Edward J Mascha

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. doi request reprint Joint hypothesis testing and gatekeeping procedures for studies with multiple endpoints
    Edward J Mascha
    Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH 44195, USA
    Anesth Analg 114:1304-17. 2012
  2. pmc Design and Organization of the Dexamethasone, Light Anesthesia and Tight Glucose Control (DeLiT) Trial: a factorial trial evaluating the effects of corticosteroids, glucose control, and depth-of-anesthesia on perioperative inflammation and morbidity from
    Basem Abdelmalak
    Department of Outcomes Research, Cleveland Clinic, Cleveland, Ohio, USA
    BMC Anesthesiol 10:11. 2010
  3. doi request reprint Factors affecting power of tests for multiple binary outcomes
    Edward J Mascha
    Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA
    Stat Med 29:2890-904. 2010
  4. ncbi request reprint Estimating treatment effect heterogeneity for binary outcomes via Dirichlet multinomial constraints
    Edward J Masch
    Department of Quantitative Health Sciences, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Biom J 49:378-93. 2007
  5. doi request reprint Statistical grand rounds: design and analysis of studies with binary- event composite endpoints: guidelines for anesthesia research
    Edward J Mascha
    Departments of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH 44195, USA
    Anesth Analg 112:1461-71. 2011
  6. doi request reprint The association between nitrous oxide and postoperative mortality and morbidity after noncardiac surgery
    Alparslan Turan
    Department of Outcomes Research, Cleveland Clinic, Cleveland, OH 44195, USA
    Anesth Analg 116:1026-33. 2013
  7. doi request reprint Pre-existing do-not-resuscitate orders are not associated with increased postoperative morbidity at 30 days in surgical patients
    Leif Saager
    Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA
    Crit Care Med 39:1036-41. 2011
  8. doi request reprint Anesthetic induction with etomidate, rather than propofol, is associated with increased 30-day mortality and cardiovascular morbidity after noncardiac surgery
    Ryu Komatsu
    From the Anesthesiology Institute, Department of Quantitative Health Sciences, and Department of Outcomes Research, Cleveland Clinic, Cleveland, Ohio and Department of Anesthesiology, Tokyo Women s Medical University, Shinjuku, Tokyo, Japan
    Anesth Analg 117:1329-37. 2013
  9. doi request reprint Development and validation of a risk quantification index for 30-day postoperative mortality and morbidity in noncardiac surgical patients
    Jarrod E Dalton
    Department of Quantitative Health Sciences and Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Anesthesiology 114:1336-44. 2011
  10. doi request reprint The association between preoperative anemia and 30-day mortality and morbidity in noncardiac surgical patients
    Leif Saager
    Dr med, Department of Outcomes Research, Cleveland Clinic, 9500 Euclid Ave, P77, Cleveland, OH 44195
    Anesth Analg 117:909-15. 2013

Collaborators

Detail Information

Publications57

  1. doi request reprint Joint hypothesis testing and gatekeeping procedures for studies with multiple endpoints
    Edward J Mascha
    Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH 44195, USA
    Anesth Analg 114:1304-17. 2012
    ..Joint hypothesis testing and gatekeeping procedures are shown to substantially improve the efficiency and interpretation of randomized and nonrandomized studies having multiple outcomes of interest...
  2. pmc Design and Organization of the Dexamethasone, Light Anesthesia and Tight Glucose Control (DeLiT) Trial: a factorial trial evaluating the effects of corticosteroids, glucose control, and depth-of-anesthesia on perioperative inflammation and morbidity from
    Basem Abdelmalak
    Department of Outcomes Research, Cleveland Clinic, Cleveland, Ohio, USA
    BMC Anesthesiol 10:11. 2010
    ..We are studying three interventions that potentially modulate perioperative inflammation: corticosteroids, tight glucose control, and light anesthesia...
  3. doi request reprint Factors affecting power of tests for multiple binary outcomes
    Edward J Mascha
    Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA
    Stat Med 29:2890-904. 2010
    ..Two clinical trials are discussed and analyzed, and recommendations for practice are made...
  4. ncbi request reprint Estimating treatment effect heterogeneity for binary outcomes via Dirichlet multinomial constraints
    Edward J Masch
    Department of Quantitative Health Sciences, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Biom J 49:378-93. 2007
    ..Methods are applied to both a randomized as well as a non-randomized study. Implications for medical decision-making at the policy and individual levels are discussed...
  5. doi request reprint Statistical grand rounds: design and analysis of studies with binary- event composite endpoints: guidelines for anesthesia research
    Edward J Mascha
    Departments of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH 44195, USA
    Anesth Analg 112:1461-71. 2011
    ..Sample data files and SAS code are included for convenience...
  6. doi request reprint The association between nitrous oxide and postoperative mortality and morbidity after noncardiac surgery
    Alparslan Turan
    Department of Outcomes Research, Cleveland Clinic, Cleveland, OH 44195, USA
    Anesth Analg 116:1026-33. 2013
    ....
  7. doi request reprint Pre-existing do-not-resuscitate orders are not associated with increased postoperative morbidity at 30 days in surgical patients
    Leif Saager
    Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA
    Crit Care Med 39:1036-41. 2011
    ..To assess the relationship between pre-existing do-not-resuscitate orders and the incidence of postoperative 30-day minor morbidity in surgical patients...
  8. doi request reprint Anesthetic induction with etomidate, rather than propofol, is associated with increased 30-day mortality and cardiovascular morbidity after noncardiac surgery
    Ryu Komatsu
    From the Anesthesiology Institute, Department of Quantitative Health Sciences, and Department of Outcomes Research, Cleveland Clinic, Cleveland, Ohio and Department of Anesthesiology, Tokyo Women s Medical University, Shinjuku, Tokyo, Japan
    Anesth Analg 117:1329-37. 2013
    ....
  9. doi request reprint Development and validation of a risk quantification index for 30-day postoperative mortality and morbidity in noncardiac surgical patients
    Jarrod E Dalton
    Department of Quantitative Health Sciences and Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Anesthesiology 114:1336-44. 2011
    ..outpatient, for morbidity)...
  10. doi request reprint The association between preoperative anemia and 30-day mortality and morbidity in noncardiac surgical patients
    Leif Saager
    Dr med, Department of Outcomes Research, Cleveland Clinic, 9500 Euclid Ave, P77, Cleveland, OH 44195
    Anesth Analg 117:909-15. 2013
    ....
  11. doi request reprint Effects of volatile anesthetic choice on hospital length-of-stay: a retrospective study and a prospective trial
    Tatyana Kopyeva
    Department of General Anesthesia, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Anesthesiology 119:61-70. 2013
    ..The authors tested the hypothesis that the duration of hospitalization is prolonged with isoflurane anesthesia...
  12. doi request reprint Incidence of intraoperative hypersensitivity reactions: a registry analysis: a registry analysis
    Leif Saager
    From the Department of Outcomes Research, Anesthesiology Institute L S, A T, C E, E J M, A K, M B, D I S, B D H and Department of Quantitative Health Sciences E J M, Cleveland Clinic, Cleveland, Ohio and Department of Epidemiology, MSD Pharmaceutical, Oss, The Netherlands H B
    Anesthesiology 122:551-9. 2015
    ..Previously reported incidences for intraoperative hypersensitivity reactions vary more than 15-fold. The goal was to determine the incidence of intraoperative hypersensitivity events at a U.S. surgical center...
  13. pmc Low vitamin D concentration is not associated with increased mortality and morbidity after cardiac surgery
    Alparslan Turan
    Department of Outcomes Research, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 8:e63831. 2013
    ..To determine the effect of vitamin D on postoperative outcomes in cardiac surgical patients...
  14. doi request reprint The Effect of Hypothyroidism on a Composite of Mortality, Cardiovascular and Wound Complications After Noncardiac Surgery: A Retrospective Cohort Analysis
    Ryu Komatsu
    From the Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio Departments of Quantitative Health Sciences and Outcomes Research, Cleveland Clinic, Cleveland, Ohio
    Anesth Analg 121:716-26. 2015
    ....
  15. doi request reprint Intraoperative transitions of anesthesia care and postoperative adverse outcomes
    Leif Saager
    From the Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio L S, B D H, J Y, A T, E J M, D I S, A K and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio J Y, E J M
    Anesthesiology 121:695-706. 2014
    ..Whether handovers worsen patient outcome remains unclear. The authors tested the hypothesis that intraoperative care transitions among anesthesia providers are associated with postoperative complications...
  16. doi request reprint Smoking and perioperative outcomes
    Alparslan Turan
    Department of Outcomes Research, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Anesthesiology 114:837-46. 2011
    ..However, effective advice may be limited by the paucity of information about smoking and perioperative risk. Thus, our goal was to determine the effect of smoking on 30-day postoperative outcomes in noncardiac surgical patients...
  17. doi request reprint Validation of the DeLiT Trial intravenous insulin infusion algorithm for intraoperative glucose control in noncardiac surgery: a randomized controlled trial
    Basem Abdelmalak
    Department of General Anesthesiology E31, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Can J Anaesth 58:606-16. 2011
    ..We therefore report the validation of the DeLit Trial insulin infusion algorithm...
  18. doi request reprint A randomized trial of prewarming on patient satisfaction and thermal comfort in outpatient surgery
    Zohaib Akhtar
    Clinical Research Fellow, Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH
    J Clin Anesth 33:376-85. 2016
    ..To test the primary hypothesis that forced-air prewarming improves patient satisfaction after outpatient surgery and to evaluate the effect on core temperature and thermal comfort...
  19. doi request reprint Impact of present-on-admission indicators on risk-adjusted hospital mortality measurement
    Jarrod E Dalton
    Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Anesthesiology 118:1298-306. 2013
    ....
  20. ncbi request reprint A personal experience with factors influencing survival after elective open repair of infrarenal aortic aneurysms
    Norman R Hertzer
    Department of Vascular Surgery, The Cleveland Clinic Foundation, OH 44195, USA
    J Vasc Surg 42:898-905. 2005
    ..To investigate risk factors that influence survival after open abdominal aortic aneurysm (AAA) repair in all elective patients treated by a single surgeon at a tertiary referral center...
  21. ncbi request reprint Intracapsular tonsillar reduction (partial tonsillectomy): reviving a historical procedure for obstructive sleep disordered breathing in children
    Peter J Koltai
    Section of Pediatric Otolaryngology, The Children s Hospital at The Cleveland Clinic Foundation, 9500 Euclid Avenue, A71, Cleveland, OH 44195, USA
    Otolaryngol Head Neck Surg 129:532-8. 2003
    ....
  22. ncbi request reprint Concordance of respiratory care plans generated by protocols from different hospitals: a comparative study
    James K Stoller
    Department of Pulmonary, Allergy, and Critical Care Medicine, A90, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195, USA
    Respir Care 52:1006-12. 2007
    ..Do protocols from different hospitals agree with regard to indications for respiratory care treatments and use of the Clinical Practice Guidelines from the American Association for Respiratory Care?..
  23. ncbi request reprint A personal experience with coronary artery bypass grafting, carotid patching, and other factors influencing the outcome of carotid endarterectomy
    Norman R Hertzer
    Department of Vascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Vasc Surg 43:959-968. 2006
    ....
  24. ncbi request reprint Intracapsular partial tonsillectomy for tonsillar hypertrophy in children
    Peter J Koltai
    Section of Pediatric Otolaryngology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Laryngoscope 112:17-9. 2002
    ..To review our experience with intracapsular tonsillectomy using powered instrumentation in the management of tonsillar hypertrophy causing obstructive sleep-disordered breathing in children...
  25. ncbi request reprint Association between hyperhomocysteinemia and primary pulmonary hypertension
    Alejandro C Arroliga
    Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue G62, Cleveland, OH 44195, USA
    Respir Med 97:825-9. 2003
    ..This case-control study was conducted to test the hypothesis that fasting homocysteine levels are higher in PPH patients than in healthy controls...
  26. ncbi request reprint A prospective, randomized study of saphenous vein patching versus synthetic patching during carotid endarterectomy
    Patrick J O'Hara
    Department of Vascular Surgery, The Cleveland Clinic Foundation, Ohio 44195, USA
    J Vasc Surg 35:324-32. 2002
    ..The objective of this study was the determination of whether the choice of either autogenous saphenous vein (ASV) or synthetic material for patch angioplasty significantly influences the results after carotid endarterectomy (CEA)...
  27. ncbi request reprint Open infrarenal abdominal aortic aneurysm repair: the Cleveland Clinic experience from 1989 to 1998
    Norman R Hertzer
    Department of Vascular Surgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Vasc Surg 35:1145-54. 2002
    ....
  28. ncbi request reprint Nature, frequency, and predictors of secondary procedures after endovascular repair of abdominal aortic aneurysm
    Ellis S K Sampram
    Department of Vascular Surgery, The Cleveland Clinic Foundation, OH 44195, USA
    J Vasc Surg 37:930-7. 2003
    ....
  29. doi request reprint Perioperative Supplemental Oxygen Does Not Worsen Long-Term Mortality of Colorectal Surgery Patients
    Attila Podolyak
    From the Departments of General Anesthesiology, Outcomes Research, and Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio Department of Anaesthesiology and General Intensive Care Medicine, Medical University of Vienna, Vienna, Austria Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, Kentucky and Department of Anesthesiology and Pain Therapy, University of Bern, Bern, Switzerland
    Anesth Analg 122:1907-11. 2016
    ..Secondarily, we evaluated whether the effect of supplemental oxygen on mortality depended on cancer status...
  30. ncbi request reprint Relationship between Intraoperative Hypotension, Defined by Either Reduction from Baseline or Absolute Thresholds, and Acute Kidney and Myocardial Injury after Noncardiac Surgery: A Retrospective Cohort Analysis
    Vafi Salmasi
    From the Departments of Outcomes Research and General Anesthesiology V S, K M, D I S, A K, Departments of Quantitative Health Sciences and Outcomes Research D Y, E J M, and Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio A S
    Anesthesiology . 2016
    ..Thus, the authors assessed the relationship between myocardial and kidney injury and intraoperative absolute (intraoperative mean arterial pressure [MAP]) and relative (reduction from preoperative pressure) MAP thresholds...
  31. doi request reprint Estimated glomerular filtration rate better predicts 30-day mortality after non-cardiac surgery than serum creatinine: a retrospective analysis of 92,888 patients
    Jacek B Cywinski
    Department of General Anesthesiology, Cleveland Clinic, 9500 Euclid Avenue G31, Cleveland, OH, USA
    Can J Anaesth 62:745-52. 2015
    ..It remains unknown if eGFR better predicts postoperative mortality in non-cardiac surgical patients. We thus tested the hypothesis that eGFR predicts 30-day mortality after non-cardiac surgery better than serum creatinine...
  32. doi request reprint A Randomized Trial of a Supplemental Alarm for Critically Low Systolic Blood Pressure
    Krit Panjasawatwong
    From the Departments of Outcomes Research, General Anesthesiology, Regional Anesthesia Practice, Anesthesiology Institute, and Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio
    Anesth Analg 121:1500-7. 2015
    ..We therefore tested the primary hypothesis that a supplemental decision support alert for critically low systolic blood pressure (SBP) decreases the duration of intraoperative hypotension...
  33. doi request reprint Intraoperative Mean Arterial Pressure Variability and 30-day Mortality in Patients Having Noncardiac Surgery
    Edward J Mascha
    From the Departments of Quantitative Health Sciences and Outcomes Research E J M, D Y and Department of Outcomes Research S W, D I S, Cleveland Clinic, Cleveland, Ohio Current affiliation Department of Emergency Medicine, University of Florida College of Medicine, Jacksonville, Florida S W
    Anesthesiology 123:79-91. 2015
    ..Therefore, the authors tested the hypothesis that blood pressure variability, independent from absolute blood pressure, is associated with increased 30-day mortality...
  34. pmc Comparison of three techniques for ultrasound-guided femoral nerve catheter insertion: a randomized, blinded trial
    Ehab Farag
    From the Departments of General Anesthesiology and Outcomes Research E F, Department of Outcomes Research A A, R G, M B, T S, M K, A K, B L U, D I S, Departments of Quantitative Health Sciences and Outcomes Research J E D, E J M, Department of General Anesthesiology L M S, S Z, W A S E, Department of Orthopaedic Surgery W B, Cleveland Clinic, Cleveland, Ohio Current affiliations Department of Anesthesiology, Gulhane Military Medical Academy, Ankara, Turkey A A Internal Medicine, St Vincent Charity Medical Center, Cleveland, Ohio R G Department of Anesthesiology, New York Presbyterian Hospital, Weill Cornell Medical Center, New York, New York M B Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio T S, M K
    Anesthesiology 121:239-48. 2014
    ..Second, the authors compared all interventions on insertion time and incremental cost...
  35. doi request reprint Comparison of the Truview PCD™ and the GlideScope(®) video laryngoscopes with direct laryngoscopy in pediatric patients: a randomized trial
    Ricardo Riveros
    Department of Pediatric Anesthesia, Cleveland Clinic Children s Hospital, P21, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Can J Anaesth 60:450-7. 2013
    ..We therefore tested our joint primary hypothesis that the GlideScope and the Truview PCD video laryngoscopes provide superior visualization to direct laryngoscopy and are non-inferior regarding time to intubation...
  36. doi request reprint Statistical grand rounds: understanding the mechanism: mediation analysis in randomized and nonrandomized studies
    Edward J Mascha
    Department of Quantitative Health Sciences, Cleveland Clinic, JJN 3 9500 Euclid Ave, Cleveland, OH 44195
    Anesth Analg 117:980-94. 2013
    ..Methods are illustrated with data collected by the National Surgical Quality Improvement Project (NSQIP) and utilized in a companion paper which assessed the effects of preoperative anemic status on postoperative outcomes. ..
  37. doi request reprint Effects of crystalloid versus colloid and the α-2 agonist brimonidine versus placebo on intraocular pressure during prone spine surgery: a factorial randomized trial
    Ehab Farag
    Department of General Anesthesiology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Anesthesiology 116:807-15. 2012
    ....
  38. doi request reprint Standard clinical risk factors for difficult laryngoscopy are not independent predictors of intubation success with the GlideScope
    José L Díaz-Gómez
    Department of Cardiothoracic Anesthesiology, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Clin Anesth 23:603-10. 2011
    ....
  39. doi request reprint Pre-transplant MELD and sodium MELD scores are poor predictors of graft failure and mortality after liver transplantation
    Jacek B Cywinski
    Departments of General Anesthesiology and Outcomes Research, Transplantation Center, Cleveland Clinic, Cleveland, OH, USA
    Hepatol Int 5:841-9. 2011
    ..We, therefore, evaluated and compared the ability of the sodium MELD and MELD scores to predict graft and patient survival after OLT...
  40. doi request reprint Equivalence and noninferiority testing in regression models and repeated-measures designs
    Edward J Mascha
    Department of Quantitative Health Sciences, Cleveland Clinic, 9500 Euclid Avenue, JJN3 Cleveland, OH 44195, USA
    Anesth Analg 112:678-87. 2011
    ..We especially address interactions between the repeated factor, usually time, and treatment. Although we focus on the analysis of continuous outcomes, extensions to other data types as well as sample size consideration are discussed...
  41. doi request reprint Association of red blood cell transfusion and postoperative outcomes after endovascular aortic repair
    Maged Y Argalious
    Department of General Anesthesiology, Cleveland Clinic, Cleveland, OH 44195, USA
    Semin Cardiothorac Vasc Anesth 15:49-55. 2011
    ..The aim of this study was to evaluate the association of RBC transfusion on the day of surgery and postoperative outcomes following endovascular aortic repair (EVAR)...
  42. doi request reprint Optimal Depth for Nasopharyngeal Temperature Probe Positioning
    Mi Wang
    From the Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio and Departments of Quantitative Health Sciences and Outcomes Research, Cleveland Clinic, Cleveland, Ohio
    Anesth Analg 122:1434-8. 2016
    ..We thus determined the range of nasopharyngeal probe insertion depths that best approximate reference core temperature measured in the distal esophagus...
  43. doi request reprint Continuous Adductor Canal Blocks: Does Varying Local Anesthetic Delivery Method (Automatic Repeated Bolus Doses Versus Continuous Basal Infusion) Influence Cutaneous Analgesia and Quadriceps Femoris Strength? A Randomized, Double-Masked, Controlled, Split
    Amanda M Monahan
    From the Department of Anesthesiology, University of California San Diego, San Diego, California Department of Anesthesiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark Outcomes Research Consortium, Cleveland, Ohio Department of Outcomes Research, Anesthesiology Institute, The Cleveland Clinic, Cleveland, Ohio Departments of Quantitative Health Sciences and Outcomes Research, The Cleveland Clinic, Cleveland, Ohio Department of Ophthalmology, University of California San Diego, San Diego, California and School of Medicine, University of California San Diego, San Diego, California
    Anesth Analg 122:1681-8. 2016
    ..Therefore, we tested the hypothesis that scheduled bolus administration is superior or noninferior to a continuous infusion on cutaneous knee sensation in volunteers...
  44. doi request reprint Lidocaine 5% Patch for Treatment of Acute Pain After Robotic Cardiac Surgery and Prevention of Persistent Incisional Pain: A Randomized, Placebo-Controlled, Double-Blind Trial
    Bruce Vrooman
    Department of Pain Management, Cleveland Clinic, Cleveland, Ohio, USA
    Pain Med 16:1610-21. 2015
    ..To test the hypotheses that lidocaine 5% patches decrease the severity of acute pain and incidence of persistent incisional pain after robotic cardiac valve surgery...
  45. doi request reprint Lack of association between carotid artery stenosis and stroke or myocardial injury after noncardiac surgery in high-risk patients
    Abraham Sonny
    From the Department of Cardiothoracic Anesthesiology, Anesthesiology Institute A S, Department of Vascular Medicine, Heart and Vascular Institute H L G, Department of Quantitative Health Sciences D Y, E J M, and Department of Outcomes Research D Y, E J M, D I S, Cleveland Clinic, Cleveland, Ohio
    Anesthesiology 121:922-9. 2014
    ..As carotid artery stenosis is also a marker for cardiovascular disease, our secondary hypothesis was that degree of carotid artery stenosis is associated with postoperative myocardial injury...
  46. doi request reprint Thoracic paravertebral regional anesthesia improves analgesia after breast cancer surgery: a randomized controlled multicentre clinical trial
    Jiang Wu
    Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA
    Can J Anaesth 62:241-51. 2015
    ..We compared the effect of a combination of paravertebral blockade and propofol general anesthesia (GA) with sevoflurane GA and opioid analgesia on postoperative pain and opioid use for patients undergoing breast cancer surgery...
  47. doi request reprint Protocol understanding and anxiety in perioperative clinical trial patients approached for consent on the day of surgery
    Alexandra Chludzinski
    Cleveland Clinic Learner College of Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Mayo Clin Proc 88:446-54. 2013
    ..To determine whether approaching patients for consent on the day of surgery impairs understanding or produces unacceptable anxiety compared with obtaining consent before the day of surgery...
  48. pmc Mitigating preventable chronic disease: Progress report of the Cleveland Clinic's Lifestyle 180 program
    Elizabeth Hw Ricanati
    Wellness Institute, Cleveland Clinic, 1950 Richmond Road, TR2 341, Lyndhurst, OH 44124, USA
    Nutr Metab (Lond) 8:83. 2011
    ..Poor lifestyle choices are key in development and progression of preventable chronic diseases. The purpose of the study was to design and test a program to mitigate the physical and fiscal consequences of chronic diseases...
  49. doi request reprint Can regional analgesia reduce the risk of recurrence after breast cancer? Methodology of a multicenter randomized trial
    Daniel I Sessler
    Department of Outcomes Research, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Contemp Clin Trials 29:517-26. 2008
    ..Confirming our hypothesis will indicate that a small modification to anesthetic management, one that can be implemented with little risk or cost, will reduce the risk of cancer recurrence - a complication that is often ultimately lethal...
  50. doi request reprint Intravenous acetaminophen analgesia after cardiac surgery: A randomized, blinded, controlled superiority trial
    Negmeldeen F Mamoun
    Department of Cardiothoracic Anesthesia, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio Electronic address
    J Thorac Cardiovasc Surg 152:881-889.e1. 2016
    ....
  51. doi request reprint Comparison of 2 resident learning tools-interactive screen-based simulated case scenarios versus problem-based learning discussions: a prospective quasi-crossover cohort study
    Shobana Rajan
    Staff Anesthesiologist, Department of General Anesthesiology, Cleveland Clinic, 9500 Euclid Ave E30, Cleveland, OH 44195 Electronic address
    J Clin Anesth 28:4-11. 2016
    ....
  52. doi request reprint Fenoldopam and renal function after partial nephrectomy in a solitary kidney: a randomized, blinded trial
    Jerome F O'Hara
    Department of General Anesthesiology, Cleveland Clinic, Cleveland, OH 44195, USA
    Urology 81:340-5. 2013
    ..To test the hypothesis that fenoldopam administration ameliorates ischemic injury, preserving the glomerular filtration rate and serum creatinine postoperatively after partial nephrectomy in patients with a solitary kidney...
  53. pmc Assessment of an anesthesiology academic department mentorship program
    Ehab Farag
    Departments of General Anesthesiology and Outcomes Research, Cleveland Clinic, Cleveland, OH
    Ochsner J 12:373-8. 2012
    ..The purpose of this study was to survey physicians in an academic anesthesiology department before and after the initiation of a formal mentorship program to evaluate the impact of the program over a 1-year period...
  54. doi request reprint Effect of follicular fluid oxidative stress parameters on intracytoplasmic sperm injection outcome
    Mohamed A Bedaiwy
    Department of Obstetrics and Gynecology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA
    Gynecol Endocrinol 28:51-5. 2012
    ....
  55. doi request reprint The association between alcohol consumption and morbidity and mortality in patients undergoing coronary artery bypass surgery
    Ankit Maheshwari
    Department of Outcomes Research, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Cardiothorac Vasc Anesth 24:580-5. 2010
    ..Therefore, the authors tested the hypothesis that alcohol consumption of 3 or more drinks per week improves postoperative outcomes in patients undergoing coronary artery bypass graft (CABG) surgery...
  56. ncbi request reprint Assessing treatment effect heterogeneity in clinical trials with blocked binary outcomes
    Jeffrey M Albert
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Biom J 47:662-73. 2005
    ..Some remaining challenges (including the possibility of further reducing bound widths) are discussed...
  57. ncbi request reprint The effect of craniotomy location on postoperative pain and nausea
    Samuel A Irefin
    Department of General Anesthesiology, The Cleveland Clinic Foundation, 9500 Euclid Avenue E31, Cleveland, OH 44195, USA
    J Anesth 17:227-31. 2003
    ..This prospective study was performed to examine the hypothesis that patients who have had infratentorial craniotomy experience more severe pain and more frequent nausea than those with supratentorial procedures...