Jennifer M Kaplan

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Pioglitazone reduces inflammation through inhibition of NF-κB in polymicrobial sepsis
    Jennifer Kaplan
    Division of Critical Care Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Innate Immun 20:519-28. 2014
  2. pmc Short-term high fat feeding increases organ injury and mortality after polymicrobial sepsis
    Jennifer M Kaplan
    Division of Critical Care Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 20:1995-2002. 2012
  3. pmc Changes in peroxisome proliferator-activated receptor-gamma activity in children with septic shock
    Jennifer M Kaplan
    Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 2005, Cincinnati, OH 45229 3039, USA
    Intensive Care Med 36:123-30. 2010
  4. pmc Phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 Is associated with the downregulation of peroxisome proliferator-activated receptor (PPAR)-γ during polymicrobial sepsis
    Jennifer M Kaplan
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    Mol Med 16:491-7. 2010
  5. ncbi request reprint 15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock
    Jennifer M Kaplan
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and the College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Shock 24:59-65. 2005
  6. pmc Obesity enhances sepsis-induced liver inflammation and injury in mice
    Jennifer M Kaplan
    Department of Pediatrics, Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 24:1480-8. 2016
  7. pmc Biomarker discovery and development in pediatric critical care medicine
    Jennifer M Kaplan
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pediatr Crit Care Med 12:165-73. 2011
  8. pmc Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of concept
    Hector R Wong
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Crit Care Med 38:1955-61. 2010

Detail Information

Publications8

  1. pmc Pioglitazone reduces inflammation through inhibition of NF-κB in polymicrobial sepsis
    Jennifer Kaplan
    Division of Critical Care Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Innate Immun 20:519-28. 2014
    ..Pioglitazone reduces the inflammatory response in polymicrobial sepsis in part through inhibition of NF-κB and may be a novel therapy in sepsis. ..
  2. pmc Short-term high fat feeding increases organ injury and mortality after polymicrobial sepsis
    Jennifer M Kaplan
    Division of Critical Care Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 20:1995-2002. 2012
    ..CD-fed mice. Short duration high fat feeding increases mortality and organ injury following polymicrobial sepsis. These effects correspond to changes in NF-κB...
  3. pmc Changes in peroxisome proliferator-activated receptor-gamma activity in children with septic shock
    Jennifer M Kaplan
    Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 2005, Cincinnati, OH 45229 3039, USA
    Intensive Care Med 36:123-30. 2010
    ..Additionally, to investigate the effects of sepsis on the endogenous activator of PPARgamma, 15-deoxy-(12,14)-PGJ(2) (15d-PGJ(2)), and the downstream targets of PPARgamma activity, adiponectin and resistin...
  4. pmc Phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 Is associated with the downregulation of peroxisome proliferator-activated receptor (PPAR)-γ during polymicrobial sepsis
    Jennifer M Kaplan
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    Mol Med 16:491-7. 2010
    ..The inflammatory effects of sepsis cause changes in PPARγ expression and activation, in part, because of phosphorylation of PPARγ by ERK1/2. This phosphorylation can be reversed by ERK1/2 inhibition, thereby improving lung injury...
  5. ncbi request reprint 15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock
    Jennifer M Kaplan
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and the College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Shock 24:59-65. 2005
    ..Our data demonstrate that 15d-PGJ2 ameliorates endotoxic shock most likely through repressing the proinflammatory pathway of NF-kappaB and enhancement of the cytoprotective heat shock response...
  6. pmc Obesity enhances sepsis-induced liver inflammation and injury in mice
    Jennifer M Kaplan
    Department of Pediatrics, Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 24:1480-8. 2016
    ..How obesity affects the response to sepsis was not completely understood. It was hypothesized that obesity alters adipose and hepatic tissue inflammation through signal transducer and activator of transcription (STAT3) activation...
  7. pmc Biomarker discovery and development in pediatric critical care medicine
    Jennifer M Kaplan
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pediatr Crit Care Med 12:165-73. 2011
    ..To frame the general process of biomarker discovery and development; and to describe a proposal for the development of a multibiomarker-based risk model for pediatric septic shock...
  8. pmc Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of concept
    Hector R Wong
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Crit Care Med 38:1955-61. 2010
    ..To develop a clinically feasible stratification strategy for pediatric septic shock, using gene expression mosaics and a 100-gene signature representing the first 24 hrs of admission to the pediatric intensive care unit...