Justin D Lathia

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. pmc Deadly teamwork: neural cancer stem cells and the tumor microenvironment
    Justin D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44118, USA
    Cell Stem Cell 8:482-5. 2011
  2. pmc High-throughput flow cytometry screening reveals a role for junctional adhesion molecule a as a cancer stem cell maintenance factor
    Justin D Lathia
    Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA Case Comprehensive Cancer Center, Cleveland, OH 44106, USA Electronic address
    Cell Rep 6:117-29. 2014
  3. pmc Laminin alpha 2 enables glioblastoma stem cell growth
    Justin D Lathia
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    Ann Neurol 72:766-78. 2012
  4. doi request reprint Holding on to stemness
    Justin D Lathia
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nat Cell Biol 14:450-2. 2012
  5. pmc Seeing is believing: are cancer stem cells the Loch Ness monster of tumor biology?
    Justin D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Stem Cell Rev 7:227-37. 2011
  6. pmc Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions
    J D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell Death Dis 2:e200. 2011
  7. pmc Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells
    Justin D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 6:e24807. 2011
  8. pmc Integrin alpha 6 regulates glioblastoma stem cells
    Justin D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell Stem Cell 6:421-32. 2010
  9. pmc Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation
    Yi Fan
    1 Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue Cleveland, Ohio 44195, USA 2 Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard Philadelphia, Pennsylvania 19104, USA
    Nat Cell Biol 16:445-56. 2014
  10. pmc Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity
    Youngmi Kim
    Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Genes Dev 26:1247-62. 2012

Collaborators

Detail Information

Publications35

  1. pmc Deadly teamwork: neural cancer stem cells and the tumor microenvironment
    Justin D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44118, USA
    Cell Stem Cell 8:482-5. 2011
    ..The CSC-microenvironment relationship is complex, as CSCs can modify their environment and extrinsic forces induce plasticity in the cellular hierarchy...
  2. pmc High-throughput flow cytometry screening reveals a role for junctional adhesion molecule a as a cancer stem cell maintenance factor
    Justin D Lathia
    Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA Case Comprehensive Cancer Center, Cleveland, OH 44106, USA Electronic address
    Cell Rep 6:117-29. 2014
    ..Our results demonstrate that GBM-targeting strategies can be identified through screening adhesion receptors and JAM-A represents a mechanism for niche-driven CSC maintenance. ..
  3. pmc Laminin alpha 2 enables glioblastoma stem cell growth
    Justin D Lathia
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    Ann Neurol 72:766-78. 2012
    ..Extracellular matrix (ECM) cues instruct neural stem/progenitor cell-niche interactions, and the objective of our study was to elucidate its composition and contribution to GSC maintenance in the perivascular niche...
  4. doi request reprint Holding on to stemness
    Justin D Lathia
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nat Cell Biol 14:450-2. 2012
    ..Id transcription factors are now shown to link cell-intrinsic maintenance programs and extrinsic cues by promoting adhesion of neural stem cells to the niche...
  5. pmc Seeing is believing: are cancer stem cells the Loch Ness monster of tumor biology?
    Justin D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Stem Cell Rev 7:227-37. 2011
    ..What remains clear is that a population of cells is present in many tumors which are resistant to conventional therapies and must be considered in the design of the next generation of cancer treatments...
  6. pmc Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions
    J D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell Death Dis 2:e200. 2011
    ....
  7. pmc Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells
    Justin D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 6:e24807. 2011
    ....
  8. pmc Integrin alpha 6 regulates glioblastoma stem cells
    Justin D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell Stem Cell 6:421-32. 2010
    ..Our results provide evidence that GSCs express high levels of integrin alpha6, which can serve not only as an enrichment marker but also as a promising antiglioblastoma therapy...
  9. pmc Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation
    Yi Fan
    1 Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue Cleveland, Ohio 44195, USA 2 Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard Philadelphia, Pennsylvania 19104, USA
    Nat Cell Biol 16:445-56. 2014
    ..These findings suggest that targeting Pfn-1 phosphorylation may offer a selective strategy for therapeutic intervention of malignant solid tumours. ..
  10. pmc Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity
    Youngmi Kim
    Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Genes Dev 26:1247-62. 2012
    ..Our results may explain mixed clinical responses of anti-PDGFR-based approaches and suggest the need for integration of models of cancer as an organ system into development of cancer therapies...
  11. pmc Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth
    Lin Cheng
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell 153:139-52. 2013
    ..Thus, GSCs contribute to vascular pericytes that may actively remodel perivascular niches. Therapeutic targeting of GSC-derived pericytes may effectively block tumor progression and improve antiangiogenic therapy...
  12. pmc Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3
    Olga A Guryanova
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cancer Cell 19:498-511. 2011
    ..These data demonstrate that BMX represents a GSC therapeutic target and reinforces the importance of STAT3 signaling in stem-like cancer phenotypes...
  13. pmc Development of a Sox2 reporter system modeling cellular heterogeneity in glioma
    Kevin Stoltz
    Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio K S, M S, J S H, B O, J D L Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio Q W, J N R Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, Ohio M S, J D L Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama K W, A B H Image I Q, Cleveland, Ohio A V Case Comprehensive Cancer Center, Cleveland, Ohio J N R, J D L
    Neuro Oncol 17:361-71. 2015
    ..Mouse models recapitulate these genetic aberrations, but readily observable heterogeneity remains challenging...
  14. pmc Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake
    William A Flavahan
    1 Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, Ohio, USA 2 Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Nat Neurosci 16:1373-82. 2013
    ..As altered metabolism represents a cancer hallmark, metabolic reprogramming may maintain the tumor hierarchy and portend poor prognosis. ..
  15. pmc Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells
    David L Schonberg
    Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Cancer Cell 28:441-55. 2015
    ..Iron is a unique, primordial metal fundamental for earliest life forms, on which CSCs have an epigenetically programmed, targetable dependence. ..
  16. pmc Differential connexin function enhances self-renewal in glioblastoma
    Masahiro Hitomi
    Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44915, USA Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA
    Cell Rep 11:1031-42. 2015
    ..Our data demonstrate a pro-tumorigenic role for gap junctions that is dependent on connexin expression. ..
  17. pmc Lyn facilitates glioblastoma cell survival under conditions of nutrient deprivation by promoting autophagy
    Wei Michael Liu
    Department of Cancer Biology, The Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 8:e70804. 2013
    ..As the levels of Lyn protein or its activity are elevated in several cancers these findings may be of broad relevance to cancer biology. ..
  18. doi request reprint Chemokine receptor CXCR4 signaling modulates the growth factor-induced cell cycle of self-renewing and multipotent neural progenitor cells
    Meizhang Li
    Department of Neuroscience, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Glia 59:108-18. 2011
    ..In addition, AMD3100 treatment of pregnant mice reduced the generation of neurospheres from E12.5 embryos. Our data suggest that CXCR4 is a potential cell surface marker for early embryonic NSCs and modulates growth-factor signaling...
  19. pmc The malignant social network: cell-cell adhesion and communication in cancer stem cells
    James S Hale
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
    Cell Adh Migr 6:346-55. 2012
    ..In this review, we will discuss our current understanding of cell-cell adhesion mechanisms used by CSCs and how these local interactions have global consequences for tumor biology...
  20. pmc Endothelial expression of TNF receptor-1 generates a proapoptotic signal inhibited by integrin α6β1 in glioblastoma
    Ping Huang
    Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA
    Cancer Res 72:1428-37. 2012
    ..Together, our findings indicate that the laminin receptor integrin α6β1 promotes the survival of brain ECs by inhibiting prodeath signaling by TNF-R1, in part by inducing cFLIP expression...
  21. pmc Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2
    Christine E Eyler
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell 146:53-66. 2011
    ..These data provide insight into how GSCs are mechanistically distinct from their less tumorigenic counterparts and suggest that NOS2 inhibition may be an efficacious approach to treating this devastating disease...
  22. pmc Development of a Fluorescent Reporter System to Delineate Cancer Stem Cells in Triple-Negative Breast Cancer
    Praveena S Thiagarajan
    Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Stem Cells 33:2114-25. 2015
    ..Our data indicate that we have defined and developed a robust system to monitor differences between CSCs and non-CSCs in TNBC that can be used to identify CSC-specific targets for the development of future therapeutic strategies...
  23. pmc Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells
    Qiao Zheng
    Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA Department of Nutritional Sciences, The University of Texas, Austin, Texas, USA Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, Texas, USA Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA ImageIQ, Cleveland, Ohio, USA Case Comprehensive Cancer Center, Cleveland, Ohio, USA
    Endocr Relat Cancer 20:797-808. 2013
    ..Given the emergence of NANOG as a pro-carcinogenic protein in multiple cancers, these studies suggest that inhibition of LEPR may be a promising therapeutic approach to inhibit NANOG and thereby neutralize CSC functions...
  24. pmc Cancer stem cell-specific scavenger receptor 36 drives glioblastoma progression
    James S Hale
    Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Stem Cells 32:1746-58. 2014
    ..These results provide a paradigm for CSCs to thrive by the selective enhanced expression of scavenger receptors, providing survival, and metabolic advantages...
  25. pmc Targeting A20 decreases glioma stem cell survival and tumor growth
    Anita B Hjelmeland
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS Biol 8:e1000319. 2010
    ..A20 anticancer therapies should therefore be viewed with caution as effects will likely differ depending on the tumor type...
  26. pmc Cx25 contributes to leukemia cell communication and chemosensitivity
    Maksim Sinyuk
    Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    Oncotarget 6:31508-21. 2015
    ..Taken together, our data demonstrate the presence of homotypic communication in leukemia through a Cx25-dependent gap junction mechanism that can be exploited for the development of anti-leukemia therapies. ..
  27. pmc The Lgr5 transgene is expressed specifically in glycinergic amacrine cells in the mouse retina
    Kumar Sukhdeo
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Exp Eye Res 119:106-10. 2014
    ..We further interrogated the spatiotemporal labeling of individual amacrine cells with controlled fluorophore expression. This "fluorofilling" technique provides a tool to study amacrine morphology and dissect neural networks. ..
  28. pmc Chemokine CXCL12 in neurodegenerative diseases: an SOS signal for stem cell-based repair
    Meizhang Li
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Trends Neurosci 35:619-28. 2012
    ..These observations suggest that the CXCL12-CXCR4 axis maintains NSCs and serves as an emergent salvage signal for initiating endogenous stem cell-based tissue repair...
  29. pmc Twisted tango: brain tumor neurovascular interactions
    Anita B Hjelmeland
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Nat Neurosci 14:1375-81. 2011
    ..Interrogating the codependence of BTSCs and the perivascular niche may directly inform clinical approaches for brain tumor therapy through targeting of highly angiogenic and tumorigenic cellular subsets...
  30. pmc Multiplex flow cytometry barcoding and antibody arrays identify surface antigen profiles of primary and metastatic colon cancer cell lines
    Kumar Sukhdeo
    Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA
    PLoS ONE 8:e53015. 2013
    ..Multiplexed antibody arrays can easily be applied to other tumor types or pathologies for discovery-based approaches to target identification...
  31. pmc The intersection of cancer, cancer stem cells, and the immune system: therapeutic opportunities
    Daniel J Silver
    Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio D J S, M S, J D L Rose Ella Burkhardt Brain Tumor and Neuro Oncology Center, Cleveland Clinic, Cleveland, Ohio M A V, M S A, J D L Case Comprehensive Cancer Center, Cleveland, Ohio M A V, M S A, J D L Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio J D L
    Neuro Oncol 18:153-9. 2016
    ....
  32. pmc Insulin-mediated signaling promotes proliferation and survival of glioblastoma through Akt activation
    YuanYing Gong
    Department of Neurological Surgery Y G, Y M, R C T, S w C, J W, Department of Molecular Physiology and Biophysics W C, Department of Neurology S W C, Department of Pathology, Microbiology and Immunology B C M, and Department of Cancer Biology and Department of Pharmacology, Vanderbilt University, Nashville, Tennessee J W Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio M S, J D L Department of Neuroscience and Pharmacology, Meharry Medical College, Nashville, Tennessee S L Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota J N S
    Neuro Oncol 18:48-57. 2016
    ..These metabolic complications may affect tumors via profound mechanisms, including activation of insulin receptor (InsR) and the related insulin-like growth factor 1 receptor (IGF1R) in malignant cells...
  33. pmc Growth factor receptors define cancer hierarchies
    Monica Venere
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Cancer Cell 23:135-7. 2013
    ..Two papers in Cancer Cell, one in this issue (Day and colleagues) and one in a recent issue (Binda and colleagues), describe how Eph receptor tyrosine kinases critically define and regulate the growth of cancer stem cells...
  34. pmc Connexin 43 expression is associated with increased malignancy in prostate cancer cell lines and functions to promote migration
    Ao Zhang
    Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH, 44195, USA
    Oncotarget 6:11640-51. 2015
    ..These results, together with the correlation between C x 43 expression levels and the metastatic capacity of the cell lines, suggest a role of C x 43 in prostate cancer invasion and metastasis...
  35. pmc Cancer stem cells in glioblastoma
    Justin D Lathia
    Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA Department of Molecular Medicine, Cleveland Clinic, Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA
    Genes Dev 29:1203-17. 2015
    ....