen gain and clinical outcomes trial intravascular ultrasound substudy
    Ivan P Casserly
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Coll Cardiol 40:1573-8. 2002
    ..The objective of this study was to examine the relationship between quantitative volumetric and cross-sectional measures of residual atheroma burden and neointimal growth after coronary stenting...
  53. doi request reprint Characterization and outcome of patients with severe symptomatic aortic stenosis referred for percutaneous aortic valve replacement
    Samir R Kapadia
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 137:1430-5. 2009
    ..We sought to define the characteristics and outcomes of patients referred for percutaneous aortic valve replacement...
  54. ncbi request reprint Variability of area measurements obtained with different intravascular ultrasound catheter systems: Impact on clinical trials and a method for accurate calibration
    Paul Schoenhagen
    Department of Cardiology and Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Am Soc Echocardiogr 16:277-84. 2003
    ..Intravascular ultrasound allows precise measurements of coronary artery dimensions. However, the variability of measurements among different catheter systems is incompletely characterized...
  55. ncbi request reprint Automated three-dimensional assessment of coronary artery anatomy with intravascular ultrasound scanning
    Jon D Klingensmith
    Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am Heart J 145:795-805. 2003
    ..In contrast, intravascular ultrasound scanning allows the precise characterization and quantification of a wide range of atherosclerotic lesions, independent of the severity of luminal stenosis...
  56. pmc Left atrial epicardial adiposity and atrial fibrillation
    Omar Batal
    Departments of General Internal Medicine, Cardiovascular Medicine, and Diagnostic Radiology, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Circ Arrhythm Electrophysiol 3:230-6. 2010
    ..Epicardial fat is a source of several inflammatory mediators related to the development of coronary artery disease. We hypothesized that periatrial fat may have a similar role in the development of AF...
  57. ncbi request reprint Pharmacologic strategies for the prevention of atherosclerotic plaque progression
    Paul Schoenhagen
    The Cleveland Clinic Foundation, Department of Radiology, Cardiovascular Imaging, Radiology Desk Hb 6, Cleveland, OH 44195, USA
    Expert Rev Cardiovasc Ther 2:855-66. 2004
    ..This review will describe the use of intravascular ultrasound for such studies, summarize results from recent trials and outline potential future pharmacologic targets...
  58. ncbi request reprint Identification of the metabolic syndrome and imaging of subclinical coronary artery disease: early markers of cardiovascular risk
    Paul Schoenhagen
    Department of Cardiovascular Medicine, Cardiovascular Imaging, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Cardiovasc Nurs 21:291-7. 2006
    ....
  59. doi request reprint Effect of diabetes on progression of coronary atherosclerosis and arterial remodeling: a pooled analysis of 5 intravascular ultrasound trials
    Stephen J Nicholls
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 52:255-62. 2008
    ..Our goal was to characterize coronary atherosclerosis progression and arterial remodeling in diabetic patients...
  60. ncbi request reprint Comprehensive imaging of coronary artery disease: impact on contemporary treatment approaches
    Paul Schoenhagen
    Department of Radiology, and Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Compr Ther 31:159-65. 2005
    ..Together with novel therapeutic and preventive approaches, important advances of coronary imaging are currently emerging. This article describes the status of modern coronary imaging and outlines expected future developments...
  61. ncbi request reprint Application of intravascular ultrasound in anti-atherosclerotic drug development
    Stephen J Nicholls
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nat Rev Drug Discov 5:485-92. 2006
    ....
  62. ncbi request reprint Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial
    Steven E Nissen
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    JAMA 290:2292-300. 2003
    ..Infusion of recombinant ApoA-I Milano-phospholipid complexes produces rapid regression of atherosclerosis in animal models...
  63. ncbi request reprint Coronary imaging: angiography shows the stenosis, but IVUS, CT, and MRI show the plaque
    Paul Schoenhagen
    Section of Cardiovascular Imaging, Department of Radiology, The Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 70:713-9. 2003
    ....
  64. ncbi request reprint Influence of coronary pulsation on volumetric intravascular ultrasound measurements performed without ECG-gating. Validation in vessel segments with minimal disease
    Hiroshi Tsutsui
    Department of Cardiology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Int J Cardiovasc Imaging 19:51-7. 2003
    ..Despite these limitations, this method is feasible and provides reproducible volume measurements...
  65. doi request reprint In vivo imaging and computational analysis of the aortic root. Application in clinical research and design of transcatheter aortic valve systems
    Paul Schoenhagen
    Imaging Institute and Heart and Vascular Institute, The Cleveland Clinic, Desk J 1 4, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Cardiovasc Transl Res 4:459-69. 2011
    ..This paper will provide an overview of computer modeling of the aortic root and describe FEA approaches that could be applied to TAVI and have an impact on clinical practice and device design...
  66. doi request reprint Use of electrocardiographic-gated 4-dimensional CT to assess patency of abdominal aortic branch vessels in type B dissection
    Michael A Bolen
    Imaging Institute, Cardiovascular Section, Cleveland Clinic, 9500 Euclid Avenue J1 4, Cleveland, OH 44195, USA
    J Cardiovasc Comput Tomogr 3:415-6. 2009
    ..In this case, use of ECG gating and 4D imaging demonstrated of dynamically changing perfusion to an abdominal aortic visceral branch vessel in a type B dissection...
  67. ncbi request reprint Influence of various percutaneous coronary interventional devices on postinterventional luminal shape and plaque surface characteristics as determined by intravascular ultrasound
    Berkten Berkalp
    Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Cardiol 91:1269-72. 2003
  68. doi request reprint Peripheral arterial disease and progression of coronary atherosclerosis
    Ayman A Hussein
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA
    J Am Coll Cardiol 57:1220-5. 2011
    ..The purpose of this analysis was to characterize the progression of coronary atherosclerosis in patients with concomitant peripheral arterial disease (PAD)...
  69. ncbi request reprint Coronary artery calcification and end-stage renal disease: vascular biology and clinical implications
    Paul Schoenhagen
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 69:S12-20. 2002
  70. doi request reprint Cardiovascular imaging with computed tomography: responsible steps to balancing diagnostic yield and radiation exposure
    Sandra S Halliburton
    Cardiovascular Imaging, Imaging Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JACC Cardiovasc Imaging 3:536-40. 2010
    ..However, efforts to promote responsible cardiovascular CT imaging must continue to ensure this is true for every patient...
  71. ncbi request reprint Atherosclerosis imaging: intravascular ultrasound
    E Murat Tuzcu
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44950, USA
    Drugs 64:1-7. 2004
    ..Future prospective imaging studies will be necessary to identify focal or systemic characteristics of high-risk lesions and to demonstrate the relationship between plaque burden, biochemical markers and clinical events...
  72. ncbi request reprint Contrast enhancement of coronary atherosclerotic plaque: a high-resolution, multidetector-row computed tomography study of pressure-perfused, human ex-vivo coronary arteries
    Sandra S Halliburton
    Section of Cardiovascular Imaging, Division of Radiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Coron Artery Dis 17:553-60. 2006
    ..The objective of this study was to investigate the effect of contrast injection on atherosclerotic coronary plaque attenuation measured using multidetector-row computed tomography...
  73. ncbi request reprint Intravascular ultrasound in cardiovascular medicine
    Stephen J Nicholls
    Department of Cardiovascular Medicine, Cleveland Clinic, Mail Code JJ65, 9500 Euclid Ave, Cleveland, Ohio 44195, USA
    Circulation 114:e55-9. 2006
  74. ncbi request reprint Coronary atherosclerotic disease burden: an emerging endpoint in progression/regression studies using intravascular ultrasound
    Paul Schoenhagen
    The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Curr Drug Targets Cardiovasc Haematol Disord 3:218-26. 2003
    ..This review will summarize the rational of this approach and describe the use of intravascular ultrasound (IVUS) for such studies...
  75. ncbi request reprint Intravascular ultrasonography: using imaging end points in coronary atherosclerosis trials
    Paul Schoenhagen
    Department of Radiology, Section of Cardiovascular Imaging, The Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 72:487-9, 493-6. 2005
    ..Other imaging tests may also prove useful to monitor treatment of atherosclerosis and identify populations at risk for coronary artery disease (CAD)...
  76. ncbi request reprint Quantitative assessment of myocardial scar in delayed enhancement magnetic resonance imaging
    Randolph M Setser
    Department of Radiology, Cardiovascular Imaging Section, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Magn Reson Imaging 18:434-41. 2003
    ..To characterize the extent and distribution of left ventricular myocardial scar in delayed enhancement magnetic resonance imaging (MRI)...
  77. ncbi request reprint Impact of age and hyperglycemia on the mechanical behavior of intact human coronary arteries: an ex vivo intravascular ultrasound study
    Azita Tajaddini
    Department of Biomedical Engineering ND20, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Physiol Heart Circ Physiol 288:H250-5. 2005
    ..Hyperglycemia and age independently influenced the distensibility of moderately atherosclerotic LAD coronary arteries. The stiffening with age was overshadowed in the hyperglycemic group by as-yet-undetermined factors...
  78. ncbi request reprint Coronary atherosclerosis in diabetic subjects: clinical significance, anatomic characteristics, and identification with in vivo imaging
    Paul Schoenhagen
    The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cardiol Clin 22:527-40, vi. 2004
    ....
  79. ncbi request reprint Assessing coronary plaque burden and plaque vulnerability: atherosclerosis imaging with IVUS and emerging noninvasive modalities
    Paul Schoenhagen
    Department of Cardiovascular Medicine and Radiology, Section of Cardiovascular Imaging, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am Heart Hosp J 1:164-9. 2003
    ..Intravascular ultrasound is the most established invasive method with a long clinical track record. More recently, noninvasive modalities including computed tomography and magnetic resonance imaging are emerging...
  80. ncbi request reprint Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial
    Steven E Nissen
    Department of Cardiovascular Medicine, Cleveland Clinic Lerner School of Medicine, Cleveland, Ohio 44195, USA
    JAMA 295:1556-65. 2006
    ....
  81. ncbi request reprint Images in vascular medicine. Acute aortic intramural hematoma associated with severe bilateral renal artery stenosis
    Heather L Gornik
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue Desk S60, Cleveland, OH 44195, USA
    Vasc Med 11:268-70. 2006
  82. doi request reprint Effect of dual-source cardiac computed tomography on patient radiation dose in a clinical setting: comparison to single-source imaging
    Sandra S Halliburton
    Cardiovascular Imaging Laboratory, Imaging Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Cardiovasc Comput Tomogr 2:392-400. 2008
    ..The effect of these changes on radiation dose requirements for coronary CT angiography in clinical practice has not been investigated...
  83. doi request reprint Lesion characteristics and subsequent atherosclerotic disease progression. Insights into the dynamic process of coronary atherosclerosis
    Paul Schoenhagen
    Imaging Institute, The Cleveland Clinic, Cardiovascular Imaging, Desk Hb 6, 9500, Euclid Avenue, Cleveland, OH 44195, USA
    Int J Cardiovasc Imaging 24:429-31. 2008
  84. ncbi request reprint Nanotechnology and atherosclerosis imaging: emerging diagnostic and therapeutic applications
    Paul Schoenhagen
    Imaging Institute and Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Recent Pat Cardiovasc Drug Discov 3:98-104. 2008
    ..However, further development is required before nanotechnology can be applied clinically. This manuscript also includes some recent patents on this topic...
  85. doi request reprint Comparison of stent versus balloon angioplasty for pulmonary vein stenosis complicating pulmonary vein isolation
    Lourdes R Prieto
    Department of Pediatric Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Cardiovasc Electrophysiol 19:673-8. 2008
    ..Pulmonary vein stenosis (PVS) is a rare but significant complication of pulmonary vein isolation (PVI). Dilation and stent angioplasty have been described but not compared...
  86. doi request reprint Transcatheter aortic valve implantation and potential role of 3D imaging
    Paul Schoenhagen
    Imaging Institute and Heart and Vascular Institute, Desk J 14, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Expert Rev Med Devices 6:411-21. 2009
    ..In this article, we will describe how data from 3D imaging in the context of transcatheter aortic valve implantation may impact device design...
  87. doi request reprint Emergence of targeted molecular imaging in atherosclerotic cardiovascular disease
    Milind Y Desai
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk J1 15, Cleveland, OH 44195, USA
    Expert Rev Cardiovasc Ther 7:197-203. 2009
    ..Important targets include inflammatory and endothelial cells, as well as apoptosis and angiogenesis. The next decade should solidify the role of targeted molecular imaging in all aspects of cardiovascular medicine...
  88. ncbi request reprint Plaque burden, plaque morphology, and HDL: can atherosclerosis imaging provide insights into the complex, multifactorial etiology of atherosclerosis progression and vulnerability?
    Paul Schoenhagen
    Division of Radiology and Department of Cardiovascular Medicine, The Cleveland Clinic, Desk Hb 6, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Int J Cardiovasc Imaging 23:343-5. 2007
  89. doi request reprint Valsalva sinus aneurysms: findings at CT and MR imaging
    Aliye Ozsoyoglu Bricker
    Department of Radiology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Radiographics 30:99-110. 2010
    ..However, both electrocardiographically gated computed tomography and magnetic resonance (MR) imaging can provide excellent anatomic depiction, and MR imaging can provide valuable functional information...
  90. ncbi request reprint Atherosclerosis imaging in progression/regression trials: surrogate marker or direct window into the atherosclerotic disease process?
    Paul Schoenhagen
    Cleveland Clinic, Imaging Institute and Heart and Vascular Institute, Cleveland 44195, USA
    Arq Bras Cardiol 91:385-98. 2008
    ..In addition to a discussion of the results of individual imaging modalities, the emerging data comparing different modalities and approaches are presented...
  91. ncbi request reprint Characteristics of atherosclerotic plaque distribution in coronary artery bifurcations: an intravascular ultrasound analysis
    Ozer Badak
    Department of Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
    Coron Artery Dis 14:309-16. 2003
    ..Vessel bifurcations are prone to atherosclerotic plaque accumulation. Using volumetric intravascular ultrasound analysis, we investigated atheroma distribution at human coronary bifurcations in vivo...
  92. ncbi request reprint Remodeling pattern within diseased coronary segments as evidenced by intravascular ultrasound
    Atilla Iyisoy
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Cardiol 90:636-8. 2002
  93. ncbi request reprint Relation of hemoglobin A1c to left ventricular relaxation in patients with type 1 diabetes mellitus and without overt heart disease
    Mehdi H Shishehbor
    Department of Internal Medicine, Cardiovascular Imaging Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Cardiol 91:1514-7, A9. 2003
  94. ncbi request reprint CT of the heart: principles, advances, clinical uses
    Paul Schoenhagen
    Center for Integrated Non Invasive Cardiovascular Imaging, Department of Diagnostic Radiology, The Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 72:127-38. 2005
    ..We review the principles of CT and its uses in cardiovascular medicine...
  95. ncbi request reprint Surrogate markers for atherosclerotic disease
    Raaj R Sankatsing
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Curr Opin Lipidol 16:434-41. 2005
    ..Over the last decade, the use of imaging markers has been widely introduced into drug-development strategies. Here we will discuss the most commonly used techniques...
  96. pmc Understanding coronary artery disease: tomographic imaging with intravascular ultrasound
    Paul Schoenhagen
    Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Heart 88:91-6. 2002
  97. ncbi request reprint Coronary angiography with multi-detector computed tomography (MDCTA): documenting the clinical impact of technical advances
    Paul Schoenhagen
    Int J Cardiovasc Imaging 21:339-41. 2005
  98. ncbi request reprint Atherosclerosis imaging and circulating blood biomarkers: insights into subclinical atherosclerotic plaque burden and disease activity
    Paul Schoenhagen
    Int J Cardiovasc Imaging 21:443-5. 2005
  99. ncbi request reprint 3-D intravascular ultrasound (IVUS) and IVUS-palpography: insights into the mechanical behavior of the coronary vessel wall
    Paul Schoenhagen
    Int J Cardiovasc Imaging 22:153-5. 2006
  100. ncbi request reprint The role of coronary CT angiography (CTA) for patients presenting with acute chest pain. Defining problem-specific, evidence-based indications of a novel imaging modality
    Paul Schoenhagen
    Int J Cardiovasc Imaging 23:429-32. 2007
    ..Most experts agree, that there is the need for large clinical trials to determine the accuracy and precision of MDCT for triage of patients with acute chest pain...
  101. ncbi request reprint Technological development of cardiovascular computed tomography and the need for an unbiased scientific review of clinical utility
    Paul Schoenhagen
    Int J Cardiovasc Imaging 24:2 p preceding 453. 2008