Marie Dominique Filippi

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Mechanism of Diapedesis: Importance of the Transcellular Route
    Marie Dominique Filippi
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, Cincinnati, Ohio, USA University of Cincinnati College of Medicine, Cincinnati, Ohio, USA Electronic address
    Adv Immunol 129:25-53. 2016
  2. ncbi request reprint Rho GTPase Rac1 is critical for neutrophil migration into the lung
    Marie Dominique Filippi
    Division Experimental Hematology, Cincinnati Children s Research Foundation, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH 45229, USA
    Blood 109:1257-64. 2007
  3. ncbi request reprint Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases
    Yi Gu
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Science 302:445-9. 2003
  4. ncbi request reprint Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils
    Marie Dominique Filippi
    Division of Experimental Hematology, Cincinnati Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Nat Immunol 5:744-51. 2004
  5. pmc The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling
    Kathleen Szczur
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Blood 114:4527-37. 2009
  6. pmc Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules
    Sachin Kumar
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, OH, USA
    Blood 120:3563-74. 2012
  7. pmc Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment
    Lei Wang
    Division of Experimental Hematology, Children s Hospital Medical Center, University of Cincinnati, OH 45229, USA
    Blood 107:98-105. 2006
  8. ncbi request reprint Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways
    Dirk Carstanjen
    Division of Experimental Hematology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    J Immunol 174:4613-20. 2005
  9. pmc The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress
    Deidre Daria
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Department of Medicine, University of Cincinnati, OH 45229, USA
    Blood 111:1894-902. 2008
  10. pmc RhoA orchestrates glycolysis for TH2 cell differentiation and allergic airway inflammation
    Jun Qi Yang
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Cincinnati, Ohio Key Laboratory for Parasitic Disease Control and Prevention, Ministry of Health, Jiangsu Institute of Parasitic Diseases, Wuxi, China
    J Allergy Clin Immunol 137:231-45.e4. 2016

Collaborators

Detail Information

Publications19

  1. pmc Mechanism of Diapedesis: Importance of the Transcellular Route
    Marie Dominique Filippi
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, Cincinnati, Ohio, USA University of Cincinnati College of Medicine, Cincinnati, Ohio, USA Electronic address
    Adv Immunol 129:25-53. 2016
    ..I will also discuss emerging evidence highlighting key differences in the two modes of diapedesis and why it is clinically important to understand specificity in the regulation of diapedesis. ..
  2. ncbi request reprint Rho GTPase Rac1 is critical for neutrophil migration into the lung
    Marie Dominique Filippi
    Division Experimental Hematology, Cincinnati Children s Research Foundation, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH 45229, USA
    Blood 109:1257-64. 2007
    ..Overall, this study suggests that Rac1 is a physiologic integrator of signals for neutrophil recruitment into lung tissue during an inflammatory response...
  3. ncbi request reprint Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases
    Yi Gu
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Science 302:445-9. 2003
    ..Thus, Rac1 and Rac2 regulate unique aspects of hematopoietic development and function...
  4. ncbi request reprint Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils
    Marie Dominique Filippi
    Division of Experimental Hematology, Cincinnati Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Nat Immunol 5:744-51. 2004
    ..Thus, we have defined specific sequences in Rac that specify subcellular localization and determine the specificity of Rac2 in neutrophil chemotaxis and superoxide generation...
  5. pmc The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling
    Kathleen Szczur
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Blood 114:4527-37. 2009
    ..Our results uncover a new mechanism in which Cdc42 regulates the uropod through CD11b signaling to maintain polarity in migrating neutrophils. It also reveals new functions for CD11b in neutrophil polarity...
  6. pmc Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules
    Sachin Kumar
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, OH, USA
    Blood 120:3563-74. 2012
    ..Our study reveals a new function for WASp in the control of neutrophil polarity via crosstalk between CD11b and microtubules...
  7. pmc Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment
    Lei Wang
    Division of Experimental Hematology, Children s Hospital Medical Center, University of Cincinnati, OH 45229, USA
    Blood 107:98-105. 2006
    ..These results provide evidence that Cdc42 activity is important for erythropoiesis and for multiple HSP functions, including survival, adhesion, and engraftment...
  8. ncbi request reprint Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways
    Dirk Carstanjen
    Division of Experimental Hematology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    J Immunol 174:4613-20. 2005
    ..These findings suggest that binding to any single effector is not sufficient to rescue the distinct cellular phenotypes of Rac2-/- PMN, implicating multiple, distinct, and potentially parallel effector pathways...
  9. pmc The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress
    Deidre Daria
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Department of Medicine, University of Cincinnati, OH 45229, USA
    Blood 111:1894-902. 2008
    ..In summary, Rb is critical for hematopoietic stem and progenitor cell function, localization, and differentiation...
  10. pmc RhoA orchestrates glycolysis for TH2 cell differentiation and allergic airway inflammation
    Jun Qi Yang
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Cincinnati, Ohio Key Laboratory for Parasitic Disease Control and Prevention, Ministry of Health, Jiangsu Institute of Parasitic Diseases, Wuxi, China
    J Allergy Clin Immunol 137:231-45.e4. 2016
    ..Importantly, how metabolic pathways are integrated with T-cell activation and effector cell differentiation and function remains largely unknown...
  11. pmc Rho GTPases in hematopoiesis and hemopathies
    James C Mulloy
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH 45229, USA
    Blood 115:936-47. 2010
    ..In this review we discuss recent genetic studies of Rho GTPases in hematopoiesis and several blood lineages and the implications of Rho GTPase signaling in hematologic malignancies, immune pathology. and anemia...
  12. pmc Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation
    Emily E Bosco
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Chem Biol 19:228-42. 2012
    ..Our studies suggest the potential utility of Phox-I class inhibitors in NOX2 oxidase inhibition and present an application of rational targeting of a small GTPase-effector interface...
  13. pmc The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation
    Sachin Kumar
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229 University of Cincinnati College of Medicine, Cincinnati OH 45229
    J Exp Med 211:1741-58. 2014
    ..The inhibitory action of Rap1b on PI3K signaling may be mediated by activation of phosphatase SHP-1. Thus, this study reveals an unexpected role for Rap1b as a key suppressor of neutrophil migration and lung inflammation...
  14. ncbi request reprint GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis
    Kanji Uchida
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    N Engl J Med 356:567-79. 2007
    ..We tested the hypothesis that neutrophil functions are impaired in patients with pulmonary alveolar proteinosis and that GM-CSF autoantibodies cause the dysfunction...
  15. pmc An efficient and reproducible process for transmission electron microscopy (TEM) of rare cell populations
    Sachin Kumar
    Division of Experimental Hematology and Cancer Biology, Pathology Department, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA Electronic address
    J Immunol Methods 404:87-90. 2014
    ..Together, this method provides an efficient, easy and reproducible process to perform qualitative and quantitative TEM analysis from limited biological samples including cells in suspension. ..
  16. pmc Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential
    Haiming Xu
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Blood 114:3557-66. 2009
    ..Our study defines p190-B as a critical transducer element of HSC self-renewal activity and long-term engraftment, thus suggesting that p190-B is a target for HSC-based therapies requiring maintenance of engraftment phenotype...
  17. pmc Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease
    YuanYuan Gu
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Nature 458:1039-42. 2009
    ..These data indicate that IFRD1 modulates the pathogenesis of cystic fibrosis lung disease through the regulation of neutrophil effector function...
  18. pmc An Alternative Approach for Sample Preparation with Low Cell Number for TEM Analysis
    Sachin Kumar
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation
    J Vis Exp . 2016
    ..This efficient, easy and reproducible protocol allows sample preparation from a low cell number and can be used for qualitative and quantitative TEM analysis on rare cell populations from limited biological samples...
  19. ncbi request reprint Requirement for mitogen-activated protein kinase activation in the response of embryonic stem cell-derived hematopoietic cells to thrombopoietin in vitro
    Marie Dominique Filippi
    Institut National de la Sante et de la Recherche Medicale U362, Institut Gustave Roussy, Villejuif, France
    Blood 99:1174-82. 2002
    ..In contrast, the only function of the sequence comprising residues 71 to 94 was to mediate the synergistic effects of PEG-rhuMGDF with other hematopoietic growth factors. This function is not mediated by MAPK activation...