B J Hoogwerf
Affiliation: Cleveland Clinic Foundation
- Blood glucose concentrations < or = 125 mg/dl and coronary heart disease riskByron J Hoogwerf
Preventive Cardiology and Rehabilitation Department, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Cardiol 89:596-9. 2002
- Does intensive therapy of type 2 diabetes help or harm? Seeking accord on ACCORDByron J Hoogwerf
Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, OH 44195, USA
Cleve Clin J Med 75:729-37. 2008....
- Exenatide and pramlintide: new glucose-lowering agents for treating diabetes mellitusByron J Hoogwerf
Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA
Cleve Clin J Med 73:477-84. 2006..Glucagon-like peptide 1 (GLP-1), produced in the small intestine, and amylin, produced by beta cells in the pancreas, also have glucose-lowering effects. Synthetic analogues of these hormones are now available for clinical use...
- Postoperative management of the diabetic patientB J Hoogwerf
Department of Endocrinology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Med Clin North Am 85:1213-28. 2001....
- Pramlintide, the synthetic analogue of amylin: physiology, pathophysiology, and effects on glycemic control, body weight, and selected biomarkers of vascular riskByron J Hoogwerf
Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic Foundation, Cleveland, USA
Vasc Health Risk Manag 4:355-62. 2008..These data indicate that pramlintide has a role in glycemic control of both type 1 and type 2 DM. Pramlintide use is associated with favorable effects on weight, lipids and other biomarkers for atherosclerotic disease...
- The HOPE study. Ramipril lowered cardiovascular risk, but vitamin E did notB J Hoogwerf
Department of Endocrinology, Cleveland Clinic, OH 44195, USA
Cleve Clin J Med 67:287-93. 2000..On the other hand, vitamin E in the doses and duration studied (400 IU/day for 4.5 years) did not lower risk significantly...
- Perioperative management of diabetes mellitus: how should we act on the limited evidence?Byron J Hoogwerf
Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Cleve Clin J Med 73:S95-9. 2006..There is little role for oral antidiabetic medications in the early postoperative phase...
- Diabetes mellitus--overviewByron J Hoogwerf
Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Foot Ankle Clin 11:703-15. 2006..Additional management strategies include laser therapy for retinopathy and appropriate footwear to reduce the risk of lower extremity amputations...
- Effects of aggressive cholesterol lowering and low-dose anticoagulation on clinical and angiographic outcomes in patients with diabetes: the Post Coronary Artery Bypass Graft TrialB J Hoogwerf
Cleveland Clinic Foundation, OH 44195, USA
Diabetes 48:1289-94. 1999..The small number of diabetic patients provided limited power to detect significant differences between diabetic and nondiabetic patients or between diabetic patients in the aggressive versus moderate cholesterol treatment strategies...
- All-cause mortality risk predictors in a preventive cardiology clinic cohort-examining diabetes and individual metabolic syndrome criteria: a PRECIS database studyK B Doshi
Department of Endocrinology, Diabetes and Metabolism, The Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
Diabetes Obes Metab 11:102-8. 2009..We analysed which component(s) of NCEP MS criteria had greatest predictive value for mortality...
- Preoperative triglycerides predict post-coronary artery bypass graft survival in diabetic patients: a sex analysisD L Sprecher
Department of Preventive Cardiology and Rehabilitation, Cleveland Clinic Foundation, Ohio 44195, USA
Diabetes Care 23:1648-53. 2000..This study evaluates the predictive value of serum triglyceride levels on mortality in post-coronary artery bypass graft (CABG) diabetic patients with subsequent analysis by sex...
- Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trialFaramarz Ismail-Beigi
Department of Medicine, Division of Clinical and Molecular Endocrinology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4951, USA
Lancet 376:419-30. 2010..We investigated whether reduction of blood glucose concentration decreases the rate of microvascular complications in people with type 2 diabetes...
- Relation of hemoglobin A1c to left ventricular relaxation in patients with type 1 diabetes mellitus and without overt heart diseaseMehdi H Shishehbor
Department of Internal Medicine, Cardiovascular Imaging Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Am J Cardiol 91:1514-7, A9. 2003
- Clinical utility of waist circumference in predicting all-cause mortality in a preventive cardiology clinic population: a PreCIS Database StudyHarpreet S Bajaj
Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic, Cleveland, Ohio, USA
Obesity (Silver Spring) 17:1615-20. 2009....
- The relationship of glycaemic control and triglycerides in patients with diabetes mellitus: a PreCIS Database StudyM B Davidson
Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic, Cleveland, OH 44195, USA
Diabetes Obes Metab 11:118-22. 2009....
- Fluid retention after initiation of thiazolidinedione therapy in diabetic patients with established chronic heart failureW H Wilson Tang
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Ohio 44195, USA
J Am Coll Cardiol 41:1394-8. 2003..We sought to define the characteristics of fluid retention after thiazolidinedione (TZD) initiation in patients with established heart failure (HF)...
- Emerging cardiovascular risk factors that account for a significant portion of attributable mortality risk in chronic kidney diseaseMehdi H Shishehbor
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Am J Cardiol 101:1741-6. 2008..5 micromol/L (the top tertile) were associated with a sevenfold greater mortality risk. In conclusion, homocysteine and fibrinogen levels explain nearly 40% of the attributable mortality risk from CKD...
- High school body mass index and body mass index at entry to a cardiac disease risk prevention clinic and the association to all-cause mortality and coronary heart disease: a PreCIS database studyKatherine K Gambino
Preventive Cardiology and Rehabilitation and Nurse Manager, Women s Cardiovascular Center, Cleveland Clinic, Ohio, USA
J Cardiovasc Nurs 25:99-105. 2010....
- Cholesterol guidelines update: more aggressive therapy for higher-risk patientsJulie C Huang
Preventive Cardiology Section, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, OH 44195, USA
Cleve Clin J Med 72:253-62. 2005..These more aggressive guidelines are based on results of five clinical studies published since 2001...
- Serum uric acid, mortality and glucose control in patients with Type 2 diabetes mellitus: a PreCIS database studyA G Ioachimescu
Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic, Cleveland, OH 44195, USA
Diabet Med 24:1369-74. 2007..To determine the association of serum uric acid with all-cause mortality and hyperglycaemia in patients with Type 2 diabetes...
- Serum uric acid is an independent predictor of all-cause mortality in patients at high risk of cardiovascular disease: a preventive cardiology information system (PreCIS) database cohort studyAdriana G Ioachimescu
Cleveland Clinic, Cleveland, Ohio 44195, USA
Arthritis Rheum 58:623-30. 2008..The purpose of this study was to evaluate the prognostic value of serum uric acid levels in a large cohort of men and women at high risk of cardiovascular disease...
- A truly deadly quartet: obesity, hypertension, hypertriglyceridemia, and hyperinsulinemiaVijay Nambi
Department of Internal Medicine, The Cleveland Clinic Foundation, OH 44195, USA
Cleve Clin J Med 69:985-9. 2002..Thiazolidinedione drugs increase insulin sensitivity, but their use in the metabolic syndrome is only speculative at present. We recommend they be used only as indicated to treat diabetes mellitus...
- Relation of diurnal blood pressure variation and triglyceride-to-high-density lipoprotein cholesterol ratio in patients without diabetes mellitusMichael B Davidson
Department of General Internal Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Cardiol 95:123-6. 2005..3, 95% confidence interval 2.6 to 16.4, p <0.0001) before the development of abnormal levels of fasting blood glucose...
- Relation of albumin/creatinine ratio to C-reactive protein and to the metabolic syndromeAdrian W Messerli
Department of Preventive Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Am J Cardiol 92:610-2. 2003..These data demonstrate that CRP independently predicts the presence of UAE, a marker of endothelial dysfunction...
- Advances in the treatment of diabetes mellitus in the elderly. Development of insulin analoguesB J Hoogwerf
Department of Endocrinology, Cleveland Clinic Foundation, Ohio, USA
Drugs Aging 9:438-48. 1996....
- Autoantibodies to IA-2 and GAD65 in patients with type 2 diabetes mellitus of varied duration: prevalence and correlation with clinical featuresY Z Grasso
Department of Clinical Pathology, L30, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Endocr Pract 7:339-45. 2001..166; P = 0.48). CONCLUSION: Irrespective of duration of disease, measurement of IA-2Ab and GADAb can help to identify those patients with type 2 diabetes most likely to require insulin therapy...
- Association of dyslipidemia and effects of statins on nonmacrovascular diseasesSarkis B Baghdasarian
Cardiovascular Medicine Department, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Clin Ther 26:337-51. 2004..Statins have mechanisms of action that expand their effects beyond cholesterol lowering and atherosclerotic medical conditions...
- Reversible decerebrate posturing after profound and prolonged hypoglycemiaM M Kirk
Department of Pulmonary Disease, Cleveland Clinic Foundation, Ohio
Cleve Clin J Med 58:361-3. 1991..We present the case of a patient who recovered fully from prolonged decerebrate rigidity associated with hypoglycemic coma. This case emphasizes the possibility of recovery from severe, prolonged hypoglycemia...
- A summary of the findings from the Post-CABG trialB J Hoogwerf
Cleveland Clinic Foundation, University of Minnesota, Cleveland, USA
Minerva Cardioangiol 50:291-9. 2002..At the time of the extended follow-up the aggressive lipid strategy was associated with reduced clinical events; low dose warfarin was also associated with reduced clinical events...
- Pancreas transplantation in type 1 diabetes: hope vs realityJ T Mayes
Department of General Surgery, Cleveland Clinic, OH 44195, USA
Cleve Clin J Med 67:281-6. 2000..Increasing evidence suggests that it may slow the progression of long-term diabetic complications. On the other hand, patients risk the adverse effects of lifelong immunosuppression...
- Renin-angiotensin system blockade and cardiovascular and renal protectionByron J Hoogwerf
Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, Ohio, USA
Am J Cardiol 105:30A-5A. 2010..However, telmisartan showed better tolerability than ramipril in ONTARGET, with less cough and angioedema. This difference was obtained despite patients having been selected for tolerability to both drugs at study entry...
- Association of triglyceride-to-HDL cholesterol ratio with heart rate recoveryMehdi H Shishehbor
Department of Internal Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Diabetes Care 27:936-41. 2004..Utilizing triglyceride/HDL cholesterol concentration as a marker of insulin resistance, we sought to assess the association between insulin resistance and HRR...
- Elevated international normalized ratio in the ED: clinical course and physician adherence to the published recommendationsAshish Atreja
Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Am J Emerg Med 23:40-4. 2005..Describe the course of patients with an elevated international normalized ratio (INR) in the emergency department (ED) and determine physicians' adherence with treatment recommendations...
- Development of renal disease in people at high cardiovascular risk: results of the HOPE randomized studyJohannes F E Mann
Department of Cardiology and Population Health Research Institute, McMaster University, Hamilton, Canada
J Am Soc Nephrol 14:641-7. 2003..Microalbuminuria itself predicts clinical proteinuria in nondiabetic and in diabetic people. Ramipril prevents or delays the progression of albuminuria...
- Heart rate and blood pressure responses to mental stress and clinical cardiovascular events in men and women after coronary artery bypass grafting: the Post Coronary Artery Bypass Graft (Post-CABG) biobehavioral studyJ Alan Herd
Department of Medicine, Baylor College of Medicine, Houston, Tex, USA
Am Heart J 146:273-9. 2003..To the extent that CABG surgery restores myocardial blood flow and prevents myocardial ischemia, patients who have recently recovered from CABG surgery may have nearly normal HR and BP responses to MST...
- Progression of renal insufficiency in type 2 diabetes with and without microalbuminuria: results of the Heart Outcomes and Prevention Evaluation (HOPE) randomized studyJohannes F E Mann
Department of Cardiology, McMaster University, Hamilton, Canada
Am J Kidney Dis 42:936-42. 2003..We studied changes in serum creatinine levels during 3.5 to 5.5 years in a large cohort of people with diabetes at high cardiovascular risk with microalbuminuria or normalbuminuria...
- The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trialBernard Zinman
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and University of Toronto, Toronto, Ontario, Canada
Ann Intern Med 146:477-85. 2007..Exenatide therapy is effective in combination with metformin or sulfonylureas for treating type 2 diabetes. Thiazolidinediones (TZDs) also are commonly used, but the efficacy of exenatide with a TZD has not been reported...
- HgbA1c and glucose control: we cannot play it straight with patientsByron J Hoogwerf
J Lab Clin Med 147:5-6. 2006
- Effects of vitamin E on cardiovascular outcomes in people with mild-to-moderate renal insufficiency: results of the HOPE studyJohannes F E Mann
Department of Nephrology and Hypertension, Schwabing General Hospital, Munich, Germany
Kidney Int 65:1375-80. 2004..There are no data for renal insufficiency before the stage of terminal renal failure. We evaluated effects of vitamin E supplementation on cardiovascular and renal outcomes in 993 people with a serum creatinine > or =1.4 to 2.3 mg/dL...
- Nutrition recommendations and interventions for diabetes--2006: a position statement of the American Diabetes AssociationJohn P Bantle
Diabetes Care 29:2140-57. 2006
- Coronary artery bypass graft surgery and cognitive performanceGilles Dupuis
Department of Psychosomatic Medicine, Montreal Heart Institute, Montreal, Quebec, Canada
Am J Crit Care 15:471-8; quiz 479. 2006..Some studies have indicated a decline in patients' cognitive performance after coronary artery bypass graft surgery...
- Quality of life after coronary artery bypass graft: results from the POST CABG TrialNorma Lynn Fox
Maryland Medical Research Institute, Baltimore, MD, USA
Chest 126:487-95. 2004..Low-dose anticoagulation therapy did not reduce the progression of atherosclerosis. We conducted this analysis to determine the effects of both lipid-lowering and low-dose anticoagulation therapy on health-related quality of life (HRQL)...
- A DASH-like diet can decrease cardiovascular risk, but barriers to implementation existByron J Hoogwerf
Cleve Clin J Med 71:755-6. 2004
- Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes AssociationJohn P Bantle
Diabetes Care 31:S61-78. 2008