Zoran B Popovic

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. pmc Left ventricular strain distribution in healthy dogs and in dogs with tachycardia-induced dilated cardiomyopathy
    Kenya Kusunose
    Department of Cardiovascular Medicine, Cleveland Clinic, Heart and Vascular Institute, 9500 Euclid Avenue, Desk J1 5, Cleveland, OH 44195, USA
    Cardiovasc Ultrasound 11:43. 2013
  2. ncbi request reprint Ventricular rate control by selective vagal stimulation is superior to rhythm regularization by atrioventricular nodal ablation and pacing during atrial fibrillation
    Shaowei Zhuang
    Department of Cardiovascular, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 106:1853-8. 2002
  3. doi request reprint Gender differences in survival in patients with severe left ventricular dysfunction despite similar extent of myocardial scar measured on cardiac magnetic resonance
    Deborah H Kwon
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Eur J Heart Fail 11:937-44. 2009
  4. ncbi request reprint Slow rate during AF improves ventricular performance by reducing sensitivity to cycle length irregularity
    Zoran B Popovic
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Physiol Heart Circ Physiol 283:H2706-13. 2002
  5. ncbi request reprint Optimal ventricular rate slowing during atrial fibrillation by feedback AV nodal-selective vagal stimulation
    Youhua Zhang
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Physiol Heart Circ Physiol 282:H1102-10. 2002
  6. ncbi request reprint Assessment of left ventricular torsional deformation by Doppler tissue imaging: validation study with tagged magnetic resonance imaging
    Yuichi Notomi
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 111:1141-7. 2005
  7. ncbi request reprint Conduction system abnormalities in patients with obstructive hypertrophic cardiomyopathy following septal reduction interventions
    Jian Xin Qin
    Department of Cardiovascular Medicine, Cleveland, Ohio 44195, USA
    Am J Cardiol 93:171-5. 2004
  8. doi request reprint Impact of longitudinal cardiac rotation on mitral and tricuspid atrioventricular annular diastolic motion
    Zoran B Popovic
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Circ Cardiovasc Imaging 3:368-74. 2010
  9. doi request reprint Association of myocardial fibrosis, electrocardiography and ventricular tachyarrhythmia in hypertrophic cardiomyopathy: a delayed contrast enhanced MRI study
    Deborah H Kwon
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Int J Cardiovasc Imaging 24:617-25. 2008
  10. ncbi request reprint Frank-Starling mechanism contributes modestly to ventricular performance during atrial fibrillation
    Zoran B Popovic
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
    Heart Rhythm 1:482-9. 2004

Detail Information

Publications79

  1. pmc Left ventricular strain distribution in healthy dogs and in dogs with tachycardia-induced dilated cardiomyopathy
    Kenya Kusunose
    Department of Cardiovascular Medicine, Cleveland Clinic, Heart and Vascular Institute, 9500 Euclid Avenue, Desk J1 5, Cleveland, OH 44195, USA
    Cardiovasc Ultrasound 11:43. 2013
    ..We hypothesized that TIC induces specific changes in LV strain distribution pattern...
  2. ncbi request reprint Ventricular rate control by selective vagal stimulation is superior to rhythm regularization by atrioventricular nodal ablation and pacing during atrial fibrillation
    Shaowei Zhuang
    Department of Cardiovascular, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 106:1853-8. 2002
    ..We tested the hypothesis that, at comparable levels of VR slowing, AVN-VS provides hemodynamic benefits similar to those of ablation with pacemaker implantation...
  3. doi request reprint Gender differences in survival in patients with severe left ventricular dysfunction despite similar extent of myocardial scar measured on cardiac magnetic resonance
    Deborah H Kwon
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Eur J Heart Fail 11:937-44. 2009
    ....
  4. ncbi request reprint Slow rate during AF improves ventricular performance by reducing sensitivity to cycle length irregularity
    Zoran B Popovic
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Physiol Heart Circ Physiol 283:H2706-13. 2002
    ..We conclude that prolongation of the VCL during AF reduces the sensitivity of the LV performance parameters to irregularity...
  5. ncbi request reprint Optimal ventricular rate slowing during atrial fibrillation by feedback AV nodal-selective vagal stimulation
    Youhua Zhang
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Physiol Heart Circ Physiol 282:H1102-10. 2002
    ..We conclude that this novel method can be used to maintain slow anterograde conduction with best hemodynamics during AF...
  6. ncbi request reprint Assessment of left ventricular torsional deformation by Doppler tissue imaging: validation study with tagged magnetic resonance imaging
    Yuichi Notomi
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 111:1141-7. 2005
    ..The present study tested the accuracy of a novel method that uses Doppler tissue imaging (DTI) for quantifying LV torsion in humans with tagged magnetic resonance imaging (MRI) as a reference...
  7. ncbi request reprint Conduction system abnormalities in patients with obstructive hypertrophic cardiomyopathy following septal reduction interventions
    Jian Xin Qin
    Department of Cardiovascular Medicine, Cleveland, Ohio 44195, USA
    Am J Cardiol 93:171-5. 2004
    ..0001). Thus, RBBB often develops after PTSMA and LBBB is very frequently produced by myectomy. A possible requirement of a permanent pacemaker should always be considered before intervention when patients have preexisting RBBB or LBBB...
  8. doi request reprint Impact of longitudinal cardiac rotation on mitral and tricuspid atrioventricular annular diastolic motion
    Zoran B Popovic
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Circ Cardiovasc Imaging 3:368-74. 2010
    ....
  9. doi request reprint Association of myocardial fibrosis, electrocardiography and ventricular tachyarrhythmia in hypertrophic cardiomyopathy: a delayed contrast enhanced MRI study
    Deborah H Kwon
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Int J Cardiovasc Imaging 24:617-25. 2008
    ..Delayed hyperenhancement magnetic resonance imaging (DHE-MRI) accurately detects myocardial fibrosis (scar). We sought to determine the association between septal thickness, myocardial scar and VT...
  10. ncbi request reprint Frank-Starling mechanism contributes modestly to ventricular performance during atrial fibrillation
    Zoran B Popovic
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
    Heart Rhythm 1:482-9. 2004
    ..The aim of this study was to assess whether Frank-Starling mechanism has an independent effect on left ventricular (LV) performance in atrial fibrillation (AF)...
  11. ncbi request reprint Mitral valve repair without cardiopulmonary bypass or atriotomy using the coapsys device: device design and implantation procedure in canine functional mitral regurgitation model
    Masahiro Inoue
    Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, Ohio, USA
    Heart Surg Forum 7:E117-21. 2004
    ..This study was conducted to test the feasibility of the Coapsys implantation procedure in a canine functional MR model...
  12. pmc Impact of left ventricular volume/mass ratio on diastolic function
    Adisai Buakhamsri
    Division of Cardiovascular Medicine, Department of Cardiology, Desk F 15, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Eur Heart J 30:1213-21. 2009
    ..To assess the impact of left ventricular (LV) volume/mass ratio on diastolic function parameters in subjects with dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM) and healthy controls...
  13. ncbi request reprint Ventricular untwisting: a temporal link between left ventricular relaxation and suction
    Yuichi Notomi
    Department of Cardiovascular Medicine F15, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Physiol Heart Circ Physiol 294:H505-13. 2008
    ..Untwisting rate may be a useful marker of diastolic function or even serve as a therapeutic target for improving diastolic function...
  14. ncbi request reprint Evaluation of a novel device for left atrial appendage exclusion: the second-generation atrial exclusion device
    Keiji Kamohara
    Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 132:340-6. 2006
    ..The purpose of this study was to evaluate this second-generation atrial exclusion device during a midterm period in a canine model...
  15. doi request reprint Opposing wall mechanics are significantly influenced by longitudinal cardiac rotation in the assessment of ventricular dyssynchrony
    Karen P Phillips
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    JACC Cardiovasc Imaging 2:379-86. 2009
    ..This study sought to assess whether longitudinal rotation (LR) affects myocardial systolic velocity profiles and to compare velocity-based measures of dyssynchrony with LR for predicting cardiac resynchronization therapy (CRT) response...
  16. ncbi request reprint Geometric differences of the mitral apparatus between ischemic and dilated cardiomyopathy with significant mitral regurgitation: real-time three-dimensional echocardiography study
    Jun Kwan
    Cardiovascular Imaging Center, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 107:1135-40. 2003
    ....
  17. doi request reprint Biventricular mechanics in constrictive pericarditis comparison with restrictive cardiomyopathy and impact of pericardiectomy
    Kenya Kusunose
    Heart and Vascular Institute and Imaging Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Circ Cardiovasc Imaging 6:399-406. 2013
    ....
  18. pmc Non-invasive assessment of left ventricular relaxation during atrial fibrillation using mitral flow propagation velocity
    Junko Asada-Kamiguchi
    Section of Cardiovascular Imaging, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Eur J Echocardiogr 10:826-32. 2009
    ..To elucidate the usefulness of the early diastolic mitral flow propagation velocity (V(p)) obtained from colour M-mode Doppler for non-invasively assessing left-ventricular (LV) relaxation during atrial fibrillation (AF)...
  19. ncbi request reprint Scaling of diastolic intraventricular pressure gradients is related to filling time duration
    Zoran B Popovic
    Cardiovascular Imaging Center, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Physiol Heart Circ Physiol 291:H762-9. 2006
    ..65, P < 0.001). We conclude that IVPD decrease, while IVPG increase with decreasing animal size. High IVPG in small mammals may be an adaptive mechanism to short filling times...
  20. doi request reprint Extent of left ventricular scar predicts outcomes in ischemic cardiomyopathy patients with significantly reduced systolic function: a delayed hyperenhancement cardiac magnetic resonance study
    Deborah H Kwon
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JACC Cardiovasc Imaging 2:34-44. 2009
    ....
  21. ncbi request reprint Mitral annulus size links ventricular dilatation to functional mitral regurgitation
    Zoran B Popovic
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Soc Echocardiogr 18:959-63. 2005
    ..68, P = .002). Mitral annulus dilation is the strongest predictor of functional mitral regurgitation in this animal dilated cardiomyopathy model...
  22. ncbi request reprint Importance of mitral valve repair associated with left ventricular reconstruction for patients with ischemic cardiomyopathy: a real-time three-dimensional echocardiographic study
    Jian Xin Qin
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Circulation 108:II241-6. 2003
    ..This study was designed to evaluate the impact of mitral valve (MV) repair associated with LV reconstruction on LV function 1-year after surgery in ICM patients assessed by real-time 3-dimensional echocardiography (3DE)...
  23. pmc Differences in left ventricular long-axis function from mice to humans follow allometric scaling to ventricular size
    Zoran B Popovic
    Department of Cardiology, Desk F 15, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Physiol 568:255-65. 2005
    ..019 (P<0.0001 versus 0). We conclude that MA velocity, displacement, and long-to-short axis displacement ratio scale allometrically to heart size. This reduces the relative long-axis contribution to heart function in small mammals...
  24. ncbi request reprint Speckle-tracking echocardiography correctly identifies segmental left ventricular dysfunction induced by scarring in a rat model of myocardial infarction
    Zoran B Popovic
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Physiol Heart Circ Physiol 292:H2809-16. 2007
    ..0001) than on percent fibrosis (P<0.002). STE correctly identifies segmental LV dysfunction induced by scarring that follows myocardial infarction in rats...
  25. pmc How similar are the mice to men? Between-species comparison of left ventricular mechanics using strain imaging
    Kenya Kusunose
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 7:e40061. 2012
    ..We used 2-D speckle tracking strain imaging to determine whether LV myocardial strains and strain rates scale to heart size...
  26. doi request reprint Increased aorto-mitral curtain thickness independently predicts mortality in patients with radiation-associated cardiac disease undergoing cardiac surgery
    Milind Y Desai
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio Electronic address
    Ann Thorac Surg 97:1348-55. 2014
    ..We sought to identify clinical and transthoracic echocardiography predictors of long-term mortality in patients with RACD...
  27. ncbi request reprint The effects of altering time delays of coupled pacing during acute atrial fibrillation
    Hirotsugu Yamada
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, OH 44195, USA
    Heart Rhythm 3:722-7. 2006
    ..It also has been established that CP improves pump function by enhancing external cardiac work and myocardial efficiency...
  28. ncbi request reprint Noninvasive assessment of cardiac resynchronization therapy for congestive heart failure using myocardial strain and left ventricular peak power as parameters of myocardial synchrony and function
    Zoran B Popovic
    Cardiovascular Imaging Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Cardiovasc Electrophysiol 13:1203-8. 2002
    ..The aim of this study was to assess the acute effects of cardiac resynchronization therapy by noninvasive techniques...
  29. ncbi request reprint Mitral annular motion as a surrogate for left ventricular ejection fraction: real-time three-dimensional echocardiography and magnetic resonance imaging studies
    Jian Xin Qin
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Eur J Echocardiogr 5:407-15. 2004
    ..To validate the accuracy of mitral annular motion assessed by real-time three-dimensional echocardiography (RT3DE) as a surrogate for determination of the left ventricular function in comparison with magnetic resonance imaging (MRI)...
  30. ncbi request reprint Survival in patients with severe ischemic cardiomyopathy undergoing revascularization versus medical therapy: association with end-systolic volume and viability
    Deborah H Kwon
    Heart and Vascular Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    Circulation 126:S3-8. 2012
    ..We sought to determine whether the contribution of viability as myocardial scar burden (SB) to predict revascularization outcomes could be modulated by end-systolic volume index (ESVi)...
  31. doi request reprint Impact of mitral regurgitation on reverse remodeling and outcome in patients undergoing cardiac resynchronization therapy
    David Verhaert
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Circ Cardiovasc Imaging 5:21-6. 2012
    ..We sought to evaluate the relationship between serial measurements of functional MR and reverse remodeling and outcomes in patients undergoing CRT...
  32. doi request reprint Pericardial delayed hyperenhancement with CMR imaging in patients with constrictive pericarditis undergoing surgical pericardiectomy: a case series with histopathological correlation
    Andrew O Zurick
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JACC Cardiovasc Imaging 4:1180-91. 2011
    ....
  33. doi request reprint Speckle tracking echocardiography in the assessment of mouse models of cardiac dysfunction
    Yu Peng
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Am J Physiol Heart Circ Physiol 297:H811-20. 2009
    ..45 and r = -0.44, respectively, and P = 0.006 for both). STE correctly identifies LV dysfunction and histological changes in mice and can be used for the serial assessment of cardiac remodeling in murine models...
  34. doi request reprint Prognostic significance of exercise-induced right ventricular dysfunction in asymptomatic degenerative mitral regurgitation
    Kenya Kusunose
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA
    Circ Cardiovasc Imaging 6:167-76. 2013
    ..The aim of this study was to assess the role of RV measures at rest and during exercise as predictors of prognosis in asymptomatic mitral regurgitation...
  35. ncbi request reprint Measurement of ventricular torsion by two-dimensional ultrasound speckle tracking imaging
    Yuichi Notomi
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Coll Cardiol 45:2034-41. 2005
    ....
  36. doi request reprint Relative apical sparing of longitudinal strain using two-dimensional speckle-tracking echocardiography is both sensitive and specific for the diagnosis of cardiac amyloidosis
    Dermot Phelan
    Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Heart 98:1442-8. 2012
    ..The diagnosis of cardiac amyloidosis (CA) is challenging owing to vague symptomatology and non-specific echocardiographic findings...
  37. ncbi request reprint Preload-adjusted right ventricular maximal power: concept and validation
    Soren Schenk
    Dept of Biomedical Engineering ND20, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Physiol Heart Circ Physiol 287:H1632-40. 2004
    ..Thus preload adjustment of PWR(mx) should consider a linear PWR(mx) versus EDV relationship with distinct V(0PWR). PAMP(V0PWR) is a preload-independent estimate of RV contractility that may eventually be determined noninvasively...
  38. doi request reprint Association between regional ventricular function and myocardial fibrosis in hypertrophic cardiomyopathy assessed by speckle tracking echocardiography and delayed hyperenhancement magnetic resonance imaging
    Zoran B Popovic
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Soc Echocardiogr 21:1299-305. 2008
    ..003). Longitudinal, circumferential, and radial strains are decreased in patients with HCM even in the absence of fibrosis. Myocardial fibrosis is associated with depressed longitudinal strain in patients with HCM...
  39. pmc Myocardial scar burden predicts survival benefit with implantable cardioverter defibrillator implantation in patients with severe ischaemic cardiomyopathy: influence of gender
    Deborah H Kwon
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Heart 100:206-13. 2014
    ..In addition, we sought to determine the impact of gender on survival benefit with ICD implantation...
  40. doi request reprint Independent association of left atrial function with exercise capacity in patients with preserved ejection fraction
    Kenya Kusunose
    Heart and Vascular Institute, Cleveland Clinic J1 5, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Heart 98:1311-7. 2012
    ..The purpose of this study was to assess the role of LA function in the left ventricular (LV) filling pressure (E/e') response to exercise and exercise tolerance in patients with preserved LV ejection fraction (LVEF)...
  41. doi request reprint A novel device for left atrial appendage exclusion: the third-generation atrial exclusion device
    Hideyuki Fumoto
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 136:1019-27. 2008
    ..The third-generation atrial exclusion device, modified to provide uniform distribution of pressure at appendage exclusion, was assessed for safety and effectiveness in a canine model and compared with a surgical stapler...
  42. ncbi request reprint Intraventricular pressure gradients in left ventricular aneurysms determined by color M-mode Doppler method: an animal study
    Junko Asada-Kamiguchi
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Soc Echocardiogr 19:1112-8. 2006
    ..The aim of this study was to validate the accuracy of CMM echocardiography for assessing the existence and size of LVA and to determine the intraventricular pressure gradient in LVA...
  43. ncbi request reprint Noninvasive quantification of regional myocardial function using Doppler-derived velocity, displacement, strain rate, and strain in healthy volunteers: effects of aging
    Jing Ping Sun
    Department of Cardiovascular Imaging, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44196, USA
    J Am Soc Echocardiogr 17:132-8. 2004
    ..Like pulsed Doppler mitral inflow velocity, tissue velocity and strain rate show age-related changes...
  44. ncbi request reprint Relationship among diastolic intraventricular pressure gradients, relaxation, and preload: impact of age and fitness
    Zoran B Popovic
    Cardiovascular Imaging Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Physiol Heart Circ Physiol 290:H1454-9. 2006
    ..The ability to regulate IVPGs during changes in preload is impaired with aging. Preserving ventricular compliance during aging by lifelong exercise training does not prevent this impairment...
  45. doi request reprint Reproducibility of echocardiographic techniques for sequential assessment of left ventricular ejection fraction and volumes: application to patients undergoing cancer chemotherapy
    Paaladinesh Thavendiranathan
    Department of Cardiology, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA
    J Am Coll Cardiol 61:77-84. 2013
    ..The aim of this study was to identify the best echocardiographic method for sequential quantification of left ventricular (LV) ejection fraction (EF) and volumes in patients undergoing cancer chemotherapy...
  46. doi request reprint Prognostic utility of 64-slice computed tomography in patients with suspected but no documented coronary artery disease
    Thomas P Carrigan
    Department of Cardiovascular Medicine, Desk F 15, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Eur Heart J 30:362-71. 2009
    ..We sought to assess the incremental prognostic value of 64-slice CT in patients with suspected but no documented CAD...
  47. doi request reprint Acute reduction of functional mitral regurgitation in canine model using an epicardial device
    Masatoshi Akiyama
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland, Ohio, USA
    Ann Thorac Surg 85:1771-5. 2008
    ..This study evaluated the short-term feasibility of a novel epicardial device that treats functional mitral regurgitation by simultaneously changing the mitral and the left ventricular geometry...
  48. doi request reprint Chronic vagus nerve stimulation improves autonomic control and attenuates systemic inflammation and heart failure progression in a canine high-rate pacing model
    Youhua Zhang
    Department of Molecular Cardiology and Cardiovascular Medicine, Cleveland Clinic, USA
    Circ Heart Fail 2:692-9. 2009
    ..We have investigated the impact of enhancing vagal tone (achieved through chronic cervical vagus nerve stimulation, [VNS]) on HF development in a canine high-rate ventricular pacing model...
  49. ncbi request reprint Echocardiographic assessment of regional ventricular function after device-based change of left ventricular shape
    Zoran B Popovic
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, OH 44195, USA
    J Am Soc Echocardiogr 17:411-7. 2004
    ..02 and P =.01, respectively). Structural modeling confirmed that Myosplint implantation increases regional stress heterogeneity and curvature heterogeneity. LV cross-sectional shape markedly affects regional LV performance...
  50. ncbi request reprint Effect of cell-based intercellular delivery of transcription factor GATA4 on ischemic cardiomyopathy
    Jing Bian
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, OH, USA
    Circ Res 100:1626-33. 2007
    ....
  51. doi request reprint Decision making in asymptomatic aortic regurgitation in the era of guidelines: incremental values of resting and exercise cardiac dysfunction
    Kenya Kusunose
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH
    Circ Cardiovasc Imaging 7:352-62. 2014
    ..The aim of this study was to assess the role of echocardiographic measurements at rest and during exercise as predictors of valve surgery in asymptomatic aortic regurgitation...
  52. doi request reprint Relation between echocardiographically estimated and invasively measured filling pressures in constrictive pericarditis
    M Chadi Alraies
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio
    Am J Cardiol 113:1911-6. 2014
    ..The relation between the mitral annular velocity and thickness of the parietal pericardium may affect this phenomenon...
  53. pmc Predictors of mitral annulus early diastolic velocity: impact of long-axis function, ventricular filling pattern, and relaxation
    Zoran B Popovic
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Eur J Echocardiogr 12:818-25. 2011
    ..Although left ventricular (LV) relaxation is well recognized as a predictor of mitral annulus (MA) early diastolic (E') velocity, its significance relative to other predictors of E' is less well understood...
  54. ncbi request reprint Planimetric assessment of anatomic valve area overestimates effective orifice area in bicuspid aortic stenosis
    Erwan Donal
    Department of Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Soc Echocardiogr 18:1392-8. 2005
    ..Not uncommonly, however, anatomic valve area (AVAA) obtained by planimetry overestimates continuity-derived effective valve area (AVAE) in bicuspid AS...
  55. doi request reprint Heart rate variability in a progressive heart failure model with rapid ventricular pacing
    Chiyo Ootaki
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Heart Surg Forum 11:E295-9. 2008
    ..The purpose of this study was to evaluate the progressive changes of autonomic system activity in progressive heart failure by rapid ventricular pacing in an animal model...
  56. ncbi request reprint Mechanical and electrical effects of cell-based gene therapy for ischemic cardiomyopathy are independent
    Indu Deglurkar
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Hum Gene Ther 17:1144-51. 2006
    ..However, despite improved mechanical function, the risk of ventricular tachycardia increased. We propose that future studies on functional effects of cell-based gene therapies should address both mechanical and electrical consequences...
  57. doi request reprint Coupled pacing reverses the effects of persistent atrial fibrillation on the left ventricle
    George E Yanulis
    Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 86:984-7. 2008
    ..The purpose of this study was to determine whether or not the benefits of coupled pacing (ie, a proposed rate control therapy) could be used during persistent AF...
  58. ncbi request reprint Stem cell therapy enhances electrical viability in myocardial infarction
    William R Mills
    The Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, Cleveland, OH 44109, USA
    J Mol Cell Cardiol 42:304-14. 2007
    ..In addition, only MSC therapy was associated with enhanced electrical viability, diffuse engraftment, and connexin expression, which may explain the differences in arrhythmia inducibility...
  59. ncbi request reprint Changes in mitral annular and left ventricular dimensions and left ventricular pressure-volume relations after off-pump treatment of mitral regurgitation with the Coapsys device
    Kiyotaka Fukamachi
    Department of Biomedical Engineering ND 20, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Eur J Cardiothorac Surg 25:352-7. 2004
    ....
  60. doi request reprint Long-term reverse remodeling with cardiac resynchronization therapy: results of extended echocardiographic follow-up
    David Verhaert
    Department of Cardiovascular Medicine, Section of Cardiac Imaging, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Coll Cardiol 55:1788-95. 2010
    ..The purpose of this study was to describe the long-term course of left ventricular remodeling induced by cardiac resynchronization therapy (CRT), adjusting for the confounding effect of patient loss due to disease...
  61. ncbi request reprint A novel technique for functional mitral regurgitation therapy: mitral annular remodeling
    Keiji Kamohara
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland, Ohio, USA
    Heart Surg Forum 9:E888-92. 2006
    ..The purpose of this study is to describe a novel procedure for treatment of functional AIR and report its effects on the geometry of the mitral annulus and degree of AIR...
  62. ncbi request reprint Coupled pacing improves cardiac efficiency during acute atrial fibrillation with or without cardiac dysfunction
    Hirotsugu Yamada
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Physiol Heart Circ Physiol 287:H2016-22. 2004
    ..Thus this pacing therapy may be a viable therapy for patients with concurrent atrial fibrillation and heart failure...
  63. doi request reprint Aortic stiffness independently predicts exercise capacity in hypertrophic cardiomyopathy: a multimodality imaging study
    Bethany A Austin
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Heart 96:1303-10. 2010
    ..Pulse wave velocity (PWV), determined by cardiac magnetic resonance (CMR), measures aortic stiffness and is abnormal in patients with HCM in comparison with controls...
  64. ncbi request reprint SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction
    Ming Zhang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    FASEB J 21:3197-207. 2007
    ..These results indicate that stem cell transplantation may have significant beneficial effects on injured organ function independent of tissue regeneration and identify SDF-1:CXCR4 binding as a novel target for myocardial preservation...
  65. doi request reprint Prospective ECG-triggered, axial 4-D imaging of the aortic root, valvular, and left ventricular structures: a lower radiation dose option for preprocedural TAVR imaging
    Michael A Bolen
    Imaging Institute, Cleveland Clinic, 9500 Euclid Ave, Desk J1 5, Cleveland, OH 44195, USA
    J Cardiovasc Comput Tomogr 6:393-8. 2012
    ..Transcatheter valve interventions rely on imaging for patient selection, preprocedural planning, and intraprocedural guidance...
  66. doi request reprint Long-term survival of patients with radiation heart disease undergoing cardiac surgery: a cohort study
    Willis Wu
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Circulation 127:1476-85. 2013
    ..We sought to measure long-term survival in RAHD patients undergoing CTS, to compare them with a matched control population undergoing similar surgical procedures, and to identify potential predictors of long-term survival...
  67. ncbi request reprint Non-invasive evaluation of orthotopic heart transplant rejection by echocardiography
    Jing Ping Sun
    Cardiovascular Imaging Center and Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Heart Lung Transplant 24:160-5. 2005
    ..The purpose of this study was to identify demographic and echocardiographic factors associated with transplant rejection and develop a predictive model, which may reduce the number of cardiac biopsies...
  68. ncbi request reprint Association of total cholesterol/ high-density lipoprotein cholesterol ratio with proximal coronary atherosclerosis detected by multislice computed tomography
    Deepu Nair
    Cardiovascular Imaging Laboratory, Heart and Vascular Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Prev Cardiol 12:19-26. 2009
    ..04) and significant CAD (19% vs 9%, P = .009). On multivariate logistic regression analysis, only age, sex, and TC/HDL-C ratio > or = 4 were associated with significant CAD and proximal plaque...
  69. pmc Right ventricular response to intensive medical therapy in advanced decompensated heart failure
    David Verhaert
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Circ Heart Fail 3:340-6. 2010
    ..Our objective was to compare the clinical significance of changes in RV echocardiographic indices in response to intensive medical treatment in patients admitted to the hospital with acute decompensated heart failure (ADHF)...
  70. pmc Blockade of NF-kappaB using IkappaB alpha dominant-negative mice ameliorates cardiac hypertrophy in myotrophin-overexpressed transgenic mice
    David Young
    Department of Molecular Cardiology, NB 50, Cleveland Clinic, Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Mol Biol 381:559-68. 2008
    ..Therefore, development of therapeutic strategies targeting NF-kappaB may provide an effective approach to prevent adverse cardiac pathophysiological consequences...
  71. doi request reprint High-pitch ECG-synchronized pulmonary CT angiography versus standard CT pulmonary angiography: a prospective randomized study
    Michael A Bolen
    1 Imaging Institute, Cleveland Clinic, Cardiovascular Imaging Laboratory, Desk J1 5, 9500 Euclid Ave, Cleveland, OH 44195
    AJR Am J Roentgenol 201:971-6. 2013
    ..The purpose of this study was to compare high-pitch ECG-synchronized pulmonary CT angiography (CTA) with standard pulmonary CTA with regard to radiation dose and image quality in patients with suspected pulmonary embolism...
  72. doi request reprint Therapeutic effects of selective atrioventricular node vagal stimulation in atrial fibrillation and heart failure
    Youhua Zhang
    Department of Molecular Cardiology, The Cleveland Clinic, Cleveland, Ohio, USA
    J Cardiovasc Electrophysiol 24:86-91. 2013
    ..Accordingly, this study was designed to evaluate the therapeutic effects of AVN-VS to control ventricular rate in AF and HF...
  73. doi request reprint Improved interobserver variability and accuracy of echocardiographic visual left ventricular ejection fraction assessment through a self-directed learning program using cardiac magnetic resonance images
    Paaladinesh Thavendiranathan
    Department of Cardiology, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio
    J Am Soc Echocardiogr 26:1267-73. 2013
    ..The aim of this study was to determine whether self-directed education could improve the accuracy and interobserver variability of visual estimation of EF and whether a multireader estimate improves measurement precision...
  74. doi request reprint Percutaneous adventitial delivery of allogeneic bone marrow-derived stem cells via infarct-related artery improves long-term ventricular function in acute myocardial infarction
    Satish Medicetty
    Regenerative Medicine Department, Athersys, Inc, Cleveland, OH 44309, USA
    Cell Transplant 21:1109-20. 2012
    ....
  75. doi request reprint Normal ranges of left ventricular strain: a meta-analysis
    Teerapat Yingchoncharoen
    Cleveland Clinic, Cleveland, Ohio, USA
    J Am Soc Echocardiogr 26:185-91. 2013
    ..The investigators performed a meta-analysis of normal ranges and sought to identify factors that contribute to reported variations...
  76. doi request reprint Image quality, contrast enhancement, and radiation dose of ECG-triggered high-pitch CT versus non-ECG-triggered standard-pitch CT of the thoracoabdominal aorta
    Michael A Bolen
    Imaging Institute, Cardiovascular Section, Cleveland Clinic, OH 44195, USA
    AJR Am J Roentgenol 198:931-8. 2012
    ..We sought to compare image quality, contrast enhancement, and radiation dose in patients undergoing ECG-triggered high-pitch helical CT or non-ECG-synchronized helical CT of the thoracoabdominal aorta...
  77. pmc Thrombospondin-4 regulates fibrosis and remodeling of the myocardium in response to pressure overload
    Ella G Frolova
    Department of Molecular Cardiology, Case Western Reserve University School of Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    FASEB J 26:2363-73. 2012
    ..Our study showed a direct influence of TSP-4 on heart function and to identify the mechanism of its effects on heart remodeling...
  78. pmc Longitudinal study of cardiac remodelling in rabbits following infarction
    Yves T Wang
    Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Can J Cardiol 28:230-8. 2012
    ..Cardiac remodelling following myocardial infarction (MI) is a complex, dynamic process. There have been few longitudinal studies of these changes...
  79. doi request reprint Effect of recommendations on interobserver consistency of diastolic function evaluation
    Samuel Unzek
    Department of Cardiovascular Medicine, Cleveland Clinic Heart and Vascular Institute, Cleveland, Ohio, USA
    JACC Cardiovasc Imaging 4:460-7. 2011
    ..We sought the impact of recent recommendations on observer concordance on interpretation of diastolic stage and assessment of filling pressure...