Gary W Falk

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi Barrett's esophagus in women: demographic features and progression to high-grade dysplasia and cancer
    Gary W Falk
    Center for Swallowing and Esophageal Disorders, Department of Gastroenterology and Hepatology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Clin Gastroenterol Hepatol 3:1089-94. 2005
  2. ncbi Barrett's esophagus at a tertiary care center: association of age on incidence and prevalence of dysplasia and adenocarcinoma
    Jason M Guardino
    Center for Swallowing and Esophageal Disorders, Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 101:2187-93. 2006
  3. ncbi Fluorescence in situ hybridization of cytologic specimens from Barrett's esophagus: a pilot feasibility study
    Gary W Falk
    Center for Swallowing and Esophageal Disorders, Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Gastrointest Endosc 60:280-4. 2004
  4. ncbi Chromosomal gains and genomic loss of p53 and p16 genes in Barrett's esophagus detected by fluorescence in situ hybridization of cytology specimens
    Mona Fahmy
    Department of Anatomic and Clinical Pathology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mod Pathol 17:588-96. 2004
  5. doi Risk factors for esophageal cancer development
    Gary W Falk
    Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Desk A 31, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Surg Oncol Clin N Am 18:469-85. 2009
  6. ncbi Is FDG-PET indicated for superficial esophageal cancer?
    Sherard G Little
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
    Eur J Cardiothorac Surg 31:791-6. 2007
  7. doi The Seattle protocol does not more reliably predict the detection of cancer at the time of esophagectomy than a less intensive surveillance protocol
    Revital Kariv
    Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 7:653-8; quiz 606. 2009
  8. pmc Variation in age at cancer diagnosis in familial versus nonfamilial Barrett's esophagus
    Amitabh Chak
    Division of Gastroenterology, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Cancer Epidemiol Biomarkers Prev 21:376-83. 2012
  9. ncbi Cytology in Barrett's esophagus
    Gary W Falk
    Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A 30, Cleveland, OH 44195, USA
    Gastrointest Endosc Clin N Am 13:335-48. 2003
  10. doi An open-label, prospective trial of cryospray ablation for Barrett's esophagus high-grade dysplasia and early esophageal cancer in high-risk patients
    John A Dumot
    Departments of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio, USA
    Gastrointest Endosc 70:635-44. 2009

Collaborators

Detail Information

Publications33

  1. ncbi Barrett's esophagus in women: demographic features and progression to high-grade dysplasia and cancer
    Gary W Falk
    Center for Swallowing and Esophageal Disorders, Department of Gastroenterology and Hepatology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Clin Gastroenterol Hepatol 3:1089-94. 2005
    ..The aims of this study were to compare the demographic features of Barrett's esophagus in men and women and to determine the prevalence and incidence of high-grade dysplasia and cancer in these patients...
  2. ncbi Barrett's esophagus at a tertiary care center: association of age on incidence and prevalence of dysplasia and adenocarcinoma
    Jason M Guardino
    Center for Swallowing and Esophageal Disorders, Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 101:2187-93. 2006
    ..Little is known about BE in younger patients. We sought to assess the effect of age on features of BE including the prevalence and incidence of dysplasia and carcinoma...
  3. ncbi Fluorescence in situ hybridization of cytologic specimens from Barrett's esophagus: a pilot feasibility study
    Gary W Falk
    Center for Swallowing and Esophageal Disorders, Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Gastrointest Endosc 60:280-4. 2004
    ....
  4. ncbi Chromosomal gains and genomic loss of p53 and p16 genes in Barrett's esophagus detected by fluorescence in situ hybridization of cytology specimens
    Mona Fahmy
    Department of Anatomic and Clinical Pathology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mod Pathol 17:588-96. 2004
    ..Selected biomarkers from this study merit further investigation to determine their potential to detect genetic changes in patients with Barrett's esophagus prior to the development of high-grade dysplasia...
  5. doi Risk factors for esophageal cancer development
    Gary W Falk
    Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Desk A 31, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Surg Oncol Clin N Am 18:469-85. 2009
    ..Factors that may protect against the development of adenocarcinoma include infection with Helicobacter pylori, a diet rich in fruits and vegetables, and consumption of aspirin and NSAIDs...
  6. ncbi Is FDG-PET indicated for superficial esophageal cancer?
    Sherard G Little
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
    Eur J Cardiothorac Surg 31:791-6. 2007
    ....
  7. doi The Seattle protocol does not more reliably predict the detection of cancer at the time of esophagectomy than a less intensive surveillance protocol
    Revital Kariv
    Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 7:653-8; quiz 606. 2009
    ....
  8. pmc Variation in age at cancer diagnosis in familial versus nonfamilial Barrett's esophagus
    Amitabh Chak
    Division of Gastroenterology, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Cancer Epidemiol Biomarkers Prev 21:376-83. 2012
    ..In this study, we determine whether cancers develop at an earlier age in multiplex Familial Barrett's Esophagus (FBE) kindreds, defined by 3 or more members affected by Barrett's esophagus (BE) or esophageal adenocarcinoma (EAC)...
  9. ncbi Cytology in Barrett's esophagus
    Gary W Falk
    Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A 30, Cleveland, OH 44195, USA
    Gastrointest Endosc Clin N Am 13:335-48. 2003
    ..Cytology could then conceivably accomplish the goals of improved efficiency, risk stratification, and decreased costs in BE surveillance programs...
  10. doi An open-label, prospective trial of cryospray ablation for Barrett's esophagus high-grade dysplasia and early esophageal cancer in high-risk patients
    John A Dumot
    Departments of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio, USA
    Gastrointest Endosc 70:635-44. 2009
    ..Endoscopic ablation of Barrett's esophagus (BE) is a treatment option for patients with high-grade dysplasia (HGD) and intramucosal carcinoma (IMCA)...
  11. pmc Association of insulin and insulin-like growth factors with Barrett's oesophagus
    Katarina B Greer
    Division of Gastroenterology and Liver Disease, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Gut 61:665-72. 2012
    ..The relationship of insulin, IGF-1 and IGF binding proteins (IGFBP) with Barrett's oesophagus (BO) has not been well examined...
  12. doi The role of allergy evaluation in adults with eosinophilic esophagitis
    Joshua D Penfield
    Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Clin Gastroenterol 44:22-7. 2010
    ..Allergy evaluation and skin prick testing for foods are recommended in all patients with eosinophilic esophagitis. However, the yield of allergy evaluation in adult eosinophilic esophagitis is not known...
  13. doi Autofluorescence endoscopy
    Gary W Falk
    Department of Gastroenterology and Hepatology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, OH 44195, USA
    Gastrointest Endosc Clin N Am 19:209-20. 2009
    ..Autofluorescence technology detects indirect measures of dysplasia and carcinoma, and is nonspecific, so additional enhancements are clearly desirable...
  14. ncbi Barrett's esophagus-is it bad for your health?
    Gary W Falk
    Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 100:2622-3. 2005
    ..Findings such as these point out the need for large, well-done epidemiologic studies of Barrett's esophagus cohorts in order to develop a better understanding of the natural history of this disease...
  15. pmc Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis
    Florian Rieder
    Dept of Gastroenterology and Hepatology, NC22, Cleveland Clinic Foundation 9500 Euclid Ave, Cleveland, OH, 44195
    Am J Physiol Gastrointest Liver Physiol 298:G571-81. 2010
    ..Novel findings regarding the pathophysiology of esophageal inflammation should enhance our understanding of GERD and its complications and provide new treatment insights...
  16. ncbi A coxib a day won't keep the doctor away
    Eric J Topol
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Lancet 364:639-40. 2004
  17. ncbi Barrett's esophagus
    Gary W Falk
    Department of Gastroenterology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Gastroenterology 122:1569-91. 2002
    ..Treatment options include aggressive acid suppression, antireflux surgery, chemoprevention, and ablation therapy, but there is still no clear consensus on the optimal treatment for these patients...
  18. ncbi p53 expression in low grade dysplasia in Barrett's esophagus: correlation with interobserver agreement and disease progression
    Marek Skacel
    Department of Anatomic Pathology, The Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Gastroenterol 97:2508-13. 2002
    ..In the current study, we analyzed the immunohistochemical staining for p53 in patients diagnosed with LGD with known clinical outcome and interobserver agreement data...
  19. doi Is conventional endoscopic identification of non-erosive reflux disease adequate?
    Gary W Falk
    Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Digestion 78:17-23. 2008
    ..Furthermore, it is essential that we do not repeat the mistakes of the past as poor interobserver agreement has already been shown for minimal change esophagitis, albeit with more primitive technology...
  20. ncbi Esophageal manometry: assessment of interpreter consistency
    Devjit S Nayar
    Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 3:218-24. 2005
    ..Manometry is used widely in the evaluation of esophageal disorders. Our aim was to assess the intra- and interobserver reliability of esophageal manometry and identify potential causes for diagnostic variability...
  21. doi Low Risk of High-grade Dysplasia or Esophageal Adenocarcinoma Among Patients with Barrett's Esophagus Less Than 1 cm (Irregular Z Line) Within 5 Years of Index Endoscopy
    Prashanthi N Thota
    Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, United States Electronic address
    Gastroenterology . 2016
    ..However, little is known about their risk of high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC). We aimed to determine the incidence of HGD and EAC in patients with irregular Z line with intestinal metaplasia...
  22. pmc Metformin does not reduce markers of cell proliferation in esophageal tissues of patients with Barrett's esophagus
    Amitabh Chak
    Department of Gastroenterology and Hepatology, University Hospitals Case Medical Center, Cleveland, Ohio Electronic address
    Clin Gastroenterol Hepatol 13:665-72.e1-4. 2015
    ..We conducted a randomized, double-blind, placebo-controlled, phase 2 study of patients with Barrett's esophagus (BE) to assess the effect of metformin on phosphorylated S6 kinase (pS6K1), a biomarker of insulin pathway activation...
  23. doi Role of barium esophagography in evaluating dysphagia
    Brian C Allen
    Imaging Institute, Hb6, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cleve Clin J Med 76:105-11. 2009
    ..We usually recommend that most patients with dysphagia initially undergo barium esophagography, and in this paper we discuss its role in evaluating dysphagia...
  24. ncbi Eosinophilic esophagitis: an increasingly recognized cause of dysphagia, food impaction, and refractory heartburn
    Ilche T Nonevski
    Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 75:623-6, 629-33. 2008
    ..Its cause is unknown, but allergic and immune-mediated mechanisms similar to those of asthma and other atopic diseases are implicated...
  25. ncbi [American Gastroenterological Association Institute medical position statement on the use of endoscopic therapy for gastroesophageal reflux disease]
    Gary W Falk
    Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic, Cleveland, Ohio, USA
    Rev Gastroenterol Mex 71:512-43. 2006
  26. ncbi AGA Institute technical review on the use of endoscopic therapy for gastroesophageal reflux disease
    Gary W Falk
    Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic, Cleveland, OH, USA
    Gastroenterology 131:1315-36. 2006
  27. doi Chemoprevention and Barrett's esophagus: decisions, decisions
    Gary W Falk
    Am J Gastroenterol 103:2443-5. 2008
    ..The role of chemoprevention in Barrett's esophagus still awaits the results of ongoing clinical trials in the United Kingdom and North America...
  28. ncbi Helicobacter pylori infection, not gastroesophageal reflux, is the major cause of inflammation and intestinal metaplasia of gastric cardiac mucosa
    John R Goldblum
    Center for Swallowing and Esophageal Disorders and Department of Anatomic Pathology, Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Gastroenterol 97:302-11. 2002
    ..pylori infection, and intestinal metaplasia in patients with GERD and Barrett's esophagus compared with age-matched controls...
  29. ncbi Dysplasia and cancer in a large multicenter cohort of patients with Barrett's esophagus
    Prateek Sharma
    University of Kansas School of Medicine and Veterans Affairs Medical Center, Kansas City, Missouri 64128 2295, USA
    Clin Gastroenterol Hepatol 4:566-72. 2006
    ..The goal of this study was to define the prevalence and incidence of dysplasia and cancer and evaluate the paths of progression in a large multicenter cohort of BE patients...
  30. ncbi Risk factors for dysplasia in patients with Barrett's esophagus (BE): results from a multicenter consortium
    Deepak V Gopal
    Oregon Health and Science University and Portland VA Medical Center, Portland, Oregon, USA
    Dig Dis Sci 48:1537-41. 2003
    ..These preliminary results can be used to develop a strategy for screening/surveillance based on age and length of Barrett's epithelium...
  31. ncbi Acid suppression therapy may not alter malignant progression in Barrett's metaplasia showing p53 protein accumulation
    Nicole Carlson
    Department of Pathology and Medicine, Baylor College of Medicine, Methodist Hospital, Houston, Texas 77030, USA
    Am J Gastroenterol 97:1340-5. 2002
    ..The aim of this study was to test the hypothesis that AST may not alter malignant progression in BM if key genes involved in DNA repair and cell cycle control, particularly p53, are defective...
  32. ncbi Gastric and esophageal pH in patients with Barrett's esophagus treated with three esomeprazole dosages: a randomized, double-blind, crossover trial
    Stuart J Spechler
    Dallas Department of Veterans Affairs Medical Center, University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA
    Am J Gastroenterol 101:1964-71. 2006
    ..It has been suggested that patients with Barrett's esophagus (BE) are unusually resistant to the antisecretory effects of proton pump inhibitors (PPIs)...
  33. ncbi Extent of low-grade dysplasia in Barrett's esophagus: is it useful for risk stratification?
    Gary W Falk
    Am J Gastroenterol 102:494-6. 2007
    ..However, these findings, if confirmed by studies utilizing a simpler measure of the extent of low-grade dysplasia, may help us determine the prognostic significance of this lesion in the future...