J Robbins

Summary

Affiliation: Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi Remodeling the cardiac sarcomere using transgenesis
    J Robbins
    Department of Pediatrics, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    Annu Rev Physiol 62:261-87. 2000
  2. ncbi Manipulating the contractile apparatus: genetically defined animal models of cardiovascular disease
    F Dalloz
    Department of Pediatrics, Children's Hospital Research Foundation, Cincinnati, OH 45229-3039, USA
    J Mol Cell Cardiol 33:9-25. 2001
  3. ncbi Mouse model of desmin-related cardiomyopathy
    X Wang
    Divisions of Molecular Cardiovascular Biology, Children's Hospital Research Foundation, Cincinnati, Ohio, USA
    Circulation 103:2402-7. 2001
  4. pmc Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice
    M C Colbert
    Division of Molecular Cardiovascular Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 100:1958-68. 1997
  5. ncbi Examining the in vivo role of the amino terminus of the essential myosin light chain
    A Sanbe
    Department of Pediatrics, Division of Molecular Cardiovascular Biology, The Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 276:32682-6. 2001
  6. ncbi Phenotypic deficits in mice expressing a myosin binding protein C lacking the titin and myosin binding domains
    Q Yang
    Children's Hospital Research Foundation, Department of Pediatrics, Division of Molecular Cardiovascular Biology, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
    J Mol Cell Cardiol 33:1649-58. 2001
  7. ncbi Transgenic overexpression of cardiac actin in the mouse heart suggests coregulation of cardiac, skeletal and vascular actin expression
    A Kumar
    Division of Developmental Biology, University of Cincinnati, College of Medicine, Cincinnati, OH 45229, USA
    Transgenic Res 13:531-40. 2004
  8. ncbi Transgenic over-expression of a motor protein at high levels results in severe cardiac pathology
    J James
    Children s Hospital Research Foundation, Department of Pediatrics, Cincinnati, OH 45229 3039, USA
    Transgenic Res 8:9-22. 1999
  9. ncbi In vivo modeling of myosin binding protein C familial hypertrophic cardiomyopathy
    Q Yang
    Department of Pediatrics, Division of Molecular Cardiovascular Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    Circ Res 85:841-7. 1999
  10. ncbi Altered kinetics of contraction of mouse atrial myocytes expressing ventricular myosin regulatory light chain
    S H Buck
    Department of Pediatrics, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Am J Physiol 276:H1167-71. 1999

Collaborators

Detail Information

Publications27

  1. ncbi Remodeling the cardiac sarcomere using transgenesis
    J Robbins
    Department of Pediatrics, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    Annu Rev Physiol 62:261-87. 2000
    ....
  2. ncbi Manipulating the contractile apparatus: genetically defined animal models of cardiovascular disease
    F Dalloz
    Department of Pediatrics, Children's Hospital Research Foundation, Cincinnati, OH 45229-3039, USA
    J Mol Cell Cardiol 33:9-25. 2001
    ....
  3. ncbi Mouse model of desmin-related cardiomyopathy
    X Wang
    Divisions of Molecular Cardiovascular Biology, Children's Hospital Research Foundation, Cincinnati, Ohio, USA
    Circulation 103:2402-7. 2001
    ..However, the D7-des mutation is dominant negative, and expression of the mutant protein leads to the appearance of aggregates that are characteristic of and diagnostic for human desmin-related cardiomyopathy...
  4. pmc Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice
    M C Colbert
    Division of Molecular Cardiovascular Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 100:1958-68. 1997
    ..Thus, expression of a constitutively active RAR in developing atria and/ or in postnatal ventricles is relatively benign, while ventricular expression during gestation can lead to significant cardiac dysfunction...
  5. ncbi Examining the in vivo role of the amino terminus of the essential myosin light chain
    A Sanbe
    Department of Pediatrics, Division of Molecular Cardiovascular Biology, The Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 276:32682-6. 2001
    ..The data indicate that the previously postulated importance of this region in mediating critical protein interactions between the cardiac ELCs and the carboxyl-terminal residues of actin in vivo should be reassessed...
  6. ncbi Phenotypic deficits in mice expressing a myosin binding protein C lacking the titin and myosin binding domains
    Q Yang
    Children's Hospital Research Foundation, Department of Pediatrics, Division of Molecular Cardiovascular Biology, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
    J Mol Cell Cardiol 33:1649-58. 2001
    ..We conclude that the mouse model recapitulates some of the known aspects of the human disease, particularly its late onset and benign phenotype. However, cardiac stress can lead to severe bradycardia and death...
  7. ncbi Transgenic overexpression of cardiac actin in the mouse heart suggests coregulation of cardiac, skeletal and vascular actin expression
    A Kumar
    Division of Developmental Biology, University of Cincinnati, College of Medicine, Cincinnati, OH 45229, USA
    Transgenic Res 13:531-40. 2004
    ..However, these putative mechanisms are either inoperative in the high copy number transgenic line or are countered by the enhanced expression of skeletal and vascular actin during cardiomyocyte hypertrophy...
  8. ncbi Transgenic over-expression of a motor protein at high levels results in severe cardiac pathology
    J James
    Children s Hospital Research Foundation, Department of Pediatrics, Cincinnati, OH 45229 3039, USA
    Transgenic Res 8:9-22. 1999
    ..These data indicate that very high expression levels of a contractile protein can cause a cardiac pathology that is unrelated to its degree of replacement in the sarcomere and the unique role(s) it may assume in motor protein function...
  9. ncbi In vivo modeling of myosin binding protein C familial hypertrophic cardiomyopathy
    Q Yang
    Department of Pediatrics, Division of Molecular Cardiovascular Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    Circ Res 85:841-7. 1999
    ..Fiber mechanics showed decreased unloading shortening velocity, maximum shortening velocity, and relative maximal power output...
  10. ncbi Altered kinetics of contraction of mouse atrial myocytes expressing ventricular myosin regulatory light chain
    S H Buck
    Department of Pediatrics, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Am J Physiol 276:H1167-71. 1999
    ..The faster rate of cycling in the presence of MLC2v suggests that the MLC2v isoform may contribute to the greater power-generating capabilities of the ventricle compared with the atrium...
  11. ncbi Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice
    X Wang
    Division of Molecular Cardiovascular Biology, Children's Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Circ Res 89:84-91. 2001
    ..The data show that the R120G mutation causes a desminopathy, is dominant negative, and results in cardiac hypertrophy...
  12. ncbi PKA-dependent phosphorylation of cardiac myosin binding protein C in transgenic mice
    Q Yang
    Department of Pediatrics, Division of Molecular Cardiovascular Biology, The Children's Hospital Research Foundation, 333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
    Cardiovasc Res 51:80-8. 2001
    ..01). CONCLUSIONS: Cardiac MyBP-C phosphorylation plays an important physiological role and that the protein's degree of phosphorylation is coordinated with the phosphorylation levels of other proteins within the contractile apparatus...
  13. ncbi Abnormal cardiac structure and function in mice expressing nonphosphorylatable cardiac regulatory myosin light chain 2
    A Sanbe
    Department of Pediatrics, Division of Molecular Cardiovascular Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 274:21085-94. 1999
    ..We conclude that regulated phosphorylation of the regulatory myosin light chains appears to play an important role in maintaining normal cardiac function over the lifetime of the animal...
  14. pmc A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy
    Q Yang
    Department of Pediatrics, Division of Molecular Cardiovascular Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 102:1292-300. 1998
    ..Additionally, expression of the mutant protein leads to decreased levels of endogenous MyBP-C, resulting in a striking pattern of sarcomere disorganization and dysgenesis...
  15. ncbi Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy
    G Wu
    Department of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio, USA
    Circ Res 89:1130-7. 2001
    ..These results indicate that increased expression of Rab1 GTPase in myocardium distorts subcellular localization of proteins and is sufficient to cause cardiac hypertrophy and failure...
  16. pmc Proinflammatory consequences of transgenic fas ligand expression in the heart
    D P Nelson
    Division of Molecular Cardiovascular Biology, and Division of Cardiology, Department of Pediatrics, The Children s Hospital Research Foundation, Cincinnati, Ohio, USA
    J Clin Invest 105:1199-208. 2000
    ..The data suggest that the FasL expression level and other tissue-specific microenvironmental factors can modulate the proinflammatory consequences of FasL...
  17. pmc Altered regional cardiac wall mechanics are associated with differential cardiomyocyte calcium handling due to nebulette mutations in preclinical inherited dilated cardiomyopathy
    K Maiellaro-Rafferty
    The Heart Institute, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Mol Cell Cardiol 60:151-60. 2013
    ..We suggest that these abnormalities correlate with detectable myocardial wall motion patterns...
  18. ncbi [Genetically modified animal models in cardiovascular research]
    F Dalloz
    Department of Pediatrics, Division of Molecular Cardiovascular Biology, Children's Hospital Research Foundation, Cincinnati, USA
    Rev Esp Cardiol 54:764-89. 2001
    ....
  19. ncbi Three-dimensional MR microscopy of a transgenic mouse model of dilated cardiomyopathy
    R W Sze
    Department of Radiology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Pediatr Radiol 31:55-61. 2001
    ..Ultrasound may be used to generate continuous time course data, but is limited by interobserver variation, limited acoustic windows, and relatively low resolution...
  20. pmc Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin
    A Kumar
    Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 94:4406-11. 1997
    ..These results demonstrate that alterations in actin composition in the fetal and adult heart are associated with severe structural and functional perturbations...
  21. pmc Functional significance of cardiac myosin essential light chain isoform switching in transgenic mice
    J G Fewell
    Department of Pediatrics, Division of Molecular Cardiovascular Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 101:2630-9. 1998
    ..This increase in cardiac function occurred in the absence of a hypertrophic response. Thus, ELC1a expression in the ventricle appears to be advantageous to the heart, resulting in increased cardiac function...
  22. ncbi The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival
    G Schwartzbauer
    Department of Pediatrics, Division of Molecular Cardiovascular Biology, Children s Hospital Research Foundation, Cincinnati Ohio 45229 3039, USA
    J Biol Chem 276:35786-93. 2001
    ..This hypertrophy was accompanied by an increase in Akt activity and improved cell viability in culture...
  23. ncbi Remodeling the mammalian heart using transgenesis
    J Palermo
    Division of Molecular Cardiovascular Biology, Children s Hospital Research Foundation, Cincinnati, OH 45267, USA
    Cell Mol Biol Res 41:501-9. 1995
    ..Using the whole working heart preparation, we show that an MLC2a --> MLC2v shift in the atrium severely affects contractile function and performance...
  24. pmc Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart
    W K Jones
    Division of Molecular Cardiovascular Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 98:1906-17. 1996
    ..Thus, two alpha-MyHC+ alleles are necessary for normal cardiac development, and hemizygosity for the normal allele can result in altered cardiac function...
  25. ncbi Endogenous retinoic acid signaling colocalizes with advanced expression of the adult smooth muscle myosin heavy chain isoform during development of the ductus arteriosus
    M C Colbert
    Department of Pediatrics, Children s Hospital Research Foundation, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Circ Res 78:790-8. 1996
    ..These data suggest that RA may play a role in inducing and maintaining smooth muscle differentiation in the developing ductus arteriosus and may promote precocious expression of the adult vascular phenotype...
  26. ncbi Murine pulmonary myocardium: developmental analysis of cardiac gene expression
    W K Jones
    Department of Pediatrics, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039
    Dev Dyn 200:117-28. 1994
    ....
  27. ncbi Unprocessed myogenin transcripts accumulate during mouse embryogenesis
    A Sanchez
    Department of Pediatrics, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039
    J Biol Chem 269:1587-90. 1994
    ..5 days post coitum). These results indicate that post-transcriptional regulation of myogenin may occur at the RNA processing level...