Alex R Hoffmaster

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc Molecular subtyping of Bacillus anthracis and the 2001 bioterrorism-associated anthrax outbreak, United States
    Alex R Hoffmaster
    Centers for Desease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 8:1111-6. 2002
  2. pmc Characterization of Bacillus cereus isolates associated with fatal pneumonias: strains are closely related to Bacillus anthracis and harbor B. anthracis virulence genes
    Alex R Hoffmaster
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, MS G34, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, Georgia 30333, USA
    J Clin Microbiol 44:3352-60. 2006
  3. pmc Bacillus anthracis in China and its relationship to worldwide lineages
    Tatum S Simonson
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
    BMC Microbiol 9:71. 2009
  4. pmc Genetic diversity of clinical isolates of Bacillus cereus using multilocus sequence typing
    Alex R Hoffmaster
    National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, USA
    BMC Microbiol 8:191. 2008
  5. pmc Phylogeographic reconstruction of a bacterial species with high levels of lateral gene transfer
    Talima Pearson
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, USA
    BMC Biol 7:78. 2009
  6. pmc Characterization of novel Brucella strains originating from wild native rodent species in North Queensland, Australia
    Rebekah V Tiller
    Centers for Disease Control and Prevention, Mail Stop G34, 1600 Clifton Road, Atlanta, GA 30333, USA
    Appl Environ Microbiol 76:5837-45. 2010
  7. pmc Genetic diversity in a Bacillus anthracis historical collection (1954 to 1988)
    David Sue
    Bacterial Zoonoses Branch, Division of Foodborne, Bacterial and Mycotic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, NE, Atlanta, Georgia 30333, USA
    J Clin Microbiol 45:1777-82. 2007
  8. pmc Identification of anthrax toxin genes in a Bacillus cereus associated with an illness resembling inhalation anthrax
    Alex R Hoffmaster
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 101:8449-54. 2004
  9. pmc Identification of an unusual Brucella strain (BO2) from a lung biopsy in a 52 year-old patient with chronic destructive pneumonia
    Rebekah V Tiller
    Division of Foodborne, Bacterial, and Mycotic Diseases and Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    BMC Microbiol 10:23. 2010
  10. pmc Capsule production in Bacillus cereus strains associated with severe pneumonia
    David Sue
    Bacterial Zoonoses Branch, Division of Foodborne, Bacterial and Mycotic Diseases, National Center for Zoonotic Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, Georgia 30333, USA
    J Clin Microbiol 44:3426-8. 2006

Detail Information

Publications36

  1. pmc Molecular subtyping of Bacillus anthracis and the 2001 bioterrorism-associated anthrax outbreak, United States
    Alex R Hoffmaster
    Centers for Desease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 8:1111-6. 2002
    ..In addition, subtyping rapidly identified laboratory contaminants and nonoutbreak-related isolates...
  2. pmc Characterization of Bacillus cereus isolates associated with fatal pneumonias: strains are closely related to Bacillus anthracis and harbor B. anthracis virulence genes
    Alex R Hoffmaster
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, MS G34, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, Georgia 30333, USA
    J Clin Microbiol 44:3352-60. 2006
    ..cereus strains can cause severe and even fatal infections in patients who appear to be otherwise healthy...
  3. pmc Bacillus anthracis in China and its relationship to worldwide lineages
    Tatum S Simonson
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
    BMC Microbiol 9:71. 2009
    ..Canonical single nucleotide polymorphism (canSNP) and multiple locus VNTR analysis (MLVA) typing has been used to examine this archival collection of isolates...
  4. pmc Genetic diversity of clinical isolates of Bacillus cereus using multilocus sequence typing
    Alex R Hoffmaster
    National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, USA
    BMC Microbiol 8:191. 2008
    ..thuringiensis. In this study we used MLST to determine if B. cereus isolates associated with illnesses of varying severity (e.g., severe, systemic vs. gastrointestinal (GI) illness) were clonal or formed clonal complexes...
  5. pmc Phylogeographic reconstruction of a bacterial species with high levels of lateral gene transfer
    Talima Pearson
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, USA
    BMC Biol 7:78. 2009
    ..We compared and searched 43 whole genome sequences of B. pseudomallei and its closest relatives for single nucleotide polymorphisms in orthologous shared regions to use in phylogenetic reconstruction...
  6. pmc Characterization of novel Brucella strains originating from wild native rodent species in North Queensland, Australia
    Rebekah V Tiller
    Centers for Disease Control and Prevention, Mail Stop G34, 1600 Clifton Road, Atlanta, GA 30333, USA
    Appl Environ Microbiol 76:5837-45. 2010
    ..Our findings strongly suggest that this group of Brucella strains isolated from wild Australian rodents defines a new species in the Brucella genus...
  7. pmc Genetic diversity in a Bacillus anthracis historical collection (1954 to 1988)
    David Sue
    Bacterial Zoonoses Branch, Division of Foodborne, Bacterial and Mycotic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, NE, Atlanta, Georgia 30333, USA
    J Clin Microbiol 45:1777-82. 2007
    ..MLVA revealed that 39 of the 124 isolates were previously undocumented genotypes and that 1 isolate was found to be in the C cluster when it was subtyped by MLVA...
  8. pmc Identification of anthrax toxin genes in a Bacillus cereus associated with an illness resembling inhalation anthrax
    Alex R Hoffmaster
    Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 101:8449-54. 2004
    ..In this study, we combined a public health approach with genome analysis to provide insight into the correlation of phenotypic characteristics and their genetic basis...
  9. pmc Identification of an unusual Brucella strain (BO2) from a lung biopsy in a 52 year-old patient with chronic destructive pneumonia
    Rebekah V Tiller
    Division of Foodborne, Bacterial, and Mycotic Diseases and Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    BMC Microbiol 10:23. 2010
    ..In this study we report on the identification of an unusual Brucella-like strain (BO2) isolated from a lung biopsy in a 52-year-old patient in Australia with a clinical history of chronic destructive pneumonia...
  10. pmc Capsule production in Bacillus cereus strains associated with severe pneumonia
    David Sue
    Bacterial Zoonoses Branch, Division of Foodborne, Bacterial and Mycotic Diseases, National Center for Zoonotic Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, Georgia 30333, USA
    J Clin Microbiol 44:3426-8. 2006
    ..cereus isolates associated with human illness. We found that the extent of capsule expression was influenced by culturing conditions. Our findings highlight consequent clinical and laboratory diagnostic challenges posed by such isolates...
  11. pmc Molecular approaches to identify and differentiate Bacillus anthracis from phenotypically similar Bacillus species isolates
    Chung K Marston
    Meningitis and Special Pathogens Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS G34, Atlanta, Georgia 30333, USA
    BMC Microbiol 6:22. 2006
    ....
  12. pmc Molecular epidemiology of anthrax cases associated with recreational use of animal hides and yarn in the United States
    Chung K Marston
    Bacterial Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e28274. 2011
    ..e., contamination by a single genotype versus widespread contamination of numerous genotypes). These cases illustrate the need to acquire and genotype global isolates so that accurate assignments can be made about isolate origins...
  13. pmc Effects of long-term storage on plasmid stability in Bacillus anthracis
    Chung K Marston
    Centers for Disease Control and Prevention, 1600 Clifton Rd, MS G34, Atlanta, GA 30333, USA
    Appl Environ Microbiol 71:7778-80. 2005
    ..25), but there was a statistical interdependence between the two plasmids (P = 0.004). Loss of viability of B. anthracis cultures stored on agar slants is also discussed...
  14. doi request reprint Identification and characterization of clinical Bacillus spp. isolates phenotypically similar to Bacillus anthracis
    Cari A Beesley
    Centers for Disease Control and Prevention, Atlanta, GA, USA
    FEMS Microbiol Lett 313:47-53. 2010
    ..Further work is necessary to understand whether these strains are opportunistic pathogens or just contaminates...
  15. pmc Lethal factor toxemia and anti-protective antigen antibody activity in naturally acquired cutaneous anthrax
    Anne E Boyer
    Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Infect Dis 204:1321-7. 2011
    ..This is the first report of quantitative analysis of serum LF in cutaneous anthrax and the first to associate acute stage toxemia with subsequent antitoxin antibody responses...
  16. pmc Bioterrorism-related inhalational anthrax in an elderly woman, Connecticut, 2001
    Kevin S Griffith
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 9:681-8. 2003
    ..The evidence suggests she was exposed through a cross-contaminated bulk mail letter. Such cross-contamination of letters and postal facilities has implications for managing the response to future B. anthracis-contaminated mailings...
  17. pmc Use of 16S rRNA gene sequencing for rapid identification and differentiation of Burkholderia pseudomallei and B. mallei
    Jay E Gee
    Meningitis and Special Pathogens Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 41:4647-54. 2003
    ..This report provides a basis for rapidly identifying and differentiating B. pseudomallei and B. mallei by molecular methods...
  18. pmc Kinetics of lethal factor and poly-D-glutamic acid antigenemia during inhalation anthrax in rhesus macaques
    Anne E Boyer
    Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Infect Immun 77:3432-41. 2009
    ..This study emphasizes the value of LF detection as a tool for early diagnosis of inhalation anthrax before the onset of fulminant systemic infection...
  19. pmc A Review of Melioidosis Cases in the Americas
    Tina J Benoit
    Bacterial Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia Universidade de Fortaleza UNIFOR, Fortaleza, Brazil School of Pathology and Laboratory Medicine, University of Western Australia, Western Australia, Australia
    Am J Trop Med Hyg 93:1134-9. 2015
    ..Burkholderia pseudomallei appears to be widespread in South, Central, and North America. ..
  20. pmc High-sensitivity MALDI-TOF MS quantification of anthrax lethal toxin for diagnostics and evaluation of medical countermeasures
    Anne E Boyer
    Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA
    Anal Bioanal Chem 407:2847-58. 2015
    ..This demonstrated the importance of LTx as a diagnostic and therapeutic target. This method provides a sensitive, accurate tool for anthrax toxin detection and evaluation of PA-directed therapeutics...
  21. pmc Natural infection of Burkholderia pseudomallei in an imported pigtail macaque (Macaca nemestrina) and management of the exposed colony
    Crystal H Johnson
    National Center for Emerging and Zoonotic Infectious Diseases, Division of Scientific Resources, Animal Resources Branch, Atlanta, Georgia, USA Center for Comparative Medicine and Surgery, Icahn School of Medicine at Mt Sinai, New York, New York, USA
    Comp Med 63:528-35. 2013
    ..This article also provides relevant information on addressing matters related to regulatory issues and risk management of potentially exposed animals and animal care staff. ..
  22. pmc A two-component direct fluorescent-antibody assay for rapid identification of Bacillus anthracis
    Barun K De
    Centers for Desease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 8:1060-5. 2002
    ..The two-component DFA assay is a sensitive, specific, and rapid confirmatory test for B. anthracis in cultures and may be useful directly on clinical specimens...
  23. pmc Anthrax Toxin-Expressing Bacillus cereus Isolated from an Anthrax-Like Eschar
    Chung K Marston
    National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States of America
    PLoS ONE 11:e0156987. 2016
    ..cereus infection which resulted in the detection of anthrax lethal factor toxemia, a quantifiable serum antibody response to protective antigen (PA), and lethal toxin neutralization activity. ..
  24. doi request reprint Contact investigation of melioidosis cases reveals regional endemicity in Puerto Rico
    Thomas J Doker
    Epidemic Intelligence Service Bacterial Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia
    Clin Infect Dis 60:243-50. 2015
    ..Fatal and nonfatal melioidosis cases were identified in Puerto Rico in 2010 and 2012, respectively, which prompted contact investigations to identify risk factors for infection and evaluate endemicity...
  25. pmc Comparison of DNA extraction kits for detection of Burkholderia pseudomallei in spiked human whole blood using real-time PCR
    Nicole L Podnecky
    Bacterial Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 8:e58032. 2013
    ....
  26. pmc Swab protocol for rapid laboratory diagnosis of cutaneous anthrax
    Leslie A Dauphin
    Bioterrorism Rapid Response and Advanced Technology BRRAT Laboratory, Division of Preparedness and Emerging Infections DPEI, National Center for Emerging and Zoonotic Infectious Diseases NCEZID, Centers for Disease Control and Prevention CDC, Atlanta, Georgia, USA
    J Clin Microbiol 50:3960-7. 2012
    ..anthracis from swabs at ≥ 7 days. Thus, we recommend the use of the SETS method with subsequent testing by culture and real-time PCR for diagnosis of cutaneous anthrax from clinical swabs of cutaneous lesions...
  27. doi request reprint Comparison of four commercial IgM and IgG ELISA kits for diagnosing brucellosis
    Moustafa Abdel Fadeel
    National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    J Med Microbiol 60:1767-73. 2011
    ..None of the diagnostic assays was 100% reliable for diagnosing brucellosis; therefore, serology results need to be considered in tandem with patient history, clinical signs and other test results...
  28. pmc Comparison of two multiple-locus variable-number tandem-repeat analysis methods for molecular strain typing of human Brucella melitensis isolates from the Middle East
    Rebekah V Tiller
    US Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Clin Microbiol 47:2226-31. 2009
    ..melitensis strains...
  29. doi request reprint Safety assessment of recalled Haemophilus influenzae type b (Hib) conjugate vaccines--United States, 2007-2008
    Wan Ting Huang
    Epidemic Intelligence Service, Career Development Division, Office of the Workforce and Career Development, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Pharmacoepidemiol Drug Saf 19:306-10. 2010
    ..Enhanced postrecall surveillance was conducted to detect vaccine-associated B. cereus infections...
  30. ncbi request reprint Comparison of four selective media for the isolation of Burkholderia mallei and Burkholderia pseudomallei
    Mindy B Glass
    Bacterial Zoonoses Branch, Division of Foodborne, Bacterial, and Mycotic Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 80:1023-8. 2009
    ..mallei. Pseudomonas cepacia agar was highly sensitive and selective for both organisms. In non-endemic areas, we suggest the use of the commercially available PC agar for the isolation of B. mallei and B. pseudomallei...
  31. pmc Rapid identification and discrimination of Brucella isolates by use of real-time PCR and high-resolution melt analysis
    Jonas M Winchell
    National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 48:697-702. 2010
    ..This assay provides a useful diagnostic tool that can rapidly type Brucella isolates and has the potential to detect novel species. This approach may also prove helpful for clinical, epidemiological and veterinary investigations...
  32. doi request reprint Detection of pathogenic Leptospira spp. through TaqMan polymerase chain reaction targeting the LipL32 gene
    Robyn A Stoddard
    National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Diagn Microbiol Infect Dis 64:247-55. 2009
    ..Leptospira spiked at the same concentration was better detected in centrifuged urine. This real-time PCR assay with high specificity and sensitivity may prove to be a rapid method for diagnosing acute leptospirosis...
  33. pmc Draft Genome Sequence of Bacillus cereus Strain BcFL2013, a Clinical Isolate Similar to G9241
    Jay E Gee
    Bacterial Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Department of Health and Human Services, Atlanta, Georgia, USA
    Genome Announc 2:. 2014
    ..Bacillus cereus strains, such as G9241, causing anthrax-like illnesses have recently been discovered. We report the genome sequence of a clinical strain, B. cereus BcFL2013, which is similar to G9241, recovered from a patient in Florida. ..
  34. pmc Evaluation of a latex agglutination assay for the identification of Burkholderia pseudomallei and Burkholderia mallei
    Brea D Duval
    Bacterial Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 90:1043-6. 2014
    ..A total of 110 B. pseudomallei and B. mallei were tested, and 36 closely related Burkholderia species. The latex agglutination assay was positive for 109 of 110 (99.1% sensitivity) B. pseudomallei and B. mallei isolates tested. ..
  35. pmc Fatal Burkholderia pseudomallei infection initially reported as a Bacillus species, Ohio, 2013
    Thomas J Doker
    Epidemic Intelligence Service, and Bacterial Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia Ohio Department of Health, Columbus, Ohio Pike County General Health District, Waverly, Ohio
    Am J Trop Med Hyg 91:743-6. 2014
    ..Physicians and laboratories should be aware of this potentially emerging disease and refer positive cultures to a Laboratory Response Network laboratory. ..
  36. pmc Viability of Leptospira isolates from a human outbreak in Thailand in various water types, pH, and temperature conditions
    Robyn A Stoddard
    Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 91:1020-2. 2014
    ..Lengthening the study and looking at virulence and maintenance in the host could yield additional information about this outbreak. ..