Keiko Omori

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. ncbi request reprint Improvement of human islet cryopreservation by a p38 MAPK inhibitor
    K Omori
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center Beckman Research Institute, Duarte, CA, USA
    Am J Transplant 7:1224-32. 2007
  2. doi request reprint Mechanisms of islet damage mediated by pancreas cold ischemia/rewarming
    Keiko Omori
    Division of Developmental and Translational Diabetes and Endocrinology Research, Department of Diabetes and Metabolic Researches, Beckman Research Institute of City of Hope, 1500 East Duarte Rd, Duarte, CA 91010, USA Electronic address
    Cryobiology 73:126-34. 2016
  3. pmc Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming
    Keiko Omori
    Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute of the City of Hope, Duarte, California
    Am J Physiol Endocrinol Metab 310:E1016-26. 2016
  4. ncbi request reprint Pharmacological strategies for protection of extrahepatic islet transplantation
    K Omori
    Division of Developmental and Translational, Research and Cellular Therapeutics, City of Hope, Diabetes and Metabolism Research Institute, Duarte, CA, USA
    Minerva Endocrinol 40:85-103. 2015
  5. pmc Microassay for glucose-induced preproinsulin mRNA expression to assess islet functional potency for islet transplantation
    Keiko Omori
    Department of Diabetes, Endocrinology and Metabolism, Southern California Islet Cell Resources Center, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Transplantation 89:146-54. 2010
  6. doi request reprint mRNA of the pro-apoptotic gene BBC3 serves as a molecular marker for TNF-α-induced islet damage in humans
    K Omori
    Beckman Research Institute of the City of Hope, 1500 East Duarte Rd, Duarte, CA 91010, USA
    Diabetologia 54:2056-66. 2011
  7. pmc P38alpha-selective mitogen-activated protein kinase inhibitor for improvement of cultured human islet recovery
    Keiko Omori
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Pancreas 39:436-43. 2010
  8. pmc Improvement of canine islet yield by donor pancreas infusion with a p38MAPK inhibitor
    Taihei Ito
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Transplantation 86:321-9. 2008
  9. pmc Maintaining functional islets through encapsulation in an injectable saccharide-peptide hydrogel
    Sophia W Liao
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute of the City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA
    Biomaterials 34:3984-91. 2013
  10. doi request reprint Human Pancreatic Islets Isolated From Donors With Elevated HbA1c Levels: Islet Yield and Graft Efficacy
    Meirigeng Qi
    Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute of the City of Hope, Duarte, CA, USA
    Cell Transplant 24:1879-86. 2015

Collaborators

  • Y Mullen
  • Masafumi Takahashi
  • Eiji Kobayashi
  • H Komatsu
  • Masato Mitsuhashi
  • Satyanarayana Medicherla
  • C Orr
  • Kohei Ishiyama
  • Keh Dong Shiang
  • Fouad Kandeel
  • Meirigeng Qi
  • Ivan Todorov
  • Jeffrey Rawson
  • Indu Nair
  • Luis Valiente
  • Ismail H Al-Abdullah
  • Kevin Ferreri
  • Taihei Ito
  • Jemily Juan
  • Shiela Bilbao
  • Brian McFadden
  • Donald Dafoe
  • Stephen Scott
  • Alina R Oancea
  • Zhanhong Wu
  • Sophia W Liao
  • Takeru Matsuda
  • Craig V Smith
  • Michael Pascual
  • Tommy Vuong
  • Bernard R Tegtmeier
  • Valiente Luis
  • Mohamed Ei-Shahawy
  • Mohamed El-Shahawy
  • John E Shively
  • Zibo Li
  • Shuanglong Liu
  • Peter S Conti
  • Davoud Mozhdehi
  • Zhibin Guan
  • Itzia Iglesias-Meza
  • Alina Avakian-Mansoorian
  • Akio Kuroda
  • Sadaki Asari
  • Jonathan Shintaku
  • Shin Itakura
  • Jeffery Rawson
  • Yoshikazu Kuroda

Detail Information

Publications18

  1. ncbi request reprint Improvement of human islet cryopreservation by a p38 MAPK inhibitor
    K Omori
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center Beckman Research Institute, Duarte, CA, USA
    Am J Transplant 7:1224-32. 2007
    ..This improvement may provide an opportunity to establish islet banks and allow the use of cryopreserved islets for clinical transplantation...
  2. doi request reprint Mechanisms of islet damage mediated by pancreas cold ischemia/rewarming
    Keiko Omori
    Division of Developmental and Translational Diabetes and Endocrinology Research, Department of Diabetes and Metabolic Researches, Beckman Research Institute of City of Hope, 1500 East Duarte Rd, Duarte, CA 91010, USA Electronic address
    Cryobiology 73:126-34. 2016
    ..Our study indicates the involvement of both apoptosis and necrosis in islet death, and suggests oxidative stress and disruption of membranes are critical mechanisms mediated by pancreas cold ischemia/rewarming. ..
  3. pmc Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming
    Keiko Omori
    Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute of the City of Hope, Duarte, California
    Am J Physiol Endocrinol Metab 310:E1016-26. 2016
    ..These results demonstrated the involvement of BBC3/Bbc3 in cold preservation/rewarming-mediated islet injury, possibly through modulating HMGB1- and oxidative stress-mediated injury to islets. ..
  4. ncbi request reprint Pharmacological strategies for protection of extrahepatic islet transplantation
    K Omori
    Division of Developmental and Translational, Research and Cellular Therapeutics, City of Hope, Diabetes and Metabolism Research Institute, Duarte, CA, USA
    Minerva Endocrinol 40:85-103. 2015
    ..Furthermore, the development of methods designed to release these agents over an extended period, will further increase their efficacy. This requires the combined efforts of both islet transplant biologists and bioengineers. ..
  5. pmc Microassay for glucose-induced preproinsulin mRNA expression to assess islet functional potency for islet transplantation
    Keiko Omori
    Department of Diabetes, Endocrinology and Metabolism, Southern California Islet Cell Resources Center, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Transplantation 89:146-54. 2010
    ..We developed a microassay that evaluates the potency of human islets by measuring changes in glucose-induced human insulin gene (INS) expression using a single islet in octuplicate samples...
  6. doi request reprint mRNA of the pro-apoptotic gene BBC3 serves as a molecular marker for TNF-α-induced islet damage in humans
    K Omori
    Beckman Research Institute of the City of Hope, 1500 East Duarte Rd, Duarte, CA 91010, USA
    Diabetologia 54:2056-66. 2011
    ..In light of this, we examined the involvement of a pro-apoptotic gene, BBC3 (also known as PUMA), in TNF-α-mediated beta cell dysfunction and destruction in human islets...
  7. pmc P38alpha-selective mitogen-activated protein kinase inhibitor for improvement of cultured human islet recovery
    Keiko Omori
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Pancreas 39:436-43. 2010
    ..We investigated whether the recovery of cultured human islets is improved through the addition of a p38alpha-selective mitogen-activated protein kinase inhibitor, SD-282, to clinically used serum-free culture medium...
  8. pmc Improvement of canine islet yield by donor pancreas infusion with a p38MAPK inhibitor
    Taihei Ito
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Transplantation 86:321-9. 2008
    ..This damage may be prevented by treating pancreata with a p38MAPK inhibitor (p38IH) before cold preservation...
  9. pmc Maintaining functional islets through encapsulation in an injectable saccharide-peptide hydrogel
    Sophia W Liao
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute of the City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA
    Biomaterials 34:3984-91. 2013
    ....
  10. doi request reprint Human Pancreatic Islets Isolated From Donors With Elevated HbA1c Levels: Islet Yield and Graft Efficacy
    Meirigeng Qi
    Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute of the City of Hope, Duarte, CA, USA
    Cell Transplant 24:1879-86. 2015
    ..013) and islet particle number (IPN)/g (prepurification, 2,519 ± 336 vs. 4,433 ± 143, p = 0.001; postpurification, 1,760 ± 229 vs. 2,715 ± 85, p = 0.007). Islets from T2D pancreata had significantly lower viability (T2D vs...
  11. pmc Quantitative assessment of β-cell apoptosis and cell composition of isolated, undisrupted human islets by laser scanning cytometry
    Ivan Todorov
    Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute of the City of Hope, Duarte, CA, USA
    Transplantation 90:836-42. 2010
    ..We have developed fluorescence-based assays using laser scanning cytometry for assessing β-cell apoptosis and islet cell composition on serial sections of intact isolated islets...
  12. ncbi request reprint Generation of human islets through expansion and differentiation of non-islet pancreatic cells discarded (pancreatic discard) after islet isolation
    Ivan Todorov
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center Beckman Research Institute, Duarte, CA 91010, USA
    Pancreas 32:130-8. 2006
    ..Islet transplantation is hampered by the shortage of donor tissues. Our objective was to generate islet-like cell clusters (ICCs) from cultures of non-islet pancreatic cells...
  13. pmc Prophylactically Decontaminating Human Islet Product for Safe Clinical Application: Effective and Potent Method
    Meirigeng Qi
    Department of Translational Research and Cellular Therapeutics, Diabetes and Metabolism Research Institute, Beckman Research Institute of City of Hope
    Transplant Direct 2:e63. 2016
    ..Islet quality and quantity are important, however, the final product must also be free from microbial contamination and low endotoxin levels...
  14. ncbi request reprint Inhibition of p38 pathway suppresses human islet production of pro-inflammatory cytokines and improves islet graft function
    Takeru Matsuda
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology and Metabolism, City of Hope National Medical Center Beckman Research Institute, Duarte, CA, USA
    Am J Transplant 5:484-93. 2005
    ..These results suggest that inhibition of the p38 pathway may become a new therapeutic strategy to improve graft survival in clinical islet transplantation...
  15. doi request reprint Isolated human islets require hyperoxia to maintain islet mass, metabolism, and function
    Hirotake Komatsu
    Division of Developmental and Translational Diabetes and Endocrinology Research, Department of Diabetes and Metabolic Researches, Beckman Research Institute of City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA Electronic address
    Biochem Biophys Res Commun 470:534-8. 2016
    ..We predict that maintaining pre- and post-transplanted islets in a hyperoxic environment will alleviate islet volume loss and maintain islet quality thereby improving transplant outcomes. ..
  16. doi request reprint Liver natural killer cells play a role in the destruction of islets after intraportal transplantation
    Kohei Ishiyama
    Department of Diabetes, Endocrinology and Metabolism, Southern California Islet Cell Resource Center, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Transplantation 91:952-60. 2011
    ..We hypothesize that natural killer (NK) cells in the liver play a role in the islet graft destruction...
  17. doi request reprint Sodium levels of human pancreatic donors are a critical factor for determination of islet efficacy and survival
    Meirigeng Qi
    Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute of the City of Hope, Duarte, California
    Am J Physiol Endocrinol Metab 308:E362-9. 2015
    ..022 and 0.042, respectively). In conclusion, duration of donor hypernatremia is associated with reduced islet recovery postculture. The efficacy of islets from hypernatremia donors diminished when transplanted into diabetic recipients...
  18. pmc (64)Cu labeled sarcophagine exendin-4 for microPET imaging of glucagon like peptide-1 receptor expression
    Zhanhong Wu
    1 Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Theranostics 4:770-7. 2014
    ..Dimerization of exendin-4 could successfully lead to increased tumor uptake in vivo. Both (64)Cu-BaMalSar-exendin-4 and (64)Cu-Mal2Sar-(exendin-4)2 hold a great potential for GLP-1R targeted imaging...