James M Hempe

Summary

Affiliation: Children's Hospital
Country: USA

Publications

  1. pmc The hemoglobin glycation index identifies subpopulations with harms or benefits from intensive treatment in the ACCORD trial
    James M Hempe
    Department of Pediatrics, Louisiana State University Health Sciences Center and Children s Hospital Research Institute for Children, New Orleans, LA
    Diabetes Care 38:1067-74. 2015
  2. doi Two-dimensional analysis of glycated hemoglobin heterogeneity in pediatric type 1 diabetes patients
    James M Hempe
    Research Institute for Children, Children s Hospital, New Orleans, LA 70118, USA Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA Electronic address
    Anal Biochem 442:205-12. 2013
  3. doi Characterization of unstable hemoglobin A1c complexes by dynamic capillary isoelectric focusing
    James M Hempe
    Research Institute for Children, Children s Hospital, New Orleans, LA 70118, USA
    Anal Biochem 424:149-55. 2012
  4. ncbi High and low hemoglobin glycation phenotypes in type 1 diabetes: a challenge for interpretation of glycemic control
    James M Hempe
    Children s Hospital Research Institute for Children, 200 Henry Clay Avenue, New Orleans, LA 70118, USA
    J Diabetes Complications 16:313-20. 2002
  5. doi Analysis of murine S-glutathionyl hemoglobins and beta globin haplotype by dynamic capillary isoelectric focusing
    James M Hempe
    Research Institute for Children, Children s Hospital, New Orleans, LA 70118, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:3462-6. 2009
  6. ncbi Genetic variation in mouse beta globin cysteine content modifies glutathione metabolism: implications for the use of mouse models
    James M Hempe
    Research Institute for Children, Children s Hospital, 200 Henry Clay Avenue, New Orleans, LA 70118, USA
    Exp Biol Med (Maywood) 232:437-44. 2007
  7. ncbi Advanced glycation end-products in sickle cell anaemia
    Saika S Somjee
    Department of Pediatrics, Division of Hematology Oncology, Louisiana State University Health Sciences Center and Children s Hospital, New Orleans, LA, USA
    Br J Haematol 128:112-8. 2005
  8. pmc Estimated average glucose and self-monitored mean blood glucose are discordant estimates of glycemic control
    James M Hempe
    Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Diabetes Care 33:1449-51. 2010
  9. ncbi A comparison of the Glycosylation Gap and Hemoglobin Glycation Index in patients with diabetes
    Stuart A Chalew
    Division of Pediatric Endocrinology, Louisiana State University Health Sciences Center, The Research Institute for Children, The Children s Hospital of New Orleans, 200 Henry Clay Avenue, New Orleans, LA 70118, USA
    J Diabetes Complications 19:218-22. 2005
  10. pmc Labile A1C is inversely correlated with the hemoglobin glycation index in children with type 1 diabetes
    Stuart A Chalew
    Division of Pediatric Endocrinology, Department of Pediatrics, Louisiana State University Health Sciences Center and the Children s Hospital of New Orleans, New Orleans, Louisiana, USA
    Diabetes Care 33:273-4. 2010

Collaborators

  • Stuart A Chalew
  • Jovanny Zabaleta
  • Yingnan Zhao
  • Jodi L Kamps
  • Lizheng Shi
  • Shuqian Liu
  • Robert J McCarter
  • Ricardo Gomez
  • Dania L Felipe
  • Alfonso Vargas
  • Sara J Coulon
  • Cruz Velasco-Gonzalez
  • Mahmoud Adeeb Ahmad Hamdan
  • Saika S Somjee
  • Shreepal Shah
  • Arlette A Soros
  • Giddel G A Thom
  • Lolie C Yu
  • Saika Somjee
  • Richard Scribner
  • Sarah Stender
  • Patrice Clesi
  • Chi L Park
  • Shengxu Li
  • Vivian A Fonseca
  • Eileen A Baez
  • John D Maynard
  • Vivian Fonseca
  • John Maynard
  • Carmen Linares
  • Nate Matter
  • Rachel Shepard
  • Chandra Kallanagowdar
  • Maria C Velez
  • Rajasekharan P Warrier
  • Jeannine Ory-Ascani
  • Jessica L Thomson
  • Arthur F Hagar

Detail Information

Publications25

  1. pmc The hemoglobin glycation index identifies subpopulations with harms or benefits from intensive treatment in the ACCORD trial
    James M Hempe
    Department of Pediatrics, Louisiana State University Health Sciences Center and Children s Hospital Research Institute for Children, New Orleans, LA
    Diabetes Care 38:1067-74. 2015
    ....
  2. doi Two-dimensional analysis of glycated hemoglobin heterogeneity in pediatric type 1 diabetes patients
    James M Hempe
    Research Institute for Children, Children s Hospital, New Orleans, LA 70118, USA Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA Electronic address
    Anal Biochem 442:205-12. 2013
    ..These results show that interindividual variation in glycated hemoglobin levels was evident in diabetes patients with similar blood glucose levels regardless of which glycated hemoglobins were measured. ..
  3. doi Characterization of unstable hemoglobin A1c complexes by dynamic capillary isoelectric focusing
    James M Hempe
    Research Institute for Children, Children s Hospital, New Orleans, LA 70118, USA
    Anal Biochem 424:149-55. 2012
    ..Evidence of multiple unstable hemoglobin complexes with different rates of glycation suggests that new models are needed to describe nonenzymatic hemoglobin glycation...
  4. ncbi High and low hemoglobin glycation phenotypes in type 1 diabetes: a challenge for interpretation of glycemic control
    James M Hempe
    Children s Hospital Research Institute for Children, 200 Henry Clay Avenue, New Orleans, LA 70118, USA
    J Diabetes Complications 16:313-20. 2002
    ..We conclude that MBG and HbA1c are not necessarily interchangeable estimates of glycemic control and that hemoglobin glycation phenotype may be important for the clinical assessment of diabetic patients...
  5. doi Analysis of murine S-glutathionyl hemoglobins and beta globin haplotype by dynamic capillary isoelectric focusing
    James M Hempe
    Research Institute for Children, Children s Hospital, New Orleans, LA 70118, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:3462-6. 2009
    ..This method could prove useful for in vivo study of factors that influence thiol protein modification...
  6. ncbi Genetic variation in mouse beta globin cysteine content modifies glutathione metabolism: implications for the use of mouse models
    James M Hempe
    Research Institute for Children, Children s Hospital, 200 Henry Clay Avenue, New Orleans, LA 70118, USA
    Exp Biol Med (Maywood) 232:437-44. 2007
    ..These fundamental differences in mouse and human beta globin genetics have important implications for the study of mouse biology and for the use of some mouse strains as models for humans...
  7. ncbi Advanced glycation end-products in sickle cell anaemia
    Saika S Somjee
    Department of Pediatrics, Division of Hematology Oncology, Louisiana State University Health Sciences Center and Children s Hospital, New Orleans, LA, USA
    Br J Haematol 128:112-8. 2005
    ..We conclude that circulating AGE levels are strongly influenced by endogenous antioxidant status and may play a role in the vascular pathology of SCA...
  8. pmc Estimated average glucose and self-monitored mean blood glucose are discordant estimates of glycemic control
    James M Hempe
    Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Diabetes Care 33:1449-51. 2010
    ..We compared eAG with self-monitored mean blood glucose (MBG) to determine whether eAG is systematically biased due to biological variation in the relationship between MBG and A1C...
  9. ncbi A comparison of the Glycosylation Gap and Hemoglobin Glycation Index in patients with diabetes
    Stuart A Chalew
    Division of Pediatric Endocrinology, Louisiana State University Health Sciences Center, The Research Institute for Children, The Children s Hospital of New Orleans, 200 Henry Clay Avenue, New Orleans, LA 70118, USA
    J Diabetes Complications 19:218-22. 2005
    ..We sought to simultaneously compare GGAP with HGI and other estimates of glycemia...
  10. pmc Labile A1C is inversely correlated with the hemoglobin glycation index in children with type 1 diabetes
    Stuart A Chalew
    Division of Pediatric Endocrinology, Department of Pediatrics, Louisiana State University Health Sciences Center and the Children s Hospital of New Orleans, New Orleans, Louisiana, USA
    Diabetes Care 33:273-4. 2010
    ..We hypothesized that labile A1C (LA1C) is directly correlated with stable A1C (SA1C) and between-patient differences in SA1C, which are independent of mean blood glucose (MBG)...
  11. doi Advanced glycation endproducts in children with diabetes
    Shreepal Shah
    Division of Pediatric Endocrinology Diabetes, Louisiana State University Health Sciences Center and Children s Hospital, New Orleans, LA
    J Pediatr 163:1427-31. 2013
    ..To estimate skin content of advanced glycation endproducts (AGEs) by measurements of skin intrinsic fluorescence (SIF) from youth with diabetes in comparison with a population of youth and adults without diabetes...
  12. pmc Racial disparity in A1C independent of mean blood glucose in children with type 1 diabetes
    Jodi L Kamps
    Department of Psychology, Children s Hospital, New Orleans, Louisiana, USA
    Diabetes Care 33:1025-7. 2010
    ..Race was related to A1C independent of MBG in adults. The goal of this study was to determine if racial disparity exists in A1C independent of MBG in children with diabetes...
  13. ncbi Biological variation in HbA1c predicts risk of retinopathy and nephropathy in type 1 diabetes
    Robert J McCarter
    Endocrinology Diabetes, Children s Hospital of New Orleans, 200 Henry Clay Avenue, New Orleans, LA 70118, USA
    Diabetes Care 27:1259-64. 2004
    ..We hypothesized that biological variation in HbA(1c), distinct from variation attributable to mean blood glucose (MBG), would predict risk for microvascular complications in the Diabetes Control and Complications Trial (DCCT)...
  14. doi Hemoglobin glycation index: a robust measure of hemoglobin A1c bias in pediatric type 1 diabetes patients
    Arlette A Soros
    Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Pediatr Diabetes 11:455-61. 2010
    ..We tested the hypothesis that biological variation in A1c can be assessed by HGI calculated using routine MBG and A1c data obtained from a typical diabetes clinic...
  15. pmc Clinically significant disagreement between mean blood glucose and estimated average glucose in two populations: implications for diabetes management
    Stuart A Chalew
    Pediatric Endocrinology Diabetes and Research Institute for Children, Children s Hospital of New Orleans, New Orleans, Louisiana 70118, USA
    J Diabetes Sci Technol 3:1128-35. 2009
    ..Pertinent to the clinical utility of eAG would be the degree of agreement between eAG and MBG estimated from multiple sampled glucose measurements over time...
  16. doi Characterization of S-glutathionyl hemoglobin in homozygous sickle cell disease
    Giddel G A Thom
    Division of Hematology Oncology, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    J Pediatr Hematol Oncol 31:895-900. 2009
    ..We conclude that blood from sickle cell patients contained up to 2.2% HbSSG, and that endogenous HbSSG is a minor interferent in the measurement of HbF in fresh blood but a major interferent in improperly stored samples...
  17. doi Economic burden of hypoglycemia in patients with Type 2 diabetes
    Shuqian Liu
    School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, New Orleans, LA 70112, USA
    Expert Rev Pharmacoecon Outcomes Res 12:47-51. 2012
    ..Recently, an increased risk of hypoglycemia with intensive glycemic control has been identified as an important problem in optimally controlling blood glucose levels in patients with Type 2 diabetes...
  18. pmc Racial differences in neighborhood disadvantage, inflammation and metabolic control in black and white pediatric type 1 diabetes patients
    Sara J Coulon
    School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Pediatr Diabetes . 2016
    ..Understanding why HbA1c is persistently higher in blacks than whites could help reduce racial disparity in diabetes outcomes...
  19. pmc Skin intrinsic fluorescence is associated with hemoglobin A(1c )and hemoglobin glycation index but not mean blood glucose in children with type 1 diabetes
    Dania L Felipe
    Department of Pediatric Endocrinology and Diabetes, Louisiana State University Health SciencesCenter, New Orleans, LA, USA
    Diabetes Care 34:1816-20. 2011
    ..To evaluate the relationship between skin advanced glycation end products (sAGEs) with mean blood glucose (MBG), hemoglobin A(1c) (HbA(1c)), and MBG-independent, between-patient differences in HbA(1c) among children with type 1 diabetes...
  20. pmc Association between Inflammation and Biological Variation in Hemoglobin A1c in U.S. Nondiabetic Adults
    Shuqian Liu
    Department of Medicine S L, V A F, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 Department of Global Health System and Development S L, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112 Department of Pediatrics J M H, Louisiana State University Health Sciences Center and Children s Hospital Research Institute for Children, New Orleans, Louisiana 70118 Research Division of Biostatistics and Study Methodology R J M, Children s National Medical Center, Washington, District of Columbia 20010 Department of Epidemiology S L, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112
    J Clin Endocrinol Metab 100:2364-71. 2015
    ..Inflammation is associated with higher glycated hemoglobin (HbA1c) levels. Whether the relationship is independent of blood glucose concentration remains unclear...
  21. ncbi Mean blood glucose and biological variation have greater influence on HbA1c levels than glucose instability: an analysis of data from the Diabetes Control and Complications Trial
    Robert J McCarter
    Biostatistics and Informatics Unit, Children s Research Institute of Children s National Medical Center, Washington, DC, USA
    Diabetes Care 29:352-5. 2006
    ..To assess the relative importance of MBG, BV, and glucose instability on A1C, we analyzed patient data from the Diabetes Control and Complications Trial (DCCT)...
  22. doi Differences in Red Blood Cell Indices Do Not Explain Racial Disparity in Hemoglobin A1c in Children with Type 1 Diabetes
    Mahmoud Adeeb Ahmad Hamdan
    Pediatric Endocrinology, Children s Hospital of New Orleans, New Orleans, LA Louisiana State University Health Science Center, New Orleans, LA
    J Pediatr 176:197-9. 2016
    ..Blacks still had higher HbA1c after adjustment for mean blood glucose, red blood cell indices, age, and sex. Such differences need to be taken into account when interpreting HbA1c in Black patients. ..
  23. doi Simultaneous analysis of reduced glutathione and glutathione disulfide by capillary zone electrophoresis
    James M Hempe
    Research Institute for Children, Children s Hospital, New Orleans, LA, USA Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Electrophoresis 35:967-71. 2014
    ..95) with results obtained using a commercial dithionitrobenze-based glutathione assay. The modified CZE assay has proven useful for the analysis of glutathione in both mouse and human RBC...
  24. ncbi Diagnosis and characterization of Hb C/Hb Iowa: a rare but easily misidentified compound heterozygous condition
    Saika Somjee
    Department of Pediatric Hematology Oncology, Children s Hospital of New Orleans, New Orleans, Louisiana 70118, USA
    Hemoglobin 28:7-13. 2004
    ....