Affiliation: Children's Hospital of Pittsburgh
- Montelukast in 2- to 5-year-old children with asthmaD Skoner
Department of Allergy and Immunology, Children s Hospital of Pittsburgh, 3705 Fifth Ave, 4B 320, Pittsburgh, PA 15213, USA
Pediatr Pulmonol Suppl 21:46-8. 2001..A 4-mg chewable tablet administered once daily was determined to be the correct dose and was subsequently found to be safe and effective in asthmatic children 2-5 years of age...
- Balancing safety and efficacy in pediatric asthma managementDavid P Skoner
Section of Allergy and Immunology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Pediatrics 109:381-92. 2002..Physicians must evaluate and compare the balance of safety and efficacy for each agent to determine the appropriate asthma therapy for individual patients...
- Evidence for cytokine mediation of disease expression in adults experimentally infected with influenza A virusD P Skoner
Department of Pediatrics, Allergy Immunology Section, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
J Infect Dis 180:10-4. 1999..These data support a causal relationship between viral replication, cytokine production, and symptom expression, and they suggest that IL-6 may have a role in mediating symptom and sign expression during influenza A infection...
- Detection of growth suppression in children during treatment with intranasal beclomethasone dipropionateD P Skoner
Children s Hospital, Pittsburgh, Pennsylvania 15231, USA
Pediatrics 105:E23. 2000..This study was undertaken to assess the effects of 1 year of treatment with intranasal BDP on growth in children...
- Growth effects of asthma and asthma therapyDavid P Skoner
Pediatrics and Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 2583, USA
Curr Opin Pulm Med 8:45-9. 2002..Ultimately, no child whose disease severity warrants ICS therapy should be denied the tremendous benefits that this therapy can provide because of relatively minor concerns about growth effects...
- The effects of intranasal triamcinolone acetonide and intranasal fluticasone propionate on short-term bone growth and HPA axis in children with allergic rhinitisDavid P Skoner
Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Ann Allergy Asthma Immunol 90:56-62. 2003....
- Outcome measures in childhood asthmaDavid P Skoner
Sections of Allergy and Immunology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Pediatrics 109:393-8. 2002..Whether 1 or more of these outcome measures will prove useful clinically in improving the diagnosis and management of childhood asthma remains uncertain, although early research results are encouraging...
- Increased interleukin-6 levels in nasal lavage samples following experimental influenza A virus infectionD Gentile
Department of Pediatrics, The Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
Clin Diagn Lab Immunol 5:604-8. 1998..These results suggest a role for locally produced IL-6 in the pathogenesis and expressed symptomatology of influenza A virus infection...
- Inhaled steroids and the risk of adrenal suppression in childrenJamar D Robinson
Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
Expert Opin Drug Saf 1:237-44. 2002..This review will discuss adrenal suppression found with common ICS...
- Association between TNF-alpha and TGF-beta genotypes in infants and parental history of allergic rhinitis and asthmaDeborah A Gentile
Department of Pediatrics, Allegheny General Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA 15212, USA
Hum Immunol 65:347-51. 2004..If confirmed by future studies, cytokine genotyping may be a useful tool for identifying at-risk infants who may benefit from the selective use of preventative and/or early intervention treatments for these disorders...
- Diminished dendritic cell interleukin 10 production in atopic childrenDeborah A Gentile
Division of Allergy, Asthma and Immunology, Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
Ann Allergy Asthma Immunol 92:538-44. 2004..Diminished interleukin 10 (IL-10) and/or IL-12 production may contribute to the pathogenesis of asthma and atopy. Dendritic cells (DCs) produce these cytokines and have been implicated in the pathogenesis of these disorders...
- Concerns about intranasal corticosteroids for over-the-counter use: position statement of the Joint Task Force for the American Academy of Allergy, Asthma and Immunology and the American College of Allergy, Asthma and ImmunologyLeonard Bielory
Department of Medicine, UMDNJ New Jersey Medical School, Newark, USA
Ann Allergy Asthma Immunol 96:514-25. 2006..Thus, as stated, we recommend that intranasal corticosteroids remain prescription-only drugs...
- Evaluation of levalbuterol metered dose inhaler in pediatric patients with asthma: a double-blind, randomized, placebo- and active-controlled trialWilliam E Berger
Allergy and Asthma Associates of Southern California, Mission Viejo, CA, USA
Curr Med Res Opin 22:1217-26. 2006..To evaluate the efficacy and safety of levalbuterol metered dose inhaler (MDI) in children aged 4-11 years (n = 173)...
- Assessment of the long-term safety of inhaled ciclesonide on growth in children with asthmaDavid P Skoner
Allegheny General Hospital, Department of Pediatrics, 320 E North Ave, South Tower, Seventh Floor, Pittsburgh, PA 15212, USA
Pediatrics 121:e1-14. 2008..To assess the effects of the new inhaled corticosteroid ciclesonide on growth in children with asthma...
- The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthmaWilliam W Busse
Department of Medicine, University of Wisconsin School of Medicine and Public Health, J5 219 CSC, Box 2454, 600 Highland Ave, Madison, WI 53792, USA
J Allergy Clin Immunol 121:1167-74. 2008....
- Emotional style and susceptibility to the common coldSheldon Cohen
Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213 3890, USA
Psychosom Med 65:652-7. 2003..We tested these hypotheses for host resistance to the common cold...
- Effect on growth of long-term treatment with intranasal triamcinolone acetonide aqueous in children with allergic rhinitisDavid P Skoner
Division of Allergy, Asthma, and Immunology, Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
Ann Allergy Asthma Immunol 101:431-6. 2008..Guidelines recommend treatment with intranasal corticosteroids for patients with allergic rhinitis (AR), but concerns remain about possible adverse effects...
- Cytokine gene polymorphisms moderate illness severity in infants with respiratory syncytial virus infectionDeborah A Gentile
Department of Pediatrics, Children s Hospital of Pittsburgh, PA 15213, USA
Hum Immunol 64:338-44. 2003..If future prospective studies confirm these observations, cytokine genotyping may be a useful tool for identifying "at risk" infants who may benefit from the selective use of preventive or early intervention treatments for RSV...
- Effect of respiratory syncytial virus infection during early infancy on the ontogeny of cytokine immune responsesDeborah A Gentile
Department of Pediatrics, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
Allergy Asthma Proc 23:399-405. 2002..Such strategies may include administration of IL-12 or manipulation of DC maturation or function...
- Nasal and oral nitric oxide levels during experimental respiratory syncytial virus infection of adultsDeborah A Gentile
Department of Pediatrics, Children s Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
Acta Otolaryngol 122:61-6. 2002..These results do not support the hypothesis of increased NO production during RSV infection and complement earlier studies that reported a lack of change in nasal NO concentration during experimental influenza and rhinovirus infections...
- Cytokine gene polymorphisms moderate responses to respiratory syncytial virus in adultsDeborah A Gentile
Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
Hum Immunol 64:93-8. 2003..These results suggest that certain cytokine gene polymorphisms moderate immune responses and illness severity in adults experimentally exposed to RSV...
- Nasal and otologic effects of experimental respiratory syncytial virus infection in adultsCraig A Buchman
Department of Otolaryngology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA
Am J Otolaryngol 23:70-5. 2002..This study was conducted to more clearly define the extent and frequency of nasal and otologic effects of respiratory syncytial virus infection in healthy adult volunteers...
- A randomized, double-blind, parallel-group, multicenter, placebo-controlled study of the safety and efficacy of extended-release guaifenesin/pseudoephedrine hydrochloride for symptom relief as an adjunctive therapy to antibiotic treatment of acute respiraCraig LaForce
North Carolina Clinical Research Inc, Raleigh, NC, USA
Postgrad Med 120:53-9. 2008....
- Use of intranasal cromolyn sodium for allergic rhinitisPaul H Ratner
Sylvana Research Associates and Department of Pediatrics, University of Texas Health Science Center, San Antonio, USA
Mayo Clin Proc 77:350-4. 2002..Intranasal cromolyn has an excellent safety record, is available as an over-the-counter medication, and has been proved to be efficacious in patients with allergic rhinitis...
- Allergy skin test responses during experimental infection with respiratory syncytial virusDavid P Skoner
Department of Pediatrics, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania 15212, USA
Ann Allergy Asthma Immunol 96:834-9. 2006..False-positive allergen skin test results are known to occur; however, contributing factors are not well understood...
- Viral infection and allergy: lower airwayDavid P Skoner
Department of Pediatrics and Otolaryngology, University of Pittsburgh School of Medicine, Department of Allergy and Immunology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
Allergy Asthma Proc 23:229-32. 2002..Undoubtedly, future efforts will be aimed at the prevention of asthma exacerbations via well-targeted and well-conceived strategies for prevention and/or treatment of upper respiratory infections...
- Evaluation of the safety and efficacy of levalbuterol in 2-5-year-old patients with asthmaDavid P Skoner
Allegheny General Hospital, Division of Allergy, Asthma and Immunology, Pittsburgh, Pennsylvania, USA
Pediatr Pulmonol 40:477-86. 2005..In this study of levalbuterol in children aged 2-5 years with asthma, LEV was generally well-tolerated, and in children able to perform PEF, led to significant bronchodilation compared with placebo...
- Nasal cytokines as mediators of illness during the common coldWilliam J Doyle
Allegheny Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA
Curr Allergy Asthma Rep 5:173-81. 2005..The available evidence for mediation of the common cold is the subject of this manuscript...
- State and trait affect as predictors of salivary cortisol in healthy adultsDeborah E Polk
Psychology Department, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
Psychoneuroendocrinology 30:261-72. 2005..Differences in rhythmicity found here are noteworthy given the possible role of cortisol dysregulation in disease incidence, morbidity, mortality, and severity...
- New enzyme immunoassay for salivary cortisolHershel Raff
Clin Chem 49:203-4. 2003
- Elevations of local leukotriene C4 levels during viral upper respiratory tract infectionsDeborah A Gentile
Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
Ann Allergy Asthma Immunol 91:270-4. 2003..One potential mechanism by which respiratory viruses trigger illness and complications is via the local elaboration of inflammatory mediators...
- Comparison of subject-reported allergy versus skin test results in a common cold trialJason S Krahnke
Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Rhinol 17:159-62. 2003..The objective of this study was to compare the results of self-reported allergy via verbal questioning with the results of allergy skin testing by the puncture method in 237 healthy adult subjects enrolled in a common cold study...