Yi Zheng

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation
    E E Bosco
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Oncogene 29:2540-9. 2010
  2. pmc Essential role of Cdc42 in Ras-induced transformation revealed by gene targeting
    Kristy R Stengel
    Division of Experimental Hematology and Cancer Biology, Children s Research Foundation, Ohio, United States of America
    PLoS ONE 7:e37317. 2012
  3. pmc Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity
    S Akunuru
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Cell Death Dis 3:e352. 2012
  4. pmc HSPCs get their motors running for asymmetric fate choice
    Yi Zheng
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA Electronic address
    Cell Stem Cell 14:1-2. 2014
  5. pmc Activation of the Ras superfamily of small GTPases. Workshop on exchange factors
    Yi Zheng
    Division of Experimental Hematology, Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    EMBO Rep 4:463-8. 2003
  6. pmc Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis
    Fukun Guo
    Department of Biotechnology, Jinan University, Guangzhou, Guangdong, China
    Haematologica 98:1353-8. 2013
  7. pmc Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis
    Muthuvel Arumugam
    Division of Biochemistry, National Institute of Siddha, Chennai, India
    BMC Immunol 12:14. 2011
  8. pmc Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts
    Linda Yang
    Division of Experimental Hematology, Children s Hospital Medical Center, Molecular Developmental Biology Graduate Program, University of Cincinnati, Cincinnati, OH 45229, USA
    Mol Biol Cell 17:4675-85. 2006
  9. ncbi request reprint A role of STAT3 in Rho GTPase-regulated cell migration and proliferation
    Marcella Debidda
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 280:17275-85. 2005
  10. pmc Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis
    Linda Yang
    Division of Experimental Hematology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 110:3853-61. 2007

Research Grants

Collaborators

Detail Information

Publications118 found, 100 shown here

  1. pmc NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation
    E E Bosco
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Oncogene 29:2540-9. 2010
    ..Thus, Rac1-mediated canonical Wnt signaling is essential for the loss of contact inhibition in NF2-deficient cells...
  2. pmc Essential role of Cdc42 in Ras-induced transformation revealed by gene targeting
    Kristy R Stengel
    Division of Experimental Hematology and Cancer Biology, Children s Research Foundation, Ohio, United States of America
    PLoS ONE 7:e37317. 2012
    ..Moreover, disruption of Cdc42 function in established tumors inhibited continued tumor growth. These studies implicate Cdc42 in Ras-driven tumor growth and suggest that targeting Cdc42 is beneficial in Ras-mediated malignancies...
  3. pmc Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity
    S Akunuru
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Cell Death Dis 3:e352. 2012
    ....
  4. pmc HSPCs get their motors running for asymmetric fate choice
    Yi Zheng
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA Electronic address
    Cell Stem Cell 14:1-2. 2014
    ....
  5. pmc Activation of the Ras superfamily of small GTPases. Workshop on exchange factors
    Yi Zheng
    Division of Experimental Hematology, Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    EMBO Rep 4:463-8. 2003
  6. pmc Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis
    Fukun Guo
    Department of Biotechnology, Jinan University, Guangzhou, Guangdong, China
    Haematologica 98:1353-8. 2013
    ..These results demonstrate that mTOR is essential for hematopoietic stem cell engraftment and multi-lineage hematopoiesis. ..
  7. pmc Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis
    Muthuvel Arumugam
    Division of Biochemistry, National Institute of Siddha, Chennai, India
    BMC Immunol 12:14. 2011
    ..v infusion were assessed. Bone marrow mast cell (BMMC)s were examined for FcεRI, c-kit, degranulation efficiency, proliferation, apoptosis and cytokine profile...
  8. pmc Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts
    Linda Yang
    Division of Experimental Hematology, Children s Hospital Medical Center, Molecular Developmental Biology Graduate Program, University of Cincinnati, Cincinnati, OH 45229, USA
    Mol Biol Cell 17:4675-85. 2006
    ..These results demonstrate a different requirement of Cdc42 activity in primary MEFs from ES or ES-derived clonal fibroblastoid cells and suggest that Cdc42 plays cell-type-specific signaling roles...
  9. ncbi request reprint A role of STAT3 in Rho GTPase-regulated cell migration and proliferation
    Marcella Debidda
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 280:17275-85. 2005
    ....
  10. pmc Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis
    Linda Yang
    Division of Experimental Hematology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 110:3853-61. 2007
    ..Thus, Cdc42 is an essential regulator of the balance between myelopoiesis and erythropoiesis...
  11. pmc RhoA and Cdc42 are required in pre-migratory progenitors of the medial ganglionic eminence ventricular zone for proper cortical interneuron migration
    Kei Ichi Katayama
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Development 140:3139-45. 2013
    ..These findings provide genetic evidence that RhoA and Cdc42 are required in progenitors of the MGE in the VZ, but not the SVZ, for proper cortical interneuron migration. ..
  12. pmc Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly
    Lei Chen
    Divisios of Experimental Hematology, University of Cincinnati, Cincinnati, OH 45229, USA
    Dev Biol 325:162-70. 2009
    ..Together, these results suggest that Rac1 regulates self-renewal, survival, and differentiation of telencephalic neural progenitors, and that dysfunctions of Rac1 may lead to primary microcephaly...
  13. pmc Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment
    Lei Wang
    Division of Experimental Hematology, Children s Hospital Medical Center, University of Cincinnati, OH 45229, USA
    Blood 107:98-105. 2006
    ..These results provide evidence that Cdc42 activity is important for erythropoiesis and for multiple HSP functions, including survival, adhesion, and engraftment...
  14. pmc Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen
    Theodosia A Kalfa
    Division of Hematology Oncology, Oncology, Cincinnati Children s Research Foundation, Cincinnati Children s Hospital Medical Center, MLC 7015 Cincinnati, OH 45229 3039, USA
    Haematologica 95:27-35. 2010
    ..The role of these Rac GTPases in erythropoiesis has not yet been fully elucidated...
  15. pmc Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development
    Fukun Guo
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, OH, USA
    Blood 112:1767-75. 2008
    ..Thus, Rac1 and Rac2 have unique roles in CLP production and share a redundant but essential role in later stages of T-cell development by regulating survival and proliferation signals...
  16. pmc R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization
    Xun Shang
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:24068-78. 2011
    ..These results indicate that R-Ras is a critical regulator of Rac signaling required for HPC migration, homing, and mobilization...
  17. pmc Signaling and cytoskeletal requirements in erythroblast enucleation
    Diamantis G Konstantinidis
    Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Blood 119:6118-27. 2012
    ....
  18. pmc RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors
    Xuan Zhou
    Division of Experimental Hematology and Cancer Biology, 2 Molecular and Development Biology Graduate Program, 3 Division of Ophthalmology, and 4 Division of Developmental Biology, Cincinnati Children s Research Foundation, University of Cincinnati, Cincinnati, OH 45229
    J Exp Med 210:2371-85. 2013
    ..These results show that RhoA is a critical and specific regulator of multipotent HPCs during cytokinesis and thus essential for multilineage hematopoiesis. ..
  19. pmc Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential
    Haiming Xu
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Blood 114:3557-66. 2009
    ..Our study defines p190-B as a critical transducer element of HSC self-renewal activity and long-term engraftment, thus suggesting that p190-B is a target for HSC-based therapies requiring maintenance of engraftment phenotype...
  20. pmc Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow
    Linda Yang
    Division of Experimental Hematology and Pathology, Cincinnati Children s Research Foundation, Molecular Developmental Biology Graduate Program, University of Cincinnati, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 104:5091-6. 2007
    ..Thus, Cdc42 is a critical coordinator of HSC quiescence maintenance and interaction with the BM niche...
  21. pmc Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules
    Sachin Kumar
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, OH, USA
    Blood 120:3563-74. 2012
    ..Our study reveals a new function for WASp in the control of neutrophil polarity via crosstalk between CD11b and microtubules...
  22. pmc Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation
    Kei Ichi Katayama
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 108:7607-12. 2011
    ..These results demonstrate a critical role of RhoA in the maintenance of apical adherens junctions and the regulation of neural progenitor proliferation in the developing mammalian brain...
  23. pmc Rho GTPase Cdc42 is essential for B-lymphocyte development and activation
    Fukun Guo
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, OH 45229, USA
    Blood 114:2909-16. 2009
    ..These results reveal multifaceted roles of Cdc42 in B-cell development and activation...
  24. ncbi request reprint Cell type-specific functions of Rho GTPases revealed by gene targeting in mice
    Lei Wang
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Trends Cell Biol 17:58-64. 2007
    ....
  25. ncbi request reprint Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly
    Fukun Guo
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 281:18652-9. 2006
    ....
  26. ncbi request reprint Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons
    Lei Chen
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Neurosci 27:3884-93. 2007
    ..Moreover, they indicate that Rac1 has a critical role in axon guidance and in acquisition of migratory competency during differentiation of the progenitors for the ventral telencephalon-derived interneurons...
  27. pmc Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis
    Fukun Guo
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 107:18505-10. 2010
    ..Thus, T-cell homeostasis is maintained through a concerted regulation of Gfi-1-IL-7R-controlled cytokine responsiveness and ERK-mediated TCR signaling strength by the Cdc42-PAK1 signaling axis...
  28. ncbi request reprint Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization
    Jose A Cancelas
    Hoxworth Blood Center, University of Cincinnati Medical Center, 3130 Highland Avenue, Cincinnati, Ohio, 45267, USA
    Nat Med 11:886-91. 2005
    ....
  29. ncbi request reprint Rational design and applications of a Rac GTPase-specific small molecule inhibitor
    Huzoor Akbar
    Division of Experimental Hematology, Children s Hospital Research Foundation, Cincinnati, OH, USA
    Methods Enzymol 406:554-65. 2006
    ..Thus, NSC23766 is a lead small molecule inhibitor of Rac activity and could be useful for studying Rac-mediated cellular functions and for modulating pathological conditions in which Rac-deregulation may play a role...
  30. ncbi request reprint Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment
    Gabriel Ghiaur
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 7013, Cincinnati, OH 45229, USA
    Blood 108:2087-94. 2006
    ..This mechanism could provide a novel therapeutic target to enhance HSC therapies...
  31. pmc Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation
    Fukun Guo
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e18002. 2011
    ..Collectively, these data establish that Cdc42 is critically involved in thymopoiesis and plays a restrictive role in effector and memory T cell differentiation and autoimmunity...
  32. doi request reprint Rho GTPases and regulation of hematopoietic stem cell localization
    David A Williams
    Division of Experimental Hematology, Cincinnati Children s Research Foundation, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Methods Enzymol 439:365-93. 2008
    ..In addition, it reviews abnormalities of Rho GTPases implicated in human immunohematopoietic diseases and in leukemia/lymphoma...
  33. doi request reprint Rho GTPases in hematopoietic stem/progenitor cell migration
    Wei Liu
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Methods Mol Biol 750:307-19. 2011
    ....
  34. pmc Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A
    Xiaoling Zhang
    Division of Experimental Hematology, Cincinnati Children s Research Foundation and Fanconi Anemia Comprehensive Care Center, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Blood 112:1683-6. 2008
    ..These results provide the first evidence that FA proteins influence human BM progenitor homing and adhesion via the small GTPase Cdc42-regulated signaling pathway...
  35. pmc Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation
    Huzoor Akbar
    Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio, United States of America
    PLoS ONE 6:e22117. 2011
    ..However, the role of Cdc42 in platelet activation remains controversial. This study was undertaken to better understand the role of Cdc42 in platelet activation...
  36. pmc Rho GTPases in hematopoiesis and hemopathies
    James C Mulloy
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH 45229, USA
    Blood 115:936-47. 2010
    ..In this review we discuss recent genetic studies of Rho GTPases in hematopoiesis and several blood lineages and the implications of Rho GTPase signaling in hematologic malignancies, immune pathology. and anemia...
  37. pmc Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia
    Benjamin Mizukawa
    Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Blood 118:5235-45. 2011
    ..Furthermore, concurrent exposure to NSC23766, a small-molecule inhibitor of Rac activation, increases the apoptotic effect of ABT-737, indicating the Rac/Bcl-2 survival pathway may be targeted synergistically...
  38. pmc RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts
    Jaime Melendez
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:15132-7. 2011
    ..These genetic results demonstrate that in primary mouse embryonic fibroblasts, RhoA is uniquely required for cell mitosis but is redundant with related RhoB and RhoC GTPases in actomyosin regulation...
  39. pmc Fanca-/- hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766
    Michael D Milsom
    Division of Experimental Hematology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH, USA
    Haematologica 94:1011-5. 2009
    ..In view of these data, we propose that targeting Rac signaling may enhance G-CSF-induced HSC mobilization in Fanconi anemia...
  40. pmc Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors
    Xun Shang
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 110:3155-60. 2013
    ....
  41. pmc Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia
    Bharesh K Chauhan
    Division of Pediatric Ophthalmology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 108:18289-94. 2011
    ..The ubiquity of the Rho family GTPases suggests that these mechanisms are likely to apply generally where epithelial morphogenesis occurs...
  42. pmc MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration
    Lin Zhang
    Department of Environmental Health, University of Cincinnati, 123 E Shields St, Cincinnati, OH 45267 0056, USA
    Mol Cell Biol 25:60-5. 2005
    ..Together, these pathways lead to the control of actin cytoskeleton reorganization and epithelial cell migration, contributing to the physiologic and pathological effects of activins on epithelial morphogenesis...
  43. pmc Cdc42 regulates Schwann cell radial sorting and myelin sheath folding through NF2/merlin-dependent and independent signaling
    Li Guo
    Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children s Hospital University of Cincinnati, Cincinnati, Ohio
    Glia 61:1906-21. 2013
    ..Thus, Cdc42 regulates SC radial sorting in vivo through NF2/merlin dependent signaling pathways, while Cdc42 modulation of myelin sheath folding is NF2/merlin independent...
  44. pmc Increased hematopoietic stem cell mobilization in aged mice
    Zhenlan Xing
    Division of Experimental Hematology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Blood 108:2190-7. 2006
    ..These results might indicate that stroma-stem cell interactions are dynamic over a lifetime and result in physiologically relevant changes in the biology of primitive hematopoietic cells with age...
  45. ncbi request reprint Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease
    Emily K Thomas
    Division of Experimental Hematology, Cincinnati Children s Research Foundation, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Cancer Cell 12:467-78. 2007
    ..These data demonstrate that Rac is an additional therapeutic target in p210-BCR-ABL-mediated MPD...
  46. ncbi request reprint Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways
    Dirk Carstanjen
    Division of Experimental Hematology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    J Immunol 174:4613-20. 2005
    ..These findings suggest that binding to any single effector is not sufficient to rescue the distinct cellular phenotypes of Rac2-/- PMN, implicating multiple, distinct, and potentially parallel effector pathways...
  47. pmc Left-right locomotor circuitry depends on RhoA-driven organization of the neuroepithelium in the developing spinal cord
    Kei Ichi Katayama
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Neurosci 32:10396-407. 2012
    ..These results demonstrate that RhoA functions to maintain neuroepithelial structures in the developing spinal cord and that proper organization of the neuroepithelium is required for appropriate left-right motor behavior...
  48. ncbi request reprint Oncogenic Dbl, Cdc42, and p21-activated kinase form a ternary signaling intermediate through the minimum interactive domains
    Lei Wang
    Division of Experimental Hematology, Children s Hospital Research Foundation, Graduate Program of Molecular Developmental Biology, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Biochemistry 43:14584-93. 2004
    ....
  49. pmc A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination
    Timothy F Plageman
    The Visual Systems Group, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Development 138:5177-88. 2011
    ..Furthermore, we identify Trio as a RhoA-GEF required for Shroom3-dependent AC in MDCK cells and in the lens pit. Collectively, these data indicate that a Trio-RhoA-Shroom3 pathway is required for AC during lens pit invagination...
  50. pmc The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling
    Kathleen Szczur
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Blood 114:4527-37. 2009
    ..Our results uncover a new mechanism in which Cdc42 regulates the uropod through CD11b signaling to maintain polarity in migrating neutrophils. It also reveals new functions for CD11b in neutrophil polarity...
  51. ncbi request reprint p200 RhoGAP promotes cell proliferation by mediating cross-talk between Ras and Rho signaling pathways
    Xun Shang
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 282:8801-11. 2007
    ....
  52. pmc Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity
    Shailaja Akunuru
    Division of Experimental Hematology and Cancer Biology, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e16951. 2011
    ..These studies indicate that Rac1 represents a useful target in NSCLA, and its blockade may have therapeutic value in suppressing CSC proliferation and metastasis...
  53. pmc Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia
    Junping Wei
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Cancer Cell 13:483-95. 2008
    ..Targeting the Rac signaling pathway by pharmacologic or genetic means resulted in rapid and specific apoptosis of MLL-AF9 cells, suggesting that the Rac signaling pathway may be a valid therapeutic target in MLL-rearranged AML...
  54. pmc Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis
    Emily E Bosco
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, University of Cincinnati, OH, USA
    Blood 115:3320-8. 2010
    ..Because the Rac1 signaling axis is a critical determinant of apoptosis and tumorigenesis, it may represent an important basis for therapy in the treatment of p53-deficient lymphomas...
  55. pmc Cdc42 is an antihypertrophic molecular switch in the mouse heart
    Marjorie Maillet
    Department of Pediatrics, Division of Molecular Cardiovascular Biology, University of Cincinnati, and Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Clin Invest 119:3079-88. 2009
    ....
  56. pmc Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization
    Marnie A Ryan
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center CCHMC, Cincinnati, Ohio, USA
    Nat Med 16:1141-6. 2010
    ..Our findings reveal a previously unknown signaling pathway regulating stem cell mobilization and provide a new pharmacological approach for improving HSPC mobilization and thereby transplantation outcomes...
  57. pmc Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development
    Shuangmin Zhang
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229 and
    J Immunol 193:5973-82. 2014
    ....
  58. pmc Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes
    Lei Wang
    Division of Experimental Hematology, Molecular Developmental Biology Graduate Program, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 104:1248-53. 2007
    ..Furthermore, Cdc42 activation is sufficient to promote a premature cellular senescence phenotype that depends on p53. These results suggest a role of Cdc42 activity in regulating mammalian genomic stability and aging-related physiology...
  59. ncbi request reprint Rho family GTPases cooperate with p53 deletion to promote primary mouse embryonic fibroblast cell invasion
    Fukun Guo
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, OH 45229, USA
    Oncogene 23:5577-85. 2004
    ....
  60. pmc Cdc42 coordinates proliferation, polarity, migration, and differentiation of small intestinal epithelial cells in mice
    Jaime Melendez
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Department of Pharmacy, Faculty of Chemistry, P Catholic University of Chile, Santiago, Chile
    Gastroenterology 145:808-19. 2013
    ..In the intestinal epithelium, a balance among these events maintains homeostasis. We used genetic techniques to investigate the role of Cdc42 in intestinal homeostasis and its mechanisms...
  61. pmc Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation
    Emily E Bosco
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Chem Biol 19:228-42. 2012
    ..Our studies suggest the potential utility of Phox-I class inhibitors in NOX2 oxidase inhibition and present an application of rational targeting of a small GTPase-effector interface...
  62. pmc Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton
    Theodosia A Kalfa
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC 7015, Cincinnati, OH 45229, USA
    Blood 108:3637-45. 2006
    ..Thus, deficiency of Rac1 and Rac2 GTPases in mice alters actin assembly in RBCs and causes microcytic anemia with reticulocytosis, implicating Rac GTPases as dynamic regulators of the erythrocyte cytoskeleton organization...
  63. pmc Cdc42GAP regulates c-Jun N-terminal kinase (JNK)-mediated apoptosis and cell number during mammalian perinatal growth
    Lei Wang
    Division of Experimental Hematology, Children s Hospital Medical Center, Molecular Developmental Biology Graduate Program, University of Cincinnati, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 102:13484-9. 2005
    ..These results reveal a role of Cdc42GAP in mammalian perinatal growth and implicate the c-Jun N-terminal kinase-mediated apoptosis machinery as a Cdc42 effector pathway in vivo...
  64. ncbi request reprint Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant
    Balazs Debreceni
    Division of Experimental Hematology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    J Biol Chem 279:3777-86. 2004
    ....
  65. ncbi request reprint RhoH GTPase: a key regulator of hematopoietic cell proliferation and apoptosis?
    Yi Gu
    Division of Experimental Hematology, Cincinnati Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Cell Cycle 4:201-2. 2005
    ..In addition, RhoH appears to counteract Rac GTPase activities, suggesting a possible mechanism by which RhoH functions as an antagonist of Rac signaling in the regulation of cell growth and actin-based functions in blood lineages...
  66. pmc Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly
    Lei Chen
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 103:16520-5. 2006
    ..Taken together, these results indicate that Cdc42 has an essential role in establishing the apical-basal polarity of the telencephalic NE, which is needed for the expansion and bifurcation of cerebral hemispheres...
  67. pmc A Rac-cGMP signaling pathway
    Dagang Guo
    Department of Physiology, Cornell University Weill Medical College, New York, NY 10021, and Division of Experimental Hematology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Cell 128:341-55. 2007
    ..Our findings connect two important regulators of cellular physiological functions and provide a general mechanism for diverse receptors to modulate physiological responses through elevating cellular cGMP levels...
  68. pmc Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases
    Xun Shang
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Chem Biol 19:699-710. 2012
    ..Thus, the rational designed RhoA subfamily-specific small molecule inhibitor is useful for studying the physiological and pathologic roles of Rho GTPase...
  69. pmc Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination
    Bharesh K Chauhan
    The Visual Systems Group, Children s Hospital Research Foundation, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Development 136:3657-67. 2009
    ..Although invagination of the archenteron in sea urchins and dorsal closure in Drosophila are known to be partly dependent on filopodia, this mechanism of morphogenesis has not previously been identified in vertebrates...
  70. pmc Rac1 controls Schwann cell myelination through cAMP and NF2/merlin
    Li Guo
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital, Cincinnati, Ohio 45229, USA
    J Neurosci 32:17251-61. 2012
    ..Thus, NF2/merlin and cAMP function downstream of Rac1 signaling in SC myelination, and cAMP levels control Rac1-regulated SC myelination...
  71. pmc Signaling role of Cdc42 in regulating mammalian physiology
    Jaime Melendez
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:2375-81. 2011
    ..Recent studies by conditional gene targeting of cdc42 in mice have revealed its tissue- and cell type-specific role and provide definitive information of the physiological signaling functions of Cdc42 in vivo...
  72. pmc Cdc42 in oncogenic transformation, invasion, and tumorigenesis
    Kristy Stengel
    Division of Experimental Hematology and Cancer Biology, Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Cell Signal 23:1415-23. 2011
    ....
  73. pmc Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure
    Esmond Geh
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 108:17349-54. 2011
    ..MAP3K1 is therefore the nexus of an intracrine regulatory loop connecting the TGF-α/EGFR/RhoA-c-Jun and JNK-c-Jun-AP-1 pathways in developmental eyelid closure...
  74. pmc Cdc42 regulates extracellular matrix remodeling in three dimensions
    Nisha S Sipes
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:36469-77. 2011
    ..Thus, in addition to the previously implicated roles in intracellular regulation of actin organization, proliferation, and vesicle trafficking, Cdc42 is essential in ECM remodeling in three dimensions...
  75. pmc Transforming human blood stem and progenitor cells: a new way forward in leukemia modeling
    James C Mulloy
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Cell Cycle 7:3314-9. 2008
    ..We focus specifically on the Rho family of small guanosine triphosphatases (GTPases) as potential therapeutic targets, which we have implicated in the pathogenesis of AML associated with MA9 expression...
  76. ncbi request reprint Rac1 GTPase regulates cell genomic stability and senescence
    Marcella Debidda
    Division of Experimental Hematology, Cincinnati Children s Research Foundation, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Biol Chem 281:38519-28. 2006
    ..Taken together, our results show that Rac1 activity serves as a regulator of cell senescence through modulation of cellular ROS, genomic stability, and p53 activity...
  77. ncbi request reprint Cdc42: a signal coordinator in hematopoietic stem cell maintenance
    Linda Yang
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Cell Cycle 6:1445-50. 2007
    ..The study also highlights a cell-type specific role of Cdc42 in cell cycle regulation...
  78. ncbi request reprint Targeting rho GTPases by peptidic structures
    Filippo Marchioni
    Division of Experimental Hematology and Cancer Biology, Children s Research Foundation, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Curr Pharm Des 15:2481-7. 2009
    ..The implication of these studies in the pathobiology of various human diseases makes targeting Rho GTPases a valid strategy for future therapies...
  79. ncbi request reprint Structure-function based design of small molecule inhibitors targeting Rho family GTPases
    Nicolas Nassar
    Division of Experimental Hematology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Curr Top Med Chem 6:1109-16. 2006
    ....
  80. ncbi request reprint Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils
    Marie Dominique Filippi
    Division of Experimental Hematology, Cincinnati Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Nat Immunol 5:744-51. 2004
    ..Thus, we have defined specific sequences in Rac that specify subcellular localization and determine the specificity of Rac2 in neutrophil chemotaxis and superoxide generation...
  81. pmc Altered phosphorylation of cytoskeleton proteins in sickle red blood cells: the role of protein kinase C, Rac GTPases, and reactive oxygen species
    Alex George
    Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Blood Cells Mol Dis 45:41-5. 2010
    ..We discuss in particular the known and potential roles of protein kinase C and the Rac GTPases in these two processes...
  82. pmc Calcium mobilization and Rac1 activation are required for VCAM-1 (vascular cell adhesion molecule-1) stimulation of NADPH oxidase activity
    Joan M Cook-Mills
    Department of Pathology, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Biochem J 378:539-47. 2004
    ..Thus VCAM-1 stimulates the mobilization of intracellular and extracellular calcium and Rac1 activity that are required for the activation of NADPH oxidase...
  83. ncbi request reprint A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells
    Lei Wang
    Division of Experimental Hematology and Molecular Developmental Biology Program, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 278:44617-25. 2003
    ....
  84. ncbi request reprint p19Arf-p53 tumor suppressor pathway regulates cell motility by suppression of phosphoinositide 3-kinase and Rac1 GTPase activities
    Fukun Guo
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, Ohio 45229, USA
    J Biol Chem 278:14414-9. 2003
    ....
  85. ncbi request reprint Rho GTPase-activating proteins in cell regulation
    Sun Young Moon
    Division of Experimental Hematology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Trends Cell Biol 13:13-22. 2003
    ..Progress has also been made in understanding how various intracellular signals might converge on or diverge from RhoGAPs leading to their tight regulation or GAP-independent function...
  86. ncbi request reprint Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells
    Yoko Nakai
    Division of Experimental Hematology, Cincinnati Children s Hospital Research Foundation, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Neurosci 26:3390-5. 2006
    ..The data support the significance of regulated Rac signaling in mediating Schwann cell-axon interaction and suggest that controlling Rac activity as a possible therapy for schwannomas...
  87. pmc Involvement of Rho family GTPases in p19Arf- and p53-mediated proliferation of primary mouse embryonic fibroblasts
    Fukun Guo
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Mol Cell Biol 24:1426-38. 2004
    ....
  88. pmc Rational design and characterization of a Rac GTPase-specific small molecule inhibitor
    Yuan Gao
    Division of Experimental Hematology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 101:7618-23. 2004
    ..Thus, NSC23766 constitutes a Rac-specific small-molecule inhibitor that could be useful to study the role of Rac in various cellular functions and to reverse tumor cell phenotypes associated with Rac deregulation...
  89. ncbi request reprint Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP
    Sun Young Moon
    Division of Experimental Hematology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    J Biol Chem 278:4151-9. 2003
    ..These results suggest that p200RhoGAP is involved in the regulation of neurite outgrowth by exerting its RhoGAP activity and that its cellular activity may be regulated through interaction with Src-like tyrosine kinases...
  90. ncbi request reprint RhoC is essential for the metastasis of gastric cancer
    Na Liu
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, Shaanxi Province, People s Republic of China
    J Mol Med (Berl) 85:1149-56. 2007
    ..In conclusion, RhoC may play a very important role in the metastasis of gastric carcinoma. Therapeutic strategies targeting RhoC and RhoC-mediated pathways may be a novel approach for treating metastasis of gastric cancer...
  91. ncbi request reprint AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner
    Kyriacos N Felekkis
    Department of Medicine, Section of Hematology and Oncology, Boston Medical Center, Boston, MA 02118, USA
    Mol Cancer Res 3:32-41. 2005
    ..Our studies suggest that AND-34-mediated PI3K activation induces Rac activation and anti-estrogen resistance in human breast cancer cell lines...
  92. pmc The GTPase Rac regulates the proliferation and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients
    Amanda Chan
    Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore LIJ, Manhasset, New York 11030, USA
    Mol Med 13:297-304. 2007
    ..In conclusion, Rac-controlled signaling pathways may present a new source of drug targets for therapeutic intervention in RA...
  93. ncbi request reprint Evaluation of the catalytic mechanism of the p21-activated protein kinase PAK2
    Hao Wu
    National Laboratory of Biomacromolecules, Center for Molecular Biology, Institute of Biophysics, Academia Sinica, Beijing 100101, People s Republic of China
    Biochemistry 42:1129-39. 2003
    ..These results complement previous structure-function studies of PAKs and provide important insight for mechanistic interpretation of the kinase functions...
  94. ncbi request reprint ARAP1: a point of convergence for Arf and Rho signaling
    Koichi Miura
    Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Mol Cell 9:109-19. 2002
    ..The Arf GAP and Rho GAP activities both contributed to inhibiting cell spreading. Thus, ARAP1 is a PIP3-dependent Arf GAP that regulates Arf-, Rho-, and Cdc42-dependent cell activities...
  95. pmc Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility
    Sonali P Barwe
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Mol Biol Cell 16:1082-94. 2005
    ..Thus, these results demonstrate a new role for Na,K-ATPase in regulating carcinoma cell motility...
  96. ncbi request reprint Inhibition of endothelial cell proliferation by targeting Rac1 GTPase with small interference RNA in tumor cells
    Yan Xue
    Institute of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, Xi an, Shaanxi, PR China
    Biochem Biophys Res Commun 320:1309-1315. 2004
    ..Our results suggest that Racl may be involved in angiogenesis by controlling the expression of angiogenesis-related factors and provide a possible strategy for the treatment of tumor angiogenesis by targeting the Racl GTPase...
  97. doi request reprint An essential role for Rac1 in endothelial cell function and vascular development
    Wenfu Tan
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Dr, Bethesda, MD 20892, USA
    FASEB J 22:1829-38. 2008
    ....
  98. ncbi request reprint Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor
    Ana Barac
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4330, USA
    J Biol Chem 279:6182-9. 2004
    ....
  99. ncbi request reprint Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells
    Mei Ann Lim
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Oncogene 23:9348-58. 2004
    ..Our findings suggest that PDK-1/Akt signaling pathway plays a major role in regulating cell migration induced by PTEN deficiency...
  100. ncbi request reprint Vitamin k epoxide reductase: a protein involved in angiogenesis
    Yibo Wang
    Sino German Laboratory for Molecular Medicine and Hypertension Division, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishilu, Xicheng District, Beijing 100037, P R China
    Mol Cancer Res 3:317-23. 2005
    ..Our findings support the impact of VKOR in the process of angiogenesis; hence, the molecule may have a potential application in cardiovascular disease and cancer therapy...
  101. ncbi request reprint Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy
    Priya Sethu Chockalingam
    Department of Molecular Sciences, University of Tennessee Health Sciences Center, Memphis, Tennessee 38163, USA
    Am J Physiol Cell Physiol 283:C500-11. 2002
    ..Dominant-negative Cdc42, introduced with a retroviral vector, resulted in fibers that appeared atrophic. These data support a putative role for the DGC in transduction of mechanical signals in muscle...

Research Grants4

  1. INTERACTION OF RHO GTPASES WITH REGULATORS AND EFFECTORS
    Yi Zheng; Fiscal Year: 2007
    ....
  2. Targeting RhoA Lymphomagenesis
    Yi Zheng; Fiscal Year: 2007
    ..These studies will provide an animal model to implicate RhoA GTPase in tumorigenesis and for testing anti-cancer strategies by targeting RhoA pathways. [unreadable] [unreadable] [unreadable]..
  3. Rho GTPase-Activating Proteins in Cancer
    Yi Zheng; Fiscal Year: 2008
    ..These studies will provide mechanistic insights into the regulatory function of RhoGAPs in cell signaling and may generate therapeutic reagents targeting Rho GTPase pathways in human cancers. ..
  4. Dbl-like Regulators of Small GTP-binding Proteins
    Yi Zheng; Fiscal Year: 2008
    ..The results may also provide valuable pharmacological reagents for the intervention of the GEF-mediated signaling. ..