Naim Alkhouri

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. doi request reprint A combination of the pediatric NAFLD fibrosis index and enhanced liver fibrosis test identifies children with fibrosis
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 9:150-5. 2011
  2. ncbi request reprint Long Term Complications in Pediatric Liver Transplant Recipients: What Every Pediatrician Should Know
    Dalia Youssef
    Cleveland Clinic, Mail Code A111, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Curr Pediatr Rev 12:209-221. 2016
  3. doi request reprint Evaluation of circulating markers of hepatic apoptosis and inflammation in obese children with and without obstructive sleep apnea
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, USA Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44195, USA Electronic address
    Sleep Med 16:1031-5. 2015
  4. doi request reprint Circulating Soluble Fas and Fas Ligand Levels Are Elevated in Children with Nonalcoholic Steatohepatitis
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    Dig Dis Sci 60:2353-9. 2015
  5. pmc OxNASH score correlates with histologic features and severity of nonalcoholic fatty liver disease
    Naim Alkhouri
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    Dig Dis Sci 59:1617-24. 2014
  6. doi request reprint Combined paediatric NAFLD fibrosis index and transient elastography to predict clinically significant fibrosis in children with fatty liver disease
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, Ohio, USA
    Liver Int 33:79-85. 2013
  7. doi request reprint Development and validation of a new histological score for pediatric non-alcoholic fatty liver disease
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, United States
    J Hepatol 57:1312-8. 2012
  8. doi request reprint Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease
    Naim Alkhouri
    Digestive Disease Institute, Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, USA
    Liver Int 32:297-302. 2012
  9. doi request reprint The inflamed liver and atherosclerosis: a link between histologic severity of nonalcoholic fatty liver disease and increased cardiovascular risk
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Dig Dis Sci 55:2644-50. 2010
  10. pmc Johanson-Blizzard syndrome with mild phenotypic features confirmed by UBR1 gene testing
    Naim Alkhouri
    Department of Pediatric Gastroenterology and Nutrition, Cleveland Clinic, 9500 Euclid Avenue, Desk A 111, Cleveland, OH 44195, USA
    World J Gastroenterol 14:6863-6. 2008

Collaborators

Detail Information

Publications58

  1. doi request reprint A combination of the pediatric NAFLD fibrosis index and enhanced liver fibrosis test identifies children with fibrosis
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 9:150-5. 2011
    ..We prospectively evaluated the performance of PNFI and ELF in assessing fibrosis in children with biopsy-proven NAFLD...
  2. ncbi request reprint Long Term Complications in Pediatric Liver Transplant Recipients: What Every Pediatrician Should Know
    Dalia Youssef
    Cleveland Clinic, Mail Code A111, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Curr Pediatr Rev 12:209-221. 2016
    ..Hence, general pediatricians should to be aware of these potential complications in order to optimize the medical care and the quality of life for children with liver transplantation...
  3. doi request reprint Evaluation of circulating markers of hepatic apoptosis and inflammation in obese children with and without obstructive sleep apnea
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, USA Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44195, USA Electronic address
    Sleep Med 16:1031-5. 2015
    ....
  4. doi request reprint Circulating Soluble Fas and Fas Ligand Levels Are Elevated in Children with Nonalcoholic Steatohepatitis
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    Dig Dis Sci 60:2353-9. 2015
    ..Increased hepatocyte apoptosis plays a central role in the development of NASH...
  5. pmc OxNASH score correlates with histologic features and severity of nonalcoholic fatty liver disease
    Naim Alkhouri
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    Dig Dis Sci 59:1617-24. 2014
    ..The aims of this study were to assess the utility of OxNASH as a predictor of NASH and study the association between OxNASH and specific histologic features of NAFLD...
  6. doi request reprint Combined paediatric NAFLD fibrosis index and transient elastography to predict clinically significant fibrosis in children with fatty liver disease
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, Ohio, USA
    Liver Int 33:79-85. 2013
    ..To prospectively evaluate the performance of PNFI and TE in assessing clinically significant fibrosis in children with biopsy-proven NAFLD...
  7. doi request reprint Development and validation of a new histological score for pediatric non-alcoholic fatty liver disease
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, United States
    J Hepatol 57:1312-8. 2012
    ..We aimed at developing a new grading score for pediatric NAFLD to be used in clinical trials that takes into account the presence of PI and the weight of histological features...
  8. doi request reprint Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease
    Naim Alkhouri
    Digestive Disease Institute, Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, USA
    Liver Int 32:297-302. 2012
    ..The neutrophil/lymphocyte ratio (N/L) integrates information on the inflammatory milieu and physiological stress...
  9. doi request reprint The inflamed liver and atherosclerosis: a link between histologic severity of nonalcoholic fatty liver disease and increased cardiovascular risk
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Dig Dis Sci 55:2644-50. 2010
    ..Growing evidence links NAFLD to cardiovascular (CV) disease; however, the association between the histologic severity of NAFLD and CV risk remains poorly understood...
  10. pmc Johanson-Blizzard syndrome with mild phenotypic features confirmed by UBR1 gene testing
    Naim Alkhouri
    Department of Pediatric Gastroenterology and Nutrition, Cleveland Clinic, 9500 Euclid Avenue, Desk A 111, Cleveland, OH 44195, USA
    World J Gastroenterol 14:6863-6. 2008
    ..We report the case of a 7-year-old female with pancreatic insufficiency and mild phenotypic features, in whom the diagnosis of JBS was established using recently described molecular testing for the UBR1 gene...
  11. pmc Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Expert Rev Gastroenterol Hepatol 5:201-12. 2011
    ..In particular, it will highlight the efforts for the development of both novel diagnostic and therapeutic strategies based on this knowledge...
  12. pmc Ultrasonographic quantitative estimation of hepatic steatosis in children With NAFLD
    Angela Shannon
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH, USA
    J Pediatr Gastroenterol Nutr 53:190-5. 2011
    ..The aim of this study was to prospectively evaluate the clinical utility of ultrasonographic quantification of hepatic steatosis...
  13. doi request reprint Serum cytokeratin-18 fragment levels are useful biomarkers for nonalcoholic steatohepatitis in children
    Ariel E Feldstein
    Department of Pediatric Gastroenterology, Hepatology and Nutrition, Rady Children s Hosptial, University of California San Diego UCSD, San Diego, CA, USA
    Am J Gastroenterol 108:1526-31. 2013
    ..The aim of this study was to evaluate the use of plasma cytokeratin-18 (CK18) fragment levels, a marker of increased hepatocyte apoptosis, as a non-invasive biomarker for pediatric NASH...
  14. doi request reprint Analysis of breath volatile organic compounds as a noninvasive tool to diagnose nonalcoholic fatty liver disease in children
    Naim Alkhouri
    Departments of aPediatric Gastroenterology and Hepatology bQuantitative Health Sciences cDepartment of Gastroenterology and Hepatology, Digestive Disease Institute dDepartment of Pathobiology, Lerner Research Institute eDepartment of Pulmonary, Allergy and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Eur J Gastroenterol Hepatol 26:82-7. 2014
    ..Nonalcoholic fatty liver disease (NAFLD) is one of the most common complications of childhood obesity. Our objective was to investigate the association of breath volatile organic compounds with the diagnosis of NAFLD in children...
  15. pmc An apoptosis panel for nonalcoholic steatohepatitis diagnosis
    Tarek I Abu Rajab Tamimi
    Digestive Disease Institute, Sioux Falls, SD, USA
    J Hepatol 54:1224-9. 2011
    ..Our aims were to create and validate a noninvasive prediction model for NASH diagnosis based on specific circulating markers of apoptosis...
  16. pmc Serum retinol-binding protein 4 levels in patients with nonalcoholic fatty liver disease
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic Foundation, OH 44195, USA
    J Clin Gastroenterol 43:985-9. 2009
    ..The aims of this study were to determine serum RBP4 levels in patients with biopsy proven NAFLD, and to correlate these levels with the metabolic profile and histologic features in this population...
  17. doi request reprint Analysis of breath volatile organic compounds in children with chronic liver disease compared to healthy controls
    Katharine Eng
    Department of Pediatric Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, USA
    J Breath Res 9:026002. 2015
    ..Further analysis of these compounds in external cohorts are needed to validate our findings...
  18. doi request reprint Health-related quality of life in children with autoimmune liver disease
    Reema Gulati
    Division of Pediatric Gastroenterology and Nutrition Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH Division of Pediatric Gastroenterology and Nutrition, UC San Diego, Rady Children s Hospital, San Diego, CA
    J Pediatr Gastroenterol Nutr 57:444-50. 2013
    ..The aim of this study was to determine HRQOL in children with AILD and the factors affecting it...
  19. pmc Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Expert Rev Gastroenterol Hepatol 3:445-51. 2009
    ....
  20. doi request reprint Hepatitis B immunity and response to booster vaccination in children with inflammatory bowel disease treated with infliximab
    Jonathan Moses
    Department of Pediatric Gastroenterology, Cleveland Clinic, Ohio, USA
    Am J Gastroenterol 107:133-8. 2012
    ..The objectives of this study were to determine HBV immunity in children with IBD on infliximab therapy and to determine response to a booster dose of the HBV vaccine in patients who were found to be non-immune...
  21. doi request reprint Relations of steatosis type, grade, and zonality to histological features in pediatric nonalcoholic fatty liver disease
    Christine Carter-Kent
    Department of Pathology, Cleveland Clinic, USA
    J Pediatr Gastroenterol Nutr 52:190-7. 2011
    ..The aims of the present study were to establish associations between steatosis amount, type, and distribution in a well-characterized group of children with biopsy-proven nonalcoholic fatty liver disease (NAFLD)...
  22. doi request reprint The evaluation of hepatic fibrosis scores in children with nonalcoholic fatty liver disease
    Sana Mansoor
    Department of Pediatric Gastroenterology and Hepatology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    Dig Dis Sci 60:1440-7. 2015
    ..The aim of our study was to evaluate some of these scores in assessing the presence of fibrosis in children with biopsy-proven NAFLD...
  23. doi request reprint Monitoring peripheral blood CD4+ adenosine triphosphate activity in recurrent hepatitis C and its correlation to fibrosis progression
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, USA
    Liver Transpl 16:155-62. 2010
    ..Post-OLT monitoring of CD4+ ATP activity may identify a subset of patients at greatest risk for early fibrosis progression...
  24. pmc Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis
    Naim Alkhouri
    Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 285:3428-38. 2010
    ..Inhibition of adipocyte apoptosis may be a new therapeutic strategy for the treatment of obesity-associated metabolic complications...
  25. doi request reprint Plasma Cytokeratin-18 Level As a Novel Biomarker for Liver Fibrosis in Children With Nonalcoholic Fatty Liver Disease
    Chetan Mandelia
    Pediatric Institute Department of Pediatric Gastroenterology Digestive Disease Institute Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    J Pediatr Gastroenterol Nutr 63:181-7. 2016
    ..The aim of the present study was to evaluate the use of plasma cytokeratin-18 (CK18) fragment levels, a marker of hepatocyte apoptosis, as a noninvasive biomarker in detecting liver fibrosis in pediatric NAFLD...
  26. pmc A Distinct Colon-Derived Breath Metabolome is Associated with Inflammatory Bowel Disease, but not its Complications
    Florian Rieder
    Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Clin Transl Gastroenterol 7:e201. 2016
    ..We analyzed volatile organic compounds (VOCs) in the breath of IBD patients and controls for diagnosis and differentiation of IBD as well as their link with disease location, activity, and phenotype...
  27. pmc The breathprints in patients with liver disease identify novel breath biomarkers in alcoholic hepatitis
    Ibrahim A Hanouneh
    Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio
    Clin Gastroenterol Hepatol 12:516-23. 2014
    ..We investigated whether concentrations of volatile compounds in breath samples correlate with the diagnosis of alcoholic hepatitis (AH) and the severity of liver disease in patients with AH...
  28. doi request reprint Autoimmune hepatitis in children--impact of cirrhosis at presentation on natural history and long-term outcome
    Kadakkal R Radhakrishnan
    Department of Pediatric Gastroenterology, Cleveland Clinic, 9500 Euclid Avenue, A 111, Cleveland, OH 44195, United States
    Dig Liver Dis 42:724-8. 2010
    ..The aims of this longitudinal cohort study were to determine the long-term prognosis of children with autoimmune hepatitis and to determine the effect of cirrhosis at presentation on survival...
  29. doi request reprint Portal Hypertension Complications Are Frequently the First Presentation of NAFLD in Patients Undergoing Liver Transplantation Evaluation
    Sajan Jiv Singh Nagpal
    Department of Gastroenterology and Hepatology and Digestive Disease Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    Dig Dis Sci 61:2102-7. 2016
    ....
  30. doi request reprint Liver Transplant in Young Adults with Chronic Hepatitis C Virus: An Argument for Hepatitis C Treatment in Childhood
    Bashar Mohamad
    From the Department of Gastroenterology and Hepatology and Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA
    Exp Clin Transplant 14:201-6. 2016
    ..We sought to assess the characteristics of hepatitis C virus-positive young adults who received a liver transplant and to evaluate posttransplant outcomes...
  31. doi request reprint Liver transplantation for nonalcoholic steatohepatitis in young patients
    Naim Alkhouri
    Department of Gastroenterology and Hepatology and Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA
    Transpl Int 29:418-24. 2016
    ..In conclusion, NASH can progress to end-stage liver disease requiring LT in childhood and early adulthood. A significant number of young patients transplanted for NASH cirrhosis required retransplantation. ..
  32. doi request reprint A non-invasive prediction model for non-alcoholic steatohepatitis in paediatric patients with non-alcoholic fatty liver disease
    Katharine Eng
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH, United States
    Dig Liver Dis 46:1008-13. 2014
    ..Non-alcoholic fatty liver disease encompasses a spectrum of diseases that range from simple steatosis to the aggressive form of non-alcoholic steatohepatitis. Non-alcoholic steatohepatitis is currently diagnosed through liver biopsy...
  33. doi request reprint Characterization of hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD) patients without cirrhosis
    Bashar Mohamad
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    Hepatol Int 10:632-9. 2016
    ..The present study was conducted to characterize patients with NAFLD presenting with HCC in non-cirrhotic liver (NCL) compared to the NAFLD- HCC patients in association with cirrhotic liver (CL)...
  34. doi request reprint The development of a non-invasive model to predict the presence of non-alcoholic steatohepatitis in patients with non-alcoholic fatty liver disease
    George Bb Goh
    Department of Gastroenterology, MetroHealth Medical Center, Cleveland, Ohio, USA
    J Gastroenterol Hepatol 31:995-1000. 2016
    ..Hyperferritinemia has increasingly been associated with the presence of NASH. Hence, we sought to explore the relationship between ferritin and NASH and to develop a composite model based on ferritin to predict the presence of NASH...
  35. doi request reprint Sofosbuvir and simeprevir without ribavirin effectively treat hepatitis C virus genotype 1 infection after liver transplantation in a two-center experience
    Whitney E Jackson
    Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, USA
    Clin Transplant 30:709-13. 2016
    ..However, there is scarcity of safety and efficacy data in this regimen after liver transplantation (LT)...
  36. pmc The Protein-Sparing Modified Fast Diet: An Effective and Safe Approach to Induce Rapid Weight Loss in Severely Obese Adolescents
    Marwan Bakhach
    Cleveland Clinic Foundation, Cleveland, OH, USA
    Glob Pediatr Health 3:2333794X15623245. 2016
    ..Although adult studies have shown the PSMF to be effective, data in adolescents are lacking. The aim of this study was to determine the efficacy and safety of the PSMF in severely obese adolescents...
  37. doi request reprint Reduced lysosomal acid lipase activity - A potential role in the pathogenesis of non alcoholic fatty liver disease in pediatric patients
    Praveen Kumar Conjeevaram Selvakumar
    Department of Pediatric Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, USA
    Dig Liver Dis 48:909-13. 2016
    ..This has not been studied in pediatric patients with NAFLD...
  38. doi request reprint A122: metabolomic analysis of breath volatile organic compounds reveals unique breathprints in children with juvenile idiopathic arthritis
    Andrew Zeft
    The Cleveland Clinic, Cleveland, OH
    Arthritis Rheumatol 66:S159. 2014
    ..The aim of this study was to analyze exhaled volatile organic compounds (VOCs) to evaluate for the presence of a unique breath pattern to differentiate pediatric patients with JIA from healthy controls...
  39. doi request reprint Serum bilirubin level is inversely associated with nonalcoholic steatohepatitis in children
    Kanika Puri
    Department of Pediatrics, SUNY Downstate, Brooklyn, NY, USA
    J Pediatr Gastroenterol Nutr 57:114-8. 2013
    ..We aimed to study the clinical correlation between bilirubin, a potent endogenous antioxidant with cytoprotective properties, and histopathological findings in pediatric patients with NAFLD...
  40. doi request reprint Survival outcomes scores (SOFT, BAR, and Pedi-SOFT) are accurate in predicting post-liver transplant survival in adolescents
    Praveen Kumar Conjeevaram Selvakumar
    Department of Pediatric Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, USA
    Pediatr Transplant 20:807-12. 2016
    ..81, 0.80, and 0.81, respectively. All three scores provided good accuracy for predicting 3-month survival post-LT in adolescents and may help clinical decision making to optimize survival rate and organ utilization. ..
  41. doi request reprint Sofosbuvir-based treatment is safe and effective in patients with chronic hepatitis C infection and end stage renal disease: a case series
    Tavankit Singh
    Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA
    Liver Int 36:802-6. 2016
    ..We report our experience on the safety and efficacy of sofosbuvir/simeprevir and sofosbuvir/ledipasvir therapy in patients on haemodialysis...
  42. ncbi request reprint Sofosbuvir/Ledipasvir without Ribavirin Achieved High Sustained Virologic Response for Hepatitis C Recurrence after Liver Transplantation: Two-Center Experience
    Mohamed Elfeki
    1 Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, United States 2 Hepato Pancreato Biliary and Transplant Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, United States 3 Department of Gastroenterology and Hepatology, Cleveland Clinic Florida, Weston, Florida 4 Department of Tropical Medicine and Hepatology, Mansoura University, Faculty of Medicine, Mansoura, Egypt
    Transplantation . 2016
    ..We aimed to assess the efficacy and safety of Sofosbuvir/Ledipasvir fixed-dose combination without RBV in patients with HCV recurrence post-transplant...
  43. doi request reprint Cardiovascular risk factors and cardiac disorders in long-term survivors of pediatric liver transplantation
    Shankar Baskar
    Department of Pediatrics, Cleveland Clinic, Cleveland, OH, USA
    Pediatr Transplant 19:48-55. 2015
    ..05). Echocardiography data were available for 23 patients, of whom 43.4% had LVH and 13% had evidence of PH. The spectrum of cardiac disorders in this population is much wider than in adults. ..
  44. pmc The development of the pediatric NAFLD fibrosis score (PNFS) to predict the presence of advanced fibrosis in children with nonalcoholic fatty liver disease
    Naim Alkhouri
    Department of Pediatric Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio, United States of America Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 9:e104558. 2014
    ..The aims of our study were to assess the utility of commonly used adult fibrosis scores in pediatric NAFLD and to develop a pediatric specific fibrosis score that can predict advanced fibrosis...
  45. doi request reprint Novel therapeutic targets for nonalcoholic fatty liver disease
    Akiko Eguchi
    Rady Children s Hospital, Department of Pediatric Gastroenterology, University of California San Diego, CA 92123, USA
    Expert Opin Ther Targets 17:773-9. 2013
    ..It is now estimated to affect 30% of adults and about 10% of children in the U.S. Hispanics are disproportionably affected with not only higher rates of NAFLD but also more severe disease. Treatment options are currently limited...
  46. doi request reprint Changes in body composition after transjugular intrahepatic portosystemic stent in cirrhosis: a critical review of literature
    Jaividhya Dasarathy
    Department of Family Medicine, MetroHealth Medical Center, Cleveland, OH 44195, USA
    Liver Int 31:1250-8. 2011
    ..The mechanism of these is unclear, but its clinical implication is that this may contribute to the improved survival after TIPS...
  47. doi request reprint Ileoscopy via stoma after diverting ileostomy: a safe and effective tool to evaluate for Crohn's recurrence of neoterminal ileum
    Narendra Vadlamudi
    Department of Pediatric Gastroenterology and Hepatology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Dig Dis Sci 56:866-70. 2011
    ..Retrograde ileoscopy via stoma is also a valuable tool for recognition of CD recurrence; however, this technique has not been formally studied...
  48. doi request reprint Similarities and differences between pediatric and adult nonalcoholic fatty liver disease
    Maricruz Crespo
    Department of Pediatric Gastroenterology, Rainbow Babies and Children s Hospital, Cleveland, OH, USA
    Metabolism 65:1161-71. 2016
    ..Recent advances in development of noninvasive diagnostic modalities and the potential for identifying effective pharmacological interventions may result in significant progress in the management of NAFLD in the pediatric population. ..
  49. doi request reprint Three-dimensional printing and pediatric liver disease
    Naim Alkhouri
    aDepartment of Pediatric Gastroenterology and Hepatology, Cleveland Clinic bDigestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Curr Opin Pediatr 28:626-30. 2016
    ..The purpose of the current review is to provide a concise summary of the role of three-dimensional printing technology as it relates to the field of pediatric hepatology and liver transplantation...
  50. doi request reprint Treating Nonalcoholic Steatohepatitis (NASH) in Children: Not a Cinch Task
    Naim Alkhouri
    Department of Pediatric Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, USA
    Hepatology . 2017
    ..We performed a randomized controlled trial to determine whether 52 weeks of cysteamine bitartrate delayed release (CBDR) reduces the severity of liver disease in children with NAFLD...
  51. doi request reprint A guide to managing acute liver failure
    Tavankit Singh
    Department of Internal Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA
    Cleve Clin J Med 83:453-62. 2016
    ..This article reviews the definition, epidemiology, etiology, and management of acute liver failure. ..
  52. pmc Noninvasive diagnosis of nonalcoholic fatty liver disease: Are we there yet?
    Naim Alkhouri
    Department of Pediatric Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, USA Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA
    Metabolism 65:1087-95. 2016
    ..These tests can be divided into those that predict the presence of NASH and those that predict the presence of fibrosis. In this review, we provide a concise overview of different noninvasive methods for staging the severity of NAFLD. ..
  53. pmc Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury
    Sanjoy Roychowdhury
    Department of Pathobiology, Cleveland Clinic, Cleveland, OH
    Hepatology 64:1518-1533. 2016
    ..Culture of AML12 hepatocytes with palmitic acid increased cytotoxicity through apoptosis and necrosis. Inhibition of RIP1 with necrostatin-1 or small interfering RNA knockdown of RIP3 reduced palmitic acid-induced cytotoxicity...
  54. doi request reprint A comprehensive review of noninvasive liver fibrosis tests in pediatric nonalcoholic Fatty liver disease
    Sana Mansoor
    Cleveland Clinic Children s Hospital, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    Curr Gastroenterol Rep 17:23. 2015
    ..Radiologic imaging studies estimate liver stiffness as a surrogate for liver fibrosis; these include transient elastography (TE), magnetic resonance elastography (MRE), and acoustic radiation force impulse imaging (ARFI). ..
  55. pmc Plant-based, no-added-fat or American Heart Association diets: impact on cardiovascular risk in obese children with hypercholesterolemia and their parents
    Michael Macknin
    Department of General Pediatrics, Cleveland Clinic Children s, Cleveland, OH
    J Pediatr 166:953-9.e1-3. 2015
    ..To perform a randomized trial to determine whether there is cardiovascular disease (CVD) risk reduction from a plant-based (PB), no-added-fat diet and the American Heart Association (AHA) diet in children...
  56. doi request reprint Short bowel syndrome in children: current and potential therapies
    Victor Uko
    Department of Pediatric Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA
    Paediatr Drugs 14:179-88. 2012
    ..Intestinal transplantation is a last resort option when the process of adaptation is unsuccessful. This review article is intended to provide an overview of the conventional and emerging therapies for pediatric SBS...
  57. doi request reprint Chronic constipation due to delayed diagnosis of a congenital anal web
    Neilendu Kundu
    Department of General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA
    J Gastrointest Surg 16:1429-32. 2012
    ..To our best knowledge, this is the first report of an anal web in a patient with Down's syndrome presenting with severe chronic constipation...
  58. doi request reprint Protease inhibitors: silver bullets for chronic hepatitis C infection?
    Naim Alkhouri
    Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA
    Cleve Clin J Med 79:213-22. 2012
    ..These drugs open the door for triple therapy and other new therapies involving combinations of other direct-acting antiviral agents to become the new standard of care for this population...