Michael Lan

Summary

Affiliation: Children's Hospital
Country: USA

Publications

  1. doi request reprint Expression of biologically active TAT-fused recombinant islet transcription factors
    Michael S Lan
    The Research Institute for Children, Children s Hospital, New Orleans, LA, USA Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA, USA Electronic address
    Life Sci 114:45-50. 2014
  2. pmc Both polymorphic variable number of tandem repeats and autoimmune regulator modulate differential expression of insulin in human thymic epithelial cells
    Chuan Qi Cai
    The Research Institute for Children, Children s Hospital, New Orleans, Louisiana, USA
    Diabetes 60:336-44. 2011
  3. pmc Comparative analysis of the transduction efficiency of five adeno associated virus serotypes and VSV-G pseudotype lentiviral vector in lung cancer cells
    Chiachen Chen
    Research Institute for Children, Children s Hospital New Orleans, New Orleans, LA 70118, USA
    Virol J 10:86. 2013
  4. pmc The transcription factor encyclopedia
    Dimas Yusuf
    Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Genome Biol 13:R24. 2012
  5. pmc Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation
    Michael S Lan
    Research Institute for Children, Children s Hospital, 200 Henry Clay Ave, Research and Education Bldg, Rm 2211, New Orleans, LA 70118, USA
    FASEB J 23:2024-33. 2009
  6. ncbi request reprint An effective alternate cloning strategy for unstable mouse genomic sequences
    Michael S Lan
    The Research Institute for Children, Children s Hospital, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA
    Biochem Biophys Res Commun 330:641-4. 2005
  7. ncbi request reprint Coupling of glucose response element from L-type pyruvate kinase and G6Pase promoter enhances glucose responsive activity in hepatoma cells
    Michael S Lan
    The Research Institute for Children, Departments of Pediatrics and Genetics, Children s Hospital, Louisiana State University Health Sciences Center, 200 Henry Clay Avenue, New Orleans, LA 70118, USA
    Mol Cell Biochem 300:191-6. 2007
  8. pmc Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription
    Hong Wei Wang
    The Research Institute for Children, Children s Hospital, 200 Henry Clay Avenue, New Orleans, Louisiana 70118, USA
    J Endocrinol 198:29-39. 2008
  9. pmc Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence
    Mary B Breslin
    Research Institute for Children, Children s Hospital, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Nucleic Acids Res 30:1038-45. 2002
  10. ncbi request reprint Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells
    Min Zhu
    Research Institute for Children, Children s Hospital, 520 Elmwood Park Blvd, Harahan, Louisiana 70123, U S A
    Pancreas 24:139-45. 2002

Research Grants

Collaborators

  • T A Reh
  • Branden R Nelson
  • Mary B Breslin
  • Hong Wei Wang
  • Tao Zhang
  • Chiachen Chen
  • Wei Dong Liu
  • Dimas Yusuf
  • Victoria Akerstrom
  • Chuan Qi Cai
  • Nicolle A Saunee
  • Min Zhu
  • Jingping Xie
  • Michelle Muguira
  • Keiichi Saeki
  • Abner Louis Notkins
  • James Baus
  • Xin M Luo
  • Simon J Rhodes
  • Wyeth W Wasserman
  • Roland H Wenger
  • Chunyan Zhao
  • Gieri Camenisch
  • Jake M Schnabl
  • Shyam Biswal
  • Jan J Brosens
  • Gaylor Boulay
  • Sylvie Mader
  • Amy Ticoll
  • Kyster K Nanan
  • Ralf Kist
  • Michael Taggart
  • Bérénice A Benayoun
  • Karin Dahlman-Wright
  • Rumela Chakrabarti
  • Jarrod Bailey
  • Alison H Banham
  • Elizabeth Wederell
  • Scott Ferrell
  • Juliet M Daniel
  • Marieke Rozendaal
  • Mireille Vasseur-Cognet
  • Pamela A Hoodless
  • Tiziana De Cristofaro
  • Mariastella Zannini
  • Angie Rizzino
  • Lars Grontved
  • Jason P Debruyne
  • Reiner A Veitia
  • Eugene Bolotin
  • Robert F Hevner
  • Harini Chakravarthy
  • Douglas Forrest
  • G Nicholas Europe-Finner
  • Dominique Leprince
  • Kelly L Prince
  • Gerhart U Ryffel
  • Matthew E Witek
  • Margaret R Hough
  • Marissa Cathleen Blank
  • Michal Mikula
  • Mario P Tschan
  • Luis del Peso
  • Marrit Putker
  • Rebecca L Cullum
  • Peggy J Farnham
  • Elodie Portales-Casamar
  • Philip J Brown
  • Sekhar P Reddy
  • Jonathan S Lim
  • Scott A Waldman
  • Edwin Chen
  • Daniel J Peet
  • Xiao Yu Cindy Zhang
  • Michelle Vaz
  • Richard M Gronostajski
  • Farhad Vesuna
  • Christophe Heligon
  • Philip H Bradley
  • Satrajit Sinha
  • David P LeBrun
  • Bianca Blom
  • John B Hogenesch
  • Frances M Sladek
  • KATHLEEN JOYCE MILLEN
  • Raquel Marco-Ferreres
  • Warren A Cheung
  • David S Sharlin
  • Miranda S C Wilson
  • Susanne Mandrup

Detail Information

Publications20

  1. doi request reprint Expression of biologically active TAT-fused recombinant islet transcription factors
    Michael S Lan
    The Research Institute for Children, Children s Hospital, New Orleans, LA, USA Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA, USA Electronic address
    Life Sci 114:45-50. 2014
    ..These studies are focused on developing a system to deliver individual ITF from different stages of islet cell development to promote precursors or other cell types to trans-differentiate into islet-like insulin-positive cells...
  2. pmc Both polymorphic variable number of tandem repeats and autoimmune regulator modulate differential expression of insulin in human thymic epithelial cells
    Chuan Qi Cai
    The Research Institute for Children, Children s Hospital, New Orleans, Louisiana, USA
    Diabetes 60:336-44. 2011
    ..In this study, we determined the mechanistic components underlying the differential insulin gene expression in human thymic epithelial cells, which should have profound effects on the insulin autoimmune tolerance induction...
  3. pmc Comparative analysis of the transduction efficiency of five adeno associated virus serotypes and VSV-G pseudotype lentiviral vector in lung cancer cells
    Chiachen Chen
    Research Institute for Children, Children s Hospital New Orleans, New Orleans, LA 70118, USA
    Virol J 10:86. 2013
    ..The efficiency of the gene delivery system is one of the most important factors directly related to the success of gene therapy...
  4. pmc The transcription factor encyclopedia
    Dimas Yusuf
    Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Genome Biol 13:R24. 2012
    ..TFe aims to rapidly educate scientists about the TFs they encounter through the delivery of succinct summaries written and vetted by experts in the field. TFe is available at http://www.cisreg.ca/tfe...
  5. pmc Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation
    Michael S Lan
    Research Institute for Children, Children s Hospital, 200 Henry Clay Ave, Research and Education Bldg, Rm 2211, New Orleans, LA 70118, USA
    FASEB J 23:2024-33. 2009
    ..Taken together, all of these features of INSM1 strongly support its role as an important regulator during neuroendocrine differentiation...
  6. ncbi request reprint An effective alternate cloning strategy for unstable mouse genomic sequences
    Michael S Lan
    The Research Institute for Children, Children s Hospital, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA
    Biochem Biophys Res Commun 330:641-4. 2005
    ..Here, we show that a single-copy cloning technique is effective to clone the unstable mouse genomic DNA into the targeting vector...
  7. ncbi request reprint Coupling of glucose response element from L-type pyruvate kinase and G6Pase promoter enhances glucose responsive activity in hepatoma cells
    Michael S Lan
    The Research Institute for Children, Departments of Pediatrics and Genetics, Children s Hospital, Louisiana State University Health Sciences Center, 200 Henry Clay Avenue, New Orleans, LA 70118, USA
    Mol Cell Biochem 300:191-6. 2007
    ..The construction of a chimeric promoter with stronger and more sensitive responsive activity to glucose and insulin in liver cells could further advance studies in insulin gene therapy...
  8. pmc Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription
    Hong Wei Wang
    The Research Institute for Children, Children s Hospital, 200 Henry Clay Avenue, New Orleans, Louisiana 70118, USA
    J Endocrinol 198:29-39. 2008
    ..These data strongly support the view that INSM1 is a new zinc-finger transcription factor that modulates insulin gene transcription during early pancreas development...
  9. pmc Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence
    Mary B Breslin
    Research Institute for Children, Children s Hospital, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Nucleic Acids Res 30:1038-45. 2002
    ..These findings suggest that the IA-1 protein may be auto-regulated and play a role in pancreas and neuronal development, specifically in the regulation of the NeuroD/beta2 gene...
  10. ncbi request reprint Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells
    Min Zhu
    Research Institute for Children, Children s Hospital, 520 Elmwood Park Blvd, Harahan, Louisiana 70123, U S A
    Pancreas 24:139-45. 2002
    ..IA-1, an insulinoma-associated cDNA-1, encodes a zinc-finger DNA-binding protein originally isolated from a human insulinoma subtraction library...
  11. pmc Neurogenin 3 recruits CBP co-activator to facilitate histone H3/H4 acetylation in the target gene INSM1
    Mary B Breslin
    The Research Institute for Children, Children s Hospital in New Orleans, 200 Henry Clay Avenue, Research and Education Building, Rm 2211, New Orleans, LA 70118, USA
    FEBS Lett 581:949-54. 2007
    ..Additionally, adenoviral ngn3 can induce endogenous INSM-1 expression in pancreatic ductal carcinoma-1 cells through the recruitment of CBP to the INSM1 promoter and increase the acetylation of the INSM1 promoter region...
  12. pmc Insulinoma-associated antigen-1 zinc-finger transcription factor promotes pancreatic duct cell trans-differentiation
    Tao Zhang
    Children s Hospital, Research and Education Building, New Orleans, Louisiana 70118, USA
    Endocrinology 151:2030-9. 2010
    ..The consistent functional effect of INSM1, either with or without other ITFs, promotes pancreatic duct cell differentiation as well as induces Panc-1 cell cycle arrest...
  13. ncbi request reprint Pdx-1 modulates histone H4 acetylation and insulin gene expression in terminally differentiated alpha-TC-1 cells
    Hong Wei Wang
    The Research Institute for Children, Children s Hospital, 200 Henry Clay Avenue, Research and Education Building, Rm 2211, New Orleans, LA 70118, USA
    Pancreas 34:248-53. 2007
    ..In this study, we demonstrated that Pdx-1 is a potent transcriptional regulator of endogenous insulin gene expression in alpha-TC-1 cells...
  14. pmc NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system
    Mary B Breslin
    Research Institute for Children, Children s Hospital, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70118, USA
    J Biol Chem 278:38991-7. 2003
    ..Therefore, we concluded that the IA-1 gene is developmentally expressed in the nervous system and the NeuroD1/E47 transcription factors up-regulate IA-1 gene expression through the proximal E-box element of the IA-1 promoter...
  15. pmc Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest
    Tao Zhang
    Research Institute for Children, Children s Hospital, New Orleans, Louisiana 70118, USA
    J Biol Chem 284:5574-81. 2009
    ..Taken together, we provide evidence to support that INSM1 binds to cyclin D1, interrupts cell cycle signaling, and inhibits cellular proliferation...
  16. pmc INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases
    Wei Dong Liu
    The Research Institute for Children, Children s Hospital, New Orleans, LA 70118, USA
    Biochem J 397:169-77. 2006
    ..Thus we conclude that INSM1 recruits cyclin D1 and HDACs, which confer transcriptional repressor activity...
  17. pmc INSM1 promoter-driven adenoviral herpes simplex virus thymidine kinase cancer gene therapy for the treatment of primitive neuroectodermal tumors
    Hong Wei Wang
    Research Institute for Children, Children s Hospital, New Orleans, LA 70118, USA
    Hum Gene Ther 20:1308-18. 2009
    ..Taken together, our data show that the INSM1 promoter is specific and effective for targeted cancer gene therapy in PNETs...
  18. pmc Transient inactivation of Notch signaling synchronizes differentiation of neural progenitor cells
    Branden R Nelson
    Department of Biological Structure, Box 357420, University of Washington, Seattle, WA 98195, and The Research Institute for Children, Children s Hospital, New Orleans, LA 70118, USA
    Dev Biol 304:479-98. 2007
    ..Thus, transient inactivation of Notch signaling synchronizes progenitor cell differentiation, and allows for a systematic analysis of key steps in this process...
  19. pmc The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein
    Jingping Xie
    Experimental Medicine Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, 20892 4322, USA
    Genomics 80:54-61. 2002
    ..These findings raise the possibility that during embryo development CAP may enter the nucleus through its own nuclear localization signal or by binding to INSM1...
  20. ncbi request reprint Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion
    Keiichi Saeki
    Experimental Medicine Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes 51:1842-50. 2002
    ..001) and 42% (P < 0.01) less insulin, respectively, than mice carrying the wild-type gene. We concluded that IA-2 is involved in glucose-stimulated insulin secretion...

Research Grants1

  1. Transcription Factors in Neuroendocrine Differentiation
    Michael Lan; Fiscal Year: 2009
    ..Results from this study should help us to define the interplay between the IA-1 zinc-finger transcription factor and other neuroendocrine-specific transcription factors in pancreatic endocrine and neuronal development. ..