Genomes and Genes
Affiliation: Cincinnati Children's Hospital Medical Center
- Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signalingMark Charlton-Perkins
Department of Pediatric Ophthalmology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Neural Dev 6:20. 2011..However, many questions remain unanswered related to how downstream events of these two signaling pathways mediate distinct cell fate decisions...
- Separable transcriptional regulatory domains within Otd control photoreceptor terminal differentiation eventsElizabeth C McDonald
Molecular and Developmental Biology Graduate Program, Division of Developmental Biology and Department of Pediatric Ophthalmology, Cincinnati Children s Hospital Medical Center, USA
Dev Biol 347:122-32. 2010..Thus, these studies provide a basis for identifying shared molecular pathways involved in a wide range of developmental processes...
- Senseless functions as a molecular switch for color photoreceptor differentiation in DrosophilaBaotong Xie
Department of Pediatric Ophthalmology, Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Development 134:4243-53. 2007..Interestingly, Pros has recently been shown to function as a tumor suppressor, whereas Gfi1 is a well-characterized oncogene. Thus, we propose that sens/pros antagonism is important for regulating many biological processes...
- The lens in focus: a comparison of lens development in Drosophila and vertebratesMark Charlton-Perkins
Divisions of Pediatric Ophthalmology and Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Mol Genet Genomics 286:189-213. 2011..Finally, we provide a comparative analysis that highlights areas of research that would help further clarify the degree of conservation between the formation of dioptric systems in invertebrates and vertebrates...
- Building a fly eye: terminal differentiation events of the retina, corneal lens, and pigmented epitheliaMark Charlton-Perkins
Department of Pediatric Ophthalmology, Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
Curr Top Dev Biol 93:129-73. 2010..In addition, we discuss emerging evidence that the different functional components of the fly eye share developmental pathways and functions with the vertebrate eye...
- Drosophila Dyrk2 plays a role in the development of the visual systemNathan Luebbering
Department of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
PLoS ONE 8:e76775. 2013..Together, these data indicate that DmDyrk2 is expressed in developing sensory systems, that it is required for the development of the visual system, and that the eye is a good model to identify DmDyrk2 targets. ..