Jennifer L Goldman

Summary

Affiliation: Children's Mercy Hospital
Country: USA

Publications

  1. pmc Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes
    Jennifer L Goldman
    Divisions of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children s Mercy Hospital, University of Missouri, Kansas City, Missouri J L G, J S L Department of Medicinal Chemistry, University of Kansas School of Pharmacy, Lawrence, Kansas Y M K, R P H Baker and McKenzie LLP, Dallas, Texas S A R and Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina K L
    Drug Metab Dispos 44:1603-7. 2016
  2. doi request reprint In Vitro Hepatic Oxidative Biotransformation of Trimethoprim
    Jennifer L Goldman
    Divisions of Clinical Pharmacology, Toxicology and Therapeutic Innovation J L G, J S L, L v H, R E P and Infectious Diseases J L G, Departments of Pediatrics J L G, J S L, L v H, R E P and Pharmacology J S L R E P, Children s Mercy Hospital, University of Missouri, Kansas City, Missouri
    Drug Metab Dispos 43:1372-80. 2015
  3. pmc New Horizons for Pediatric Antibiotic Stewardship
    Jennifer L Goldman
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Children s Mercy Hospitals and Clinics, University of Missouri Kansas City School of Medicine, 2401 Gillham Road, Kansas City, MO 64108, USA Division of Clinical Pharmacology, Department of Pediatrics, Children s Mercy Hospitals and Clinics, University of Missouri Kansas City School of Medicine, 2401 Gillham Road, Kansas City, MO 64108, USA Electronic address
    Infect Dis Clin North Am 29:503-11. 2015
  4. pmc Trends in adverse reactions to trimethoprim-sulfamethoxazole
    Jennifer L Goldman
    Section of Pediatric Infectious Diseases, Division of Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics, University of Missouri, Kansas City, Missouri 64108, USA
    Pediatrics 131:e103-8. 2013
  5. pmc Clinical Impact of an Antibiotic Stewardship Program at a Children's Hospital
    Brian R Lee
    Division of Pediatric Infectious Diseases, Children s Mercy Hospital and Clinics, Kansas City, MO, USA
    Infect Dis Ther . 2016
  6. pmc Clinical diagnoses and antimicrobials predictive of pediatric antimicrobial stewardship recommendations: a program evaluation
    Jennifer L Goldman
    1Department of Pediatrics, Children s Mercy Hospitals and Clinics and University of Missouri Kansas City, Kansas City, Missouri
    Infect Control Hosp Epidemiol 36:673-80. 2015
  7. ncbi request reprint Outpatient Parenteral Antimicrobial Therapy in Pediatric Medicaid Enrollees
    Jennifer L Goldman
    Children s Mercy Hospitals and Clinics, Kansas City, Missouri University of Missouri Kansas City
    J Pediatric Infect Dis Soc . 2016
  8. doi request reprint Urinary biomarkers of trimethoprim bioactivation in vivo following therapeutic dosing in children
    Leon van Haandel
    Division of Clinical Pharmacology and Therapeutic Innovation, Children s Mercy Hospitals and Clinics, and Department of Pediatrics, School of Medicine, University of Missouri Kansas City, 2401 Gillham Road, Kansas City, Missouri 64108, United States
    Chem Res Toxicol 27:211-8. 2014

Collaborators

Detail Information

Publications8

  1. pmc Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes
    Jennifer L Goldman
    Divisions of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children s Mercy Hospital, University of Missouri, Kansas City, Missouri J L G, J S L Department of Medicinal Chemistry, University of Kansas School of Pharmacy, Lawrence, Kansas Y M K, R P H Baker and McKenzie LLP, Dallas, Texas S A R and Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina K L
    Drug Metab Dispos 44:1603-7. 2016
    ..These results demonstrate for the first time that TMP bioactivation can lead directly to protein adduct formation, suggesting that TMP has been overlooked as a potential contributor of TMP-SMX IADRs. ..
  2. doi request reprint In Vitro Hepatic Oxidative Biotransformation of Trimethoprim
    Jennifer L Goldman
    Divisions of Clinical Pharmacology, Toxicology and Therapeutic Innovation J L G, J S L, L v H, R E P and Infectious Diseases J L G, Departments of Pediatrics J L G, J S L, L v H, R E P and Pharmacology J S L R E P, Children s Mercy Hospital, University of Missouri, Kansas City, Missouri
    Drug Metab Dispos 43:1372-80. 2015
    ..Overall, CYP2C9 and CYP3A4 appear to be the most significant contributors to TMP primary metabolism. ..
  3. pmc New Horizons for Pediatric Antibiotic Stewardship
    Jennifer L Goldman
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Children s Mercy Hospitals and Clinics, University of Missouri Kansas City School of Medicine, 2401 Gillham Road, Kansas City, MO 64108, USA Division of Clinical Pharmacology, Department of Pediatrics, Children s Mercy Hospitals and Clinics, University of Missouri Kansas City School of Medicine, 2401 Gillham Road, Kansas City, MO 64108, USA Electronic address
    Infect Dis Clin North Am 29:503-11. 2015
    ..Collaborative efforts are underway among pediatric ASPs to enhance best practices and develop efficient and effective strategies to minimize unnecessary antimicrobial use in children. ..
  4. pmc Trends in adverse reactions to trimethoprim-sulfamethoxazole
    Jennifer L Goldman
    Section of Pediatric Infectious Diseases, Division of Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics, University of Missouri, Kansas City, Missouri 64108, USA
    Pediatrics 131:e103-8. 2013
    ..To examine temporal trends of adverse drug reactions (ADRs) associated with trimethoprim-sulfamethoxazole (TMP-SMX) use in children...
  5. pmc Clinical Impact of an Antibiotic Stewardship Program at a Children's Hospital
    Brian R Lee
    Division of Pediatric Infectious Diseases, Children s Mercy Hospital and Clinics, Kansas City, MO, USA
    Infect Dis Ther . 2016
    ..Data are limited on the clinical benefit of ASPs in children's hospitals. This study's objective was to determine the impact of an ASP on length of stay (LOS) and readmission rate among patients admitted to children's hospitals...
  6. pmc Clinical diagnoses and antimicrobials predictive of pediatric antimicrobial stewardship recommendations: a program evaluation
    Jennifer L Goldman
    1Department of Pediatrics, Children s Mercy Hospitals and Clinics and University of Missouri Kansas City, Kansas City, Missouri
    Infect Control Hosp Epidemiol 36:673-80. 2015
    ..The number of pediatric antimicrobial stewardship programs (ASPs) is increasing and program evaluation is a key component to improve efficiency and enhance stewardship strategies...
  7. ncbi request reprint Outpatient Parenteral Antimicrobial Therapy in Pediatric Medicaid Enrollees
    Jennifer L Goldman
    Children s Mercy Hospitals and Clinics, Kansas City, Missouri University of Missouri Kansas City
    J Pediatric Infect Dis Soc . 2016
    ..However, the scope of OPAT use for children nationwide is poorly understood. Our objective was to characterize OPAT use and clinical outcomes for a large population of pediatric Medicaid enrollees treated with OPAT...
  8. doi request reprint Urinary biomarkers of trimethoprim bioactivation in vivo following therapeutic dosing in children
    Leon van Haandel
    Division of Clinical Pharmacology and Therapeutic Innovation, Children s Mercy Hospitals and Clinics, and Department of Pediatrics, School of Medicine, University of Missouri Kansas City, 2401 Gillham Road, Kansas City, Missouri 64108, United States
    Chem Res Toxicol 27:211-8. 2014
    ..As a result, the TMP component of TMP-SMX should be considered as well when evaluating adverse drug reactions to TMP-SMX. ..