Seema S Aceves

Summary

Affiliation: Children's Hospital and Health Center
Country: USA

Publications

  1. ncbi request reprint Topical viscous budesonide suspension for treatment of eosinophilic esophagitis
    Seema S Aceves
    J Allergy Clin Immunol 116:705-6. 2005
  2. ncbi request reprint Distinguishing eosinophilic esophagitis in pediatric patients: clinical, endoscopic, and histologic features of an emerging disorder
    Seema S Aceves
    Division of Allergy, Rady Children s Hospital San Diego, University of California, San Diego, CA 92123, USA
    J Clin Gastroenterol 41:252-6. 2007
  3. ncbi request reprint Oral viscous budesonide: a potential new therapy for eosinophilic esophagitis in children
    Seema S Aceves
    Division of Allergy and Immunology, Children s Hospital, San Diego, La Jolla, California, USA
    Am J Gastroenterol 102:2271-9; quiz 2280. 2007
  4. ncbi request reprint Esophageal remodeling in pediatric eosinophilic esophagitis
    Seema S Aceves
    Division of Allergy, Immunology, Children s Hospital, San Diego, and the University of California, San Diego, CA 92123, USA
    J Allergy Clin Immunol 119:206-12. 2007
  5. pmc Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis
    Iris M Otani
    Division of Allergy and Immunology, University of California, San Diego, Rady Children s Hospital, San Diego, Calif, USA
    J Allergy Clin Immunol 131:1576-82. 2013
  6. doi request reprint Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-β1, and increase esophageal smooth muscle contraction
    Seema S Aceves
    Division of Allergy and Immunology, University of California and Rady Children s Hospital, San Diego, USA
    J Allergy Clin Immunol 126:1198-204.e4. 2010
  7. pmc Long-term assessment of esophageal remodeling in patients with pediatric eosinophilic esophagitis treated with topical corticosteroids
    Jessica Rajan
    Division of Allergy and Immunology, University of California, San Diego, La Jolla, Rady Children s Hospital San Diego, San Diego, Calif Center for Immunity, Infection, and Inflammation, University of California, San Diego, La Jolla, Rady Children s Hospital San Diego, San Diego, Calif Department of Pediatrics, University of California, San Diego, La Jolla, Rady Children s Hospital San Diego, San Diego, Calif
    J Allergy Clin Immunol 137:147-56.e8. 2016
  8. pmc TGF-β1-induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitis
    Renee Rawson
    Division of Allergy and Immunology, Departments of Pediatrics and Medicine, University of California, San Diego, La Jolla, and Rady Children s Hospital, San Diego, Calif Center for Infection, Immunity, and Inflammation, Departments of Pediatrics and Medicine, University of California, San Diego, La Jolla, and Rady Children s Hospital, San Diego, Calif
    J Allergy Clin Immunol 138:791-800.e4. 2016
  9. pmc TGF-β1-induced phospholamban expression alters esophageal smooth muscle cell contraction in patients with eosinophilic esophagitis
    Lisa Y Beppu
    Division of Allergy and Immunology, University of California, San Diego, Calif Department of Pediatrics, University of California, San Diego, Calif
    J Allergy Clin Immunol 134:1100-1107.e4. 2014
  10. pmc Relationships between eosinophilic inflammation, tissue remodeling, and fibrosis in eosinophilic esophagitis
    Seema S Aceves
    Division of Allergy and Immunology, Rady Children s Hospital, 3020 Children s Way, MC 5114, San Diego, CA 92123 6791, USA
    Immunol Allergy Clin North Am 29:197-211, xiii-xiv. 2009

Collaborators

  • M E Rothenberg
  • Ranjan Dohil
  • Richard C Kurten
  • Glenn T Furuta
  • Jae Youn Cho
  • S J Spechler
  • P E Putnam
  • Margaret H Collins
  • David H Broide
  • Robert O Newbury
  • Renee Rawson
  • Lisa Y Beppu
  • Jessica Rajan
  • Arjun Anilkumar
  • Melissa Aquino
  • Tom Yang
  • Jacob Palmquist
  • Lisa Beppu
  • Arjun A Anilkumar
  • Iris M Otani
  • Eitan Rubinstein
  • Michael R Konikoff
  • Amy Wagelie-Steffen
  • Ashmi Doshi
  • Braxton Bell
  • Vineet Bafna
  • Michelle Luk
  • Hal M Hoffman
  • James L Mueller
  • Monica Bhagat
  • Peter Rosenthal
  • James Chao
  • Marina Miller
  • Ajit Varki
  • Alexa Pham
  • Amal H Assa'ad
  • Sean C Jameson
  • Bridget K Buckmeier
  • Mitchell B Cohen
  • Carine Blanchard
  • Rachel Akers
  • Cassie Kirby
  • Richard J Noel

Detail Information

Publications16

  1. ncbi request reprint Topical viscous budesonide suspension for treatment of eosinophilic esophagitis
    Seema S Aceves
    J Allergy Clin Immunol 116:705-6. 2005
  2. ncbi request reprint Distinguishing eosinophilic esophagitis in pediatric patients: clinical, endoscopic, and histologic features of an emerging disorder
    Seema S Aceves
    Division of Allergy, Rady Children s Hospital San Diego, University of California, San Diego, CA 92123, USA
    J Clin Gastroenterol 41:252-6. 2007
    ..To determine the clinical, endoscopic, and histologic criteria that distinguish children with eosinophilic esophagitis (EE) from those with non-EE diagnoses...
  3. ncbi request reprint Oral viscous budesonide: a potential new therapy for eosinophilic esophagitis in children
    Seema S Aceves
    Division of Allergy and Immunology, Children s Hospital, San Diego, La Jolla, California, USA
    Am J Gastroenterol 102:2271-9; quiz 2280. 2007
    ..Eosinophilic esophagitis (EE) is a disorder characterized typically by pan-esophageal eosinophilia. We evaluate a palatable, long-acting topical corticosteroid preparation for the treatment of EE...
  4. ncbi request reprint Esophageal remodeling in pediatric eosinophilic esophagitis
    Seema S Aceves
    Division of Allergy, Immunology, Children s Hospital, San Diego, and the University of California, San Diego, CA 92123, USA
    J Allergy Clin Immunol 119:206-12. 2007
    ..Eosinophils are associated with airway remodeling in asthma, but studies have not yet determined whether eosinophilic esophagitis (EE) is associated with esophageal remodeling...
  5. pmc Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis
    Iris M Otani
    Division of Allergy and Immunology, University of California, San Diego, Rady Children s Hospital, San Diego, Calif, USA
    J Allergy Clin Immunol 131:1576-82. 2013
    ..IL-5 is essential for eosinophil trafficking, and anti-IL-5 therapy decreases esophageal eosinophilia. EoE is associated with prominent mast cell infiltration...
  6. doi request reprint Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-β1, and increase esophageal smooth muscle contraction
    Seema S Aceves
    Division of Allergy and Immunology, University of California and Rady Children s Hospital, San Diego, USA
    J Allergy Clin Immunol 126:1198-204.e4. 2010
    ..However, mast cell infiltration into the esophageal lamina propria (LP) and smooth muscle (SM) and the effects of their products on SM function has not been determined...
  7. pmc Long-term assessment of esophageal remodeling in patients with pediatric eosinophilic esophagitis treated with topical corticosteroids
    Jessica Rajan
    Division of Allergy and Immunology, University of California, San Diego, La Jolla, Rady Children s Hospital San Diego, San Diego, Calif Center for Immunity, Infection, and Inflammation, University of California, San Diego, La Jolla, Rady Children s Hospital San Diego, San Diego, Calif Department of Pediatrics, University of California, San Diego, La Jolla, Rady Children s Hospital San Diego, San Diego, Calif
    J Allergy Clin Immunol 137:147-56.e8. 2016
    ..Effects of therapy on long-term remodeling in patients with pediatric eosinophil-associated diseases have not been previously described...
  8. pmc TGF-β1-induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitis
    Renee Rawson
    Division of Allergy and Immunology, Departments of Pediatrics and Medicine, University of California, San Diego, La Jolla, and Rady Children s Hospital, San Diego, Calif Center for Infection, Immunity, and Inflammation, Departments of Pediatrics and Medicine, University of California, San Diego, La Jolla, and Rady Children s Hospital, San Diego, Calif
    J Allergy Clin Immunol 138:791-800.e4. 2016
    ..Complications are due to tissue remodeling and involve TGF-β1-mediated fibrosis. Plasminogen activator inhibitor 1 (PAI-1/serpinE1) can be induced by TGF-β1, but its role in EoE is not known...
  9. pmc TGF-β1-induced phospholamban expression alters esophageal smooth muscle cell contraction in patients with eosinophilic esophagitis
    Lisa Y Beppu
    Division of Allergy and Immunology, University of California, San Diego, Calif Department of Pediatrics, University of California, San Diego, Calif
    J Allergy Clin Immunol 134:1100-1107.e4. 2014
    ..TGF-β1 is a central regulator of EoE remodeling and increases esophageal smooth muscle (ESM) cell contraction...
  10. pmc Relationships between eosinophilic inflammation, tissue remodeling, and fibrosis in eosinophilic esophagitis
    Seema S Aceves
    Division of Allergy and Immunology, Rady Children s Hospital, 3020 Children s Way, MC 5114, San Diego, CA 92123 6791, USA
    Immunol Allergy Clin North Am 29:197-211, xiii-xiv. 2009
    ..Current and potential therapeutic interventions are discussed that may impact the development or resolution of chronic esophageal remodeling and fibrosis in EE...
  11. pmc The TGFβ1 Promoter SNP C-509T and Food Sensitization Promote Esophageal Remodeling in Pediatric Eosinophilic Esophagitis
    Renee Rawson
    Division of Allergy, Immunology, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 10:e0144651. 2015
    ..The functional TGFβ1 promoter SNP C-509 associates with renal fibrosis and asthma. The effect of TGFβ1 genotype and EoE severity or potential gene-environment interactions have not been previously reported in EoE...
  12. ncbi request reprint Integrated approach to treatment of children and adults with eosinophilic esophagitis
    Seema S Aceves
    Division of Allergy, Immunology, Rady Children s Hospital, San Diego, Pediatrics University of California, 3020 Childrens Way, San Diego, CA 92123, USA
    Gastrointest Endosc Clin N Am 18:195-217; xi. 2008
    ..In this article, three authors from diverse backgrounds combine their resources to propose treatment paths with justification based on their clinical experience and interpretation of the literature...
  13. pmc MMPs-2 and -14 Are Elevated in Eosinophilic Esophagitis and Reduced Following Topical Corticosteroid Therapy
    Lisa Beppu
    Division of Allergy, Immunology, Center for Immunity, Infection, and Inflammation Department of Pediatrics, University of California Department of Physiology and Biophysics, University of Arkansas Medical Center, Little Rock
    J Pediatr Gastroenterol Nutr 61:194-9. 2015
    ..The expression of the remodeling-associated matrix metalloproteinases (MMPs) has not been previously detailed in EoE...
  14. pmc Siglec-F inhibition reduces esophageal eosinophilia and angiogenesis in a mouse model of eosinophilic esophagitis
    Eitan Rubinstein
    Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of California, San Diego, CA 92093 0635, USA
    J Pediatr Gastroenterol Nutr 53:409-16. 2011
    ..We investigated whether administration of an anti-Siglec-F Ab would reduce esophageal eosinophilic inflammation and remodeling in a mouse model of egg ovalbumin (OVA)-induced EoE...
  15. ncbi request reprint Eosinophilic disorders in children
    Amy Wagelie-Steffen
    Division of Allergy, Immunology, Children s Hospital of San Diego, 3020 Children s Way MC 5114, San Diego, CA 92123, USA
    Curr Allergy Asthma Rep 6:475-82. 2006
    ..Eosinophilic disorders such as eosinophilic esophagitis are increasingly being diagnosed in children, but many lessons in disease pathogenesis, diagnosis, optimal treatment, and natural history continue to be learned...
  16. ncbi request reprint A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis
    Michael R Konikoff
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gastroenterology 131:1381-91. 2006
    ..Although several therapies are advocated, no placebo-controlled trials have been conducted. We aimed to determine the efficacy of swallowed fluticasone propionate (FP) in the treatment of eosinophilic esophagitis...