Thomas G Fraser
Affiliation: Cleveland Clinic Foundation
- Do fluoroquinolones predispose patients to Clostridium difficile associated disease? A review of the evidenceAbhishek Deshpande
Cleveland Clinic, Cleveland, OH, USA
Curr Med Res Opin 24:329-33. 2008..The data suggesting that fluoroquinolones are an important risk factor for CDAD is becoming stronger. Also, different fluoroquinolones may pose different risks for CDAD development...
- Necessary but not sufficient: a comparison of surveillance definitions of Clostridium difficile-associated diarrheaThomas G Fraser
Cleveland Clinic, Department of Infectious Disease, Cleveland, Ohio 44195, USA
Infect Control Hosp Epidemiol 30:377-9. 2009..Surveillance definitions mandated by the Ohio Department of Health overrepresented the number of cases attributable to nosocomial transmission at our institution...
- CLABSI rates in immunocompromised patients: a valuable patient centered outcome?Thomas G Fraser
Department of Infectious Disease, Cleveland Clinic, Cleveland, Ohio, USA
Clin Infect Dis 52:1446-50. 2011..Beyond definitions, IP programs must critically assess the value of their current approach to surveillance to assure that patient-centered outcomes are the focus of prevention efforts...
- Decrease in Staphylococcus aureus colonization and hospital-acquired infection in a medical intensive care unit after institution of an active surveillance and decolonization programThomas G Fraser
Medicine Institute, Department of Infectious Disease, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Infect Control Hosp Epidemiol 31:779-83. 2010..To evaluate the effects of an active surveillance program for Staphylococcus aureus linked to a decolonization protocol on the incidence of healthcare-associated infection and new nasal colonization due to S. aureus...
- Newer antibiotics for serious gram-positive infectionsThomas G Fraser
Department of Infectious Diseases, Cleveland Clinic Foundation, OH 44195, USA
Cleve Clin J Med 73:847-53. 2006....
- Active tuberculosis in a healthcare worker: are you ready?Thomas G Fraser
Cleveland Clinic Department of Infectious Disease, Quality and Patient Safety Institute, and Occupational Health, Cleveland, Ohio 44195, USA
Infect Control Hosp Epidemiol 30:80-2. 2009..Our experience demonstrates the potential benefits of therapy for latent tuberculosis infection as a component of a tuberculosis-control program...
- Accuracy of loop-mediated isothermal amplification for the diagnosis of Clostridium difficile infection: a systematic reviewAaron Lloyd
Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
Diagn Microbiol Infect Dis 82:4-10. 2015..99 (95% CI, 0.96-1.00; I(2)=97.0). LAMP is a useful diagnostic tool with high sensitivity and specificity for detecting CDI. The results should, however, be interpreted only in the presence of clinical suspicion and symptoms of CDI. ..
- Heart valve culture and sequencing to identify the infective endocarditis pathogen in surgically treated patientsNabin K Shrestha
Department of Infectious Disease, Cleveland Clinic, Cleveland, Ohio Department of Clinical Pathology, Cleveland Clinic, Cleveland, Ohio Electronic address
Ann Thorac Surg 99:33-7. 2015....
- Clinical utility of cerebral angiography in the preoperative assessment of endocarditisPeter P Monteleone
Departments of Cardiovascular Medicine, Infectious Disease, and Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio
Vasc Med 19:500-6. 2014..A novel association between viridans group streptococci and intracranial mycotic aneurysm is demonstrated. ..
- Development of a modified surveillance definition of central line-associated bloodstream infections for patients with hematologic malignanciesMegan J Digiorgio
Department of Infection Prevention, Quality and Patient Safety Institute, Cleveland, Ohio, USA
Infect Control Hosp Epidemiol 33:865-8. 2012..To develop a modified surveillance definition of central line-associated bloodstream infection (mCLABSI) specific for our population of patients with hematologic malignancies to better support ongoing improvement efforts at our hospital...
- Challenges of interferon-γ release assay conversions in serial testing of health-care workers in a TB control programKimberlee S Fong
Department of Infectious Disease, Cleveland Clinic, Cleveland, OH 44195, USA
Chest 142:55-62. 2012..Clinical data with use of serial interferon-γ release assay (IGRA) testing in US health-care workers (HCWs) are limited...
- Endovascular infections caused by Histoplasma capsulatum: a case series and review of the literatureChristopher Ledtke
Department of Infectious Diseases, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
Arch Pathol Lab Med 136:640-5. 2012..Endovascular infection is an uncommon but devastating manifestation of histoplasmosis, which is often diagnosed late in disease...
- Cardiac implantable electronic device infections: presentation, management, and patient outcomesKhaldoun G Tarakji
Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
Heart Rhythm 7:1043-7. 2010..Indications for cardiac implantable electronic devices (CIEDs) are increasing. Although CIED infections occur infrequently, the impact of this outcome is expected to be substantial...
- Anti-infective therapy at the end of life: ethical decision-making in hospice-eligible patientsPaul J Ford
The Department of Bioethics JJ60, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
Bioethics 19:379-92. 2005....
- Hospital-acquired Staphylococcus aureus primary bloodstream infection: A comparison of events that do and do not meet the central line-associated bloodstream infection definitionChristopher S Kovacs
Department of Infectious Disease, Medicine Institute, Cleveland Clinic, Cleveland, OH Electronic address
Am J Infect Control 44:1252-1255. 2016....
- Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysisAbhishek Deshpande
1Medicine Institute Center for Value Based Care Research, Cleveland Clinic, Cleveland, Ohio
Infect Control Hosp Epidemiol 36:452-60. 2015..While the actual mechanism of recurrence remains unknown, a variety of risk factors have been suggested and studied. The aim of this systematic review and meta-analysis was to evaluate current evidence on the risk factors for rCDI...
- Outcomes after surgical treatment of native and prosthetic valve infective endocarditisMahesh B Manne
Department of Internal Medicine, Medicine Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
Ann Thorac Surg 93:489-93. 2012..Recent literature has drawn conflicting conclusions on the benefit of surgery for IE. We reviewed patients treated surgically for IE at the Cleveland Clinic from 2003 to 2007 to examine their outcomes...
- Treatment and outcomes in carbapenem-resistant Klebsiella pneumoniae bloodstream infectionsElizabeth A Neuner
Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA
Diagn Microbiol Infect Dis 69:357-62. 2011..In summary, CR-Kp bloodstream infections occur in patients who are chronically and acutely ill. They are associated with high 14-day mortality and poor outcomes regardless of tigecycline or other treatment regimens selected...
- The emergence of methicillin-resistant Staphylococcus aureus in the communityRavindran A Padmanabhan
Department of Infectious Diseases, The Cleveland Clinic Foundation, OH 44195, USA
Cleve Clin J Med 72:235-41. 2005....
- Durable improvement in hand hygiene compliance following implementation of an automated observation system with visual feedbackHeather Michael
Department of Infectious Disease, Cleveland Clinic, Cleveland, OH Electronic address
Am J Infect Control . 2016..We report that an automated observation system with immediate feedback was associated with a rapid and durable improvement in hand hygiene compliance...
- Diagnostic testing methods for Clostridium difficile infection: A statewide survey of Ohio acute care hospitalsKen Koon Wong
Department of Infectious Diseases, Cleveland Clinic, Medicine Institute, Cleveland, OH
Am J Infect Control . 2016..Of 146 hospitals surveyed, 109 (84%) used nucleic acid amplification tests (NAATs) as stand-alone diagnostic assays. Only 53 (42.4%) hospitals using NAATs had a mechanism in place to prevent repeat CDI testing...
- The descriptive epidemiology of central line-associated bloodstream infection among patients in non-intensive care unit settingsRudy Tedja
Department of Infectious Disease, Medicine Institute, Cleveland Clinic, Cleveland, Ohio
Infect Control Hosp Epidemiol 35:164-8. 2014..To review and describe device utilization and central line-associated bloodstream (CLABSI) events among patients in a non-intensive care unit (ICU) setting and to examine the morbidity and mortality associated with these events...
- Impact of isolation on hospital consumer assessment of healthcare providers and systems scores: is isolation isolating?Joan Vinski
Quality and Patient Safety Institute, Department of Infection Prevention, Cleveland Clinic, Cleveland, Ohio 44195, USA
Infect Control Hosp Epidemiol 33:513-6. 2012..Isolated patients reported lower scores for questions regarding physician communication and staff responsiveness. Overall scores for these domains were lower in isolated than in nonisolated patients...
- The use of real-time polymerase chain reaction for rapid diagnosis of skeletal tuberculosisNaomi Kobayashi
Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Arch Pathol Lab Med 130:1053-6. 2006....
- A Multifaceted Approach to Reduction of Catheter-Associated Urinary Tract Infections in the Intensive Care Unit With an Emphasis on "Stewardship of Culturing"Katherine M Mullin
1Department of Infectious Diseases, Medicine Institute, Cleveland Clinic Foundation, Cleveland, Ohio
Infect Control Hosp Epidemiol . 2016..CONCLUSIONS Effectively reducing ICU CAUTI rates requires a multifaceted and collaborative approach; stewardship of culturing was a key and safe component of our successful reduction efforts. Infect Control Hosp Epidemiol 2016;1-3...
- Clostridium difficile infection after cardiac surgery: prevalence, morbidity, mortality, and resource utilizationSuresh Keshavamurthy
Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio
J Thorac Cardiovasc Surg 148:3157-65.e1-5. 2014..Heightened awareness prompted this study of the prevalence and morbidity associated with CDI after cardiac surgery...
- Vancomycin and home health careThomas G Fraser
Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Emerg Infect Dis 11:1558-64. 2005..Recommendations for prudent vancomycin use are often overlooked when selecting antimicrobial drugs for home infusion. The public health impact of this practice remains unknown...
- Persistent methicillin-resistant Staphylococcus aureus bacteremia due to a prostatic abscessThomas G Fraser
Division of Infectious Diseases, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Scand J Infect Dis 35:273-4. 2003..The literature describing complications of S. aureus bacteremia and the bacteriology of prostatic abscesses is reviewed. This was found to be the first report of a patient with persistent MRSA bacteremia maintained by a prostatic focus...