Ellen N Kersh

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. doi request reprint Evaluation of the lymphocyte trafficking drug FTY720 in SHIVSF162P3-infected rhesus macaques
    Ellen N Kersh
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Antimicrob Chemother 63:758-62. 2009
  2. doi request reprint Repeated rectal SHIVSF162P3 exposures do not consistently induce sustained T cell responses prior to systemic infection in the repeat-low dose preclinical macaque model
    Ellen N Kersh
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 25:905-17. 2009
  3. pmc Reduced inflammation and CD4 loss in acute SHIV infection during oral pre-exposure prophylaxis
    Ellen N Kersh
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 206:770-9. 2012
  4. pmc Susceptibility to repeated, low-dose, rectal SHIVSF162P3 challenge is independent of TRIM5 genotype in rhesus macaques
    Katherine Butler
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    AIDS Res Hum Retroviruses 29:1091-4. 2013
  5. doi request reprint Resistance to Simian HIV infection is associated with high plasma interleukin-8, RANTES and Eotaxin in a macaque model of repeated virus challenges
    Nattawan Promadej-Lanier
    From the Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Acquir Immune Defic Syndr 53:574-81. 2010
  6. doi request reprint Short communication: no evidence of occult SHIV infection as demonstrated by CD8+ cell depletion after chemoprophylaxis-induced protection from mucosal infection in rhesus macaques
    Ellen N Kersh
    Division of HIV AIDS Prevention, NCHHSTP, CCID, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 24:543-6. 2008
  7. pmc T cell chemo-vaccination effects after repeated mucosal SHIV exposures and oral pre-exposure prophylaxis
    Ellen N Kersh
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e19295. 2011
  8. doi request reprint High susceptibility to repeated, low-dose, vaginal SHIV exposure late in the luteal phase of the menstrual cycle of pigtail macaques
    Sundaram A Vishwanathan
    Division of HIV AIDS Prevention, CDC, Atlanta, GA 30329, USA
    J Acquir Immune Defic Syndr 57:261-4. 2011
  9. pmc Short communication: Viremic control is independent of repeated low-dose SHIVSF162p3 exposures
    Tara R Henning
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia
    AIDS Res Hum Retroviruses 30:1125-9. 2014
  10. pmc Relationship of Estimated SHIV Acquisition Time Points During the Menstrual Cycle and Thinning of Vaginal Epithelial Layers in Pigtail Macaques
    Ellen N Kersh
    From the National Center for HIV AIDS, Viral Hepatitis, STD and TB Prevention and National Center for Emerging and Zoonotic Infectious Diseases, CDC, Atlanta, GA and Total Solutions Inc, Atlanta, GA
    Sex Transm Dis 42:694-701. 2015

Collaborators

  • Walid Heneine
  • J Gerardo Garcia-Lerma
  • Sunita Sharma
  • Qi Zheng
  • Dennis Ellenberger
  • James M Smith
  • James Arthos
  • Claudia Cicala
  • Lutz Walter
  • Welkin E Johnson
  • Janet M McNicholl
  • Katherine Butler
  • Tara R Henning
  • Sundaram A Vishwanathan
  • Siddappa N Byrareddy
  • Charles Dobard
  • Debra L Hanson
  • Sharon Dietz Ostergaard
  • Theodros S Tsegaye
  • MONICA R MORRIS
  • Francois Villinger
  • Aftab A Ansari
  • Tara C Henning
  • Jessica Radzio
  • Debra Hanson
  • Wei Luo
  • Priya Srinivasan
  • R Michael Hendry
  • Patricia C Guenthner
  • Debra R Adams
  • Ron A Otten
  • Nattawan Promadej-Lanier
  • Jeltley Montague
  • Nathaniel Powell
  • George Lathrop
  • David Garber
  • Ryan Johnson
  • Rachael D Aubert
  • Sherif Zaki
  • Jeanine Sanders
  • Shanon Ellis
  • Jana Ritter
  • Sherif R Zaki
  • Jana M Ritter
  • Anthony S Fauci
  • Gerardo Garcia-Lerma
  • Tara Villinger
  • Kenneth Rogers
  • Keith A Reimann
  • Brianne Kallam
  • Philip J Santangelo
  • Dawn Little
  • Joseph Hiatt
  • Markus Brameier
  • Fatima Nawaz
  • Paul Dunbar
  • Ann E Mayne
  • Tristram G Parslow
  • Jennifer S Morgan
  • Janet McNicholl
  • Debra Adams
  • Carol Y Lin
  • Sal Butera

Detail Information

Publications19

  1. doi request reprint Evaluation of the lymphocyte trafficking drug FTY720 in SHIVSF162P3-infected rhesus macaques
    Ellen N Kersh
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Antimicrob Chemother 63:758-62. 2009
    ..We address here whether therapeutic use of FTY720 in simian human immunodeficiency virus (SHIV)-infected rhesus macaques could also decrease viraemia...
  2. doi request reprint Repeated rectal SHIVSF162P3 exposures do not consistently induce sustained T cell responses prior to systemic infection in the repeat-low dose preclinical macaque model
    Ellen N Kersh
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 25:905-17. 2009
    ..Our results provide further insights into the repeat exposure macaque model. We find that this model can be used for testing biomedical prevention strategies without concern of eliciting a systemic vaccination effect...
  3. pmc Reduced inflammation and CD4 loss in acute SHIV infection during oral pre-exposure prophylaxis
    Ellen N Kersh
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 206:770-9. 2012
    ..We addressed the hypothesis that SHIV(SF162P3) infection despite active PrEP results in altered early immune parameters, compared with untreated infection...
  4. pmc Susceptibility to repeated, low-dose, rectal SHIVSF162P3 challenge is independent of TRIM5 genotype in rhesus macaques
    Katherine Butler
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    AIDS Res Hum Retroviruses 29:1091-4. 2013
    ..The finding that TRIM5 alleles do not restrict mucosal infection or ensuing replication rates suggests that SHIVSF162P3 is indeed suitable for RLD experimentation...
  5. doi request reprint Resistance to Simian HIV infection is associated with high plasma interleukin-8, RANTES and Eotaxin in a macaque model of repeated virus challenges
    Nattawan Promadej-Lanier
    From the Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Acquir Immune Defic Syndr 53:574-81. 2010
    ..Future direct evaluation of these or other factors in the animal model may be beneficial for developing new immunomodulation strategies for HIV prevention...
  6. doi request reprint Short communication: no evidence of occult SHIV infection as demonstrated by CD8+ cell depletion after chemoprophylaxis-induced protection from mucosal infection in rhesus macaques
    Ellen N Kersh
    Division of HIV AIDS Prevention, NCHHSTP, CCID, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 24:543-6. 2008
    ..These data provide important information for PrEP usage to prevent HIV transmission, and fully support the continued pursuit of PrEP prevention measures in humans...
  7. pmc T cell chemo-vaccination effects after repeated mucosal SHIV exposures and oral pre-exposure prophylaxis
    Ellen N Kersh
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e19295. 2011
    ..Our findings highlight the importance of monitoring these responses in clinical PrEP trials and suggest that a combination of vaccines and PrEP potentially might enhance efficacy...
  8. doi request reprint High susceptibility to repeated, low-dose, vaginal SHIV exposure late in the luteal phase of the menstrual cycle of pigtail macaques
    Sundaram A Vishwanathan
    Division of HIV AIDS Prevention, CDC, Atlanta, GA 30329, USA
    J Acquir Immune Defic Syndr 57:261-4. 2011
    ..Our data support the findings of higher susceptibility to HIV in women during progesterone-dominated periods including pregnancy and contraceptive use...
  9. pmc Short communication: Viremic control is independent of repeated low-dose SHIVSF162p3 exposures
    Tara R Henning
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia
    AIDS Res Hum Retroviruses 30:1125-9. 2014
    ..These data also indicate that both the vaginal and rectal repeated low-dose virus exposure models using SHIV(SF162p3) provide a reliable system for nonhuman primate studies...
  10. pmc Relationship of Estimated SHIV Acquisition Time Points During the Menstrual Cycle and Thinning of Vaginal Epithelial Layers in Pigtail Macaques
    Ellen N Kersh
    From the National Center for HIV AIDS, Viral Hepatitis, STD and TB Prevention and National Center for Emerging and Zoonotic Infectious Diseases, CDC, Atlanta, GA and Total Solutions Inc, Atlanta, GA
    Sex Transm Dis 42:694-701. 2015
    ..This model previously revealed increased susceptibility to vaginal infection during and after progesterone-dominated periods in the menstrual cycle...
  11. pmc Repeated Vaginal SHIV Challenges in Macaques Receiving Oral or Topical Preexposure Prophylaxis Induce Virus-Specific T-Cell Responses
    Theodros S Tsegaye
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, NCHHSTP, Laboratory Branch, Atlanta, GA
    J Acquir Immune Defic Syndr 69:385-94. 2015
    ..This report expands those initial findings by examining a larger group of macaques that were given oral or topical PrEP during repeated vaginal virus exposure...
  12. pmc Relationship of menstrual cycle and vaginal infection in female rhesus macaques challenged with repeated, low doses of SIVmac251
    MONICA R MORRIS
    Total Solutions, Atlanta, GA, USA
    J Med Primatol 44:301-5. 2015
    ..Eight of nine rhesus macaques became infected around menstruation time. ..
  13. pmc Short Communication: Practical Experience with Analysis and Design of Repeat Low-Dose SHIVSF162P3 Exposure Studies in Female Pigtail Macaques with Varying Susceptibility During Menstrual Cycling
    Ellen N Kersh
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia
    AIDS Res Hum Retroviruses 31:1166-9. 2015
    ..Menstrual cycle analysis may also avoid potential overestimation of efficacy against vaginal challenges during low susceptibility periods in the cycle that are unlikely to cause infection. ..
  14. pmc SHIV susceptibility changes during the menstrual cycle of pigtail macaques
    Ellen N Kersh
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
    J Med Primatol 43:310-6. 2014
    ..Hormonal changes during menstrual cycling may affect susceptibility to HIV...
  15. pmc Macaque models of enhanced susceptibility to HIV
    Tara R Henning
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road NE, MS A 25, Atlanta, GA, 30333, USA
    Virol J 12:90. 2015
    ..The use of enhanced susceptibility macaque models would benefit multiple facets of the HIV research field, including basic acquisition and pathogenesis studies as well as the vaccine and other biomedical preventions pipeline. ..
  16. doi request reprint Analysis of putative mucosal SHIV susceptibility factors during repeated DMPA treatments in pigtail macaques
    Katherine Butler
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, Sexually Transmitted Disease and Tuberculosis Prevention, CDC, Atlanta, GA, USA
    J Med Primatol 44:286-95. 2015
    ..We used a pigtail macaque model to document the effects of repeated DMPA treatments and their potential contribution to increased SHIV susceptibility...
  17. pmc Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection
    Siddappa N Byrareddy
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Nat Med 20:1397-400. 2014
    ..Thus, targeting α4β7 reduces mucosal transmission of SIV in macaques. ..
  18. pmc A combined oral contraceptive affects mucosal SHIV susceptibility factors in a pigtail macaque (Macaca nemestrina) model
    Sharon Dietz Ostergaard
    Animal Resources Branch, Division of Scientific Resources, National Center for Emerging Zoonotic and Infectious Diseases, CDC, Atlanta, GA, USA
    J Med Primatol 44:97-107. 2015
    ..We established, for the first time, a model to investigate whether combined oral contraceptives (COC) alter SHIV susceptibility in macaques...
  19. doi request reprint Non-human primate models of hormonal contraception and HIV
    Janet M McNicholl
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Am J Reprod Immunol 71:513-22. 2014
    ..This is, in part, because some experiments which would be difficult or logistically impossible in women are more easily conducted in NHP...