James S Tweddell

Summary

Affiliation: Children's Hospital of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Ventricular septal defect and aortic valve regurgitation: pathophysiology and indications for surgery
    James S Tweddell
    Division of Cardiothoracic Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu . 2006
  2. doi request reprint All this monitoring…what's necessary, what's not?
    James S Tweddell
    Herma Heart Center, Milwaukee, WI Children s Hospital of Wisconsin, Milwaukee, WI Department of Surgery, Division of Cardiothoracic Surgery, Milwaukee, WI Electronic address
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 17:81-90. 2014
  3. doi request reprint Valve-sparing aortic root reconstruction in children, teenagers, and young adults
    James S Tweddell
    Division of Cardiothoracic Surgery, Department of Surgery, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Thorac Surg 94:587-90; discussion 590-1. 2012
  4. doi request reprint Timing and technique of pulmonary valve replacement in the patient with tetralogy of Fallot
    James S Tweddell
    Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, WI, USA
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 15:27-33. 2012
  5. ncbi request reprint Improved survival of patients undergoing palliation of hypoplastic left heart syndrome: lessons learned from 115 consecutive patients
    James S Tweddell
    Cardiothoracic Surgery, Children s Hospital of Wisconsin and the Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    Circulation 106:I82-9. 2002
  6. doi request reprint Fontan palliation in the modern era: factors impacting mortality and morbidity
    James S Tweddell
    Division of Cardiothoracic Surgery, Department of Surgery, Sections of Pediatric Cardiology and Critical Care, Medical College of Wisconsin and Herma Heart Center, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Thorac Surg 88:1291-9. 2009
  7. ncbi request reprint Complex aortic valve repair as a durable and effective alternative to valve replacement in children with aortic valve disease
    James S Tweddell
    Herma Heart Center, Children s Hospital of Wisconsin, Milwaukee 53226, USA
    J Thorac Cardiovasc Surg 129:551-8. 2005
  8. ncbi request reprint Newborn heart surgery: reasonable expectations and outcomes
    James S Tweddell
    Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Pediatr Clin North Am 51:1611-23, ix. 2004
  9. doi request reprint Pro: NIRS is "standard of care" for postoperative management
    James S Tweddell
    Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, WI
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 13:44-50. 2010
  10. ncbi request reprint Mixed venous oxygen saturation monitoring after stage 1 palliation for hypoplastic left heart syndrome
    James S Tweddell
    Herma Heart Center and Children s Research Institute, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Thorac Surg 84:1301-10; discussion 1310-1. 2007

Collaborators

Detail Information

Publications90

  1. ncbi request reprint Ventricular septal defect and aortic valve regurgitation: pathophysiology and indications for surgery
    James S Tweddell
    Division of Cardiothoracic Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu . 2006
    ..Patients with perimembranous VSDs with AVP should be followed with serial echocardiography and undergo VSD closure if more than trivial AI develops...
  2. doi request reprint All this monitoring…what's necessary, what's not?
    James S Tweddell
    Herma Heart Center, Milwaukee, WI Children s Hospital of Wisconsin, Milwaukee, WI Department of Surgery, Division of Cardiothoracic Surgery, Milwaukee, WI Electronic address
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 17:81-90. 2014
    ..The evidence supporting the current standard perioperative monitoring strategies will be reviewed. In addition, evidence supporting non-routine monitoring strategies will be reviewed and their potential for added benefit assessed. ..
  3. doi request reprint Valve-sparing aortic root reconstruction in children, teenagers, and young adults
    James S Tweddell
    Division of Cardiothoracic Surgery, Department of Surgery, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Thorac Surg 94:587-90; discussion 590-1. 2012
    ..We reviewed our experience with valve-sparing aortic root reconstruction (VSARR) using the sinus of Valsalva graft in children, teenagers, and young adults with connective tissue disorders...
  4. doi request reprint Timing and technique of pulmonary valve replacement in the patient with tetralogy of Fallot
    James S Tweddell
    Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, WI, USA
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 15:27-33. 2012
    ..In a retrospective analysis of the Children's Hospital of Wisconsin experience with PVR, there was no difference in survival or freedom from reintervention between heterografts and homografts...
  5. ncbi request reprint Improved survival of patients undergoing palliation of hypoplastic left heart syndrome: lessons learned from 115 consecutive patients
    James S Tweddell
    Cardiothoracic Surgery, Children s Hospital of Wisconsin and the Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    Circulation 106:I82-9. 2002
    ....
  6. doi request reprint Fontan palliation in the modern era: factors impacting mortality and morbidity
    James S Tweddell
    Division of Cardiothoracic Surgery, Department of Surgery, Sections of Pediatric Cardiology and Critical Care, Medical College of Wisconsin and Herma Heart Center, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Thorac Surg 88:1291-9. 2009
    ..Coincident with these improvements, Fontan palliation has been applied to a wider ranger of anatomic subgroups...
  7. ncbi request reprint Complex aortic valve repair as a durable and effective alternative to valve replacement in children with aortic valve disease
    James S Tweddell
    Herma Heart Center, Children s Hospital of Wisconsin, Milwaukee 53226, USA
    J Thorac Cardiovasc Surg 129:551-8. 2005
    ..This study was undertaken to determine the utility of aortic valve repair in children...
  8. ncbi request reprint Newborn heart surgery: reasonable expectations and outcomes
    James S Tweddell
    Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Pediatr Clin North Am 51:1611-23, ix. 2004
    ....
  9. doi request reprint Pro: NIRS is "standard of care" for postoperative management
    James S Tweddell
    Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, WI
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 13:44-50. 2010
    ..NIRS provides continuous, non-invasive measures that are suitable targets for goal-directed therapy to treat deficiencies in global and regional perfusion and should be standard of care...
  10. ncbi request reprint Mixed venous oxygen saturation monitoring after stage 1 palliation for hypoplastic left heart syndrome
    James S Tweddell
    Herma Heart Center and Children s Research Institute, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Thorac Surg 84:1301-10; discussion 1310-1. 2007
    ....
  11. doi request reprint Near-infrared spectroscopy in neonates before palliation of hypoplastic left heart syndrome
    Beth Ann Johnson
    Herma Heart Center, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Thorac Surg 87:571-7; discussion 577-9. 2009
    ..We hypothesized that preoperative use of near-infrared spectroscopy (NIRS) would reduce the need for invasive therapies, including controlled ventilation and inspired gas manipulation...
  12. doi request reprint Perioperative cerebral oxygen saturation in neonates with hypoplastic left heart syndrome and childhood neurodevelopmental outcome
    George M Hoffman
    Children s Hospital of Wisconsin, Milwaukee, Wis Medical College of Wisconsin, Milwaukee, Wis Electronic address
    J Thorac Cardiovasc Surg 146:1153-64. 2013
    ..We hypothesized that cerebral hypoxia, detectable by near-infrared spectroscopy in the early postoperative period, would be related to later neurodevelopmental performance...
  13. ncbi request reprint Cardioprotection in chronically hypoxic rabbits persists on exposure to normoxia: role of NOS and KATP channels
    Colleen M Fitzpatrick
    Division of Pediatric Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 288:H62-8. 2005
    ..We conclude that cardioprotection conferred by adaptation to hypoxia from birth persists on subsequent exposure to normoxia and is associated with enhanced NOS activity and activation of K(ATP) channels...
  14. doi request reprint Perioperative monitoring in high-risk infants after stage 1 palliation of univentricular congenital heart disease
    Nancy S Ghanayem
    Herma Heart Center at the Children s Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Thorac Cardiovasc Surg 140:857-63. 2010
    ..We hypothesized that early goal-directed monitoring with venous oximetry and near-infrared spectroscopy would offset their increased vulnerability and improve survival...
  15. ncbi request reprint Early cavopulmonary anastomosis in very young infants after the Norwood procedure: impact on oxygenation, resource utilization, and mortality
    Robert D B Jaquiss
    Division of Pediatric Cardiothoracic Surgery Medical College of Wisconsin, and Children s Hospital of Wisconsin, Milwaukee, 53226, USA
    J Thorac Cardiovasc Surg 127:982-9. 2004
    ..Potential disadvantages include severe cyanosis, prolonged pleural drainage and hospitalization, and excess mortality. We reviewed our recent experience to evaluate the safety of early cavopulmonary anastomosis...
  16. doi request reprint A Pilot Study of Antithrombin Replacement Prior to Cardiopulmonary Bypass in Neonates
    Robert A Niebler
    Section of Critical Care, Medical College of Wisconsin, Milwaukee, WI, USA
    Artif Organs 40:80-5. 2016
    ..Although no safety concerns were identified in this pilot study, a larger trial is necessary to determine clinical efficacy. ..
  17. doi request reprint Renal dysfunction is common among adults after palliation for previous tetralogy of Fallot
    Matthew W Buelow
    Department of Pediatrics, Medical College of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Pediatr Cardiol 34:165-9. 2013
    ..The study findings show the importance of routine assessment of renal function and the need to limit or avoid future episodes of acute kidney injury in this at-risk population...
  18. ncbi request reprint Right ventricle-to-pulmonary artery conduit versus Blalock-Taussig shunt: a hemodynamic comparison
    Nancy S Ghanayem
    Herma Heart Center at the Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53201, USA
    Ann Thorac Surg 82:1603-9; discussion 1609-10. 2006
    ....
  19. ncbi request reprint Early cavopulmonary anastomosis after Norwood procedure results in excellent Fontan outcome
    Robert D B Jaquiss
    Division of Pediatric Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Ann Thorac Surg 82:1260-5; discussion 1265-6. 2006
    ..Early SCPA results in lower initial O2 saturation and longer hospitalization, but not increased mortality. We sought to determine the impact of early SCPA on Fontan candidacy and outcomes...
  20. doi request reprint Bilateral pulmonary artery banding as rescue intervention in high-risk neonates
    Rebecca A Russell
    Division of Critical Care, Department of Pediatrics, Medical College of Wisconsin and Herma Heart Center at Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53201, USA
    Ann Thorac Surg 96:885-90. 2013
    ..This report describes bilateral pulmonary artery banding (bPAB) in ductal-dependent lesions with systemic outflow obstruction as rescue intervention before surgery with cardiopulmonary bypass in these high-risk neonates...
  21. doi request reprint Predicting left ventricular recovery after replacement of a regurgitant aortic valve in pediatric and young adult patients: is it ever too late?
    Daniel A Cox
    Division of Cardiology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA
    Pediatr Cardiol 34:694-9. 2013
    ..LV end-systolic indices appear to be more predictive than LV end-diastolic indices. AVR should be performed prior to severe LV enlargement defined as an LV end-systolic dimension z-score >4.5...
  22. ncbi request reprint Erythropoietin protects the infant heart against ischemia-reperfusion injury by triggering multiple signaling pathways
    Parvaneh Rafiee
    Medical College of Wisconsin, Division of Pediatric Surgery, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Basic Res Cardiol 100:187-97. 2005
    ..SB203580 inhibited only p38 MAPK activation by EPO. We can conclude EPO increases immediate cardioprotection through the activation of multiple signal transduction pathways...
  23. ncbi request reprint Cellular redistribution of inducible Hsp70 protein in the human and rabbit heart in response to the stress of chronic hypoxia: role of protein kinases,
    Parvaneh Rafiee
    Division of Pediatric Surgery, Medical College of Wisconsin and Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 278:43636-44. 2003
    ..We conclude the Hsp70 signal transduction pathway plays an important role in adaptation of infant human and rabbit hearts to chronic hypoxemia...
  24. doi request reprint Late complications after Takeuchi repair of anomalous left coronary artery from the pulmonary artery: case series and review of literature
    Salil Ginde
    Division of Pediatric Cardiology, Department of Pediatrics, Medical College of Wisconsin, 9000 W Wisconsin Avenue, MS 713, Milwaukee, WI 53226, USA
    Pediatr Cardiol 33:1115-23. 2012
    ..The Takeuchi procedure is a method to establish a two-coronary repair for ALCAPA. Late complications are common, necessitating lifelong care in a center experienced with caring for adults with congenital heart disease...
  25. doi request reprint Aortic valve replacement in neonates and infants: an analysis of the Society of Thoracic Surgeons Congenital Heart Surgery Database
    Ronald K Woods
    Department of Surgery, Cardiothoracic Surgery, Children s Hospital Wisconsin, Medical College of Wisconsin, Milwaukee, WI, USA
    J Thorac Cardiovasc Surg 144:1084-89. 2012
    ..We sought to describe early outcomes of aortic valve replacement in neonates and infants across a large multicenter cohort...
  26. ncbi request reprint Darbepoetin alfa protects the rat heart against infarction: dose-response, phase of action, and mechanisms
    John E Baker
    Division of Cardiothoracic Surgery Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Cardiovasc Pharmacol 49:337-45. 2007
    ..Dpa confers immediate and sustained cardioprotection in rats, suggesting a potential therapeutic role of this long-acting erythropoietin analog for the treatment of acute myocardial infarction...
  27. ncbi request reprint Acute cardioprotective effects of erythropoietin in infant rabbits are mediated by activation of protein kinases and potassium channels
    Yang Shi
    Pediatric Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Basic Res Cardiol 99:173-82. 2004
    ..We conclude the rapid activation of potassium channels and protein kinases by erythropoietin represents an important new mechanism for increasing cardioprotection...
  28. ncbi request reprint Delayed cardioprotection with isoflurane: role of reactive oxygen and nitrogen
    Yang Shi
    Division of Pediatric Surgery, Free Radical Research Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 288:H175-84. 2005
    ..8% but not in 1.0% isoflurane-treated hearts. We conclude that isoflurane confers delayed cardioprotection in the adult rat, triggered by ROS and RNS...
  29. ncbi request reprint Changes in cerebral and somatic oxygenation during stage 1 palliation of hypoplastic left heart syndrome using continuous regional cerebral perfusion
    George M Hoffman
    Department of Pediatric Anesthesiology, Children s Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee 53226, USA
    J Thorac Cardiovasc Surg 127:223-33. 2004
    ..We examined relative changes in cerebral and somatic oxygenation with near-infrared spectroscopy while using a modified perfusion strategy that allowed continuous cerebral perfusion...
  30. ncbi request reprint Chronic hypoxia increases endothelial nitric oxide synthase generation of nitric oxide by increasing heat shock protein 90 association and serine phosphorylation
    Yang Shi
    Division of Pediatric Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Circ Res 91:300-6. 2002
    ..Such changes in eNOS function appear to play a critical role in protecting the myocardium against ischemic injury...
  31. ncbi request reprint Effect of shunt type on echocardiographic indices after initial palliations for hypoplastic left heart syndrome: Blalock-Taussig shunt versus right ventricle-pulmonary artery conduit
    Peter C Frommelt
    Division of Pediatric Cardiology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    J Am Soc Echocardiogr 20:1364-73. 2007
    ..The study objective was to compare echocardiographic indices in infants with hypoplastic left heart syndrome (HLHS) randomized to different surgical pathways...
  32. doi request reprint Ventricular Assist Device in Single-Ventricle Heart Disease and a Superior Cavopulmonary Anastomosis
    Robert A Niebler
    Department of Pediatrics, Section of Critical Care, Medical College of Wisconsin, Milwaukee, WI, USA
    Artif Organs 40:180-4. 2016
    ..VAD support can provide a successful bridge to transplantation in patients with single-ventricle circulation following SCPA. A thorough understanding of the challenges encountered during this support is necessary for successful outcomes...
  33. doi request reprint Restrictive versus nonrestrictive physiology following repair of tetralogy of Fallot: is there a difference?
    Margaret M Samyn
    Department of Pediatrics, Division of Cardiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Am Soc Echocardiogr 26:746-55. 2013
    ..The aim of this study was to characterize clinical differences between restrictive and nonrestrictive RV physiology in young patients with repaired TOF...
  34. pmc Normal interstage growth after the norwood operation associated with interstage home monitoring
    David A Hehir
    Division of Pediatric Critical Care, Children s Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI, 53201, USA
    Pediatr Cardiol 33:1315-22. 2012
    ..Daily observation of oxygen saturation, weight change, and enteral intake together with implementation of a multidisciplinary feeding protocol is associated with excellent interstage growth and survival...
  35. pmc Coarctectomy combined with an interdigitating arch reconstruction results in a lower incidence of recurrent arch obstruction after the Norwood procedure than coarctectomy alone
    Luke J Lamers
    Section of Pediatric Cardiology, Department of Pediatrics, The Medical College of Wisconsin, Milwaukee, WI, USA
    J Thorac Cardiovasc Surg 143:1098-102. 2012
    ..We sought to determine if a modified interdigitating technique for aortic arch reconstruction during the Norwood procedure decreased recurrent arch obstruction...
  36. ncbi request reprint Near infrared spectroscopy monitoring during pediatric aortic coarctation repair
    Richard J Berens
    Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, WI, USA
    Paediatr Anaesth 16:777-81. 2006
    ..Near infrared spectroscopy (NIRS) measures regional tissue oxygenation continuously and noninvasively and may allow assessment of changes in regional perfusion in real time...
  37. doi request reprint Impact of mitral stenosis and aortic atresia on survival in hypoplastic left heart syndrome
    Jenifer A Glatz
    Division of Cardiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Ann Thorac Surg 85:2057-62. 2008
    ..Our objective was to determine if mitral valve patency with aortic atresia is associated with increased mortality in hypoplastic left heart syndrome (HLHS)...
  38. ncbi request reprint Optimal timing of the second stage of palliation for hypoplastic left heart syndrome facilitated through home monitoring, and the results of early cavopulmonary anastomosis
    Nancy S Ghanayem
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Cardiol Young 16:61-6. 2006
  39. ncbi request reprint Alteration of the critical arteriovenous oxygen saturation relationship by sustained afterload reduction after the Norwood procedure
    George M Hoffman
    Department of Anesthesiology, Pediatric Anesthesiology and Critical Care Medicine, Children s Hospital of Wisconsin, 735, 9000 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    J Thorac Cardiovasc Surg 127:738-45. 2004
    ..In this investigation, we tested the hypothesis that intense afterload reduction with phenoxybenzamine would modify the SvO(2)-SaO(2) relationship by preventing deterioration of systemic oxygen delivery at high SaO(2)...
  40. pmc Restrictive lung disease is an independent predictor of exercise intolerance in the adult with congenital heart disease
    Salil Ginde
    Division of Cardiology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Congenit Heart Dis 8:246-54. 2013
    ..Restrictive lung disease (RLD) may contribute to reduced exercise capacity in this population. The aim of this study was to determine the prevalence of RLD and its impact on exercise tolerance in the adult with CHD...
  41. doi request reprint Aortic aneurysms remain a significant source of morbidity and mortality after use of Dacron(®) patch aortoplasty to repair coarctation of the aorta: results from a single center
    Jonathan W Cramer
    Department of Pediatrics, Division of Cardiology, Medical College of Wisconsin, Children s Hospital of Wisconsin, Herma Heart Center, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Pediatr Cardiol 34:296-301. 2013
    ..More frequent imaging should be obtained for patients previously repaired with Dacron(®) patch aortoplasty...
  42. doi request reprint Abnormal mitral valve anatomy in d-transposition of the great arteries: anatomic characterization and surgical outcomes
    Joseph A Camarda
    Department of Pediatrics, The Children s Hospital of Wisconsin, Medical College of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Pediatr Cardiol 34:70-4. 2013
    ..Unusual mitral valve apparatus positioning and chordal redundancy can suggest the need for valvuloplasty and chordal resection preoperatively, but this is rarely needed...
  43. pmc Intestinal microbiota determine severity of myocardial infarction in rats
    Vy Lam
    Division of Cardiothoracic Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    FASEB J 26:1727-35. 2012
    ..This proof-of-concept study is the first to identify a mechanistic link between changes in intestinal microbiota and myocardial infarction and demonstrates that a probiotic supplement can reduce myocardial infarct size...
  44. ncbi request reprint Monitoring the brain before, during, and after cardiac surgery to improve long-term neurodevelopmental outcomes
    Nancy S Ghanayem
    Department of Pediatrics, Division of Cardiothoracic Surgery, Medical College of Wisconsin 53122, USA
    Cardiol Young 16:103-9. 2006
  45. pmc Nitrite confers protection against myocardial infarction: role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels
    John E Baker
    Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Mol Cell Cardiol 43:437-44. 2007
    ..Inhibition of NADPH oxidase and K(ATP) channels abolished nitrite-induced cardioprotection. Nitrite but not nitrate protects against infarction by a mechanism involving xanthine oxidoreductase, NADPH oxidase and K(ATP) channels...
  46. ncbi request reprint Systemic venous oxygen saturation after the Norwood procedure and childhood neurodevelopmental outcome
    George M Hoffman
    Department of Pediatric Anesthesiology, Medical College of Wisconsin, Milwaukee, Wis, USA
    J Thorac Cardiovasc Surg 130:1094-100. 2005
    ..We hypothesized that decreased postoperative oxygen delivery, as measured on the basis of systemic venous oxyhemoglobin saturation, would be related to persistent neurodevelopmental abnormality assessed in childhood...
  47. doi request reprint Use of a HeartWare ventricular assist device in a patient with failed Fontan circulation
    Robert A Niebler
    Herma Heart Center, Children s Hospital of Wisconsin, Milwaukee, Wisconsin Department of Pediatrics, Section of Critical Care, Medical College of Wisconsin, Milwaukee, Wisconsin Electronic address
    Ann Thorac Surg 97:e115-6. 2014
    ..We present a successful case of the use of a HeartWare ventricular assist device as a bridge to transplantation in an 11-year-old with a hypoplastic left heart and failed Fontan circulation. ..
  48. doi request reprint Urinary interleukin-18 and urinary neutrophil gelatinase-associated lipocalin predict acute kidney injury following pulmonary valve replacement prior to serum creatinine
    Matthew W Buelow
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Congenit Heart Dis 7:441-7. 2012
    ..We sought to determine the efficacy of urinary IL-18 and NGAL for detecting early AKI in patients undergoing surgical pulmonary valve replacement (PVR)...
  49. ncbi request reprint Postoperative management in patients with complex congenital heart disease
    James S Tweddell
    Divisions of Cardiothoracic Surgery, Pediatric Anesthesia, and Critical Care, The Children s Hospital of Wisconsin, Milwaukee, WI 53226, USA
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 5:187-205. 2002
    ..Management of any individual patient should be driven by objective analysis of available data and must include efforts to re-evaluate the treatment plan as well as to identify unanticipated problems...
  50. doi request reprint Ten-year experience with surgical unroofing of anomalous aortic origin of a coronary artery from the opposite sinus with an interarterial course
    Peter C Frommelt
    Division of Pediatric Cardiology, Department of Pediatrics, Children s Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    J Thorac Cardiovasc Surg 142:1046-51. 2011
    ....
  51. ncbi request reprint Neurodevelopmental outcome in preschool survivors of complex congenital heart disease: implications for clinical practice
    Cheryl L Brosig
    Medical College of Wisconsin, Department of Pediatrics, Milwaukee, Wisconsin, USA
    J Pediatr Health Care 21:3-12. 2007
    ..The purpose of this study was to describe the neurodevelopmental outcome of preschool survivors of Hypoplastic Left Heart Syndrome (HLHS) and Transposition of the Great Arteries (TGA) in the modern surgical era...
  52. pmc Impact of MYH6 variants in hypoplastic left heart syndrome
    Aoy Tomita-Mitchell
    Department of Surgery, Division of Cardiovascular Surgery and Children s Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin
    Physiol Genomics 48:912-921. 2016
    ..These findings indicate that the etiology of MYH6-associated HLHS can be informed using iPSCs and suggest utility in future clinical applications...
  53. doi request reprint The Impact of Obesity on Postoperative Outcomes in Adults with Congenital Heart Disease Undergoing Pulmonary Valve Replacement
    Matthew W Buelow
    Department of Pediatrics, Division of Pediatric Cardiology, Medical College of Wisconsin, Milwaukee, Wis, USA
    Congenit Heart Dis 10:E197-202. 2015
    ..The aim of our study was to investigate the impact of obesity on postoperative outcomes in adults with congenital heart disease undergoing reoperation for pulmonary valve replacement...
  54. doi request reprint Improving interstage survival after Norwood operation: outcomes from 10 years of home monitoring
    Nancy A Rudd
    Section of Cardiology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wis Herma Heart Center, Children s Hospital of Wisconsin, Milwaukee, Wis Electronic address
    J Thorac Cardiovasc Surg 148:1540-7. 2014
    ..Routine care during the interstage period is associated with 10% to 20% mortality. This report illustrates the sustained reduction of interstage mortality over 10 years associated with use of home monitoring...
  55. doi request reprint Long-term outcomes of the neoaorta after arterial switch operation for transposition of the great arteries
    Jennifer G Co-Vu
    Department of Pediatrics, Division of Pediatric Cardiology, Milwaukee, Medical College of Wisconsin, Wisconsin
    Ann Thorac Surg 95:1654-9. 2013
    ..The aim of this study was to determine the prevalence and progression of neoaortic root dilation and neoaortic valve regurgitation in patients with TGA repaired with the ASO...
  56. pmc Fontan fenestration closure and event-free survival
    Bartlomiej R Imielski
    Division of Cardiothoracic Surgery, Department of Surgery, Medical College of Wisconsin and Herma Heart Center, Children s Hospital of Wisconsin, Milwaukee, Wis 53226, USA
    J Thorac Cardiovasc Surg 145:183-7. 2013
    ..The purpose of the present study was to evaluate the association of open and closed Fontan fenestration status with event-free survival...
  57. doi request reprint Unobstructive total anomalous pulmonary venous return: impact of early elective repair on the need for prolonged mechanical ventilatory support
    Peter C Frommelt
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Pediatr Cardiol 31:1191-7. 2010
    ..Patients with unobstructive TAPVR do very well, but potential morbidity related to prolonged MV appears to be significantly reduced by early elective surgery...
  58. ncbi request reprint Safety of aprotinin use and re-use in pediatric cardiothoracic surgery
    Robert D B Jaquiss
    Medical College of Wisconsin, and the Children s Hospital of Wisconsin, Milwaukee, Wisc, USA
    Circulation 106:I90-4. 2002
    ..This study describes the incidence and impact of aprotinin hypersensitivity reactions in children undergoing cardiothoracic surgery...
  59. ncbi request reprint Home monitoring of infants after stage one palliation for hypoplastic left heart syndrome
    Nancy S Ghanayem
    Department of Pediatrics, Division of Critical Care, Children s Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 7:32-8. 2004
    ..All 36 survivors of the stage one palliation discharged from the hospital and entered into the home monitoring program survived the interstage period...
  60. pmc Human thrombopoietin reduces myocardial infarct size, apoptosis, and stunning following ischaemia/reperfusion in rats
    John E Baker
    Division of Cardiothoracic Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Cardiovasc Res 77:44-53. 2008
    ..Thrombopoietin (Tpo) is known for its ability to stimulate platelet production. However, it is currently unknown whether Tpo plays a physiological function in the heart...
  61. doi request reprint Impact of Intrauterine Growth Restriction on Cardiac Surgical Outcomes and Resource Use
    Ryan Graf
    Medical College of Wisconsin, Milwaukee, Wisconsin
    Ann Thorac Surg 100:1411-5. 2015
    ..We sought to evaluate outcomes of congenital heart operations and resource use in patients with intrauterine growth restriction (IUGR)...
  62. pmc Risk Factors for Abnormal Developmental Trajectories in Young Children With Congenital Heart Disease
    Kathleen A Mussatto
    From Herma Heart Center, Children s Hospital of Wisconsin, Milwaukee K A M, J T and Departments of Pediatrics R H, L B, Y C, C B, Anesthesiology G H, and Surgery J S T, Medical College of Wisconsin, Milwaukee
    Circulation 132:755-61. 2015
    ..Children with congenital heart disease are at risk for developmental delay. This study sought to identify early risk factors for abnormal developmental trajectories in children with congenital heart disease...
  63. doi request reprint Long-term outcomes after surgical repair of complete atrioventricular septal defect
    Salil Ginde
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wis Electronic address
    J Thorac Cardiovasc Surg 150:369-74. 2015
    ..We examined the long-term survival, need for reoperation, and associated risk factors after CAVSD repair at our institution...
  64. doi request reprint Tricuspid repair at pulmonary valve replacement does not alter outcomes in tetralogy of Fallot
    Jonathan W Cramer
    Department of Pediatrics, Division of Cardiology, Medical College of Wisconsin, Milwaukee, Wisconsin
    Ann Thorac Surg 99:899-904. 2015
    ..For those with significant tricuspid regurgitation at the time of pulmonary valve replacement, it is unknown whether concomitant tricuspid valve repair improves postoperative outcomes...
  65. doi request reprint Atrial tachyarrhythmias and the Cox-maze procedure in congenital heart disease
    Sherrill D Gutierrez
    Department of Pediatrics and Internal Medicine, Medical College of Wisconsin, Milwaukee, Wis, USA
    Congenit Heart Dis 8:434-9. 2013
    ..Though the Cox-maze procedure has been used for atrial tachyarrhythmias in patients with congenital heart disease, few studies have looked at its effectiveness...
  66. pmc Risk and prevalence of developmental delay in young children with congenital heart disease
    Kathleen A Mussatto
    Herma Heart Center, Children s Hospital of Wisconsin, Milwaukee, Wisconsin and
    Pediatrics 133:e570-7. 2014
    ..We report the results of a structured approach using longitudinal testing to identify problems and ensure early intervention in accordance with published guidelines...
  67. doi request reprint Transposition of the great arteries--outcomes and time interval of early neonatal repair
    Michael T Cain
    Medical College of Wisconsin, Milwaukee, WI, USA
    World J Pediatr Congenit Heart Surg 5:241-7. 2014
    ..This study evaluates the relationship of morbidity and resource utilization with the timing of early neonatal repair of transposition of the great arteries and intact ventricular septum (d-TGA/IVS)...
  68. doi request reprint Changes in cerebral oxygen saturation correlate with S100B in infants undergoing cardiac surgery with cardiopulmonary bypass
    Samer Abu-Sultaneh
    1Section of Pediatric Critical Care Medicine, Department of Pediatrics, Indiana University School of Medicine and Riley Hospital for Children at Indiana University Health, Indianapolis, IN 2Division of Critical Care, Department of Pediatrics, Children s Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, WI 3Division of Cardiology, Department of Pediatrics, Children s Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, WI 4Division of Neonatology, Department of Pediatrics, Children s Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, WI 5Division of Quantitative Health Sciences, Department of Pediatrics, Children s Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, WI 6Division of Cardiothoracic Surgery, Department of Pediatrics, Children s Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, WI 7Banyan Biomarkers Inc, Alachua, FL 8Department of Pediatric Anesthesiology, Children s Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, WI
    Pediatr Crit Care Med 15:219-28. 2014
    ..The relationship of cerebral saturation measured by near-infrared spectroscopy with serum biomarker of brain injury S100B was investigated in infants undergoing cardiac surgery with cardiopulmonary bypass...
  69. doi request reprint Incidence and outcome of pediatric patients with intracranial hemorrhage while supported on ventricular assist devices
    Robert A Niebler
    Department of Pediatrics, Section of Critical Care, The Medical College of Wisconsin, Milwaukee, WI, USA Herma Heart Center, Children s Hospital of Wisconsin, Milwaukee, WI, USA
    Artif Organs 38:73-8. 2014
    ..ICH is a devastating complication of VAD support. Prior ischemic infarcts and interruptions to anticoagulation may put a patient at risk for ICH. Prompt neurosurgical evaluation/intervention can result in positive outcomes. ..
  70. doi request reprint Thromboelastography in the assessment of bleeding following surgery for congenital heart disease
    Robert A Niebler
    Department of Pediatrics, Division of Critical Care, Medical College of Wisconsin, Milwaukee, WI, USA
    World J Pediatr Congenit Heart Surg 3:433-8. 2012
    ..Thromboelastography illustrates derangements in the coagulation system and may aid in the treatment of postoperative bleeding. ..
  71. doi request reprint Noninvasive assessment of liver fibrosis in adult patients following the Fontan procedure
    Salil Ginde
    Departments of Pediatrics, Division of Pediatric Cardiology Radiology Internal Medicine, Division of Cardiovascular Medicine Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Congenit Heart Dis 7:235-42. 2012
    ..We sought to determine the prevalence of liver disease in adult patients following the Fontan procedure using computed tomography (CT) and serum biomarkers of liver fibrosis...
  72. ncbi request reprint Surgical therapy for sudden cardiac death in children
    Robert D B Jaquiss
    Division of Cardiothoracic Surgery, Medical College of Wisconsin, 9000 West Wisconsin Avenue, MS 715, Milwaukee, WI 53226, USA
    Pediatr Clin North Am 51:1389-400. 2004
    ....
  73. ncbi request reprint Characterizing the inflammatory response to cardiopulmonary bypass in children
    Deborah J Kozik
    The Herma Heart Center, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Ann Thorac Surg 81:S2347-54. 2006
    ..In addition the current and evolving strategies to prevent, limit, and treat the inflammatory response to cardiopulmonary bypass in children are examined...
  74. ncbi request reprint A medical strategy to reduce persistent chest tube drainage after the fontan operation
    Joseph R Cava
    Division of Pediatric Cardiology, Herma Heart Center, Children s Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Cardiol 96:130-3. 2005
    ..The duration of chest tube drainage, hospital stay, and the need for pleural sclerosis were significantly reduced, indicating that postoperative management plays an important role in reducing this morbidity...
  75. ncbi request reprint Prospective echocardiographic diagnosis and surgical repair of anomalous origin of a coronary artery from the opposite sinus with an interarterial course
    Peter C Frommelt
    Division of Pediatric Cardiology, Department of Pediatrics, Children s Hospital of Wisconsin, Medical College of Wisconsin, 9000West Wisconsin Avenue, Milwaukee, WI 53226, USA
    J Am Coll Cardiol 42:148-54. 2003
    ....
  76. pmc Intermediate-term mortality and cardiac transplantation in infants with single-ventricle lesions: risk factors and their interaction with shunt type
    James S Tweddell
    Medical College of Wisconsin, Milwaukee, Wis, USA
    J Thorac Cardiovasc Surg 144:152-9. 2012
    ....
  77. doi request reprint Surgery and critical care for anomalous coronary artery from the pulmonary artery
    Timothy A Fehrenbacher
    Division of Cardiothoracic Surgery, Department of Surgery and Section of Critical Care, Herma Heart Center, Children s Hospital of Wisconsin, Medical College of Wisconsin, Wisconsin 53226, United States of America
    Cardiol Young 20:35-43. 2010
    ..Mechanical support, with either extracorporeal membrane oxygenation or left ventricular assist device, should be available for use if necessary...
  78. ncbi request reprint Rosiglitazone antagonizes vascular endothelial growth factor signaling and nuclear factor of activated T cells activation in cardiac valve endothelium
    Tara L Sander
    Department of Surgery, Medical College of Wisconsin and Children s Research Institute, Milwaukee, Wisconsin 53226, USA
    Endothelium 13:181-90. 2006
    ..These data provide the first demonstration that ROSI negatively regulates VEGF signaling in the valve endothelium by a mechanism involving NFATc1 activation and nuclear translocation...
  79. doi request reprint Intensive care of the pediatric ventricular assist device patient
    David A Hehir
    Division of Pediatric Critical Care, Children s Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI, USA
    World J Pediatr Congenit Heart Surg 3:58-66. 2012
    ..Specific aspects of postoperative and long-term care including device troubleshooting, hemostasis and anticoagulation, support of the right ventricle, incidence and prevention of neurologic injury, and other complications are reviewed. ..
  80. pmc Human gene copy number spectra analysis in congenital heart malformations
    Aoy Tomita-Mitchell
    Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Physiol Genomics 44:518-41. 2012
    ..3% had likely causal (significantly enriched), large, rare CNVs. CNV frequency spectra combined with precision phenotyping may lead to increased molecular understanding of etiologic pathways...
  81. ncbi request reprint Complete staged palliation of hypoplastic left heart syndrome in a child with cystic fibrosis
    Eckehard A E Stuth
    Department of Anesthesiology, Section of Pediatric Anesthesia, Children s Hospital of Wisconsin and Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA
    Paediatr Anaesth 13:345-8. 2003
    ....
  82. ncbi request reprint Activation of protein kinases in chronically hypoxic infant human and rabbit hearts: role in cardioprotection
    Parvaneh Rafiee
    Division of Pediatric Surgery, Medical College of Wisconsin, Milwaukee 53226, USA
    Circulation 106:239-45. 2002
    ..However, the signaling pathways by which infant hearts adapt to chronic hypoxia and resist subsequent surgical ischemia is unknown...
  83. ncbi request reprint The neonate with congenital heart disease: what the cardiac surgeon needs to know from the neonatologist and the cardiologist
    Robert D B Jaquiss
    Medical College of Wisconsin, 9000 West Wisconsin Avenue, MS 715, Milwaukee, WI 53221, USA
    Clin Perinatol 32:947-61, ix. 2005
    ..Unique perioperative considerations attach to each cardiac anomaly and are briefly reviewed, and the importance of continuity of care for the patient and family is emphasized...
  84. ncbi request reprint Orthotopic heart transplantation in a child with histiocytoid cardiomyopathy
    Steven D Zangwill
    Division of Cardiology, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Heart Lung Transplant 23:902-4. 2004
    ..We reviewed the clinical and pathologic findings and compared them to previous studies...
  85. doi request reprint Antithrombin replacement during extracorporeal membrane oxygenation
    Robert A Niebler
    Department of Pediatrics, Section of Critical Care, The Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, WI, USA
    Artif Organs 35:1024-8. 2011
    ..ATIII administration resulted in higher ATIII activity levels for 24 h without a significant effect on heparin dose, ACT, or measures of bleeding...
  86. pmc Multiplexed quantitative real-time PCR to detect 22q11.2 deletion in patients with congenital heart disease
    Aoy Tomita-Mitchell
    Division of Cardiovascular Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 42:52-60. 2010
    ..The MQPCR assay is a rapid, inexpensive, sensitive, and specific assay that can be used to screen for 22q11.2 deletion syndrome. The assay is readily adaptable to high throughput...
  87. ncbi request reprint Extracorporeal membrane oxygenation for pediatric cardiac failure: limitations and future directions
    James S Tweddell
    Crit Care Med 32:1091-2. 2004
  88. doi request reprint The safety, efficacy, and pharmacokinetics of esmolol for blood pressure control immediately after repair of coarctation of the aorta in infants and children: a multicenter, double-blind, randomized trial
    Sarah Tabbutt
    Cardiac Intensive Care Unit, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 136:321-8. 2008
    ..We report the first prospective multi-institutional trial addressing the safety and efficacy of esmolol after repair of coarctation of the aorta in infants and children...
  89. ncbi request reprint Aspirin: a treatment for the headache of shunt-dependent pulmonary blood flow and parallel circulation?
    James S Tweddell
    Circulation 116:236-7. 2007
  90. ncbi request reprint The vertical vein: to ligate or not to ligate
    James S Tweddell
    J Thorac Cardiovasc Surg 133:1135-6. 2007