Jonathan S Towner
Affiliation: Centers for Disease Control and Prevention
- Seasonal pulses of Marburg virus circulation in juvenile Rousettus aegyptiacus bats coincide with periods of increased risk of human infectionBrian R Amman
Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
PLoS Pathog 8:e1002877. 2012..aegyptiacus bats existing as a large meta-population with associated virus circulation over broad geographic ranges. These findings provide a basis for developing Marburg hemorrhagic fever risk reduction strategies...
- Large serological survey showing cocirculation of Ebola and Marburg viruses in Gabonese bat populations, and a high seroprevalence of both viruses in Rousettus aegyptiacusXavier Pourrut
Institut de Recherche pour le Developpement, UR 178, Marseille, France
BMC Infect Dis 9:159. 2009..Recently, bats of multiple species have been identified as possible natural hosts of Zaire ebolavirus (ZEBOV) in Gabon and Republic of Congo, and also of marburgvirus (MARV) in Gabon and Democratic Republic of Congo...
- Isolation of genetically diverse Marburg viruses from Egyptian fruit batsJonathan S Towner
Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA
PLoS Pathog 5:e1000536. 2009..These data indicate common Egyptian fruit bats can represent a major natural reservoir and source of Marburg virus with potential for spillover into humans...
- Molecular evolution of viruses of the family Filoviridae based on 97 whole-genome sequencesSerena A Carroll
Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Virol 87:2608-16. 2013....
- Marburg virus infection detected in a common African batJonathan S Towner
Centers for Disease Control and Prevention, Special Pathogens Branch, Atlanta, Georgia, United States of America
PLoS ONE 2:e764. 2007..These data imply that more areas are at risk for MHF outbreaks than previously realized and correspond well with a recently published report in which three species of fruit bats were demonstrated to be likely reservoirs for Ebola virus...
- Increased detection of Sin Nombre hantavirus RNA in antibody-positive deer mice from Montana, USA: evidence of male bias in RNA viremiaKaroun H Bagamian
Viral Special Pathogens Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30033, USA
Viruses 5:2320-8. 2013....
- Newly discovered ebola virus associated with hemorrhagic fever outbreak in UgandaJonathan S Towner
Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
PLoS Pathog 4:e1000212. 2008....
- High-throughput, luciferase-based reverse genetics systems for identifying inhibitors of Marburg and Ebola virusesLuke S Uebelhoer
Centers for Disease Control and Prevention, Atlanta, USA
Antiviral Res 106:86-94. 2014..We anticipate that both approaches will prove highly useful in the development of anti-filovirus therapies, as well as in basic research on the filovirus life cycle. ..
- Inhibition of IRF-3 activation by VP35 is critical for the high level of virulence of ebola virusAmy L Hartman
Centers for Disease Control and Prevention, 1600 Clifton Rd, MS G 14, Atlanta, GA 30329, USA
J Virol 82:2699-704. 2008..Given that these viruses differ by only a single amino acid in the IRF-3 inhibitory domain of VP35, the level of alteration of virulence is remarkable and highlights the importance of VP35 for the pathogenesis of Ebola virus...
- Development of a reverse genetics system to generate recombinant Marburg virus derived from a bat isolateCesar G Albarino
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Virology 446:230-7. 2013..Surprisingly, when these recombinant MARVs were propagated in primary human macrophages, a dramatic difference was found in their ability to grow and to elicit anti-viral cytokine responses. ..
- Multiple virus lineages sharing recent common ancestry were associated with a Large Rift Valley fever outbreak among livestock in Kenya during 2006-2007Brian H Bird
Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 14, Atlanta, GA 30329, USA
J Virol 82:11152-66. 2008....
- Proportion of deaths and clinical features in Bundibugyo Ebola virus infection, UgandaAdam MacNeil
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 16:1969-72. 2010..Although signs and symptoms were largely nonspecific and similar to those of EHF outbreaks caused by Zaire and Sudan Ebola viruses, proportion of deaths among those infected was lower (≈40%)...
- Transmission ecology of Sin Nombre hantavirus in naturally infected North American deermouse populations in outdoor enclosuresKaroun H Bagamian
Population Biology, Ecology and Evolution Program, Emory University, Atlanta, Georgia, United States of America
PLoS ONE 7:e47731. 2012..The techniques pioneered in this study have implications for a wide range of zoonotic disease studies...
- High-throughput molecular detection of hemorrhagic fever virus threats with applications for outbreak settingsJonathan S Towner
Special Pathogens Branch, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Infect Dis 196:S205-12. 2007..Furthermore, the applicability of this method to an outbreak setting was demonstrated by correct analysis of >500 specimens at a field laboratory established during a recent outbreak of Marburg hemorrhagic fever in Angola...
- Marburgvirus genomics and association with a large hemorrhagic fever outbreak in AngolaJonathan S Towner
Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop G14, Atlanta, GA 30333, USA
J Virol 80:6497-516. 2006..This is in contrast to the 1998 to 2000 marburgvirus outbreak, where evidence of several virus genetic lineages (with up to 21% divergence) and multiple virus introductions into the human population was found...