Robert H Squires
Affiliation: Children's Hospital of Pittsburgh
- Autoimmune hepatitis in childrenRobert H Squires
Division of Gastroenterology Hepatology, Children s Hospital of Pittsburgh and the University of Pittsburgh Medical Center, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
Curr Gastroenterol Rep 6:225-30. 2004..Treatment with prednisone and azathioprine, alone or in combination, reverses the clinical course and improves biochemical abnormalities. Should liver transplantation be necessary, autoimmune injury may recur in the allograft...
- Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study groupRobert H Squires
University of Pittsburgh, Children s Hospital of Pittsburgh, PA 15213, USA
J Pediatr 148:652-658. 2006..To determine short-term outcome for children with acute liver failure (ALF) as it relates to cause, clinical status, and patient demographics and to determine prognostic factors...
- Intravenous N-acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: a placebo-controlled clinical trialRobert H Squires
Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
Hepatology 57:1542-9. 2013..0493). There were no significant differences between treatment arms for hospital or ICU length of stay, organ systems failing, or highest recorded grade of HE...
- Data-Driven Modeling for Precision Medicine in Pediatric Acute Liver FailureRuben Zamora
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213
Mol Med 22:. 2016..Our results suggest that increasing inflammatory network connectivity is associated with non-survival in PALF, and may ultimately lead to better patient outcome stratification...
- Prevalence and Significance of Autoantibodies in Children with Acute Liver FailureMichael R Narkewicz
Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine and Children s Hospital Colorado, Aurora, CO Division of Gastroenterology and Hepatology, Seattle Children s Hospital and Department of Pediatrics, University of Washington School of Medicine, Seattle, WA Department of Pediatrics and Department of Developmental Biology, Washington University School of Medicine, St Louis, MO Division of Pediatric Gastroenterology, Hepatology Nutrition and Transplant and Regenerative Medicine Centre, The Hospital for Sick Children, and Department of Pediatrics, and the University of Toronto, Canada Division of Pediatric Gastroenterology, Hepatology and Nutrition, UCSF Benioff Children s Hospital, Departments of Pediatrics and Surgery, University of California, San Francisco, CA Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Emory University School of Medicine and Children s Healthcare of Atlanta Division of Gastroenterology, Hepatology and Nutrition, The Children s Hospital of Philadelphia and Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA Department of Pediatrics, University of Pittsburgh School of Medicine Division of Gastroenterology, Hepatology and Nutrition, Children s Hospital of Pittsburgh of UPMC, Pittsburgh
J Pediatr Gastroenterol Nutr . 2016..The purpose of this study is to estimate autoantibody (autoAB) frequency, clinical characteristics and 21 day outcome of participants in the Pediatric Acute Liver Failure Study Group (PALFSG) by ANA, SMA and LKM antibody status...
- King's College Hospital Criteria for non-acetaminophen induced acute liver failure in an international cohort of childrenVinay Sundaram
Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
J Pediatr 162:319-23.e1. 2013..To validate King's College Hospital criteria (KCHC) in children with non-acetaminophen induced pediatric acute liver failure (PALF) and to determine whether re-optimizing the KCHC would improve predictive accuracy...
- Current perspectives on pediatric intestinal transplantationGeorge V Mazariegos
Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
Curr Gastroenterol Rep 11:226-33. 2009..Experience at centers of excellence demonstrates 1- and 5-year patient survival rates of 95% and 77%, respectively, with ongoing investigations focusing on lowering long-term causes of graft loss such as chronic rejection...
- Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failureNabil Azhar
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 8:e78202. 2013..We hypothesized that specific, dynamic, and measurable patterns of immune/inflammatory dysregulation will correlate with outcomes in PALF...
- Prognostic scoring indices in Wilson disease: a case series and cautionary taleRyan T Fischer
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA 15238, USA
J Pediatr Gastroenterol Nutr 52:466-9. 2011..The Wilson Index is a prognostic index used to determine the risk of death without transplant in WD. We sought to determine the accuracy of this system in our own patient population...
- Neuropsychological functioning and health-related quality of life: pediatric acute liver failure study group resultsLisa G Sorensen
Department of Child and Adolescent Psychiatry Department of Pediatrics, Ann and Robert H Lurie Children s Hospital of Chicago, Chicago, IL Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA Department of Psychology and Neuroscience, Baylor University, Waco, TX Department of Pediatrics, Texas A and M University, College Station Department of Paediatrics, Hospital for Sick Children, Toronto, ON, Canada Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA
J Pediatr Gastroenterol Nutr 60:75-83. 2015..The goal was to determine the prevalence of reduced neuropsychological functioning and health-related quality of life (HRQOL) following PALF...
- Portal hypertension in children: expert pediatric opinion on the report of the Baveno v Consensus Workshop on Methodology of Diagnosis and Therapy in Portal HypertensionBenjamin L Shneider
Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
Pediatr Transplant 16:426-37. 2012..The opinions of that expert panel are reported...
- Acute liver failure in childrenRobert H Squires
University of Pittsburgh, Pittsburgh, PA 15213, USA
Semin Liver Dis 28:153-66. 2008..Overall, short-term outcomes are better in children than adults but are dependent upon the degree of encephalopathy and diagnosis...
- Screening for Wilson disease in acute liver failure: a comparison of currently available diagnostic testsJessica D Korman
Montefiore Medical Center, Bronx, NY, USA
Hepatology 48:1167-74. 2008..In addition, an AST:ALT ratio >2.2 yielded a sensitivity of 94%, a specificity of 86%, and a likelihood ratio of 7 for diagnosing fulminant WD. Combining the tests provided a diagnostic sensitivity and specificity of 100%...
- Liver disease caused by failure to racemize trihydroxycholestanoic acid: gene mutation and effect of bile acid therapyKenneth D R Setchell
Division of Clinical Mass Spectrometry, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Gastroenterology 124:217-32. 2003....
- Liver transplantation for cholestasis associated with cystic fibrosis in the pediatric populationErnesto P Molmenti
Baylor University Medical Center, Dallas, TX, USA
Pediatr Transplant 7:93-7. 2003..The presence of Aspergillus in the sputum does not constitute a contraindication for OLTX...
- Chronic Abdominal Pain In Children: a Technical Report of the American Academy of Pediatrics and the North American Society for Pediatric Gastroenterology, Hepatology and NutritionCarlo Di Lorenzo
J Pediatr Gastroenterol Nutr 40:249-61. 2005..Pediatric studies of therapeutic interventions were examined and found to be limited or inconclusive...
- Acute liver failure in childrenJohn Bucuvalas
Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Clin Liver Dis 10:149-68, vii. 2006..This article examines current knowledge of the epidemiology, pathobiology, and treatment of ALF in children and identifies potential gaps in this knowledge for future study...
- Isolated liver transplantation in infants with short gut syndrome: is less better?George V Mazariegos
Liver Transpl 12:1040-1. 2006
- Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate causeLaura P James
Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas, USA
Pediatrics 118:e676-81. 2006..The objective of this study was to use a new assay for the detection of acetaminophen cysteine protein adducts in children with acute liver failure to determine the role of acetaminophen toxicity in acute liver failure of unknown cause...
- Growth failure and outcomes in infants with biliary atresia: a report from the Biliary Atresia Research ConsortiumPatricia A DeRusso
Johns Hopkins School of Medicine and The Johns Hopkins Children s Center, Baltimore, Maryland, USA
Hepatology 46:1632-8. 2007..The combination of intermediate bilirubin concentrations and poor mean weight z-scores 3 months after HPE was also associated with poor clinical outcome...
- Acute liver failure: Summary of a workshopWilliam M Lee
Division of Digestive and Liver Diseases, University of Texas Southwestern Medical School, Dallas, TX 75390 8887, USA
Hepatology 47:1401-15. 2008..Advances in stem cell research may allow provision of cells for bioartificial liver support. ALF presents many challenging opportunities in both clinical and basic research...
- Treatment of unresectable hepatoblastoma with liver transplantation in the pediatric populationErnesto P Molmenti
Baylor University Medical Center, Transplantation Services, Dallas, TX 75246, USA
Am J Transplant 2:535-8. 2002..Early diagnosis and treatment were found to be associated with better results. Response to chemotherapy may be an important factor influencing survival. Rising AFP levels after transplantation are associated with recurrence...