Affiliation: Children's Mercy Hospital
- Osteocalcin protects pancreatic beta cell function and survival under high glucose conditionsKaren Kover
Division of Endocrine Diabetes, Children s Mercy Hospital and Clinics, Kansas City, MO 64108, USA University of Missouri Kansas City School of Medicine, Kansas City, MO 64108, USA Electronic address
Biochem Biophys Res Commun 462:21-6. 2015..We conclude that osteocalcin can protect beta cells from the negative effects of glucose-induced oxidative stress, in part, by reducing TXNIP expression, thereby preserving beta cell function and survival. ..
- Expression and regulation of nampt in human isletsKaren Kover
Section of Endocrine Diabetes, Children s Mercy Hospital and University of Missouri Kansas City School of Medicine, Kansas City, Missouri, United States of America
PLoS ONE 8:e58767. 2013..Enzymatically active eNampt is secreted by human islets, is regulated by glucose and requires membrane depolarization...
- Bone marrow cavity: a supportive environment for islet engraftmentKaren Kover
Children s Mercy Hospital and University of Missouri Kansas City, Kansas City, MO, USA
Islets 3:93-101. 2011..In addition, the bone marrow cavity may provide an environment that is protective against post-transplant cellular stress thus increasing the chances of long-term islet function and survival...
- Decreased survival of islet allografts in rats with advanced chronic complications of diabetesWayne V Moore
Department of Endocrinology at The Children s Mercy Hospital and University of Missouri Kansas City, Kansas City, MO 64108, USA
Cell Transplant 11:707-13. 2002..This should be considered as a possible explanation for failure of islet allograft survival in human islet transplantation...
- Reduction of diffusion barriers in isolated rat islets improves survival, but not insulin secretion or transplantation outcomeS Janette Williams
Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, KS, USA
Organogenesis 6:115-24. 2010..Thus, diffusion barriers lead to low viability and poor survival for large islets, but are not solely responsible for the inferior insulin secretion or poor transplantation outcomes of large versus small islets...
- Prevention of autoimmune diabetes in the DRBB rat by CD40/154 blockadeWayne V Moore
Pediatric Endocrinology, Children s Mercy Hospital, 2401 Gilham Road, Kansas City, MO 64108, USA
J Autoimmun 19:139-45. 2002..The results indicate that the CD40/154 blockade can prevent diabetes by modifying the expansion or effector phase of the autoimmune diabetes...