Genomes and Genes
Kris A Steinbrecher
Affiliation: Cincinnati Children's Hospital Medical Center
- Guanylate cyclase C limits systemic dissemination of a murine enteric pathogenElizabeth A Mann
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
BMC Gastroenterol 13:135. 2013..Our aim was to determine if GC-C is required for host defense during infection by the murine enteric pathogen Citrobacter rodentium of the family Enterobacteriacea...
- Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammationKris A Steinbrecher
Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
J Immunol 180:2588-99. 2008..We conclude that activation of RelA is required for homeostatic regulation of cell death and division in intestinal epithelia, as well as for protection from development of severe, acute inflammation of the intestine...
- Murine guanylate cyclase C regulates colonic injury and inflammationKris A Steinbrecher
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
J Immunol 186:7205-14. 2011..These findings demonstrate a novel role for GC-C signaling in facilitating mucosal wounding and inflammation, and further suggest that this may be mediated, in part, through control of RELMβ production...
- Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferationKris A Steinbrecher
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children s Hospital Research Foundation, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Am J Pathol 161:2169-78. 2002..We speculate that the increase in colonocyte number is related to decreased levels of cGMP and that this increase in proliferation plays a role in susceptibility to intestinal adenoma formation and/or progression...
- Guanylate cyclase C deficiency causes severe inflammation in a murine model of spontaneous colitisEleana Harmel-Laws
Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
PLoS ONE 8:e79180. 2013..Familial mutations in GC-C cause chronic diarrheal disease or constipation and are associated with intestinal inflammation and infection. Here, we investigated the impact of GC-C activity on mucosal immune responses...
- Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse modelElizabeth A Mann
Division of Digestive Diseases, VA Medical Center and University of Cincinnati, Cincinnati, OH 45267, USA
Int J Cancer 116:500-5. 2005..We propose that these alterations are a possible compensatory mechanism by which loss of GC-C signaling also affects tumorigenesis...
- Intestinal CCL11 and eosinophilic inflammation is regulated by myeloid cell-specific RelA/p65 in miceAmanda Waddell
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Immunol 190:4773-85. 2013..These data indicate that targeting myeloid cells and NF-κB-dependent pathways may be of therapeutic benefit for the treatment of eosinophilic inflammation and histopathology in IBD...
- Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrierXiaonan Han
Division of Gastroenterology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
PLoS ONE 6:e16139. 2011..As a mechanism for some of these effects, we hypothesized that GCC signaling mediates regulation of intestinal barrier function...
- Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogenKris A Steinbrecher
Divisions of Gastroenterology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Cancer Res 70:2634-43. 2010....
- Transmembrane guanylate cyclase in intestinal pathophysiologyKris A Steinbrecher
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Curr Opin Gastroenterol 27:139-45. 2011..Also considered is the potential for therapeutic manipulation of intestinal guanylate cyclase/cGMP signaling for the correction of chronic constipation and gastrointestinal cancer...
- Myeloid-derived NF-κB negative regulation of PU.1 and c/EBP-β-driven pro-inflammatory cytokine production restrains LPS-induced shockSimone Vanoni
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Innate Immun . 2016..1 and CCAAT/enhancer binding protein-β to Il1b and Il6 promoters in activated inflammatory MΦs. Our data provide insight into a role for NF-κB in the negative regulation of pro-inflammatory cytokines in myeloid cells...
- Effect of guanylate cyclase-C activity on energy and glucose homeostasisDenovan P Begg
Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH School of Psychology, University of New South Wales, Sydney, New South Wales, Australia
Diabetes 63:3798-804. 2014..Our data indicate that the modest effects of uroguanylin on energy and glucose homeostasis are not mediated by central GC-C receptors. ..
- The multiple roles of guanylate cyclase C, a heat stable enterotoxin receptorKris A Steinbrecher
Department of Pediatrics, University of Cincinnati College of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
Curr Opin Gastroenterol 30:1-6. 2014..This review discusses current work on the physiological function of GC-C in the intestine...
- IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in miceIsaac T W Harley
Division of Cellular and Molecular Immunology, Cincinnati Children s Hospital Research Foundation, and the University of Cincinnati College of Medicine, Cincinnati, OH
Hepatology 59:1830-9. 2014..In contrast, SFB depletion protected from obesity-induced hepatocellular damage...
- Novel mechanism of cyclic AMP mediated extracellular signal regulated kinase activation in an intestinal cell lineJeffrey A Rudolph
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center and the University of Cincinnati, Cincinnati, Ohio, 45229, United States
Cell Signal 19:1221-8. 2007..These results directly implicate PKAII as a mediator of cell survival in T84 cells and provide evidence for an additional means by which cAMP can influence intestinal cell turnover...
- Coordinate upregulation of guanylin and uroguanylin expression by hypertonicity in HT29-18-N2 cellsKris A Steinbrecher
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children s Hospital Research Foundation, Children s Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio 45229, USA
Am J Physiol Cell Physiol 283:C1729-37. 2002..We conclude that guanylin and uroguanylin are released in response to hypertonic stress and that regulation of these genes may be mediated by PKC isoforms...
- Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infectionShokrollah Elahi
Division of Infectious Diseases and Perinatal Institute, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Nature 504:158-62. 2013..We anticipate that these results will spark renewed investigation into the need for immunosuppression in neonates, as well as improved strategies for augmenting host defence in this vulnerable population...
- Interleukin-13 (IL-13)/IL-13 receptor alpha1 (IL-13Ralpha1) signaling regulates intestinal epithelial cystic fibrosis transmembrane conductance regulator channel-dependent Cl- secretionDavid Wu
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
J Biol Chem 286:13357-69. 2011....
- Novel genes and functional relationships in the adult mouse gastrointestinal tract identified by microarray analysisMichael D Bates
Division of Gastroenterology, Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Gastroenterology 122:1467-82. 2002..We hypothesized that functional patterning along the A-P axis of the GI tract could be defined at the molecular level by analyzing expression profiles of large numbers of genes...
- Effect of secretagogues and pH on intestinal transport in guanylin-deficient miceAlan N Charney
Nephrology Section, VA Medical Center and New York University School of Medicine, 423 E 23rd Street, New York, NY 10010, USA
Biochim Biophys Acta 1671:79-86. 2004..The effectiveness of guanylin in this segment suggests a difference in the intestinal secretory actions of STa and guanylin...
- A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expressionVasiliki Anest
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Nature 423:659-63. 2003..These findings provide additional insight into the role of the IKK complex in NF-kappaB-regulated gene expression...
- Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcriptionKris A Steinbrecher
Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7295, USA
Mol Cell Biol 25:8444-55. 2005..Therefore, GSK-3beta has profound effects on transcription in a gene-specific manner through a mechanism involving control of promoter-specific recruitment of NF-kappaB...
- Wound-induced p38MAPK-dependent histone H3 phosphorylation correlates with increased COX-2 expression in enterocytesThomas Karrasch
Department of Medicine and Center for GI Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Cell Physiol 207:809-15. 2006..Targeting-signaling pathways selectively involved in healing/restitution may provide a novel means to maintain or re-establish host intestinal barrier integrity...
- Molecular cloning and promoter analysis of downregulated in adenoma (DRA)Waddah A Alrefai
University of Illinois at Chicago, Jesse Brown VA Medical Center, Medical Research Service, Chicago, IL 60612, USA
Am J Physiol Gastrointest Liver Physiol 293:G923-34. 2007..Our studies provide evidence for the involvement of HNF-4, YY1, and GATA transcription factors in DRA expression in intestinal differentiated epithelial cells...