Julio Garcia-Aguilar

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. doi Multicentric study on robotic tumor-specific mesorectal excision for the treatment of rectal cancer
    Alessio Pigazzi
    Division of General and Oncologic Surgery, City of Hope National Medical Center, Duarte, CA, USA
    Ann Surg Oncol 17:1614-20. 2010
  2. pmc Identification of a biomarker profile associated with resistance to neoadjuvant chemoradiation therapy in rectal cancer
    Julio Garcia-Aguilar
    Department of Surgery, City of Hope, Duarte, CA 91010, USA
    Ann Surg 254:486-92; discussion 492-3. 2011
  3. pmc Optimal timing of surgery after chemoradiation for advanced rectal cancer: preliminary results of a multicenter, nonrandomized phase II prospective trial
    Julio Garcia-Aguilar
    Department of Surgery, City of Hope, Duarte, CA 91010, USA
    Ann Surg 254:97-102. 2011
  4. doi Optimal management of small rectal cancers: TAE, TEM, or TME?
    Julio Garcia-Aguilar
    Department of Surgery, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
    Surg Oncol Clin N Am 19:743-60. 2010
  5. doi Evaluation of lymphadenectomy in patients receiving neoadjuvant radiotherapy for rectal adenocarcinoma
    Maithao Le
    Department of Surgery, City of Hope Comprehensive Cancer Center, Duarte, CA, USA
    Ann Surg Oncol 19:3713-8. 2012
  6. pmc Gene polymorphisms predict toxicity to neoadjuvant therapy in patients with rectal cancer
    Marjun P Duldulao
    Department of Surgery, City of Hope, Duarte, CA, USA
    Cancer 119:1106-12. 2013
  7. doi Racial and ethnic disparities in outcomes with radiation therapy for rectal adenocarcinoma
    Wendy Lee
    Department of Surgery, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Int J Colorectal Dis 27:737-49. 2012
  8. ncbi A pathologic complete response to preoperative chemoradiation is associated with lower local recurrence and improved survival in rectal cancer patients treated by mesorectal excision
    Julio Garcia-Aguilar
    Division of Colon and Rectal Surgery, Department of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA
    Dis Colon Rectum 46:298-304. 2003
  9. pmc Locoregional lymphadenectomy in the surgical management of anorectal melanoma
    Daniel R Perez
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 20:2339-44. 2013
  10. pmc Distribution of residual cancer cells in the bowel wall after neoadjuvant chemoradiation in patients with rectal cancer
    Marjun P Duldulao
    Department of General Oncologic Surgery, City of Hope Comprehensive Cancer Center, Duarte, California, USA
    Dis Colon Rectum 56:142-9. 2013

Research Grants

  1. Timing of Rectal Cancer Response to Chemoradiation
    Julio Garcia Aguilar; Fiscal Year: 2009

Detail Information

Publications56

  1. doi Multicentric study on robotic tumor-specific mesorectal excision for the treatment of rectal cancer
    Alessio Pigazzi
    Division of General and Oncologic Surgery, City of Hope National Medical Center, Duarte, CA, USA
    Ann Surg Oncol 17:1614-20. 2010
    ..The aim of the study was to verify on a multicentric basis the perioperative and oncologic outcome of RTSRS...
  2. pmc Identification of a biomarker profile associated with resistance to neoadjuvant chemoradiation therapy in rectal cancer
    Julio Garcia-Aguilar
    Department of Surgery, City of Hope, Duarte, CA 91010, USA
    Ann Surg 254:486-92; discussion 492-3. 2011
    ..To identify a biomarker profile associated with tumor response to chemoradiation (CRT) in locally advanced rectal cancer...
  3. pmc Optimal timing of surgery after chemoradiation for advanced rectal cancer: preliminary results of a multicenter, nonrandomized phase II prospective trial
    Julio Garcia-Aguilar
    Department of Surgery, City of Hope, Duarte, CA 91010, USA
    Ann Surg 254:97-102. 2011
    ....
  4. doi Optimal management of small rectal cancers: TAE, TEM, or TME?
    Julio Garcia-Aguilar
    Department of Surgery, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
    Surg Oncol Clin N Am 19:743-60. 2010
    ..With LE, patients trade a higher cancer cure rate for a lower risk of mortality and lower morbidity. The role of chemoradiation and LE in the treatment of rectal cancer is still under study...
  5. doi Evaluation of lymphadenectomy in patients receiving neoadjuvant radiotherapy for rectal adenocarcinoma
    Maithao Le
    Department of Surgery, City of Hope Comprehensive Cancer Center, Duarte, CA, USA
    Ann Surg Oncol 19:3713-8. 2012
    ..Because the exact number of examined lymph nodes (LNs) may vary with preoperative therapies, our objective was to measure the impact of neoadjuvant radiation on LN number for rectal adenocarcinoma...
  6. pmc Gene polymorphisms predict toxicity to neoadjuvant therapy in patients with rectal cancer
    Marjun P Duldulao
    Department of Surgery, City of Hope, Duarte, CA, USA
    Cancer 119:1106-12. 2013
    ..The objective of this study was to determine whether specific polymorphisms in genes associated with rectal cancer response to NT were correlated with NT-related toxicity...
  7. doi Racial and ethnic disparities in outcomes with radiation therapy for rectal adenocarcinoma
    Wendy Lee
    Department of Surgery, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Int J Colorectal Dis 27:737-49. 2012
    ..Our objective was to determine whether disparate rectal cancer outcomes result from variable efficacy of radiation therapy for major racial/ethnic groups...
  8. ncbi A pathologic complete response to preoperative chemoradiation is associated with lower local recurrence and improved survival in rectal cancer patients treated by mesorectal excision
    Julio Garcia-Aguilar
    Division of Colon and Rectal Surgery, Department of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA
    Dis Colon Rectum 46:298-304. 2003
    ..We studied the prognostic value of pathologic complete response to preoperative chemoradiation in rectal cancer patients...
  9. pmc Locoregional lymphadenectomy in the surgical management of anorectal melanoma
    Daniel R Perez
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 20:2339-44. 2013
    ..Understanding the significance of lymphatic dissemination might assist in stratifying patients for either organ preservation or radical surgery...
  10. pmc Distribution of residual cancer cells in the bowel wall after neoadjuvant chemoradiation in patients with rectal cancer
    Marjun P Duldulao
    Department of General Oncologic Surgery, City of Hope Comprehensive Cancer Center, Duarte, California, USA
    Dis Colon Rectum 56:142-9. 2013
    ..However, these staging systems do not provide information about the distribution of residual cancer cells within the bowel wall...
  11. doi An interaction of race and ethnicity with socioeconomic status in rectal cancer outcomes
    Joseph Kim
    Division of Oncologic Surgery, Department of Surgery, City of Hope, Duarte, CA 91010, USA
    Ann Surg 253:647-54. 2011
    ..Because appropriate rectal cancer care and subsequent outcomes can be influenced by several variables, our objective was to investigate how race, ethnicity, and socioeconomic status (SES) may impact rectal cancer outcomes...
  12. doi Mutations in specific codons of the KRAS oncogene are associated with variable resistance to neoadjuvant chemoradiation therapy in patients with rectal adenocarcinoma
    Marjun P Duldulao
    Department of Surgery, City of Hope, Duarte, CA, USA
    Ann Surg Oncol 20:2166-71. 2013
    ..Our objective was to establish a correlation between specific KRAS mutations and rectal cancer response to CRT and to investigate if the correlation was related to a different association between KRAS and TP53 mutations...
  13. doi A phase II trial of neoadjuvant chemoradiation and local excision for T2N0 rectal cancer: preliminary results of the ACOSOG Z6041 trial
    Julio Garcia-Aguilar
    Department of Surgery, City of Hope, Duarte, USA
    Ann Surg Oncol 19:384-91. 2012
    ..Here, we report tumor response, CRT-related toxicity, and perioperative complications (PCs)...
  14. doi Race and correlations between lymph node number and survival for patients with gastric cancer
    Rebecca Nelson
    Departments of Biostatistics RN and Surgery EBK, AA, WL, JK, JK, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
    J Gastrointest Surg 17:471-81. 2013
    ..We previously observed that Korean-American patients had the highest overall survival in Los Angeles County. Our objective was to assess lymph node (LN) number and its impact on survival for Korean-American gastric cancer patients...
  15. ncbi Endorectal ultrasound in the management of patients with malignant rectal polyps
    Julio Garcia-Aguilar
    Department of Surgery, University of California, San Francisco, California, USA
    Dis Colon Rectum 48:910-6; discussion 916-7. 2005
    ..This study was designed to determine the efficacy of endorectal ultrasound in the management of patients with malignant rectal polyps removed by snare excision during colonoscopy...
  16. doi Socioeconomic factors impact colon cancer outcomes in diverse patient populations
    Wendy Lee
    Department of Oncologic Surgery, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    J Gastrointest Surg 16:692-704. 2012
    ..Cancer disparities among racial and ethnic groups are major public health concerns. Our objective was to examine the impact of socioeconomic status (SES) on survival of colon cancer patients within major racial and ethnic groups...
  17. ncbi Surgical complications and pathologic complete response after neoadjuvant chemoradiation in locally advanced rectal cancer
    Marjun P Duldulao
    Department of Surgery, City of Hope Medical Center, Duarte, California 91010, USA
    Am Surg 77:1281-5. 2011
    ..In conclusion, postoperative complication rates do not differ between pCR and non-pCR groups. The occurrence of major postoperative complications is not associated with response to neoadjuvant CRT...
  18. doi Validation of the risk index category as a predictor of surgical site infection in elective colorectal surgery
    Carlos Pastor
    Department of Surgery, City of Hope National Medical Center, Duarte, California, USA
    Dis Colon Rectum 53:721-7. 2010
    ..This study aims to validate the risk index category as a predictor of surgical site infection in a cohort of patients who underwent colorectal operations and were prospectively surveyed for surgical site infection...
  19. pmc Gene expression variations in microsatellite stable and unstable colon cancer cells
    Marjun P Duldulao
    Department of Surgery, City of Hope Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    J Surg Res 174:1-6. 2012
    ..We used ultra high-throughput sequencing (UHTS) to assess the expression of representative genes in MSI and MSS colon cancer cell lines...
  20. pmc Chromosomal copy number alterations are associated with persistent lymph node metastasis after chemoradiation in locally advanced rectal cancer
    Zhenbin Chen
    Department of Surgery, City of Hope, Duarte, California 91010, USA
    Dis Colon Rectum 55:677-85. 2012
    ..Lymph node metastasis is an important indicator of oncologic outcome for patients with rectal cancer. Identifying predictive biomarkers of lymph node metastasis could therefore be clinically useful...
  21. pmc Molecular diagnosis of response to neoadjuvant chemoradiation therapy in patients with locally advanced rectal cancer
    Zhenbin Chen
    Department of Surgery, City of Hope, Duarte, CA, USA
    J Am Coll Surg 212:1008-1017.e1. 2011
    ..However, it is uncertain if histopathological techniques accurately detect pCR. We tested a novel molecular approach for detecting pCR and compared it with current histopathological approaches...
  22. pmc Chromosomal copy number alterations are associated with tumor response to chemoradiation in locally advanced rectal cancer
    Zhenbin Chen
    Department of Surgery, City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA
    Genes Chromosomes Cancer 50:689-99. 2011
    ..Our data indicate that chromosomal CNAs can help identify rectal cancer patients more likely to develop a pCR to CRT...
  23. pmc TP53 and let-7a micro-RNA regulate K-Ras activity in HCT116 colorectal cancer cells
    Carrie Luu
    Division of Surgical Oncology, Department of Surgery, City of Hope Comprehensive Cancer Center, Duarte, California, USA
    PLoS ONE 8:e70604. 2013
    ..In summary, our results show a complex regulatory system involving TP53, KRAS, and let-7a. Our results may provide clues to understand and target these interactions in colorectal cancer. ..
  24. doi Robot-assisted total mesorectal excision: is there a learning curve?
    Yasir Akmal
    Department of General and Oncologic Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Surg Endosc 26:2471-6. 2012
    ..Laparoscopic total mesorectal excision (TME) is associated with a steep learning curve, but the learning curve for robotic TME is unknown. This study aimed to evaluate the learning curve for robotic TME...
  25. doi Adjuvant chemotherapy improves survival in patients with American Joint Committee on Cancer stage II colon cancer
    Shaun McKenzie
    Department of Surgery, University of Kentucky School of Medicine, Lexington, Kentucky, USA
    Cancer 117:5493-9. 2011
    ..It is unclear whether the administration of adjuvant chemotherapy improves survival in patients with American Joint Committee on Cancer (AJCC) stage II colon cancer...
  26. doi Local excision for rectal carcinoma
    Edward Kim
    Department of Surgery, University of California, San Francisco, CA, USA
    Clin Colorectal Cancer 7:376-85. 2008
    ..An overview of local excision in the context of perioperative adjuvant therapies is included. Finally, we suggest a treatment algorithm for local excision in rectal cancer...
  27. ncbi The effect of circumferential tumor location in clinical outcomes of rectal cancer patients treated with total mesorectal excision
    Suk Hawn Lee
    Division of Colon and Rectal Surgery, Department of Surgery, University of Minnesota Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    Dis Colon Rectum 48:2249-57. 2005
    ..We sought to determine the effect of the tumor's position in the circumference of the rectum on the treatment and outcomes of rectal cancer patients treated by total mesorectal excision...
  28. ncbi Accuracy of computed tomography in staging colon cancer patients
    Christopher Ryan Oxner
    City of Hope, Duarte, CA City of Hope National Medical Center, Duarte, CA University of California, Irvine, Irvine, CA
    J Clin Oncol 30:614. 2012
    ..Since clinical staging to determine eligibility requires accurate preoperative imaging, our objective was to determine whether computed tomography (CT) scans can be used to detect nodal disease in colon cancer patients...
  29. ncbi Use of KRAS codon 13 mutations to predict response to neoadjuvant chemoradiation therapy in patients with rectal adenocarcinoma
    Marjun Philip Duldulao
    City of Hope National Medical Center, Duarte, CA City of Hope, Duarte, CA
    J Clin Oncol 30:453. 2012
    ..Our objectives were to determine the incidence of KRAS mutations in patients with rectal cancer and identify potential correlations with response to CRT...
  30. pmc Neoadjuvant radiation therapy prior to total mesorectal excision for rectal cancer is not associated with postoperative complications using current techniques
    Sarah A Milgrom
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 21:2295-302. 2014
    ..This study aims to quantify 30-day complication rates after total mesorectal excision (TME) using current techniques and to assess for an association of these complications with neoadjuvant RT...
  31. doi Elderly patients with colon cancer have unique tumor characteristics and poor survival
    Supriya S Patel
    Department of Surgery, University of Southern California, Los Angeles, California, USA
    Cancer 119:739-47. 2013
    ..The objective of this study was to determine the effects of increasing age on colon cancer...
  32. ncbi An appraisal of radiofrequency ablation and surgical resection for hepatocellular carcinoma: results from the surveillance, epidemiology, and end results registry
    Maithao Le
    Division of Surgical Oncology, Department of Surgery, City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA
    Am Surg 78:1091-5. 2012
    ....
  33. doi An increase in compliance with the Surgical Care Improvement Project measures does not prevent surgical site infection in colorectal surgery
    Carlos Pastor
    Department of Surgery, City of Hope National Medical Center, Duarte, California 91010, USA
    Dis Colon Rectum 53:24-30. 2010
    ..This study was designed to test the hypothesis that an increase in compliance with quality process measures decreases the rate of surgical site infections in patients undergoing colorectal surgeries...
  34. ncbi Using deep sequencing of formalin-fixed paraffin embedded (FFPE) rectal cancer biopsy tissue to analyze miRNA expression in patients with rectal cancer
    Zhenbin Chen
    City of Hope, Duarte, CA City of Hope Cancer Center Beckman Research Institute, Duarte, CA
    J Clin Oncol 30:487. 2012
    ..Our objective was to generate a miRNA expression profile in locally advanced rectal cancer using formalin fixed paraffin embedded (FFPE) biopsy tissue collected from patients with locally advanced rectal cancer...
  35. ncbi Genetic polymorphisms by race/ethnicity among colon cancer patients in Los Angeles County
    Wendy Lee
    City of Hope, Duarte, CA City of Hope National Medical Center, Duarte, CA
    J Clin Oncol 30:492. 2012
    ..Here, we evaluate the variability of genetic alterations in colon cancer patients by examining SNPs in major racial/ethnic groups...
  36. ncbi Developing a robotic colorectal cancer surgery program: understanding institutional and individual learning curves
    Hamza Guend
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA
    Surg Endosc . 2016
    ..Robotic colorectal resection continues to gain in popularity. However, limited data are available regarding how surgeons gain competency and institutions develop programs...
  37. pmc What is the significance of the circumferential margin in locally advanced rectal cancer after neoadjuvant chemoradiotherapy?
    Atthaphorn Trakarnsanga
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 20:1179-84. 2013
    ..However, its significance in the setting of long-course neoadjuvant chemoradiotherapy (nCRT) is not well defined...
  38. ncbi Endorectal ultrasound in the follow-up of rectal cancer patients treated by local excision or radical surgery
    Enrique Hernandez de Anda
    Department of Surgery, University of Minnesota Medical School and University of Minnesota Cancer Center, Minneapolis, Minnesota, USA
    Dis Colon Rectum 47:818-24. 2004
    ..This study was designed to investigate the role of a scheduled follow-up protocol using endorectal ultrasonography for the diagnosis of local recurrence after local excision and radical surgery for rectal cancer...
  39. ncbi Surgical treatment of rectal cancer: local resection
    Silvana Perretta
    Department of Surgery, Section of Colon and Rectal Surgery, University of San Francisco, 2330 Post Street, Suite 260, San Francisco, CA 94143 0144, USA
    Surg Oncol Clin N Am 15:67-93. 2006
    ..Local treatment can also be used for palliation of patients with histological unfavorable or advanced tumors, and those who are medically unfit for radical surgery...
  40. ncbi The influence of surgical oncology fellowship programs in training hepatopancreatobiliary surgeons
    Rebecca Lynn Wiatrek
    City of Hope National Medical Center, Duarte, CA City of Hope Comprehensive Cancer Center, Duarte, CA University of Texas Houston Medical School, Houston, TX
    J Clin Oncol 30:358. 2012
    ..Our objective was to assess the clinical practices of recent surgical oncology fellowship graduates to determine their contribution in caring for this patient population...
  41. ncbi Paradoxical cross-talk between the Stat3 and MAPK pathways in CCL25-CCR9 mediated pancreatic cancer growth and proliferation
    Maithao N Le
    City of Hope, Duarte, CA City of Hope National Medical Center, Duarte, CA
    J Clin Oncol 30:231. 2012
    ..Our objective was to investigate the relationship between the CCL25-CCR9 axis and Stat3 signaling in pancreatic cancer cells...
  42. ncbi Predictors of primary and distant site surgery in patients with stage IV colorectal cancer
    Lori Uyeno
    City of Hope, Duarte, CA City of Hope National Medical Center, Duarte, CA
    J Clin Oncol 30:499. 2012
    ..The purpose of our study was to describe the patterns of surgery in stage IV colorectal cancer patients in a US population-based cohort and explore patient and tumor characteristics associated with treatment selection and survival...
  43. pmc Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal
    Li Du
    Department of Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    Nat Commun 7:12326. 2016
    ..In summary, our findings suggest that SUMOylation could be a target to inhibit CSCs and ultimately to reduce treatment resistance, tumour metastasis and relapse. ..
  44. ncbi The evolution of surgical technique for total gastrectomy over a 12-year period: a single institution's experience
    Amanda K Arrington
    Department of Oncologic Surgery, City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA
    Am Surg 78:1054-8. 2012
    ..After initiation of a laparoscopic total gastrectomy program in 2009, the majority of cases in our institution are now performed by laparoscopic techniques...
  45. pmc Prognostic and predictive roles of KRAS mutation in colorectal cancer
    Amanda K Arrington
    Division of Surgical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
    Int J Mol Sci 13:12153-68. 2012
    ..In this review we examine the history of KRAS, its prognostic value in patients with colorectal cancer, and evidence supporting its predictive value in determining appropriate therapies for patients with colorectal cancer...
  46. doi Totally laparoscopic right colectomy with transvaginal specimen extraction: the authors' initial institutional experience
    Shaun McKenzie
    Department of General and Oncologic Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010 3000, USA
    Surg Endosc 24:2048-52. 2010
    ..The authors present their technique and short-term outcomes for totally laparoscopic right colectomy with transvaginal specimen extraction in a series of four patients...
  47. ncbi Selection criteria for complete cytoreduction after cytoreductive surgery for peritoneal surface malignancy: lessons learned from our first series of patients
    Shaun McKenzie
    Departments of General Oncologic Surgery, City of Hope National Medical Center, Duarte, California 91010 3000, USA
    Am Surg 77:430-7. 2011
    ..Early evaluation of the small bowel, mesentery, and periportal region for resectability prevents unnecessary surgery...
  48. ncbi Dartos muscle interposition flap for the treatment of rectourethral fistulas
    Madhulika G Varma
    Department of Surgery, Section of Colon and Rectal Surgery, University of California San Francisco, 2330 Post Street, Suite 260, Box 0144, San Francisco, California 94143 0144, USA
    Dis Colon Rectum 50:1849-55. 2007
    ..The many techniques for repairing these fistulas vary in their success rates. Our goal was to describe the use of a dartos muscle interposition flap for repair of these fistulas...
  49. ncbi Evidence of a preferred molecular pathway in patients with synchronous colorectal cancer
    Sharon L Dykes
    Department of Surgery, University of Minnesota Cancer Center, Minneapolis, Minnesota, USA
    Cancer 98:48-54. 2003
    ..In addition, the authors examined MLH1 and MSH2 expression and MLH1 promoter methylation in SCRCs...
  50. doi The association of hospital volume with rectal cancer surgery outcomes
    Jeong Heum Baek
    City of Hope National Medical Center, General and Oncologic Surgery, Duarte, CA, USA
    Int J Colorectal Dis 28:191-6. 2013
    ..Our objective was to analyze differences in surgical outcomes for patients with rectal cancer according to hospital volume in the state of California...
  51. ncbi Accuracy of endorectal ultrasonography in preoperative staging of rectal tumors
    Julio Garcia-Aguilar
    Division of Colon and Rectal Surgery, Department of Surgery, University of Minnesota, and The University of Minnesota Cancer Center, Minneapolis, Minnesota, USA
    Dis Colon Rectum 45:10-5. 2002
    ..Preoperative staging of rectal tumors is considered essential to tailor treatment for individual patients. The aim of the present study was to evaluate the accuracy of endorectal ultrasonography in preoperative staging of rectal tumors...
  52. ncbi An interaction of race and ethnicity with socioeconomic status in rectal cancer outcomes
    Joseph Kim
    Division of Oncologic Surgery, Department of Surgery, City of Hope, Duarte, CA Michael E DeBakey Department of Surgery and Houston Health Services and Research Center of Excellence, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine Houston, TX Department of Surgery, University of California Davis, Sacramento, CA and Department of Population Sciences, City of Hope, Duarte, CA Department of Population Sciences, City of Hope, Duarte, CA
    Ann Surg 253:647-54. 2011
    ..Because appropriate rectal cancer care and subsequent outcomes can be influenced by several variables, our objective was to investigate how race, ethnicity, and socioeconomic status (SES) may impact rectal cancer outcomes...
  53. doi Implementation of quality measures to reduce surgical site infection in colorectal patients
    Elizabeth C Wick
    Department of Surgery, University of California, San Francisco, California, USA
    Dis Colon Rectum 51:1004-9. 2008
    ..The goal of this study was to determine the rate of surgical site infection and compliance with process measures designed to prevent infection in a defined population of patients undergoing colorectal operations...
  54. pmc Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression
    Li Zheng
    Department of Cancer Biology, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, California 91010, USA
    Nat Commun 3:815. 2012
    ..These molecular changes rewire DNA damage response and repair gene networks in polyploid tumour cells, enabling them to escape replication stress-induced senescence barriers...
  55. ncbi The alpha2 and alpha3 integrins are required for morphologic differentiation of an intestinal epithelial cell line
    Xihong Zhang
    University of Minnesota Cancer Center, Department of Surgery, University of Minnesota, Minneapolis, MN, USA
    Surgery 133:429-37. 2003
    ..We have taken advantage of the ability of the Caco-2 cell line to acquire a glandular phenotype in 3-dimensional (3-D) culture systems to investigate the role of alpha2 and alpha3 integrins in morphologic differentiation...
  56. doi Treatment of transsphincteric anal fistulas: are fistula plugs an acceptable alternative?
    Jennifer Y Wang
    Department of Surgery, University of California, San Francisco, San Francisco, California, USA
    Dis Colon Rectum 52:692-7. 2009
    ..To examine the benefit of the anal fistula plug, we compared its success rate with a standard treatment for transsphincteric fistulas with similar indications, the transanal mucosal advancement flap...

Research Grants1

  1. Timing of Rectal Cancer Response to Chemoradiation
    Julio Garcia Aguilar; Fiscal Year: 2009
    ..This information will help develop molecular assays to diagnose pathologic complete response in transrectal biopsies of the tumor bed before removing the rectum. ..