KATHLEEN ANNE DERWIN
Affiliation: Cleveland Clinic Foundation
- Regional variability, processing methods, and biophysical properties of human fascia lata extracellular matrixKathleen A Derwin
Department of Biomedical Engineering, Lerner Research Institute and Orthopaedic Research Center, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
J Biomed Mater Res A 84:500-7. 2008..001). The mechanical, chemical and ultrastructural similarities between fascia lata and tendon may make fresh or processed fascia an attractive ECM scaffold for soft tissue, particularly tendon, repair...
- Low-dose CT imaging of radio-opaque markers for assessing human rotator cuff repair: accuracy, repeatability and the effect of arm positionK A Derwin
Department of Biomedical Engineering and Orthopedic and Rheumatologic Research Center, Cleveland Clinic, Cleveland, OH 44195, USA
J Biomech 45:614-8. 2012..8 to -1.6 mm (RMS 1.3 mm). We conclude that a range of ± 3 mm is a conservative estimate of the uncertainty in anchor-to-bead distance for patients repeatedly scanned in clinically-relevant arm positions...
- Preclinical models for translating regenerative medicine therapies for rotator cuff repairKathleen A Derwin
Department of Biomedical Engineering, Orthopaedic Research Center, Cleveland Clinic, Cleveland, Ohio 44122, USA
Tissue Eng Part B Rev 16:21-30. 2010....
- Rotator cuff repair augmentation in a canine model with use of a woven poly-L-lactide deviceKathleen A Derwin
Department of Biomedical Engineering, ND2 20, Cleveland Clinic, Cleveland, OH 44122, USA
J Bone Joint Surg Am 91:1159-71. 2009..The purpose of this study was to evaluate the extent to which augmentation of acute repair of rotator cuff tendons with a newly designed poly-L-lactide repair device would improve functional and biomechanical outcomes in a canine model...
- Assessment of the canine model of rotator cuff injury and repairKathleen A Derwin
Department of Biomedical Engineering, Lerner Research Institute and Orthopaedic Research Center, The Cleveland Clinic, Cleveland, OH 44195, USA
J Shoulder Elbow Surg 16:S140-8. 2007..Thus a partial-width injury in the canine may model the mechanical environment of many single tendon tears in the human injury condition and warrants further investigation...
- Commercial extracellular matrix scaffolds for rotator cuff tendon repair. Biomechanical, biochemical, and cellular propertiesKathleen A Derwin
Department of Biomedical Engineering, ND 20, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
J Bone Joint Surg Am 88:2665-72. 2006..In this study, the properties of GraftJacket, TissueMend, Restore, and CuffPatch were quantified and compared with each other. The elastic moduli were also compared with that of normal canine infraspinatus tendon...
- Extracellular matrix scaffold devices for rotator cuff repairKathleen A Derwin
Department of Biomedical Engineering, Orthopaedic Research Center, Cleveland Clinic, Cleveland, OH 44195, USA
J Shoulder Elbow Surg 19:467-76. 2010..We will then discuss the implications of these data on the future directions for use of these scaffolds in tendon repair procedures...
- Mechanical conditioning of cell-seeded small intestine submucosa: a potential tissue-engineering strategy for tendon repairCaroline Androjna
The Cleveland Clinic, Department of Biomedical Engineering, Cleveland, Ohio 44195, USA
Tissue Eng 13:233-43. 2007..These data provide the basis for future studies investigating in vitro conditioning (mechanical, chemical) of cell-seeded ECM scaffolds and the use of such constructs for enhancing tendon repair in vivo...
- Oxygen diffusion through natural extracellular matrices: implications for estimating "critical thickness" values in tendon tissue engineeringCaroline Androjna
Department of Biomedical Engineering, The Cleveland Clinic, Cleveland, Ohio 44195, USA
Tissue Eng Part A 14:559-69. 2008..We used the experimental oxygen diffusivity data for these natural ECMs in a mathematical model of oxygen diffusion through a cell-seeded scaffold to estimate the critical size of cell-seeded scaffold that can be cultured in vitro...
- Improved time-zero biomechanical properties using poly-L-lactic acid graft augmentation in a cadaveric rotator cuff repair modelJesse A McCarron
Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
J Shoulder Elbow Surg 19:688-96. 2010..This study was designed to determine whether application of a woven poly-L-lactic acid device (X-Repair; Synthasome, San Diego, CA) would improve the mechanical properties of rotator cuff repair in vitro...
- Changes in rotator cuff muscle volume, fat content, and passive mechanics after chronic detachment in a canine modelOri Safran
Department of Orthopaedic Surgery and the Orthopaedic Research Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
J Bone Joint Surg Am 87:2662-70. 2005..We hypothesized that infraspinatus muscle stiffness would increase, volume would decrease, and fat content would increase at twelve weeks following tendon detachment...
- Effect of altered mechanical load conditions on the structure and function of cultured tendon fasciclesEduardo L Abreu
Department of Orthopaedic Surgery, Children s Hospital of Boston, 300 Longwood Avenue, Enders 1022, Boston, Massachusetts 02115, USA
J Orthop Res 26:364-73. 2008..Together these results suggest a role for GAG but not collagen or water in the elastic and viscoelastic changes measured in tendon fascicles cultured for 1 week under altered load conditions...
- Strain-rate sensitive mechanical properties of tendon fascicles from mice with genetically engineered alterations in collagen and decorinPaul S Robinson
McKay Orthopaedic Research Laboratory, University of Pennsylvania, 3450 Hamilton Walk, 424 Stemmler Hall, Philadelphia, PA 19104 6081, USA
J Biomech Eng 126:252-7. 2004..This study provides quantitative evidence for structure-function relationships in tendon, including the role of proteoglycan in viscoelasticity...