Jonathan S Towner

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc Seasonal pulses of Marburg virus circulation in juvenile Rousettus aegyptiacus bats coincide with periods of increased risk of human infection
    Brian R Amman
    Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Pathog 8:e1002877. 2012
  2. pmc Large serological survey showing cocirculation of Ebola and Marburg viruses in Gabonese bat populations, and a high seroprevalence of both viruses in Rousettus aegyptiacus
    Xavier Pourrut
    Institut de Recherche pour le Developpement, UR 178, Marseille, France
    BMC Infect Dis 9:159. 2009
  3. pmc Isolation of genetically diverse Marburg viruses from Egyptian fruit bats
    Jonathan S Towner
    Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA
    PLoS Pathog 5:e1000536. 2009
  4. pmc Molecular evolution of viruses of the family Filoviridae based on 97 whole-genome sequences
    Serena A Carroll
    Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 87:2608-16. 2013
  5. pmc Marburg virus infection detected in a common African bat
    Jonathan S Towner
    Centers for Disease Control and Prevention, Special Pathogens Branch, Atlanta, Georgia, United States of America
    PLoS ONE 2:e764. 2007
  6. pmc Increased detection of Sin Nombre hantavirus RNA in antibody-positive deer mice from Montana, USA: evidence of male bias in RNA viremia
    Karoun H Bagamian
    Viral Special Pathogens Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30033, USA
    Viruses 5:2320-8. 2013
  7. pmc Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda
    Jonathan S Towner
    Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Pathog 4:e1000212. 2008
  8. ncbi request reprint High-throughput, luciferase-based reverse genetics systems for identifying inhibitors of Marburg and Ebola viruses
    Luke S Uebelhoer
    Centers for Disease Control and Prevention, Atlanta, USA
    Antiviral Res 106:86-94. 2014
  9. pmc Inhibition of IRF-3 activation by VP35 is critical for the high level of virulence of ebola virus
    Amy L Hartman
    Centers for Disease Control and Prevention, 1600 Clifton Rd, MS G 14, Atlanta, GA 30329, USA
    J Virol 82:2699-704. 2008
  10. ncbi request reprint Development of a reverse genetics system to generate recombinant Marburg virus derived from a bat isolate
    Cesar G Albarino
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 446:230-7. 2013

Collaborators

Detail Information

Publications15

  1. pmc Seasonal pulses of Marburg virus circulation in juvenile Rousettus aegyptiacus bats coincide with periods of increased risk of human infection
    Brian R Amman
    Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Pathog 8:e1002877. 2012
    ..aegyptiacus bats existing as a large meta-population with associated virus circulation over broad geographic ranges. These findings provide a basis for developing Marburg hemorrhagic fever risk reduction strategies...
  2. pmc Large serological survey showing cocirculation of Ebola and Marburg viruses in Gabonese bat populations, and a high seroprevalence of both viruses in Rousettus aegyptiacus
    Xavier Pourrut
    Institut de Recherche pour le Developpement, UR 178, Marseille, France
    BMC Infect Dis 9:159. 2009
    ..Recently, bats of multiple species have been identified as possible natural hosts of Zaire ebolavirus (ZEBOV) in Gabon and Republic of Congo, and also of marburgvirus (MARV) in Gabon and Democratic Republic of Congo...
  3. pmc Isolation of genetically diverse Marburg viruses from Egyptian fruit bats
    Jonathan S Towner
    Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA
    PLoS Pathog 5:e1000536. 2009
    ..These data indicate common Egyptian fruit bats can represent a major natural reservoir and source of Marburg virus with potential for spillover into humans...
  4. pmc Molecular evolution of viruses of the family Filoviridae based on 97 whole-genome sequences
    Serena A Carroll
    Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 87:2608-16. 2013
    ....
  5. pmc Marburg virus infection detected in a common African bat
    Jonathan S Towner
    Centers for Disease Control and Prevention, Special Pathogens Branch, Atlanta, Georgia, United States of America
    PLoS ONE 2:e764. 2007
    ..These data imply that more areas are at risk for MHF outbreaks than previously realized and correspond well with a recently published report in which three species of fruit bats were demonstrated to be likely reservoirs for Ebola virus...
  6. pmc Increased detection of Sin Nombre hantavirus RNA in antibody-positive deer mice from Montana, USA: evidence of male bias in RNA viremia
    Karoun H Bagamian
    Viral Special Pathogens Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30033, USA
    Viruses 5:2320-8. 2013
    ....
  7. pmc Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda
    Jonathan S Towner
    Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Pathog 4:e1000212. 2008
    ....
  8. ncbi request reprint High-throughput, luciferase-based reverse genetics systems for identifying inhibitors of Marburg and Ebola viruses
    Luke S Uebelhoer
    Centers for Disease Control and Prevention, Atlanta, USA
    Antiviral Res 106:86-94. 2014
    ..We anticipate that both approaches will prove highly useful in the development of anti-filovirus therapies, as well as in basic research on the filovirus life cycle. ..
  9. pmc Inhibition of IRF-3 activation by VP35 is critical for the high level of virulence of ebola virus
    Amy L Hartman
    Centers for Disease Control and Prevention, 1600 Clifton Rd, MS G 14, Atlanta, GA 30329, USA
    J Virol 82:2699-704. 2008
    ..Given that these viruses differ by only a single amino acid in the IRF-3 inhibitory domain of VP35, the level of alteration of virulence is remarkable and highlights the importance of VP35 for the pathogenesis of Ebola virus...
  10. ncbi request reprint Development of a reverse genetics system to generate recombinant Marburg virus derived from a bat isolate
    Cesar G Albarino
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 446:230-7. 2013
    ..Surprisingly, when these recombinant MARVs were propagated in primary human macrophages, a dramatic difference was found in their ability to grow and to elicit anti-viral cytokine responses. ..
  11. pmc Multiple virus lineages sharing recent common ancestry were associated with a Large Rift Valley fever outbreak among livestock in Kenya during 2006-2007
    Brian H Bird
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 14, Atlanta, GA 30329, USA
    J Virol 82:11152-66. 2008
    ....
  12. pmc Proportion of deaths and clinical features in Bundibugyo Ebola virus infection, Uganda
    Adam MacNeil
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 16:1969-72. 2010
    ..Although signs and symptoms were largely nonspecific and similar to those of EHF outbreaks caused by Zaire and Sudan Ebola viruses, proportion of deaths among those infected was lower (≈40%)...
  13. pmc Transmission ecology of Sin Nombre hantavirus in naturally infected North American deermouse populations in outdoor enclosures
    Karoun H Bagamian
    Population Biology, Ecology and Evolution Program, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 7:e47731. 2012
    ..The techniques pioneered in this study have implications for a wide range of zoonotic disease studies...
  14. ncbi request reprint High-throughput molecular detection of hemorrhagic fever virus threats with applications for outbreak settings
    Jonathan S Towner
    Special Pathogens Branch, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 196:S205-12. 2007
    ..Furthermore, the applicability of this method to an outbreak setting was demonstrated by correct analysis of >500 specimens at a field laboratory established during a recent outbreak of Marburg hemorrhagic fever in Angola...
  15. pmc Marburgvirus genomics and association with a large hemorrhagic fever outbreak in Angola
    Jonathan S Towner
    Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop G14, Atlanta, GA 30333, USA
    J Virol 80:6497-516. 2006
    ..This is in contrast to the 1998 to 2000 marburgvirus outbreak, where evidence of several virus genetic lineages (with up to 21% divergence) and multiple virus introductions into the human population was found...