Sonata Jodele

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. doi request reprint New approaches in the diagnosis, pathophysiology, and treatment of pediatric hematopoietic stem cell transplantation-associated thrombotic microangiopathy
    Sonata Jodele
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, OH Electronic address
    Transfus Apher Sci 54:181-90. 2016
  2. doi request reprint Terminal Complement Blockade after Hematopoietic Stem Cell Transplantation Is Safe without Meningococcal Vaccination
    Sonata Jodele
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 22:1337-40. 2016
  3. pmc Variable Eculizumab Clearance Requires Pharmacodynamic Monitoring to Optimize Therapy for Thrombotic Microangiopathy after Hematopoietic Stem Cell Transplantation
    Sonata Jodele
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 22:307-15. 2016
  4. pmc A new paradigm: Diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury
    Sonata Jodele
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, USA Electronic address
    Blood Rev 29:191-204. 2015
  5. doi request reprint Eculizumab therapy in children with severe hematopoietic stem cell transplantation-associated thrombotic microangiopathy
    Sonata Jodele
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 20:518-25. 2014
  6. doi request reprint Does early initiation of therapeutic plasma exchange improve outcome in pediatric stem cell transplant-associated thrombotic microangiopathy?
    Sonata Jodele
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Transfusion 53:661-7. 2013
  7. doi request reprint Successful early intervention for hyperacute transplant-associated thrombotic microangiopathy following pediatric hematopoietic stem cell transplantation
    Sonata Jodele
    Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children s Hospital Medical Center Hoxworth Blood Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Pediatr Transplant 16:E39-42. 2012
  8. doi request reprint Pulmonary arterial hypertension in pediatric patients with hematopoietic stem cell transplant-associated thrombotic microangiopathy
    Sonata Jodele
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Biol Blood Marrow Transplant 19:202-7. 2013
  9. doi request reprint Blood, and not urine, BK viral load predicts renal outcome in children with hemorrhagic cystitis following hematopoietic stem cell transplantation
    Hilary L Haines
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Biol Blood Marrow Transplant 17:1512-9. 2011
  10. pmc Abnormal echocardiography 7 days after stem cell transplantation may be an early indicator of thrombotic microangiopathy
    Christopher E Dandoy
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 21:113-8. 2015

Collaborators

Detail Information

Publications38

  1. doi request reprint New approaches in the diagnosis, pathophysiology, and treatment of pediatric hematopoietic stem cell transplantation-associated thrombotic microangiopathy
    Sonata Jodele
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, OH Electronic address
    Transfus Apher Sci 54:181-90. 2016
    ....
  2. doi request reprint Terminal Complement Blockade after Hematopoietic Stem Cell Transplantation Is Safe without Meningococcal Vaccination
    Sonata Jodele
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 22:1337-40. 2016
    ....
  3. pmc Variable Eculizumab Clearance Requires Pharmacodynamic Monitoring to Optimize Therapy for Thrombotic Microangiopathy after Hematopoietic Stem Cell Transplantation
    Sonata Jodele
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 22:307-15. 2016
    ..This algorithm may guide eculizumab treatment and ensure that future efficacy studies use the most clinically appropriate and cost-efficient dosing schedules. ..
  4. pmc A new paradigm: Diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury
    Sonata Jodele
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, USA Electronic address
    Blood Rev 29:191-204. 2015
    ....
  5. doi request reprint Eculizumab therapy in children with severe hematopoietic stem cell transplantation-associated thrombotic microangiopathy
    Sonata Jodele
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 20:518-25. 2014
    ....
  6. doi request reprint Does early initiation of therapeutic plasma exchange improve outcome in pediatric stem cell transplant-associated thrombotic microangiopathy?
    Sonata Jodele
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Transfusion 53:661-7. 2013
    ..The use of therapeutic plasma exchange (TPE) in hematopoietic stem cell transplant-associated thrombotic microangiopathy (TA-TMA) is controversial because the exact mechanism of injury in TA-TMA is not yet understood...
  7. doi request reprint Successful early intervention for hyperacute transplant-associated thrombotic microangiopathy following pediatric hematopoietic stem cell transplantation
    Sonata Jodele
    Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children s Hospital Medical Center Hoxworth Blood Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Pediatr Transplant 16:E39-42. 2012
    ..We report a successful outcome following early intervention for hyperacute TA-TMA after allogeneic HSCT...
  8. doi request reprint Pulmonary arterial hypertension in pediatric patients with hematopoietic stem cell transplant-associated thrombotic microangiopathy
    Sonata Jodele
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Biol Blood Marrow Transplant 19:202-7. 2013
    ..Pediatric patients with unexplained hypoxemia after HSCT should be evaluated for both transplantation complications, TA-TMA and PAH, accordingly...
  9. doi request reprint Blood, and not urine, BK viral load predicts renal outcome in children with hemorrhagic cystitis following hematopoietic stem cell transplantation
    Hilary L Haines
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Biol Blood Marrow Transplant 17:1512-9. 2011
    ..We conclude that the degree of BK viremia, and not viruria, may predict renal, urologic, and overall outcome in the post-HSCT population...
  10. pmc Abnormal echocardiography 7 days after stem cell transplantation may be an early indicator of thrombotic microangiopathy
    Christopher E Dandoy
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 21:113-8. 2015
    ..004) and may indicate early vascular injury in the lungs. These data suggest that echocardiography 7 days after HSCT can detect early cardiac complications of HSCT and may identify early vascular injury associated with TA-TMA...
  11. pmc Veno-occlusive disease of the liver in the absence of elevation in bilirubin in pediatric patients after hematopoietic stem cell transplantation
    Kasiani C Myers
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 21:379-81. 2015
    ..Early ultrasound evaluation in these patients may lead to more timely diagnosis and therapeutic interventions...
  12. doi request reprint High-dose methylprednisolone for veno-occlusive disease of the liver in pediatric hematopoietic stem cell transplantation recipients
    Kasiani C Myers
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center and University of Cincinnati, OH 45229, USA
    Biol Blood Marrow Transplant 19:500-3. 2013
    ..We conclude that high-dose steroid therapy if initiated early may reverse VOD of the liver in pediatric HSCT patients, abrogating the need for defibrotide therapy with its associated toxicities and regulatory difficulties...
  13. pmc A Reduced-Intensity Conditioning Regimen for Patients with Dyskeratosis Congenita Undergoing Hematopoietic Stem Cell Transplantation
    Adam S Nelson
    Division of Bone Marrow Transplantation and Immune Deficiency Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 22:884-8. 2016
    ..We conclude that a radiation-free RIC regimen results in durable engraftment, acceptable toxicity, and improved overall survival in patients with DC undergoing allogeneic HSCT. ..
  14. doi request reprint A Prospective Study of Alemtuzumab as a Second-Line Agent for Steroid-Refractory Acute Graft-versus-Host Disease in Pediatric and Young Adult Allogeneic Hematopoietic Stem Cell Transplantation
    Pooja Khandelwal
    Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 22:2220-2225. 2016
    ..Higher alemtuzumab levels are associated with CR. A real-time dose adjusted alemtuzumab study is needed to further optimize the dose of alemtuzumab in aGVHD...
  15. pmc An intermediate alemtuzumab schedule reduces the incidence of mixed chimerism following reduced-intensity conditioning hematopoietic cell transplantation for hemophagocytic lymphohistiocytosis
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 19:1625-31. 2013
    ..02). Our findings indicate that intermediate RIC reduces the incidence of mixed chimerism, is associated with a low incidence of upfront acute GVHD, and decreases the need for additional hematopoietic cell products after HCT. ..
  16. doi request reprint Vitamin D Deficiency in Pediatric Hematopoietic Stem Cell Transplantation Patients Despite Both Standard and Aggressive Supplementation
    Gregory Wallace
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 22:1271-4. 2016
    ..These data indicate that standard guidelines for VD replacement are inadequate in HSCT recipients, and further work is needed to define more appropriate dosing in this clinical setting. ..
  17. doi request reprint Improved outcomes for stem cell transplant recipients requiring pediatric intensive care
    Ranjit S Chima
    Divisions of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pediatr Crit Care Med 13:e336-42. 2012
    ..This study was conducted to review outcomes for patients undergoing hematopoietic stem cell transplantation requiring admission to our pediatric intensive care unit and to identify variables impacting survival...
  18. pmc Experience with Alemtuzumab, Fludarabine, and Melphalan Reduced-Intensity Conditioning Hematopoietic Cell Transplantation in Patients with Nonmalignant Diseases Reveals Good Outcomes and That the Risk of Mixed Chimerism Depends on Underlying Disease, Stem
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 21:1460-70. 2015
    ..We conclude that alemtuzumab, fludarabine, and melphalan RIC HCT offers good results for many patients and that the risk of developing mixed chimerism is influenced by underlying diagnosis, graft source, and alemtuzumab dosing...
  19. pmc Abnormalities in the alternative pathway of complement in children with hematopoietic stem cell transplant-associated thrombotic microangiopathy
    Sonata Jodele
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, OH
    Blood 122:2003-7. 2013
    ..These findings shed light on a novel mechanism of endothelial injury in transplant-TMA and may therefore guide the development of targeted treatment interventions. ..
  20. doi request reprint Renal arteriolar C4d deposition: a novel characteristic of hematopoietic stem cell transplantation-associated thrombotic microangiopathy
    Benjamin L Laskin
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Transplantation 96:217-23. 2013
    ..We hypothesized that kidney tissue from children with TA-TMA would more frequently show C4d deposition compared with HSCT recipients without histologic TA-TMA...
  21. doi request reprint Alternate-day micafungin antifungal prophylaxis in pediatric patients undergoing hematopoietic stem cell transplantation: a pharmacokinetic study
    Parinda A Mehta
    Division of Bone Marrow Transplantation Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Biol Blood Marrow Transplant 16:1458-62. 2010
    ..These data suggest that alternate day micafungin dosing, as described here, may provide an attractive alternative for antifungal prophylaxis in HSCT patients and merits further evaluation...
  22. pmc Clinical Utility of Computed Tomography and Magnetic Resonance Imaging for Diagnosis of Posterior Reversible Encephalopathy Syndrome after Stem Cell Transplantation in Children and Adolescents
    Christopher E Dandoy
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 21:2028-32. 2015
    ..Patients with clinical symptoms suggestive of PRES who have a negative CT should be treated appropriately for PRES and should undergo MRI of the brain as soon as clinically stable to confirm the diagnosis. ..
  23. doi request reprint Pulmonary hypertension after hematopoietic stem cell transplantation
    Christopher E Dandoy
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 19:1546-56. 2013
    ..We summarize the pathophysiology, clinical presentation, diagnosis, and management of PH in HSCT recipients. ..
  24. pmc Histologic Features of Intestinal Thrombotic Microangiopathy in Pediatric and Young Adult Patients after Hematopoietic Stem Cell Transplantation
    Javier El-Bietar
    Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 21:1994-2001. 2015
    ..Recognition of these histologic signs in post-transplantation patients with significant gastrointestinal symptoms may guide clinical decisions. ..
  25. doi request reprint BK virus nephropathy in a pediatric autologous stem-cell transplant recipient
    L Nelson Sanchez-Pinto
    Division of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Pediatr Blood Cancer 56:495-7. 2011
    ..Less commonly, BKV nephropathy occurs in allogeneic stem-cell transplant (SCT) recipients. We now describe the first reported case of BKV nephropathy after pediatric autologous SCT...
  26. doi request reprint Healthcare Burden, Risk Factors, and Outcomes of Mucosal Barrier Injury Laboratory-Confirmed Bloodstream Infections after Stem Cell Transplantation
    Christopher E Dandoy
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 22:1671-7. 2016
    ..Our data demonstrate that MBI-LCBIs lead to substantial use of healthcare resources and are associated with significant morbidity and mortality. Reduction in frequency of MBI-LCBI should be a major public health and scientific priority. ..
  27. doi request reprint Alemtuzumab levels impact acute GVHD, mixed chimerism, and lymphocyte recovery following alemtuzumab, fludarabine, and melphalan RIC HCT
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital, Cincinnati, OH
    Blood 127:503-12. 2016
    ..Precision dosing trials are warranted. We recommend a day 0 therapeutic range of 0.2 to 0.4 μg/mL. ..
  28. doi request reprint Bortezomib for refractory autoimmunity in pediatrics
    Pooja Khandelwal
    Bone Marrow Transplant and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 20:1654-9. 2014
    ..Our experience suggests that bortezomib may be beneficial in the treatment of refractory autoimmunity in children. ..
  29. pmc The successful use of alemtuzumab for treatment of steroid-refractory acute graft-versus-host disease in pediatric patients
    Pooja Khandelwal
    Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children s Hospital, Cincinnati, OH, USA
    Pediatr Transplant 18:94-102. 2014
    ..We conclude that alemtuzumab is effective for SR-aGVHD in pediatric patients with a tolerable spectrum of complications...
  30. doi request reprint Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation-associated thrombotic microangiopathy
    Benjamin L Laskin
    Divisions of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 118:1452-62. 2011
    ..We focus on TA-TMA as a distinct complication of hematopoietic stem cell transplantation, emphasizing the central role of the kidney in this disease...
  31. pmc Vitamin D Deficiency and Survival in Children after Hematopoietic Stem Cell Transplant
    Gregory Wallace
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio
    Biol Blood Marrow Transplant 21:1627-31. 2015
    ..1%). We conclude that all pediatric transplant recipients should be screened for vitamin D deficiency before HSCT and at day 100 post-transplant and that aggressive supplementation is needed to maintain sufficient levels...
  32. pmc The Noninvasive Urinary Polyomavirus Haufen Test Predicts BK Virus Nephropathy in Children After Hematopoietic Cell Transplantation: A Pilot Study
    Benjamin L Laskin
    1 Division of Nephrology, The Children s Hospital of Philadelphia, Philadelphia, PA 2 Division of Nephropathology, Department of Pathology and Laboratory Medicine, The University of North Carolina School of Medicine, Chapel Hill, NC 3 Divsion of Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 4 Division of Pathology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 5 Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 6 Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, OH
    Transplantation 100:e81-7. 2016
    ..We hypothesized that the detection of PV-Haufen in voided urine samples-a positive PV-Haufen test-was also clinically significant after HCT...
  33. doi request reprint Reduced-intensity conditioning significantly improves survival of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 116:5824-31. 2010
    ..0001). We conclude that RIC significantly improves the outcome of patients with HLH undergoing allogeneic HCT...
  34. doi request reprint Advances in critical care of the pediatric hematopoietic stem cell transplant patient
    Ranjit S Chima
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Pediatr Clin North Am 60:689-707. 2013
    ..Hence, familiarity with recent advances in the transplant process and complications is crucial for the intensivist. This article will highlight common complications encountered in the critically ill SCT recipient...
  35. doi request reprint Rapid cycle development of a multifactorial intervention achieved sustained reductions in central line-associated bloodstream infections in haematology oncology units at a children's hospital: a time series analysis
    Christopher E Dandoy
    Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA James M Anderson Center for Health Systems Excellence, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    BMJ Qual Saf 25:633-43. 2016
    ..Immunocompromised children are at high risk for central line-associated bloodstream infections (CLABSIs) and its associated morbidity and mortality. Prevention of CLABSIs depends on highly reliable care...
  36. doi request reprint Severe allergic reactions to thiol-based cytoprotective agents mesna and amifostine in a child with a supratentorial primitive neuroectodermal tumor
    Kathleen Dorris
    Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    J Pediatr Hematol Oncol 33:e250-2. 2011
    ....
  37. doi request reprint Plerixafor is safe and efficacious for mobilization of peripheral blood stem cells in pediatric patients
    Ashley Teusink
    Division of Pharmacy, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio
    Transfusion 56:1402-5. 2016
    ..Despite its use in adults, little evidence exists to support its use in children...
  38. ncbi request reprint BK virus nephropathy in a pediatric autologous stem-cell transplant recipient
    L Nelson Sanchez-Pinto
    Division of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio
    Pediatr Blood Cancer 56:495-7. 2011
    ..We now describe the first reported case of BKV nephropathy after pediatric autologous SCT. Pediatr Blood Cancer 2011;56:495-497. © 2010 Wiley-Liss, Inc...